PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXL13	1	RAPGEF4	8	affinity chromatography technology	Fung E (2018)	1
RAPGEF4	8	ZC3H11A	4	two hybrid	Corominas R (2014)	1
RAPGEF4	8	RAP1A	1	enzymatic study	de Rooij J (2000)	1
ATXN1	2	RAPGEF4	8	two hybrid	Lim J (2006)	1
RIMS2	1	RAPGEF4	8	affinity chromatography technology, affinity chromatography technology	Shibasaki T (2004), Kashima Y (2001)	2
RAPGEF4	8	TSPOAP1	9	two hybrid	Corominas R (2014)	1
RAPGEF4	8	TRAF2	1	two hybrid	Corominas R (2014)	1
ABCC8	11	RAPGEF4	8	affinity chromatography technology	Shibasaki T (2004)	1
ATXN1	2	TRAF2	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
RAPGEF4	8	SWAP70	2	two hybrid	Corominas R (2014)	1
RAPGEF4	8	RAP2A	0	enzymatic study	de Rooij J (2000)	1
RAPGEF4	8	C16orf45	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2