PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MALT1	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
COPS5	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
IKBKB	1	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	4
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
MALT1	1	PRMT6	2	two hybrid	Weimann M (2013)	1
BCL10	0	CAMK2G	4	affinity chromatography technology	Oruganti SR (2011)	1
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
MAP3K7	2	NFKBIA	0	enzymatic study	Kanayama A (2004)	1
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
ATXN3	2	MALT1	1	affinity chromatography technology	Kristensen LV (2018)	1
PRKCQ	3	MALT1	1	affinity chromatography technology	Shambharkar PB (2007)	1
IKBKB	1	COPS5	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Orel L (2010), Orel L (2010), Asare Y (2013), Asare Y (2013)	6
COPS5	0	CSNK1A1	1	affinity chromatography technology	Huang X (2009)	1
TRAF6	0	PRKCD	2	affinity chromatography technology	Liu Y (2012)	1
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
CARD11	4	STUB1	4	affinity chromatography technology	Wang S (2013)	1
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
TRIB1	1	MALT1	1	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	MAP3K7	2	affinity chromatography technology	Wang S (2013)	1
BCL10	0	CARD14	6	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Howes A (2016)	4
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
GPS1	1	CARD11	4	affinity chromatography technology	Welteke V (2009)	1
PRKCQ	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), Srivastava R (2010), Shambharkar PB (2007)	3
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
MALT1	1	IKBKB	1	affinity chromatography technology	Bidere N (2009)	1
DAB2	1	HNRNPL	3	affinity chromatography technology	Mulkearns EE (2012)	1
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
CSNK1A1	1	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Hatchi EM (2014), Bidere N (2009), Bidere N (2009)	4
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
CSNK1A1	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Hatchi EM (2014), Bidere N (2009)	3
SQSTM1	0	PRKCD	2	affinity chromatography technology	Linares JF (2011)	1
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
MALT1	1	TNFAIP3	3	affinity chromatography technology	Yang Y (2014)	1
BCL10	0	UBE2V2	0	pull down	Zhou H (2004)	1
COPS5	0	CARM1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
PRKCD	2	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Masoumi KC (2012), Masoumi KC (2012)	2
CARD11	4	COPS5	0	affinity chromatography technology, affinity chromatography technology	Welteke V (2009), Welteke V (2009)	2
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
CSNK1A1	1	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hatchi EM (2014), Bidere N (2009), Bidere N (2009), Bidere N (2009)	4
MALT1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
HNRNPL	3	CSNK1A1	1	affinity chromatography technology	Fei T (2017)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
CSNK1A1	1	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Carvalho G (2010)	2
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
MALT1	1	USP9X	15	affinity chromatography technology	Park Y (2013)	1
ATXN3	2	SQSTM1	0	affinity chromatography technology, pull down	Zhou L (2014), Zhou L (2014)	2
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
PRKCQ	3	IKBKB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Khoshnan A (2000), Lee KY (2005), Lee KY (2005), Srivastava R (2010), Shambharkar PB (2007)	5
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
NFKBIA	0	RELB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Robert I (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
NFKBIA	0	GPS1	1	affinity chromatography technology	Lee JH (2013)	1
UBE2G2	0	MALT1	1	affinity chromatography technology	Ewing RM (2007)	1
MALT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li Y (2013), Li Y (2013), Ginster S (2017)	3
MALT1	1	UBE2N	1	pull down	Zhou H (2004)	1
ATXN3	2	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Scaglione KM (2011), Scaglione KM (2011), Scaglione KM (2011), Todi SV (2010), Todi SV (2010), Gao XC (2011), Todi SV (2009), Kristensen LV (2018), Kristensen LV (2018)	9
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
CARD11	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
MALT1	1	TAB2	5	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
DAB2	1	MALT1	1	affinity chromatography technology	Mulkearns EE (2012)	1
MAP3K7	2	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
CARD11	4	USP2	0	affinity chromatography technology, affinity chromatography technology	Li Y (2013), Li Y (2013)	2
GPS1	1	MALT1	1	affinity chromatography technology	Welteke V (2009)	1
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
XPO1	8	RELB	1	affinity chromatography technology	Kirli K (2015)	1
RBCK1	0	MAP3K7	2	affinity chromatography technology	Tian Y (2007)	1
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
MALT1	1	MALT1	1	x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down	Qiu L (2011), Qiu L (2011), Wiesmann C (2012), Lucas PC (2001), Zhou H (2004), Zhou H (2004), Yu JW (2011), Yu JW (2011)	8
STUB1	4	UBE2V2	0	biochemical	Havugimana PC (2012)	1
HNRNPL	3	MALT1	1	affinity chromatography technology	Fei T (2017)	1
XPO1	8	BCL10	0	affinity chromatography technology	Kirli K (2015)	1
KDM1A	2	XPO1	8	genetic interference	Horlbeck MA (2018)	1
MALT1	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Martin P (2006)	2
MALT1	1	RELB	1	enzymatic study	Hailfinger S (2011)	1
PRKCD	2	DAB2	1	enzymatic study	Tseng CP (1999)	1
PRKCD	2	PRKCQ	3	affinity chromatography technology	Varjosalo M (2013)	1
CARD11	4	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (2013), Karim ZA (2015), Liu Y (2012)	3
BCL10	0	SQSTM1	0	affinity chromatography technology	Paul S (2012)	1
MALT1	1	CAMK2G	4	affinity chromatography technology	Oruganti SR (2011)	1
MALT1	1	DIABLO	2	affinity chromatography technology	Garrison JB (2009)	1
STUB1	4	SQSTM1	0	biochemical	Villella VR (2013)	1
NFKBIA	0	MALT1	1	affinity chromatography technology	Carvalho G (2010)	1
PRKCQ	3	BCL10	0	affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), Shambharkar PB (2007)	2
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
UBE2V2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
XPO1	8	NFKBIA	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	CSNK1A1	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	DAB2	1	affinity chromatography technology	Kirli K (2015)	1
BCL10	0	CARD11	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Kojo S (2009), Welteke V (2009), Oruganti SR (2011), Langel FD (2008), McCully RR (2008), Sommer K (2005), Park Y (2013), Chen J (2015), Qiao Q (2013), Qiao Q (2013), Eitelhuber AC (2011), Yang YK (2016), Liu Y (2012), Bidere N (2009)	17
MALT1	1	CARM1	0	two hybrid	Weimann M (2013)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
STUB1	4	MALT1	1	affinity chromatography technology	Wang S (2013)	1
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
XPO1	8	MALT1	1	affinity chromatography technology	Kirli K (2015)	1
NFKBIA	0	BCL10	0	affinity chromatography technology, affinity chromatography technology	Carvalho G (2010), Carvalho G (2010)	2
CSNK1A1	1	SQSTM1	0	enzymatic study	Watanabe Y (2017)	1
HECTD3	8	MALT1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Li Y (2013), Li Y (2013), Li Y (2013)	3
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
COPS5	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Wang J (2006), Wang J (2006)	2
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
SUV39H1	0	USP9X	15	affinity chromatography technology	Huttlin EL (2017)	1
PRKCQ	3	CARD11	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Srivastava R (2010), Sommer K (2005), Eitelhuber AC (2011), Liu Y (2012), Brenner D (2009)	5
BCL10	0	USP9X	15	affinity chromatography technology	Park Y (2013)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
RBCK1	0	TAB2	5	affinity chromatography technology, affinity chromatography technology	Tian Y (2007), Tian Y (2007)	2
MALT1	1	PRKCD	2	affinity chromatography technology	Liu Y (2012)	1
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
MALT1	1	RBCK1	0	enzymatic study	Klein T (2015)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
CARD11	4	PRKCD	2	affinity chromatography technology	Liu Y (2012)	1
MALT1	1	KDM1A	2	two hybrid	Weimann M (2013)	1
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
MALT1	1	CARD14	6	affinity chromatography technology, affinity chromatography technology	Afonina IS (2016), Howes A (2016)	2
TRAF6	0	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
TAB2	5	IKBKB	1	enzymatic study	Niu J (2011)	1
NFKBIA	0	ATXN3	2	affinity chromatography technology	Hein MY (2015)	1
MALT1	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
PRKCQ	3	IKBKG	0	affinity chromatography technology	Lee KY (2005)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
MALT1	1	COPS5	0	affinity chromatography technology	Welteke V (2009)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
MALT1	1	UBE2V2	0	pull down	Zhou H (2004)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26