PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KAT8	2	PAF1	6	pull down	Wu L (2014)	1
KAT8	2	MSL3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Smith ER (2005), Smith ER (2005), Sharma GG (2010), Kadlec J (2011)	4
KAT8	2	MSL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Smith ER (2005), Sharma GG (2010), Sharma GG (2010), Kadlec J (2011), Kadlec J (2011), Huttlin EL (2015), Huttlin EL (2017)	8
KAT8	2	MSL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Smith ER (2005), Sharma GG (2010), Huttlin EL (2017)	4
MSL3	4	HIST3H3	0	unspecified method	Moore SA (2010)	1
MSL3	4	HIST4H4	1	unspecified method	Moore SA (2010)	1
SOX2	4	PAF1	6	affinity chromatography technology	Cox JL (2013)	1
MSL1	0	MSL2	3	affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Smith ER (2005), Hallacli E (2012), Huttlin EL (2017)	3
DYRK1B	1	MSL3	4	affinity chromatography technology	Varjosalo M (2013)	1
8339	0	KAT8	2	bioid	Lambert JP (2015)	1
MSL3	4	HIST1H4A	0	enzymatic study	Smith ER (2005)	1
MSL1	0	PAF1	6	biochemical, biochemical, pull down, pull down	Wu L (2014), Wu L (2014), Wu L (2014), Wu L (2014)	4
MSL3	4	MSL2	3	affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Huttlin EL (2017)	2
MSL2	3	PAF1	6	biochemical, biochemical, pull down, pull down	Wu L (2014), Wu L (2014), Wu L (2014), Wu L (2014)	4
MSL3	4	PAF1	6	pull down	Wu L (2014)	1
BOD1	1	APP	1	pull down	Olah J (2011)	1
MSL2	3	HIST1H4A	0	enzymatic study	Wu L (2011)	1
DYRK1B	1	KAT8	2	affinity chromatography technology	Varjosalo M (2013)	1
FGFR1OP	0	MSL3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
8339	0	MSL1	0	bioid	Lambert JP (2015)	1
MSL3	4	APP	1	pull down	Olah J (2011)	1
KAT8	2	HIST1H4A	0	enzymatic study, affinity chromatography technology, imaging technique, enzymatic study	Smith ER (2005), Zippo A (2009), Zippo A (2009), Tropberger P (2013)	4
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
KAT8	2	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Sharma GG (2010), Sharma GG (2010)	2
HIST1H3A	3	MSL1	0	bioid	Lambert JP (2015)	1
PRKDC	12	HIST1H3A	3	imaging technique	Olsen BB (2012)	1
MSL3	4	MSL1	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Smith ER (2005), Sharma GG (2010), Kadlec J (2011), Huttlin EL (2015), Huttlin EL (2017)	5
HIST3H3	0	HIST4H4	1	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
MSL3	4	PRKDC	12	affinity chromatography technology	Sharma GG (2010)	1
HIST1H3A	3	PAF1	6	affinity chromatography technology, pull down	Wu J (2012), Wu J (2012)	2
PLEKHA1	1	MSL3	4	affinity chromatography technology	Huttlin EL (2017)	1
8339	0	MSL3	4	bioid	Lambert JP (2015)	1
BOD1	1	MSL3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOX2	4	MSL1	0	affinity chromatography technology	Cox JL (2013)	1
KAT8	2	HIST1H3A	3	enzymatic study, affinity chromatography technology	Smith ER (2005), Zippo A (2009)	2
MSL3	4	HIST1H3A	3	enzymatic study, bioid	Smith ER (2005), Lambert JP (2015)	2
CDK6	0	MSL3	4	enzymatic study	Anders L (2011)	1
SOX2	4	MSL3	4	affinity chromatography technology	Cox JL (2013)	1