PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK2	0	CDC7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin L (2007), Martin L (2007), Martin L (2007), Masai H (2000)	4
MCM3	2	DBF4	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
DBF4	2	MCM2	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
CDC7	2	MCM6	5	enzymatic study	Masai H (2000)	1
BRCA1	7	DBF4	2	two hybrid	Woods NT (2012)	1
DBF4	2	ORC4	1	affinity chromatography technology	Kneissl M (2003)	1
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
DBF4	2	ORC1	3	two hybrid	Kneissl M (2003)	1
RAD18	3	DBF4	2	affinity chromatography technology, affinity chromatography technology	Yamada M (2013), Yamada M (2013)	2
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
MEN1	1	DBF4	2	affinity chromatography technology, affinity chromatography technology	Schnepp RW (2004), Schnepp RW (2004)	2
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
RAD18	3	ORC2	0	biochemical	Centore RC (2012)	1
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
CDC7	2	RAD18	3	enzymatic study, affinity chromatography technology	Day TA (2010), Day TA (2010)	2
DBF4	2	ORC6	0	two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
BRCA1	7	MCM3	2	affinity chromatography technology	Ertych N (2016)	1
MCM2	3	EEF1A2	18	affinity chromatography technology	Drissi R (2015)	1
MCM6	5	ORC6	0	pull down	Ramachandran N (2004)	1
ORC4	1	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004)	5
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
XPO1	8	DBF4	2	affinity chromatography technology	Kirli K (2015)	1
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC4	1	pull down	Ramachandran N (2004)	1
XPO1	8	DAXX	5	affinity chromatography technology	Kirli K (2015)	1
BRCA1	7	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian F (2013), Tian F (2013), Hill SJ (2014)	3
CDC7	2	MCM3	2	enzymatic study, pull down	Sato N (1997), Ramachandran N (2004)	2
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
ORC2	0	ORC4	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010)	11
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
DBF4	2	EEF1A2	18	affinity chromatography technology	Huttlin EL (2017)	1
MCM4	3	ORC6	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
DBF4	2	NME6	1	affinity chromatography technology	Huttlin EL (2017)	1
DBF4	2	ORC5	0	two hybrid	Kneissl M (2003)	1
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
ORC4	1	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
MCM3	2	MCM6	5	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
BRCA1	7	MCM4	3	affinity chromatography technology	Ertych N (2016)	1
DBF4	2	DAXX	5	affinity chromatography technology, affinity chromatography technology	Song JJ (2003), Song JJ (2003)	2
ORC1	3	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
MCM4	3	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
DBF4	2	MCM6	5	enzymatic study	Masai H (2000)	1
CDC7	2	DBF4	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kneissl M (2003), Kumagai H (1999), Jiang W (1999), Jiang W (1999), Jiang W (1999), Kumagai H (1999), Kumagai H (1999), Liu P (2006), Masai H (2000), Masai H (2000), Huttlin EL (2017)	11
ORC2	0	DBF4	2	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003)	3
BRCA1	7	MCM6	5	affinity chromatography technology	Ertych N (2016)	1
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
XPO1	8	RAD18	3	affinity chromatography technology	Kirli K (2015)	1
ORC4	1	ORC6	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Sibani S (2005), Ramachandran N (2004)	5
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	DBF4	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
MCM6	5	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
MCM3	2	ORC4	1	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ORC1	3	ORC4	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Hein MY (2015)	3
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
LSM8	0	DBF4	2	two hybrid	Lehner B (2004)	1
ORC6	0	MCM2	3	pull down	Ramachandran N (2004)	1
DBF4	2	HDGFL2	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM7	5	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
ORC6	0	CDC7	2	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
ORC5	0	CDC7	2	pull down	Ramachandran N (2004)	1
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
DBF4	2	MCM4	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
DBF4	2	DBF4	2	affinity chromatography technology, enzymatic study	Song JJ (2003), Masai H (2000)	2
ORC2	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Matsuoka S (2007), Hill SJ (2014)	2
XPO1	8	CDC7	2	affinity chromatography technology	Kirli K (2015)	1
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
CDK2	0	DBF4	2	enzymatic study	Masai H (2000)	1