PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPARGC1A	3	MED1	4	affinity chromatography technology, pull down, pull down	Wallberg AE (2003), Wallberg AE (2003), Wallberg AE (2003)	3
PARK7	0	PPARGC1A	3	genetic interference	Zhong N (2008)	1
PPARGC1A	3	MED17	0	affinity chromatography technology, pull down	Wallberg AE (2003), Wallberg AE (2003)	2
FBXW7	2	NFKB1	2	affinity chromatography technology	Fekrmandi F (2015)	1
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
NR1H4	0	RXRA	1	two hybrid, pull down, pull down, affinity chromatography technology	Seol W (1995), Seol W (1995), Kemper JK (2009), Kemper JK (2009)	4
SIRT1	3	MYOD1	0	imaging technique	Amat R (2009)	1
NR3C1	2	NRIP1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, pull down	Tazawa H (2003), Tazawa H (2003), Zilliacus J (2001), Zilliacus J (2001), Subramaniam N (1999), Windahl SH (1999), Windahl SH (1999)	7
NRF1	2	PPARGC1A	3	pull down, affinity chromatography technology	Wu Z (1999), Wu Z (1999)	2
MED14	0	MED17	0	affinity chromatography technology, biochemical, biochemical	Ryu S (1999), Havugimana PC (2012), Wan C (2015)	3
ESR2	1	MED16	5	pull down	Kang YK (2002)	1
CDK6	0	PPARGC1A	3	enzymatic study	Anders L (2011)	1
PIAS1	4	PPARGC1A	3	affinity chromatography technology	Zhang Y (2012)	1
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
SF1	9	NFKB1	2	affinity chromatography technology, pull down	Hong CY (2003), Hong CY (2003)	2
NR3C1	2	PML	7	two hybrid	Ravasi T (2010)	1
PPARG	0	CREBBP	29	pull down, two hybrid, unspecified method, pull down, two hybrid, pull down, unspecified method	Li M (2000), Chen Q (2004), Lee G (2002), Carmona MC (2007), Carmona MC (2007), Jeninga EH (2007), Koppen A (2009)	7
GSK3B	1	NFKB1	2	enzymatic study	Demarchi F (2001)	1
USF2	3	USF1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Viollet B (1996), Viollet B (1996), Crusselle-Davis VJ (2006), Giangrande PH (2004), Giangrande PH (2004), Huang S (2007), Huang S (2007), Li X (2011), Fujimori K (2008), Hein MY (2015), Huttlin EL (2017)	12
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
NR4A2	6	RXRA	1	two hybrid, two hybrid, pull down	Albers M (2005), Perlmann T (1995), Perlmann T (1995)	3
EGFR	5	PPARGC1A	3	affinity chromatography technology	Foerster S (2013)	1
KAT2A	1	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Mao X (2009), Mao X (2009), Mao X (2009), Ivanov AA (2017)	4
MYOD1	0	EP300	36	pull down, genetic interference, pull down, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Lau P (1999), Sartorelli V (1997), Sartorelli V (1997), Sartorelli V (1997), Magenta A (2003), Serra C (2007), Jin W (2011), Yuan W (1996), Yuan W (1996)	9
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
PPARG	0	MED1	4	fluorescent resonance energy transfe, pull down, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, unspecified method, pull down, pull down, two hybrid, unspecified method	Iannone MA (2001), Yang W (2000), Shao G (2000), Treuter E (1999), Albers M (2005), Feige JN (2007), Feige JN (2007), Qin C (2004), Lee G (2002), Agostini M (2006), Carmona MC (2007), Carmona MC (2007), Koppen A (2009)	13
GSK3B	1	RELA	1	affinity chromatography technology	Neumann M (2011)	1
TP53	0	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan J (2008), Fan J (2008), Kim SJ (2012)	3
EP300	36	PIAS1	4	pull down, affinity chromatography technology	Ledsaak M (2016), Ledsaak M (2016)	2
MED14	0	MED16	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CREBBP	29	BCL6	6	enzymatic study	Pasqualucci L (2011)	1
CAPNS1	0	PPARGC1A	3	two hybrid	Wang J (2011)	1
PPARGC1A	3	SRSF6	3	affinity chromatography technology	Monsalve M (2000)	1
BCL6	6	PML	7	two hybrid	Dhordain P (2000)	1
PPARGC1A	3	SRSF5	0	affinity chromatography technology	Monsalve M (2000)	1
SRSF5	0	SRSF6	3	affinity chromatography technology	Boldt K (2016)	1
PPARGC1A	3	CREBBP	29	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
ESRRA	2	ESR1	0	pull down	Klinge CM (1997)	1
HNF4A	2	PPARGC1A	3	pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology	Surapureddi S (2008), Bhalla S (2004), Bhalla S (2004), Ponugoti B (2007), Inoue S (2011), Felder TK (2011), Zhang Z (2012), Li T (2005), Li T (2005)	9
TP53	0	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology, pull down	Sen N (2011), Sen N (2011), Sen N (2011)	3
ESR1	0	PIAS1	4	two hybrid	Kobayashi S (2004)	1
CREBBP	29	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, genetic interference, genetic interference, genetic interference, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang HD (2004), Zhong H (2002), Zhong H (2002), Parry GC (1997), Parry GC (1997), Parry GC (1997), Aarnisalo P (1998), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Liu GH (2008), Vanden Berghe W (1999), Naeaer AM (1999), Merika M (1998), Park J (2007), Verma UN (2004), Verma UN (2004), Verma UN (2004), Johnson J (2007), Aksoy E (2007), Azran I (2005), Silverman ES (1998), Huang WC (2007), Huang WC (2007), Aarnisalo P (1998), Kim HJ (1999), Hsu DS (2014), Chen Y (2015), Huang SM (2002)	30
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
PPARGC1A	3	PRKAA1	2	affinity chromatography technology	Rodrigue-Way A (2013)	1
SRSF4	2	SRSF6	3	two hybrid	Rual JF (2005)	1
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
HNF4A	2	MED21	1	pull down	Malik S (2002)	1
RNF2	1	EWSR1	2	affinity chromatography technology	Cao Q (2014)	1
GSK3B	1	CREB3L3	1	enzymatic study	Barbosa S (2015)	1
KAT2A	1	MED17	0	affinity chromatography technology	Liu X (2008)	1
UBE2I	0	NR5A2	4	enzymatic study, enzymatic study	Yang SH (2006), Ogawa H (2009)	2
ESR1	0	SRSF6	3	affinity chromatography technology	Tarallo R (2011)	1
PPARGC1A	3	HCFC1	4	affinity chromatography technology	Lin J (2002)	1
PPARGC1A	3	SIRT1	3	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Amat R (2009), Nemoto S (2005), Nemoto S (2005), Nemoto S (2005)	4
NR1I2	5	RXRA	1	two hybrid, two hybrid, pull down	Albers M (2005), Rana R (2013), Doricakova A (2013)	3
THRB	1	MED21	1	pull down	Nevado J (2004)	1
FBXW7	2	RELA	1	affinity chromatography technology	Fekrmandi F (2015)	1
PPARGC1A	3	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Park JH (2015), Park JH (2015)	2
EP300	36	RXRA	1	affinity chromatography technology, affinity chromatography technology	Zhao WX (2007), Zhao WX (2007)	2
ESR2	1	MED17	0	pull down, affinity chromatography technology	Kang YK (2002), Nassa G (2011)	2
PPARGC1A	3	NR1I3	2	affinity chromatography technology, affinity chromatography technology	Gao J (2015), Gao J (2015)	2
ESR2	1	MED14	0	pull down	Kang YK (2002)	1
HNF4A	2	TP53	0	pull down, affinity chromatography technology	Maeda Y (2002), Huttlin EL (2017)	2
PPARGC1A	3	NRIP1	4	affinity chromatography technology	Rytinki MM (2009)	1
RELA	1	USF2	3	two hybrid	Bandyopadhyay S (2010)	1
MED14	0	PPARG	0	affinity chromatography technology, affinity chromatography technology	Grontved L (2010), Grontved L (2010)	2
RELA	1	PPARA	1	pull down	Delerive P (1999)	1
PPARGC1A	3	NFKB1	2	affinity chromatography technology	Wang LH (2007)	1
UBE2I	0	SFPQ	2	enzymatic study	Matafora V (2009)	1
THRB	1	TP53	0	affinity chromatography technology	Shih A (2001)	1
MED12	11	KAT2A	1	affinity chromatography technology	Hein MY (2015)	1
RNF2	1	RELA	1	affinity chromatography technology	Cao Q (2014)	1
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
SF1	9	PML	7	imaging technique	Chuang YS (2011)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
NR4A2	6	SFPQ	2	affinity chromatography technology	Jacobs FM (2009)	1
PPARA	1	SIRT1	3	affinity chromatography technology, pull down, pull down	Purushotham A (2009), Purushotham A (2009), Purushotham A (2009)	3
NCOA6	6	PPARG	0	two hybrid, affinity chromatography technology, unspecified method, unspecified method	Albers M (2005), Lee JE (2013), Lee G (2002), Koppen A (2009)	4
SKP1	0	ESR1	0	affinity chromatography technology	Zhou W (2014)	1
NCOA6	6	NR3C1	2	pull down, two hybrid, pull down, bioid	Lee SK (1999), Mahajan MA (2000), Mahajan MA (2000), Lempiaeinen JK (2017)	4
NCOA6	6	CREBBP	29	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology	Lee SK (1999), Lee SK (1999), Lee SK (2001), Lee SK (2001), Mahajan MA (2000)	5
UBE2I	0	PPARA	1	pull down, enzymatic study	Pourcet B (2010), Pourcet B (2010)	2
ESR1	0	NCOA1	6	pull down, pull down, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	DiRenzo J (2000), Sheppard HM (2001), Kalkhoven E (1998), Kang YK (2002), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Tremblay A (2001), Llopis J (2000), Chien PY (1999), Webb P (1998), Webb P (1998), Lazennec G (1997), Heery DM (1997), Heery DM (1997), Torchia J (1997), Torchia J (1997), Fleming FJ (2004), Fujita T (2003), Fujita T (2003), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Gong EY (2010), Eng FC (1998), Needham M (2000), Needham M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Albers M (2005), Kurtev V (2004), DiRenzo J (1997), Han SJ (2016), Han SJ (2016)	37
PPARD	4	NCOA1	6	two hybrid, pull down, pull down, pull down	Albers M (2005), Molnar F (2005), Cho MC (2006), Lim HJ (2004)	4
ESR1	0	CREBBP	29	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006)	10
PPARGC1A	3	MED16	5	affinity chromatography technology	Wallberg AE (2003)	1
PPARA	1	EP300	36	two hybrid, two hybrid, pull down, two hybrid	Dowell P (1997), Dowell P (1999), Dowell P (1999), Mochizuki K (2008)	4
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
RXRA	1	PPARGC1A	3	affinity chromatography technology, pull down, two hybrid, two hybrid	Delerive P (2002), Delerive P (2002), Delerive P (2002), Delerive P (2002)	4
ESR1	0	MED12	11	affinity chromatography technology, pull down, affinity chromatography technology	Kang YK (2002), Kang YK (2002), Han SJ (2016)	3
PPARGC1A	3	MYOD1	0	imaging technique	Amat R (2009)	1
HNF4A	2	SIRT1	3	affinity chromatography technology	Chanda D (2010)	1
MED12	11	MED20	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Lambert JP (2015), Hein MY (2015)	3
PPARGC1A	3	SRSF4	2	affinity chromatography technology	Monsalve M (2000)	1
NRIP1	4	ESRRA	2	pull down, pull down, two hybrid	Castet A (2006), Castet A (2006), Albers M (2005)	3
CREBBP	29	NCOA1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Sheppard HM (2001), Sheppard HM (2001), Sheppard HM (2001), Wu RC (2002), Torchia J (1997), Torchia J (1997), Matsuda S (2004), DiRenzo J (2000), Nakuci E (2006), Ruas JL (2005), Huang SM (2002)	11
PPARA	1	RXRA	1	pull down, pull down, pull down, affinity chromatography technology, pull down	Gorla-Bajszczak A (1999), Tang C (2003), Tachibana K (2013), Nickkho-Amiry M (2012), Molnar F (2005)	5
PPARA	1	NCOA1	6	two hybrid, pull down, two hybrid, pull down, fluorescent resonance energy transfe	Dowell P (1997), Treuter E (1998), Needham M (2000), Molnar F (2005), Mukherjee R (2002)	5
ESR1	0	SRSF2	0	affinity chromatography technology	Tarallo R (2011)	1
PIAS1	4	PML	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	3
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
UBE2I	0	PPARGC1A	3	enzymatic study	Rytinki MM (2009)	1
NCOA1	6	NR4A2	6	affinity chromatography technology	Holla VR (2011)	1
NR1I3	2	MED17	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRSF2	0	PPARGC1A	3	affinity chromatography technology	Monsalve M (2000)	1
PPARGC1A	3	LRPPRC	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Cooper MP (2006), Cooper MP (2006), Cooper MP (2006), Cooper MP (2006)	4
RNF34	1	TP53	0	affinity chromatography technology	Yang W (2007)	1
HNF4A	2	NCOA6	6	pull down, pull down, two hybrid, pull down, two hybrid	Surapureddi S (2008), Surapureddi S (2008), Albers M (2005), Surapureddi S (2011), Surapureddi S (2011)	5
SFPQ	2	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology	Zhong N (2008), Zhong N (2008)	2
BCL6	6	PPARGC1A	3	affinity chromatography technology	Miles RR (2005)	1
PPARGC1A	3	MED21	1	affinity chromatography technology	Wallberg AE (2003)	1
MED16	5	MED21	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
NDN	0	TP53	0	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Taniura H (1999), Taniura H (1999), Huang Z (2013), Corominas R (2014), Hasegawa K (2008), Hasegawa K (2008)	6
UBE2I	0	NR1I2	5	enzymatic study	Hu G (2010)	1
NRIP1	4	ESRRG	2	pull down, pull down, two hybrid	Castet A (2006), Castet A (2006), Albers M (2005)	3
MED1	4	MED14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, genetic interference	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Ryu S (1999), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	8
MED1	4	MED16	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Liu X (2008), Malovannaya A (2010), Donner AJ (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	8
EWSR1	2	SRSF2	0	bioid	Elzi DJ (2014)	1
PPARGC1A	3	RNF34	1	affinity chromatography technology	Wei P (2011)	1
RELA	1	RXRA	1	pull down, imaging technique, pull down	Na SY (1999), Chen TC (2014), Gu X (2006)	3
UBE2I	0	NR3C1	2	enzymatic study	Ogawa H (2009)	1
CDK6	0	SIRT1	3	enzymatic study	Anders L (2011)	1
PPARGC1A	3	NDN	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hasegawa K (2016), Hasegawa K (2016), Hasegawa K (2016), Hasegawa K (2016)	4
ESR1	0	SFPQ	2	pull down	Nalvarte I (2010)	1
NR3C1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amat R (2007), Wang W (2012), Kino T (2002)	3
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
SIRT1	3	RELA	1	affinity chromatography technology	Yang SR (2007)	1
MYOD1	0	ESR2	1	affinity chromatography technology	Jin W (2008)	1
PPARG	0	NR4A2	6	unspecified method	Lee G (2002)	1
HNF4A	2	NCOA1	6	two hybrid	Wang JC (1998)	1
PPARGC1A	3	RELA	1	affinity chromatography technology	Wang LH (2007)	1
MED17	0	TP53	0	pull down	Ito M (1999)	1
HNF4A	2	MED14	0	affinity chromatography technology, pull down	Maeda Y (2002), Malik S (2002)	2
SRSF4	2	SRSF2	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
NR1I3	2	NCOA1	6	affinity chromatography technology, two hybrid, affinity chromatography technology	Huttlin EL (2015), Albers M (2005), Huttlin EL (2017)	3
PPARGC1A	3	PPARD	4	pull down	Koppen A (2009)	1
ESR1	0	MED1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Kang YK (2002), Kang YK (2002), Wada-Hiraike O (2005), Burakov D (2000), Burakov D (2000), Burakov D (2000), Burakov D (2000), Llopis J (2000), Llopis J (2000), Fujita T (2003), Fujita T (2003)	11
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
NCOA1	6	SF1	9	affinity chromatography technology	Kelly SN (2005)	1
THRB	1	RXRA	1	pull down, pull down, two hybrid, far western blotting, two hybrid, pull down, pull down, pull down, imaging technique	Monden T (1997), Jeyakumar M (1997), Tagami T (2009), Li H (1997), Albers M (2005), White DM (1997), Garcia-Fernandez LF (1998), Liao CS (2009), Liao CS (2009)	9
TP53	0	SRSF6	3	affinity chromatography technology	Horikawa I (2014)	1
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
SFPQ	2	SF1	9	affinity chromatography technology	Huttlin EL (2017)	1
NRIP1	4	RXRA	1	pull down, pull down	Farooqui M (2003), LHorset F (1996)	2
PML	7	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kuo HY (2013), Kuo HY (2013), Kuo HY (2013), Kuo HY (2013)	4
TP53	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPARGC1A	3	IQGAP1	1	affinity chromatography technology	Cooper MP (2006)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
TP53	0	NCOA1	6	two hybrid, pull down	Lee SK (1999), Lee SK (1999)	2
FBXW7	2	MED14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Davis MA (2013), Kourtis N (2015)	3
NCOA1	6	ESR2	1	two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, two hybrid, two hybrid	Northrop JP (2000), Iannone MA (2001), Fleming FJ (2004), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Needham M (2000), Albers M (2005)	9
MED1	4	MED21	1	affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Havugimana PC (2012), Huttlin EL (2017)	3
FBXW7	2	MED17	0	affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Kourtis N (2015)	2
ESR2	1	EP300	36	affinity chromatography technology, fluorescent resonance energy transfe	Jin W (2008), Iannone MA (2001)	2
CDK6	0	PML	7	enzymatic study	Yuan WC (2011)	1
ESR1	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology	Jin W (2008), Jin W (2008)	2
FBXW7	2	MED12	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Davis MA (2013), Kourtis N (2015)	3
UBE2I	0	THRB	1	enzymatic study	Liu YY (2012)	1
LRPPRC	7	SIRT1	3	affinity chromatography technology	Hein MY (2015)	1
RELA	1	PPARG	0	affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Hou Y (2012), Hou Y (2012), Lu X (2013), Chen F (2003), Chen F (2003), Perez A (2008), Jeninga EH (2007)	7
SKP1	0	MED21	1	pull down, pull down, protein complementation assay	Ang K (2012), Ang K (2012), Ang K (2012)	3
PPARG	0	PRKAA1	2	affinity chromatography technology	Narkar VA (2008)	1
PRKAA1	2	EP300	36	affinity chromatography technology	Lim JY (2012)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
MED20	2	MED17	0	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
NR1H4	0	NCOA1	6	two hybrid, pull down	Bramlett KS (2000), Cai SY (2010)	2
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
THRB	1	NCOA1	6	pull down, genetic interference, pull down, unspecified method, two hybrid, two hybrid, pull down, pull down	Liu Y (1998), Jeyakumar M (1997), Jeyakumar M (1997), Jeyakumar M (1997), Albers M (2005), Chan CM (2013), Kim HJ (1999), DiRenzo J (1997)	8
NR1H4	0	ESR1	0	affinity chromatography technology	Journe F (2008)	1
NDN	0	SIRT1	3	affinity chromatography technology, pull down	Hasegawa K (2008), Hasegawa K (2008)	2
TP53	0	EWSR1	2	affinity chromatography technology	Li Y (2012)	1
PPARGC1A	3	USF1	0	pull down	Moore ML (2003)	1
MED12	11	MED17	0	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Wan C (2015), Hein MY (2015)	3
EWSR1	2	SIRT1	3	bioid	Elzi DJ (2014)	1
PPARGC1A	3	NR4A2	6	affinity chromatography technology	Holla VR (2011)	1
ESR1	0	MED14	0	affinity chromatography technology, pull down, pull down	Kang YK (2002), Kang YK (2002), Burakov D (2000)	3
NCOA6	6	NR1I2	5	pull down, two hybrid	Surapureddi S (2011), Surapureddi S (2011)	2
TP53	0	IQGAP1	1	affinity chromatography technology	Fogeron ML (2013)	1
EP300	36	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
PML	7	RELA	1	affinity chromatography technology, affinity chromatography technology	Wu WS (2003), Chen Y (2015)	2
ESRRA	2	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2
SFPQ	2	SRSF5	0	biochemical	Havugimana PC (2012)	1
CREB3L3	1	PPARGC1A	3	pull down, affinity chromatography technology	Misra J (2011), Misra J (2011)	2
MED20	2	MED21	1	affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Huttlin EL (2017)	2
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
EWSR1	2	CREBBP	29	pull down, bioid	Araya N (2003), Elzi DJ (2014)	2
NFKB1	2	PML	7	two hybrid	Wang J (2011)	1
NCOA6	6	HCFC1	4	affinity chromatography technology	Tang Z (2013)	1
PML	7	NR1I3	2	affinity chromatography technology, affinity chromatography technology	Gao J (2015), Gao J (2015)	2
SIRT1	3	NR1H4	0	pull down, enzymatic study	Kemper JK (2009), Kemper JK (2009)	2
FBXW7	2	MED21	1	affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Kourtis N (2015)	2
MED17	0	MED16	5	biochemical	Wan C (2015)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
PPARGC1A	3	MED14	0	affinity chromatography technology, pull down	Wallberg AE (2003), Wallberg AE (2003)	2
TP53	0	LRPPRC	7	affinity chromatography technology, affinity chromatography technology	Lunardi A (2010), Fogeron ML (2013)	2
RNF2	1	MYEF2	2	affinity chromatography technology	Cao Q (2014)	1
PPARGC1A	3	EP300	36	affinity chromatography technology	Cooper MP (2006)	1
ESR1	0	NRIP1	4	pull down, pull down, far western blotting, pull down, pull down, two hybrid, affinity chromatography technology	Cavailles V (1995), Thenot S (1997), LHorset F (1996), LHorset F (1996), Castet A (2006), Heery DM (1997), Li W (2015)	7
MED21	1	CREBBP	29	affinity chromatography technology	Cho H (1998)	1
ESR1	0	MED21	1	pull down	Kang YK (2002)	1
ESR2	1	MED12	11	pull down	Kang YK (2002)	1
CDK6	0	SRSF2	0	enzymatic study	Anders L (2011)	1
NCOA6	6	NFKB1	2	pull down	Lee SK (2000)	1
UBE2I	0	PPARG	0	enzymatic study, fluorescent resonance energy transfe, affinity chromatography technology	Ogawa H (2009), Hartig SM (2015), Hartig SM (2015)	3
MED1	4	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Liu X (2008), Malovannaya A (2010), Donner AJ (2010), Wan C (2015), Huttlin EL (2017)	7
NR3C1	2	NCOA1	6	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Zilliacus J (2001), Kucera T (2002), Windahl SH (1999), Fryer CJ (1998), Needham M (2000), Li G (2006), Lempiaeinen JK (2017)	7
EP300	36	BCL6	6	enzymatic study, affinity chromatography technology	Bereshchenko OR (2002), Bereshchenko OR (2002)	2
EGFR	5	PRKAA1	2	affinity chromatography technology	Tong J (2014)	1
FBXW7	2	MED1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Davis MA (2013), Kourtis N (2015)	3
SKP1	0	PPARGC1A	3	enzymatic study	Gao J (2015)	1
NCOA6	6	PPARGC1A	3	pull down	Surapureddi S (2008)	1
FBXW7	2	MED20	2	affinity chromatography technology	Davis MA (2013)	1
EGFR	5	SRSF2	0	affinity chromatography technology	Yao Z (2017)	1
PPARG	0	NCOA1	6	fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, unspecified method, pull down, two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, unspecified method	Iannone MA (2001), Yang W (2000), Feige JN (2007), DiRenzo J (1997), Needham M (2000), Heinlein CA (1999), Qin C (2004), Chan CM (2013), Chou WL (2007), Nolte RT (1998), Lee G (2002), Agostini M (2006), Waku T (2010), Waku T (2010), Carmona MC (2007), Molnar F (2005), Chintharlapalli S (2007), Jeninga EH (2007), Koppen A (2009)	19
ESR2	1	MED20	2	pull down	Kang YK (2002)	1
HNF4A	2	NR1I3	2	pull down	Surapureddi S (2008)	1
NCOA6	6	RXRA	1	pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down	Lee SK (1999), Lee SK (1999), Lee SK (2001), Kong HJ (2003), Kong HJ (2003), Ko L (2002), Mahajan MA (2000), Mahajan MA (2000), Caira F (2000)	9
NR1I2	5	TP53	0	affinity chromatography technology, affinity chromatography technology	Elias A (2013), Elias A (2013)	2
NR3C1	2	NFKB1	2	pull down, affinity chromatography technology	Scheinman RI (1995), Ito K (2006)	2
EGFR	5	NDN	0	protein complementation assay	Deribe YL (2009)	1
ESR1	0	UBE2I	0	two hybrid, enzymatic study	Kobayashi S (2004), Sentis S (2005)	2
MED1	4	MED12	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Malovannaya A (2010), Donner AJ (2010), Davis MA (2013), Tsai KL (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
PPARGC1A	3	KAT2A	1	affinity chromatography technology	Rodrigue-Way A (2013)	1
BCL6	6	MED17	0	pull down	Fukasawa R (2012)	1
EWSR1	2	SRSF6	3	bioid	Elzi DJ (2014)	1
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
ESRRA	2	PPARGC1A	3	x-ray crystallography, two hybrid, pull down	Kallen J (2004), Huss JM (2002), Huss JM (2002)	3
NR3C1	2	MED1	4	pull down, pull down, bioid	Zilliacus J (2001), Hittelman AB (1999), Lempiaeinen JK (2017)	3
THRB	1	NRIP1	4	two hybrid	Albers M (2005)	1
GSK3B	1	RXRA	1	two hybrid	Vinayagam A (2011)	1
PPARGC1A	3	THRB	1	pull down, affinity chromatography technology	Wu Y (2002), Wu Y (2002)	2
HNF4A	2	NR1I2	5	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology	Li T (2006), Li T (2006), Li T (2006), Li T (2005), Li T (2005)	5
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
SFPQ	2	NR3C1	2	affinity chromatography technology	Tyson-Capper AJ (2009)	1
ESR1	0	SRSF5	0	affinity chromatography technology	Tarallo R (2011)	1
SF1	9	EWSR1	2	two hybrid, pull down	Zhang D (1998), Zhang D (1998)	2
HNF4A	2	NRIP1	4	two hybrid	Albers M (2005)	1
PML	7	PARK7	0	affinity chromatography technology	Kim SJ (2012)	1
CREBBP	29	MYOD1	0	affinity chromatography technology, pull down, genetic interference, pull down, enzymatic study, enzymatic study	Polesskaya A (2001), Polesskaya A (2001), Sartorelli V (1997), Sartorelli V (1997), Polesskaya A (2000), Col E (2002)	6
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
PARK7	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Xu J (2005), Xu J (2005)	2
ESRRA	2	SIRT1	3	pull down, enzymatic study	Wilson BJ (2010), Wilson BJ (2010)	2
NR5A2	4	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2
EP300	36	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Bouras T (2005), Bourguignon LY (2009)	2
NR1I2	5	NR5A2	4	two hybrid	Li T (2005)	1
USF1	0	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Huang S (2007), Li X (2011)	2
PARK7	0	UBE2I	0	two hybrid	Junn E (2005)	1
PML	7	RXRA	1	pull down, imaging technique	Zhong S (1999), Bellodi C (2006)	2
ESR2	1	CREBBP	29	affinity chromatography technology	Jin W (2008)	1
CREBBP	29	HNF4A	2	two hybrid, affinity chromatography technology, pull down, genetic interference, pull down, pull down, enzymatic study, pull down, affinity chromatography technology	Yoshida E (1997), Yoshida E (1997), Yoshida E (1997), Yoshida E (1997), Dell H (1999), Surapureddi S (2008), Soutoglou E (2000), Soutoglou E (2000), Green VJ (1998)	9
NR1I3	2	MED1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR3C1	2	MED14	0	two hybrid, pull down	Hittelman AB (1999), Hittelman AB (1999)	2
MED21	1	MED14	0	biochemical, biochemical, affinity chromatography technology	Sun X (1998), Havugimana PC (2012), Huttlin EL (2017)	3
PPARA	1	NRIP1	4	pull down	Treuter E (1998)	1
PPARGC1A	3	ESR1	0	pull down	Tcherepanova I (2000)	1
PPARD	4	RXRA	1	two hybrid, affinity chromatography technology, pull down, two hybrid	Albers M (2005), Nickkho-Amiry M (2012), Molnar F (2005), Gustafsson MC (2009)	4
NR1I3	2	MED12	11	affinity chromatography technology	Huttlin EL (2015)	1
MED20	2	MED16	5	affinity chromatography technology	Lambert JP (2015)	1
EWSR1	2	NCOA6	6	bioid	Elzi DJ (2014)	1
PML	7	PPARG	0	two hybrid	Ravasi T (2010)	1
RNF2	1	LRPPRC	7	affinity chromatography technology	Cao Q (2014)	1
KAT2A	1	MED16	5	affinity chromatography technology	Liu X (2008)	1
NR5A2	4	NRIP1	4	two hybrid	Albers M (2005)	1
ESRRA	2	ESRRG	2	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique	Zhang Z (2007), Zhang Z (2007), Dufour CR (2007), Albers M (2005), Albers M (2005), Wang L (2008)	6
PPARGC1A	3	SF1	9	affinity chromatography technology	Yazawa T (2010)	1
SFPQ	2	EWSR1	2	affinity chromatography technology	Huttlin EL (2017)	1
NCOA1	6	NFKB1	2	pull down, pull down	Lee SK (2000), Na SY (1998)	2
ESR2	1	MED1	4	pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid	Kang YK (2002), Iannone MA (2001), Burakov D (2000), Burakov D (2000), Burakov D (2000)	5
NCOA6	6	THRB	1	pull down, two hybrid, two hybrid, pull down	Lee SK (2001), Lee SK (1999), Ko L (2000), Ko L (2002)	4
RNF2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Calao M (2012), Wen W (2013), Wen W (2013)	3
MED1	4	KAT2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu X (2008), Liu X (2008), Krebs AR (2010)	3
NCOA6	6	EP300	36	affinity chromatography technology, pull down	Ko L (2000), Ko L (2000)	2
PML	7	SIRT1	3	affinity chromatography technology, pull down	Langley E (2002), Langley E (2002)	2
PPARG	0	PPARGC1A	3	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, unspecified method	Wallberg AE (2003), Wallberg AE (2003), Puigserver P (1999), Feige JN (2007), Kim K (2009), Qin C (2004), Narkar VA (2008), Agostini M (2006), Li Y (2008), Carmona MC (2007), Carmona MC (2007), Chintharlapalli S (2007), Wang LH (2007), Koppen A (2009), Koppen A (2009)	15
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
NCOA6	6	MED1	4	pull down	Surapureddi S (2011)	1
EP300	36	PPARG	0	pull down, fluorescent resonance energy transfe, affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology	Fajas L (2002), Iannone MA (2001), Gelman L (1999), Gelman L (1999), Gelman L (1999), Feige JN (2007), Feige JN (2007), Debril MB (2004), Subbaramaiah K (2012), Lee G (2002), Koppen A (2009), Wang C (2001)	12
PPARGC1A	3	PML	7	affinity chromatography technology, affinity chromatography technology	Gao J (2015), Gao J (2015)	2
NCOA6	6	NCOA1	6	pull down, pull down, two hybrid, affinity chromatography technology	Surapureddi S (2011), Lee SK (1999), Lee SK (1999), Goo YH (2003)	4
RNF2	1	IQGAP1	1	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
NCOA6	6	RELA	1	pull down	Lee SK (2000)	1
EGFR	5	SFPQ	2	affinity chromatography technology	Li J (2013)	1
EGFR	5	HCFC1	4	affinity chromatography technology	Tong J (2008)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
EWSR1	2	SRSF5	0	biochemical	Havugimana PC (2012)	1
EP300	36	NR1H4	0	enzymatic study	Kemper JK (2009)	1
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
RXRA	1	NR1I3	2	pull down, pull down, pull down, imaging technique, pull down	Baes M (1994), Goodwin B (2002), Yoshinari K (2010), Yoshinari K (2010), Molnar F (2005)	5
SIRT1	3	KAT2A	1	affinity chromatography technology, affinity chromatography technology	Lin Z (2012), Armour SM (2013)	2
GSK3B	1	EWSR1	2	affinity chromatography technology	Ewing RM (2007)	1
ESR1	0	MED17	0	pull down	Kang YK (2002)	1
EGFR	5	LRPPRC	7	affinity chromatography technology	Tong J (2014)	1
PPARG	0	KAT2A	1	unspecified method	Koppen A (2009)	1
PML	7	SKP1	0	affinity chromatography technology	Shima Y (2008)	1
PPARGC1A	3	NR5A2	4	affinity chromatography technology	Yazawa T (2010)	1
ESR1	0	EWSR1	2	affinity chromatography technology	Tarallo R (2011)	1
MYEF2	2	PPARGC1A	3	affinity chromatography technology	McGee SL (2004)	1
MED20	2	MED14	0	biochemical, affinity chromatography technology	Wan C (2015), Lambert JP (2015)	2
PPARD	4	EP300	36	pull down, two hybrid	Cho MC (2006), Mochizuki K (2008)	2
PPARG	0	NRIP1	4	pull down, fluorescent resonance energy transfe, unspecified method, unspecified method	Treuter E (1998), Iannone MA (2001), Lee G (2002), Koppen A (2009)	4
HNF4A	2	MED16	5	pull down	Malik S (2002)	1
PPARGC1A	3	MED20	2	affinity chromatography technology	Wallberg AE (2003)	1
PPARGC1A	3	PPARA	1	pull down	Vega RB (2000)	1
PPARGC1A	3	NR3C1	2	two hybrid, unspecified method	Knutti D (2000), Suino-Powell K (2008)	2
FBXW7	2	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology, pull down	Olson BL (2008), Olson BL (2008), Olson BL (2008)	3
TP53	0	BCL6	6	pull down	Kotlyar M (2015)	1
GSK3B	1	PPARGC1A	3	enzymatic study	Olson BL (2008)	1
ESRRG	2	NCOA1	6	pull down, two hybrid	Greschik H (2002), Albers M (2005)	2
NR3C1	2	RELA	1	affinity chromatography technology, pull down, pull down	Ray A (1994), Nissen RM (2000), Caldenhoven E (1995)	3
NR1I3	2	MED14	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFKB1	2	RXRA	1	pull down	Na SY (1999)	1
HNF4A	2	MED17	0	pull down	Malik S (2002)	1
ESR1	0	MED20	2	affinity chromatography technology, pull down	Kang YK (2002), Kang YK (2002)	2
MED1	4	MED20	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Wan C (2015), Lambert JP (2015), Huttlin EL (2017)	6
ESRRG	2	PPARGC1A	3	pull down, pull down	Liu D (2005), Wang J (2009)	2
EGFR	5	NR3C1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PPARG	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu Y (2016), Xu Y (2016), Xu Y (2016)	3
UBE2I	0	IQGAP1	1	enzymatic study	Matafora V (2009)	1
ESR2	1	PPARGC1A	3	two hybrid	Albers M (2005)	1
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
PPARD	4	RELA	1	affinity chromatography technology	Aarenstrup L (2008)	1
FBXW7	2	NR3C1	2	affinity chromatography technology, affinity chromatography technology	Malyukova A (2013), Malyukova A (2013)	2
NFKB1	2	PPARG	0	affinity chromatography technology, pull down	Perez A (2008), Perez A (2008)	2
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
TP53	0	KAT2A	1	affinity chromatography technology, fluorescent resonance energy transfe	Gamper AM (2008), Ivanov AA (2017)	2
EWSR1	2	USF1	0	bioid	Elzi DJ (2014)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
PIAS1	4	GSK3B	1	affinity chromatography technology, enzymatic study	Coon TA (2015), Coon TA (2015)	2
PPARGC1A	3	RNF2	1	affinity chromatography technology, affinity chromatography technology	Sen N (2011), Sen N (2011)	2
RXRA	1	MED1	4	imaging technique, pull down, two hybrid, two hybrid	Sinkkonen L (2005), Yang W (2000), Shao G (2000), Osburn DL (2001)	4
PPARG	0	SFPQ	2	pull down, affinity chromatography technology, two hybrid	Tsukahara T (2013), Tsukahara T (2013), Tsukahara T (2013)	3
MED12	11	MED16	5	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	4
MED12	11	MED14	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Tsai KL (2013), Wan C (2015), Hein MY (2015)	4
SFPQ	2	SRSF4	2	biochemical	Havugimana PC (2012)	1
EP300	36	USF2	3	two hybrid	Breen GA (1999)	1
NCOA6	6	NR1H4	0	pull down	Ananthanarayanan M (2011)	1
RNF2	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014), Hauri S (2016), Hauri S (2016)	4
PPARGC1A	3	NR1I2	5	pull down, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Bhalla S (2004), Bhalla S (2004), Bhalla S (2004), Albers M (2005), Li T (2006), Li T (2006), Li T (2005)	7
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	MED16	5	affinity chromatography technology, pull down	Kang YK (2002), Kang YK (2002)	2
UBE2I	0	KAT2A	1	enzymatic study	Gocke CB (2005)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
PPARG	0	PIAS1	4	affinity chromatography technology, imaging technique	Pascual G (2005), Pascual G (2005)	2
TP53	0	MED21	1	pull down	Gu W (1999)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
PPARGC1A	3	MED12	11	affinity chromatography technology, pull down	Wallberg AE (2003), Wallberg AE (2003)	2
FBXW7	2	MED16	5	affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Kourtis N (2015)	2
NCOA6	6	ESR1	0	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (1999), Lee SK (1999), Ko L (2002), Ko L (2002), Ju BG (2006), Mahajan MA (2000), Mahajan MA (2000), Caira F (2000), Han SJ (2016)	9
ESR2	1	MED21	1	pull down	Kang YK (2002)	1
ESR2	1	NRIP1	4	fluorescent resonance energy transfe, two hybrid, affinity chromatography technology	Iannone MA (2001), Albers M (2005), Nassa G (2011)	3
RXRA	1	MYOD1	0	pull down, pull down	Froeschle A (1998), Froeschle A (1998)	2
NR1I2	5	NCOA1	6	x-ray crystallography, two hybrid, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Watkins RE (2003), Rana R (2013), Takeshita A (2002), Pondugula SR (2009), Albers M (2005), Lim YP (2007), Lim YP (2007), Wang H (2008), Li T (2006), Li T (2006), Li T (2005)	11
EGFR	5	IQGAP1	1	affinity chromatography technology	Casar B (2009)	1
MED20	2	SRSF5	0	affinity chromatography technology	Lambert JP (2015)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
PPARGC1A	3	NR1H4	0	pull down, affinity chromatography technology	Zhang Y (2004), Zhang Y (2004)	2
KAT2A	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	MED1	4	affinity chromatography technology, pull down, affinity chromatography technology	Frade R (2000), Drane P (1997), Lottin-Divoux S (2005)	3
HNF4A	2	MED1	4	affinity chromatography technology, pull down, pull down	Maeda Y (2002), Maeda Y (2002), Malik S (2002)	3
MED12	11	MED21	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Hein MY (2015), Huttlin EL (2017)	4
HNF4A	2	UBE2I	0	two hybrid, enzymatic study	Albers M (2005), Zhou W (2012)	2
PPARGC1A	3	USF2	3	pull down, affinity chromatography technology	Moore ML (2003), Moore ML (2003)	2
SIRT1	3	UBE2I	0	enzymatic study	Hsieh YL (2013)	1
MED17	0	MED21	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
USF1	0	EP300	36	affinity chromatography technology	Crusselle-Davis VJ (2007)	1
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1
NCOA6	6	ESR2	1	two hybrid, two hybrid, pull down, two hybrid	Lee SK (2001), Ko L (2002), Ko L (2002), Albers M (2005)	4