PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM31	0	TRIM31	0	two hybrid	Reymond A (2001)	1
UBE2D3	1	MKRN3	2	two hybrid	Markson G (2009)	1
TRIM31	0	NLRP3	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Song H (2016), Song H (2016), Song H (2016), Song H (2016)	4
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
UBE2W	0	TRIM31	0	two hybrid	Markson G (2009)	1
MAGEA1	0	NSMCE4A	0	affinity chromatography technology, affinity chromatography technology	Hudson JJ (2011), Kozakova L (2015)	2
UBE2D3	1	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
MNAT1	0	TRIM31	0	two hybrid	Woodsmith J (2012)	1
MAGEE2	0	MNAT1	0	two hybrid	Kozakova L (2015)	1
TRIM31	0	EID3	1	pull down	Kozakova L (2015)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2K	0	TRIM31	0	two hybrid	Markson G (2009)	1
IKBKG	0	TRIM23	3	affinity chromatography technology, affinity chromatography technology	Arimoto K (2010), Arimoto K (2010)	2
UBE2K	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D1	0	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
MAGEE2	0	TRIM31	0	affinity chromatography technology	Kozakova L (2015)	1
USP7	14	TRIM31	0	two hybrid	Hayes SD (2012)	1
UBE2W	0	TRIM27	2	two hybrid	Markson G (2009)	1
TRIM23	3	UBE2W	0	pull down	Dawidziak DM (2017)	1
EID3	1	MAGEA1	0	affinity chromatography technology, affinity chromatography technology	Hudson JJ (2011), Hudson JJ (2011)	2
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
MNAT1	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2E2	1	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
TRIM23	3	UBE2D2	0	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
UBE2E2	1	TRIM23	3	two hybrid	Markson G (2009)	1
UBE2D2	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
IKBKG	0	TRIM31	0	two hybrid	Ravasi T (2010)	1
UBE2K	0	TRIM27	2	two hybrid	Markson G (2009)	1
TRIM31	0	MAGEA2B	0	two hybrid	Rolland T (2014)	1
UBE2D3	1	TRIM31	0	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
UBE2D2	0	TRIM31	0	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
UBE2D4	0	TRIM31	0	two hybrid	Markson G (2009)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
UBE2D4	0	MKRN3	2	two hybrid	Markson G (2009)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
UBE2D1	0	TRIM31	0	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
UBE2E2	1	TRIM31	0	two hybrid	Napolitano LM (2011)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
MAGEA1	0	TRIM31	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Kozakova L (2015), Kozakova L (2015), Kozakova L (2015)	5
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
TRIM31	0	ZSCAN1	2	two hybrid	Ravasi T (2010)	1
UBE2W	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRAF2	1	TRIM31	0	two hybrid	Rual JF (2005)	1
TRIM23	3	UBE2D3	1	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
TRIM31	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Liu B (2017), Liu B (2017)	2
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
UBE2D1	0	MKRN3	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRIM31	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
TRIM23	3	UBE2D4	0	pull down	Dawidziak DM (2017)	1
TRIM31	0	NSMCE4A	0	affinity chromatography technology, pull down	Kozakova L (2015), Kozakova L (2015)	2
UBE2E2	1	TRIM27	2	two hybrid	Napolitano LM (2011)	1