PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
CRK	0	FGFR1	2	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Larsson H (1999), Larsson H (1999)	3
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
CDH1	4	FRS2	0	bioid	Guo Z (2014)	1
SOS1	5	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1
FGFR2	6	FGFR1	2	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
CRK	0	GAB1	3	affinity chromatography technology	Brehme M (2009)	1
FRS2	0	NTRK2	10	pull down	Meakin SO (1999)	1
CDH1	4	SORBS1	2	bioid	Guo Z (2014)	1
INSR	9	PTPN11	20	pull down, affinity chromatography technology, pull down	Maegawa H (1994), Kharitonenkov A (1995), Kharitonenkov A (1995)	3
FGFR2	6	PTPN11	20	two hybrid	Yao Z (2017)	1
FGFR2	6	EPHA4	3	affinity chromatography technology	Yokote H (2005)	1
NTRK1	1	GAB2	3	affinity chromatography technology	Emdal KB (2015)	1
FGFR1	2	PTPN11	20	affinity chromatography technology	Vecchione A (2007)	1
FGFR2	6	CBL	7	affinity chromatography technology	Kaabeche K (2004)	1
SOS1	5	FRS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foehr ED (2000), Wong A (2002), Kouhara H (1997), Lao DH (2006)	4
SPRY2	4	CBL	7	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wong ES (2001), Wong ES (2001), Wong ES (2001), Wong ES (2002), Wong ES (2002), Ng C (2008), Ng C (2008), Chandramouli S (2008), Visser GD (2005), Hall AB (2003), Hall AB (2003), Rubin C (2003), Rubin C (2003), Rubin C (2003), Egan JE (2002), Miraoui H (2010), Mayer CE (2010), Sun Q (2010), Severe N (2011), Haglund K (2005), Lao DH (2007), Lao DH (2007), Fong CW (2003), Fong CW (2003), Mason JM (2004), DaSilva J (2006), Lao DH (2006)	27
GAB1	3	PTPN11	20	affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saito Y (2002), Rocchi S (1998), Ingham RJ (1998), Ingham RJ (1998), van den Akker E (2004), Kapoor GS (2004), Kapoor GS (2004), Kapoor GS (2010), Fan YX (2013)	9
CRK	0	RET	3	pull down, imaging technique	Bocciardi R (1997), Chen TC (2014)	2
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
CRK	0	SOS1	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Okada S (1996), Okada S (1996), Okada S (1996), Ingham RJ (1996), Brehme M (2009), Chen TC (2014)	6
FGFR1	2	FRS2	0	pull down, affinity chromatography technology, two hybrid, pull down, two hybrid, x-ray crystallography, enzymatic study, affinity chromatography technology	Yan KS (2002), Ong SH (2000), Xu H (1998), Xu H (1998), Dhalluin C (2000), Dhalluin C (2000), Larsson H (1999), Vecchione A (2007)	8
FRS2	0	SPRY2	4	affinity chromatography technology	Mason JM (2004)	1
FRS2	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ong SH (1996), Wong A (2002), Meakin SO (1999), Kouhara H (1997), Mason JM (2004), Liu BA (2012), Lao DH (2006), Bisson N (2011), Zhou L (2015)	9
LYN	2	FRS2	0	affinity chromatography technology	Zhu J (2013)	1
PRKCI	1	FRS2	0	two hybrid, pull down	Lim YP (1999), Lim YP (1999)	2
TRIM25	5	INSR	9	affinity chromatography technology	Choudhury NR (2017)	1
FRS2	0	NTRK1	1	pull down, two hybrid	Meakin SO (1999), Meakin SO (1999)	2
CDH1	4	GAB1	3	bioid	Guo Z (2014)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CBL	7	RET	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carniti C (2003), Carniti C (2003), Scott RP (2005)	3
SOS1	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hadari YR (1998), Chin H (1997), Kapoor GS (2010), Yu WM (2006)	4
NTRK1	1	NTRK3	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	LYN	2	affinity chromatography technology	Emdal KB (2015)	1
FLOT1	0	CBL	7	pull down	Baumann CA (2000)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
SPRY2	4	GRB2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Glienke J (2000), Chandramouli S (2008), Lao DH (2007), Mason JM (2004), Lao DH (2006), Lao DH (2006)	6
TMEM17	0	PRKCI	1	bioid	Gupta GD (2015)	1
FGFR1	2	GAB1	3	affinity chromatography technology	Vecchione A (2007)	1
PTPN11	20	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boudot C (2002), Boudot C (2002), Lynch DK (2002), Zhao C (1999), Crouin C (2001), Crouin C (2001), Schaeper U (2000), Cholay M (2010), van den Akker E (2004), Arnaud M (2004), Arnaud M (2004), Yu WM (2006), Yu WM (2006)	13
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
FGFR1	2	SOS1	5	imaging technique	Chen TC (2014)	1
LYN	2	GAB2	3	affinity chromatography technology	Xie ZH (2002)	1
FRS2	0	EPHA4	3	affinity chromatography technology	Yokote H (2005)	1
INSR	9	SORBS1	2	affinity chromatography technology	Lin WH (2001)	1
TRIM25	5	PTPN11	20	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	GAB1	3	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	FRS2	0	enzymatic study	Delahaye L (2000)	1
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
FRS2	0	RET	3	pull down	Kurokawa K (2001)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
TMEM17	0	FRS2	0	bioid	Gupta GD (2015)	1
LYN	2	FGFR2	6	affinity chromatography technology	Kaabeche K (2004)	1
GAB2	3	GAB1	3	two hybrid	van den Akker E (2004)	1
NTRK1	1	RPS6	1	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	RPS6	1	affinity chromatography technology	Choudhury NR (2017)	1
FGFR2	6	FRS2	0	affinity chromatography technology, affinity chromatography technology	Severe N (2011), Ceridono M (2005)	2
FRS2	0	NTRK3	2	pull down	Meakin SO (1999)	1
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
CRK	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Larsson H (1999)	2
NTRK1	1	PTPN11	20	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	FLOT1	0	bioid	Guo Z (2014)	1
EPHA4	3	FGFR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukai J (2008), Fukai J (2008), Yokote H (2005)	3
FRS2	0	BECN1	2	two hybrid	Grossmann A (2015)	1
LYN	2	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995)	6
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
TMEM17	0	LYN	2	bioid	Gupta GD (2015)	1
GRB2	2	RET	3	pull down, pull down, affinity chromatography technology, pull down	Borrello MG (1994), Pandey A (1995), Scott RP (2005), Besset V (2000)	4
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
NTRK1	1	RET	3	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	FRS2	0	affinity chromatography technology	Choudhury NR (2017)	1
FLOT1	0	SORBS1	2	affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Baumann CA (2000), Baumann CA (2000), Kimura A (2001), Limpert AS (2007), Ding Y (2005)	6
FGFR1	2	CDH1	4	imaging technique	Chen TC (2014)	1
GAB1	3	FRS2	0	affinity chromatography technology	Zhou L (2015)	1
FRS2	0	SORBS1	2	two hybrid, pull down, affinity chromatography technology	Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012)	3
TMEM17	0	INSR	9	bioid	Gupta GD (2015)	1
CRK	0	GAB2	3	affinity chromatography technology	Brehme M (2009)	1
TRIM25	5	PRKCI	1	affinity chromatography technology	Choudhury NR (2017)	1
GRB2	2	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2004), Lynch DK (2002), Zhao C (1999), Zhao C (1999), Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Rolland T (2014), Huttlin EL (2017), Yu WM (2006), Yu WM (2006)	11
FRS2	0	FLOT1	0	two hybrid, pull down, pull down, affinity chromatography technology	Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012), Tomasovic A (2012)	4
CDH1	4	CBL	7	bioid	Guo Z (2014)	1
FRS2	0	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wong A (2002), Wong A (2002), Belleudi F (2007)	3
SORBS1	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Vandenbroere I (2003), Limpert AS (2007)	4
GAB2	3	FRS2	0	affinity chromatography technology	Zhou L (2015)	1
NTRK1	1	SOS1	5	affinity chromatography technology	Emdal KB (2015)	1
FRS2	0	PTPN11	20	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, unspecified method, affinity chromatography technology	Delahaye L (2000), Delahaye L (2000), Kurokawa K (2001), Hadari YR (1998), Hadari YR (1998), Liu BA (2012), Zhou L (2015)	7
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
PRKCI	1	GAB1	3	affinity chromatography technology	Yang Z (2012)	1
GRB2	2	GAB1	3	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Oneyama C (2002), Lewitzky M (2001), Lewitzky M (2001), Lewitzky M (2001), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Bandyopadhyay S (2010), Ingham RJ (1998), Brehme M (2009), Fixman ED (1997), Bisson N (2011), Huttlin EL (2017), Kapoor GS (2010), Lehr S (1999)	15
GRB2	2	SOS1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Liu SK (1998), Oneyama C (2002), Puil L (1994), Robinson A (1996), Li N (1993), Wong A (2002), Wong A (2002), Reif K (1994), DAngelo G (1999), Nel AE (1995), Pandey P (1995), Buday L (1994), Tong XK (2000), Park RK (1999), Okada S (1996), Okada S (1996), Okada S (1996), Germani A (1999), Park RK (1999), Chin H (1997), Saci A (2002), Sastry L (1997), Spivak-Kroizman T (1994), Ingham RJ (1996), Wang Y (1999), Chu J (1998), Brehme M (2009), Houtman JC (2006), Lao DH (2006), Bisson N (2011), Wang J (2011), Ng MY (2017), Huttlin EL (2017), Kapoor GS (2010), Saito T (2004), Klint P (1995)	37
CRK	0	FRS2	0	pull down	Meakin SO (1999)	1
NTRK1	1	SORBS1	2	affinity chromatography technology	Limpert AS (2007)	1
FRS2	0	RPS6	1	two hybrid	Grossmann A (2015)	1
TRIM25	5	LYN	2	affinity chromatography technology	Choudhury NR (2017)	1