PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADAP1	3	RANBP9	5	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Haase A (2008), Haase A (2008), Haase A (2008), Haase A (2008)	4
GOLGA2	2	ADAP1	3	two hybrid	Rolland T (2014)	1
ADAP1	3	PRKD1	7	pull down, enzymatic study	Zemlickova E (2003), Zemlickova E (2003)	2
ADAP1	3	ANP32A	3	biochemical	Dubois T (2003)	1
ADAP1	3	SDCBP2	2	two hybrid	Rolland T (2014)	1
PRKCZ	5	PRKCI	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
PSME3	0	ADAP1	3	two hybrid	Stelzl U (2005)	1
PRKCZ	5	NCL	1	enzymatic study	Zhou G (1997)	1
ADAP1	3	PRKCI	1	affinity chromatography technology, pull down	Zemlickova E (2003), Zemlickova E (2003)	2
PRKCZ	5	GSK3B	1	imaging technique	Chen TC (2014)	1
GSK3B	1	ADAP1	3	two hybrid	Vinayagam A (2011)	1
PRKCE	6	ADAP1	3	enzymatic study	Zemlickova E (2003)	1
ARF6	0	ADAP1	3	affinity chromatography technology	Venkateswarlu K (2005)	1
GADD45A	1	ADAP1	3	two hybrid	Vinayagam A (2011)	1
ADAP1	3	PRKCZ	5	affinity chromatography technology, pull down, enzymatic study	Zemlickova E (2003), Zemlickova E (2003), Zemlickova E (2003)	3
ADAP1	3	NCL	1	biochemical, pull down, affinity chromatography technology, pull down	Dubois T (2003), Dubois T (2003), Dubois T (2003), Haase A (2008)	4
ADAP1	3	PIK3CA	8	pull down, enzymatic study	Zemlickova E (2003), Zemlickova E (2003)	2
CSNK1A1	1	ADAP1	3	biochemical, pull down, affinity chromatography technology	Dubois T (2002), Dubois T (2001), Dubois T (2001)	3
DVL3	7	ADAP1	3	two hybrid	Rolland T (2014)	1