PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
JUN	0	ATF7	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Li X (2015)	2
FOSL2	2	JUN	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pognonec P (1997), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	6
ATF7	0	MAPK8	3	affinity chromatography technology	Li H (2001)	1
HNRNPL	3	MEF2A	1	affinity chromatography technology	Fei T (2017)	1
FOS	0	CREB5	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
NFATC2	1	MBD3	4	affinity chromatography technology	Gabriel CH (2016)	1
PTP4A1	0	ATF7	0	two hybrid, pull down	Peters CS (2001), Peters CS (2001)	2
JDP2	1	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down	Murata T (2008), Murata T (2008), Cherasse Y (2008)	3
NFATC2	1	ATF7	0	affinity chromatography technology	Gabriel CH (2016)	1
ATF2	1	CREB1	1	biochemical	Wan C (2015)	1
JUN	0	BCL6	6	pull down, pull down, two hybrid	Vasanwala FH (2002), Vasanwala FH (2002), Vasanwala FH (2002)	3
TAF4	4	TAF12	0	far western blotting, x-ray crystallography, pull down	Guermah M (2001), Werten S (2002), Shao H (2005)	3
TAF4	4	CREB1	1	affinity chromatography technology	Mayr BM (2005)	1
FOS	0	NFATC1	12	affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016)	2
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
JUNB	0	CREB5	4	affinity chromatography technology	Huttlin EL (2017)	1
ATF2	1	FOS	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hai T (1991), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Rolland T (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	8
CREB5	4	BACH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
BATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
MLLT6	2	CREB5	4	affinity chromatography technology	Huttlin EL (2017)	1
FOS	0	PSMC5	4	two hybrid	Rolland T (2014)	1
BATF3	0	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF7	0	TMEM239	0	two hybrid	Rolland T (2014)	1
JUNB	0	YY1	7	affinity chromatography technology	Wang CC (2007)	1
ATF7	0	OCIAD1	1	pull down	Miyamoto-Sato E (2010)	1
BATF3	0	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
JDP2	1	JUN	0	affinity chromatography technology, affinity chromatography technology	Kimura M (2008), Li X (2015)	2
YY1	7	CREB1	1	pull down, two hybrid	Zhou Q (1995), Zhou Q (1995)	2
HNRNPL	3	FOSL2	2	affinity chromatography technology	Fei T (2017)	1
FOSL2	2	JUNB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mathas S (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CREB5	4	JUN	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura N (1993), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	5
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
HNRNPL	3	ATF7	0	affinity chromatography technology	Fei T (2017)	1
55844	0	JUN	0	affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2017)	2
ATF7	0	MBD3	4	two hybrid	Yu H (2011)	1
ARIH1	3	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
CREB5	4	ATF7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK8	3	JUNB	0	affinity chromatography technology	Fuchs SY (1997)	1
ATF2	1	MAPK8	3	pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study	Raingeaud J (1995), Fuchs SY (1997), Chen Z (2001), Tournier C (1997), Pipaon C (2004), Pipaon C (2004), Pillai VB (2011), Jensen LE (2003), Jensen LE (2003), Deacon K (1997), Bustelo XR (1997), Gupta S (1996), Yao K (2007), Li H (2001), Sanna MG (2002)	15
NFATC2	1	FOS	0	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
ATF2	1	BACH1	3	fluorescent resonance energy transfe	Reinke AW (2013)	1
FOSL2	2	CREB5	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
NFATC1	12	ATF7	0	affinity chromatography technology	Gabriel CH (2016)	1
HNRNPL	3	URI1	2	affinity chromatography technology	Fei T (2017)	1
NFATC1	12	NFATC2	1	affinity chromatography technology	Gabriel CH (2016)	1
ATF7	0	TAOK3	4	pull down	Miyamoto-Sato E (2010)	1
FOS	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	7
JDP2	1	ATF7	0	affinity chromatography technology	Kimura M (2008)	1
MLLT6	2	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
NFATC1	12	CREB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	3
NFATC2	1	JUN	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nguyen TN (2010), Nguyen TN (2010), Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	5
ATF2	1	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
NFATC1	12	JUNB	0	affinity chromatography technology	Gabriel CH (2016)	1
MAPK8	3	NFATC2	1	affinity chromatography technology	Zaichuk TA (2004)	1
FOSL2	2	ATF7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
BATF3	0	BACH1	3	affinity chromatography technology	Huttlin EL (2017)	1
BACH1	3	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
MEF2A	1	ATF7	0	affinity chromatography technology	Li X (2015)	1
ATF7	0	URI1	2	pull down	Miyamoto-Sato E (2010)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
ATF7	0	TAF4	4	pull down, affinity chromatography technology	Hamard PJ (2005), Hamard PJ (2005)	2
BATF3	0	ATF2	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
HNRNPL	3	TAF4	4	affinity chromatography technology	Fei T (2017)	1
JUNB	0	ARIH1	3	affinity chromatography technology	Huttlin EL (2017)	1
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
JUN	0	MEF2A	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
55844	0	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
SCGN	1	ATF7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3	4	JUN	0	affinity chromatography technology, pull down, pull down	Aguilera C (2011), Aguilera C (2011), Aguilera C (2011)	3
NFATC2	1	JUNB	0	affinity chromatography technology	Gabriel CH (2016)	1
CREB5	4	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YY1	7	ATF7	0	pull down	Zhou Q (1995)	1
ATF2	1	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF7	0	CREB1	1	biochemical	Havugimana PC (2012)	1
ARIH1	3	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF7	0	TAF12	0	affinity chromatography technology, pull down, imaging technique	Hamard PJ (2005), Hamard PJ (2005), Hamard PJ (2005)	3
HNRNPL	3	ARIH1	3	affinity chromatography technology	Fei T (2017)	1
SCGN	1	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFATC1	12	ATF2	1	affinity chromatography technology	Li X (2015)	1
HNRNPL	3	NFATC1	12	affinity chromatography technology	Fei T (2017)	1
55844	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
BCL6	6	YY1	7	affinity chromatography technology	Miles RR (2005)	1
FCER2	0	ATF7	0	two hybrid	Rolland T (2014)	1
55844	0	CREB5	4	affinity chromatography technology	Huttlin EL (2017)	1
ARIH1	3	CREB5	4	affinity chromatography technology	Huttlin EL (2017)	1
MLLT6	2	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
JUN	0	NFATC1	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015), Gabriel CH (2016)	3
ATF7	0	FAM9B	0	two hybrid	Rolland T (2014)	1
JUNB	0	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMC5	4	ATF7	0	affinity chromatography technology	Huttlin EL (2017)	1
CREB1	1	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benbrook DM (1990), Li X (2015), Li X (2015)	3
ATF7	0	MITD1	0	pull down	Miyamoto-Sato E (2010)	1
ATF7	0	CCDC155	2	two hybrid	Rolland T (2014)	1
PCF11	2	ATF7	0	biochemical	Wan C (2015)	1
JUN	0	TAF4	4	pull down	Nguyen TN (2010)	1
BCL6	6	MBD3	4	affinity chromatography technology, affinity chromatography technology	Fujita N (2004), Fujita N (2004)	2
BCL6	6	JUNB	0	pull down	Vasanwala FH (2002)	1
ARIH1	3	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
FOSL2	2	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MLLT6	2	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
FOS	0	ATF7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	3
CREB1	1	NFATC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	3
BATF3	0	CREB5	4	affinity chromatography technology	Huttlin EL (2017)	1
ATF2	1	YY1	7	two hybrid, pull down	Ravasi T (2010), Zhou Q (1995)	2
PTP4A1	0	PSMC5	4	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
BATF3	0	JUN	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Iacobelli M (2000), Reinke AW (2013), Reinke AW (2013), Li X (2015), Huttlin EL (2017)	5
BCL6	6	ATF7	0	affinity chromatography technology	Miles RR (2005)	1