PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DCTN1	6	PAFAH1B1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Tai CY (2002), Faulkner NE (2000), Faulkner NE (2000), Gupta GD (2015), Boldt K (2016)	5
FBXO7	1	MAPRE2	0	enzymatic study	Teixeira FR (2016)	1
APC	5	MAPRE2	0	two hybrid, pull down, pull down, affinity chromatography technology	Su LK (1995), Nakamura M (2001), Su LK (1995), Su LK (1995)	4
AURKA	1	HSPA8	4	affinity chromatography technology	Fogeron ML (2013)	1
CDK2	0	HSPA8	4	affinity chromatography technology	Neganova I (2011)	1
APC	5	SMC3	16	two hybrid	Bandyopadhyay S (2010)	1
PAXIP1	1	MCM6	5	affinity chromatography technology	Woods NT (2012)	1
CENPJ	6	MAPRE2	0	bioid	Gupta GD (2015)	1
DGCR8	4	MAPRE2	0	biochemical	Havugimana PC (2012)	1
AURKB	2	MAPRE3	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
TRAF3IP1	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
POC1A	3	DNAAF2	2	bioid	Gupta GD (2015)	1
APP	1	HSPA8	4	affinity chromatography technology	Yamamoto YH (2010)	1
PPP1CA	3	AURKB	2	affinity chromatography technology	Flores-Delgado G (2007)	1
MCM4	3	SMC3	16	affinity chromatography technology	Boldt K (2016)	1
PPP1CA	3	MAPRE1	0	affinity chromatography technology	Boldt K (2016)	1
MCM4	3	MAPRE2	0	biochemical	Wan C (2015)	1
RNF185	1	APP	1	pull down	Olah J (2011)	1
MCM4	3	HSF1	1	affinity chromatography technology	Boldt K (2016)	1
CDK2	0	MAPRE2	0	two hybrid	Wang J (2011)	1
SNRNP27	0	MAPRE2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPRE2	0	MAPRE1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	4
PPP1CA	3	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
TRAF3IP1	3	HSPA1L	2	affinity chromatography technology	Guo CW (2010)	1
AURKA	1	MAPRE2	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
PAFAH1B1	3	TCTEX1D2	0	affinity chromatography technology	Boldt K (2016)	1
DNAAF2	2	APP	1	pull down	Olah J (2011)	1
PPP1CA	3	CDK2	0	affinity chromatography technology	Flores-Delgado G (2007)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
SDF4	1	SMC3	16	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO7	1	HUWE1	22	affinity chromatography technology	Teixeira FR (2016)	1
PAXIP1	1	SMC3	16	affinity chromatography technology	Patel SR (2007)	1
UBC	7	MAPRE2	0	pull down	Zhang X (2017)	1
APP	1	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
DYNLT1	3	TCTEX1D2	0	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
DYNLT1	3	LMNA	2	biochemical	Wan C (2015)	1
HSPA1L	2	TXN2	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	PPP1CA	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CDK4	2	affinity chromatography technology	Rodriguez J (2016)	1
HSPA8	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Polanowska-Grabowska R (1997), Cid C (2007)	2
CEP104	4	MAPRE1	0	bioid	Gupta GD (2015)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
AURKB	2	MAPRE1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Ban R (2009), Sun L (2008), Sun L (2008), Sun L (2008), Sun L (2008)	5
MAPRE1	0	PAFAH1B1	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Boldt K (2016)	2
DGCR8	4	APP	1	pull down	Olah J (2011)	1
FBXO7	1	LMNA	2	enzymatic study	Teixeira FR (2016)	1
CEP104	4	MAPRE2	0	bioid	Gupta GD (2015)	1
MAPRE2	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
EGLN3	0	MAPRE2	0	affinity chromatography technology	Rodriguez J (2016)	1
CDK2	0	LMNA	2	affinity chromatography technology	Neganova I (2011)	1
TRIM14	1	MCM4	3	bioid	Tan P (2017)	1
HUWE1	22	MAPRE2	0	affinity chromatography technology	Thompson JW (2014)	1
MCM6	5	HSF1	1	affinity chromatography technology	Boldt K (2016)	1
DCTN1	6	MAPRE3	0	bioid	Gupta GD (2015)	1
MAPRE1	0	MAPRE3	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Xia P (2012), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	5
LRRC1	1	APP	1	pull down	Olah J (2011)	1
MAPRE2	0	MAPRE3	0	two hybrid	Rual JF (2005)	1
TRIM14	1	SDF4	1	bioid	Tan P (2017)	1
CDK2	0	PAFAH1B1	3	affinity chromatography technology	Neganova I (2011)	1
SMC3	16	MAPRE2	0	biochemical	Wan C (2015)	1
DCTN1	6	MAPRE1	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Boldt K (2016)	3
EGLN3	0	AURKB	2	affinity chromatography technology	Rodriguez J (2016)	1
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
TRAIP	0	APP	1	pull down	Olah J (2011)	1
EGLN3	0	LRRC1	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HSPA8	4	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PSMB1	1	affinity chromatography technology	Rodriguez J (2016)	1
FBXO7	1	CENPJ	6	enzymatic study	Teixeira FR (2016)	1
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
EGLN3	0	AURKA	1	affinity chromatography technology	Rodriguez J (2016)	1
DNAAF2	2	MAPRE2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF185	1	UBC	7	affinity chromatography technology	Iioka H (2007)	1
PAXIP1	1	MAPRE2	0	affinity chromatography technology, two hybrid	Woods NT (2012), Rolland T (2014)	2
HUWE1	22	MCM6	5	affinity chromatography technology	Thompson JW (2014)	1
TRAF3IP1	3	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Guo CW (2010), Guo CW (2010), Guo CW (2010), Guo CW (2010)	4
TRAF1	0	MAPRE2	0	two hybrid	Rolland T (2014)	1
RNF185	1	MAPRE2	0	affinity chromatography technology	Iioka H (2007)	1
PPP1CA	3	AURKA	1	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001)	5
UBC	7	AURKB	2	affinity chromatography technology	Huang G (2014)	1
HSPA1L	2	HSF1	1	affinity chromatography technology	Boldt K (2016)	1
HSPA1L	2	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	CENPJ	6	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	MCM7	5	affinity chromatography technology	Rodriguez J (2016)	1
MAPRE2	0	CRTAC1	5	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
LMO2	2	MAPRE3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
EGLN3	0	SMC3	16	affinity chromatography technology	Rodriguez J (2016)	1
TRAIP	0	TRAF1	0	two hybrid, pull down, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007)	3
AURKA	1	MAPRE3	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
DCTN1	6	MAPRE2	0	bioid	Gupta GD (2015)	1
MAPRE3	0	TXN2	0	two hybrid	Rolland T (2014)	1
MAPRE2	0	MAPRE2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PSMB1	1	TRAF1	0	two hybrid	Rolland T (2014)	1
PPP1CA	3	HSPA1L	2	affinity chromatography technology	Boldt K (2016)	1
LRRC1	1	MAPRE2	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
MAPRE2	0	TCTEX1D2	0	affinity chromatography technology	Boldt K (2016)	1
SDF4	1	APP	1	pull down	Olah J (2011)	1
CDK2	0	MAPRE1	0	affinity chromatography technology	Neganova I (2011)	1
TRAF3IP1	3	SMC3	16	two hybrid	Camargo LM (2007)	1
LMO2	2	MAPRE1	0	two hybrid	Rolland T (2014)	1
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
APP	1	MAPRE1	0	two hybrid, pull down	Kajiwara Y (2010), Olah J (2011)	2
EGLN3	0	APC	5	affinity chromatography technology	Rodriguez J (2016)	1
FBXO7	1	MCM7	5	affinity chromatography technology	Teixeira FR (2016)	1
TRAF1	0	APC	5	affinity chromatography technology	Greenfeld H (2015)	1
POC1A	3	HSPA1L	2	affinity chromatography technology	Huttlin EL (2015)	1
HSF1	1	HSPA8	4	pull down, pull down, affinity chromatography technology	Nunes SL (1995), Kim SA (2005), Huttlin EL (2017)	3
TRIM14	1	MCM6	5	bioid	Tan P (2017)	1
MCM7	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
PSMB1	1	MAPRE3	0	two hybrid	Rolland T (2014)	1
DCTN1	6	AURKB	2	bioid	Gupta GD (2015)	1
EGLN3	0	DCTN1	6	affinity chromatography technology	Rodriguez J (2016)	1
CDK4	2	SMC3	16	affinity chromatography technology	Ewing RM (2007)	1
APC	5	MAPRE1	0	pull down, pull down, affinity chromatography technology	Askham JM (2002), Xia P (2012), Hein MY (2015)	3
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
TRIM14	1	DYNLT1	3	bioid	Tan P (2017)	1
DYNLT1	3	APP	1	pull down	Olah J (2011)	1
POC1A	3	MAPRE2	0	bioid	Gupta GD (2015)	1
AURKB	2	MAPRE2	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
FBXO7	1	PAFAH1B1	3	enzymatic study	Teixeira FR (2016)	1
TRIM14	1	MAPRE2	0	bioid	Tan P (2017)	1
CDK4	2	APP	1	pull down	Olah J (2011)	1
EGLN3	0	MCM4	3	affinity chromatography technology	Rodriguez J (2016)	1
LMO2	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
MAPRE2	0	TXN2	0	two hybrid	Rolland T (2014)	1
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
HSPA8	4	MAPRE2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPRE2	0	MCM6	5	biochemical	Wan C (2015)	1
UBC	7	PSMB1	1	affinity chromatography technology	Matsumoto M (2005)	1
FGL1	3	MAPRE2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DYNLT1	3	DCTN1	6	bioid	Gupta GD (2015)	1
PSMB1	1	MAPRE1	0	affinity chromatography technology	Boldt K (2016)	1
DYNLT1	3	PAFAH1B1	3	affinity chromatography technology	Boldt K (2016)	1
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
CDC14A	4	MAPRE2	0	bioid	St-Denis N (2016)	1
UBC	7	APC	5	affinity chromatography technology	Matsumoto M (2005)	1
DYNLT1	3	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
SDF4	1	MAPRE2	0	affinity chromatography technology	Huttlin EL (2017)	1
LMO2	2	MAPRE2	0	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	3
MCM6	5	SMC3	16	affinity chromatography technology	Boldt K (2016)	1
LMNA	2	MAPRE2	0	two hybrid	Dittmer TA (2014)	1
POC1A	3	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAIP	0	MAPRE2	0	two hybrid	Rolland T (2014)	1
PSMB1	1	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
MAPRE2	0	HSF1	1	affinity chromatography technology	Boldt K (2016)	1
PPP1CA	3	DCTN1	6	two hybrid	Esteves SL (2012)	1
MAPRE2	0	APP	1	pull down	Olah J (2011)	1
MCM7	5	MAPRE2	0	biochemical	Wan C (2015)	1
HSPA8	4	CDK4	2	affinity chromatography technology, affinity chromatography technology	Jose-Eneriz ES (2008), Jose-Eneriz ES (2008)	2
HUWE1	22	MCM4	3	affinity chromatography technology	Thompson JW (2014)	1
TRAF3IP1	3	MAPRE2	0	affinity chromatography technology	Guo CW (2010)	1
AURKB	2	APP	1	pull down	Olah J (2011)	1
PAFAH1B1	3	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	DNAAF2	2	affinity chromatography technology	Rodriguez J (2016)	1
AURKA	1	MAPRE1	0	affinity chromatography technology	Ban R (2009)	1
FBXO7	1	PSMB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016)	3
CDK2	0	SMC3	16	affinity chromatography technology	Neganova I (2011)	1
HUWE1	22	PPP1CA	3	affinity chromatography technology	Thompson JW (2014)	1
DGCR8	4	HSPA8	4	affinity chromatography technology	Shiohama A (2007)	1
CDK4	2	MAPRE2	0	two hybrid	Wang J (2011)	1
PPP1CA	3	LRRC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
PPP1CA	3	CDK4	2	affinity chromatography technology, biochemical	Flores-Delgado G (2007), Havugimana PC (2012)	2