PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NEK6	2	PHF1	1	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
CCDC85B	0	FAM208B	4	two hybrid	Rual JF (2005)	1
NEK6	2	NEK6	2	enzymatic study	Vaz Meirelles G (2010)	1
NEK6	2	PRDX3	3	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
NEK6	2	FANCI	1	affinity chromatography technology	Ewing RM (2007)	1
TCF4	26	NEK6	2	two hybrid	Rolland T (2014)	1
HNRNPL	3	TNK2	7	affinity chromatography technology	Fei T (2017)	1
XIAP	0	NEK6	2	two hybrid	Rolland T (2014)	1
NEK6	2	RBBP6	7	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
NEK9	1	NEK7	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Belham C (2003), Behrends C (2010), Boldt K (2016)	3
NEK7	0	EML4	1	affinity chromatography technology	Boldt K (2016)	1
HNRNPL	3	ARRB1	2	affinity chromatography technology	Fei T (2017)	1
NEK6	2	IPO4	9	affinity chromatography technology	Ewing RM (2007)	1
KRT31	0	NEK6	2	two hybrid	Rolland T (2014)	1
TNK2	7	NEK6	2	two hybrid	Rolland T (2014)	1
NFATC1	12	IKZF1	2	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
ARRB1	2	NEK6	2	two hybrid	Wang J (2011)	1
NEK6	2	HSD17B14	0	two hybrid	Rolland T (2014)	1
DYNLL1	0	EML3	1	affinity chromatography technology	Hein MY (2015)	1
NEK6	2	PCID2	1	affinity chromatography technology	Ewing RM (2007)	1
HNRNPL	3	FAM208B	4	affinity chromatography technology	Fei T (2017)	1
NEK6	2	RUVBL2	4	affinity chromatography technology	Ewing RM (2007)	1
AES	2	IKZF3	1	two hybrid	Rolland T (2014)	1
NEK6	2	IKZF3	1	two hybrid	Rolland T (2014)	1
IL13RA2	0	NEK6	2	affinity chromatography technology	Huttlin EL (2017)	1
KCTD5	0	NEK6	2	two hybrid	Wang J (2011)	1
NEK6	2	PAK6	0	two hybrid	Wang J (2011)	1
NEK6	2	EML4	1	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	PRAM1	4	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
RUVBL2	4	CCAR2	9	affinity chromatography technology	Jeronimo C (2007)	1
NEK6	2	ATF4	2	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
PRAM1	4	KRT40	0	two hybrid	Rolland T (2014)	1
KCTD5	0	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rutz N (2015), Rutz N (2015), Rutz N (2015)	3
NEK6	2	FAM208B	4	two hybrid	Rolland T (2014)	1
DYNLL1	0	XIAP	0	affinity chromatography technology	Boldt K (2016)	1
PSMD2	2	PTN	0	two hybrid	Stelzl U (2005)	1
DYNLL1	0	CCDC36	1	two hybrid	Rolland T (2014)	1
NFATC1	12	NEK6	2	affinity chromatography technology	Gabriel CH (2016)	1
GCN1	6	HNRNPL	3	biochemical	Havugimana PC (2012)	1
ARRB1	2	MYO1C	5	affinity chromatography technology	Xiao K (2007)	1
NEK6	2	DYNLL1	0	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	ERCC6L2	2	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
NEK6	2	EML2	2	affinity chromatography technology	Ewing RM (2007)	1
LNX1	7	USP9X	15	affinity chromatography technology	Lenihan JA (2017)	1
CDC37	0	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
IKZF3	1	PCID2	1	two hybrid	Rolland T (2014)	1
NEK6	2	KRT40	0	two hybrid	Rolland T (2014)	1
NEK6	2	TRIP4	2	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
NECAB2	1	LNX1	7	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
AES	2	KRT31	0	two hybrid	Rolland T (2014)	1
NEK6	2	HACD3	2	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	NEK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
HNRNPL	3	AES	2	affinity chromatography technology	Fei T (2017)	1
HACD3	2	FANCI	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
IL13RA2	0	GCN1	6	affinity chromatography technology	Huttlin EL (2017)	1
IKZF1	2	NEK6	2	two hybrid	Rolland T (2014)	1
HNRNPL	3	NEK6	2	affinity chromatography technology	Fei T (2017)	1
FANCI	1	CIR1	1	affinity chromatography technology	Hein MY (2015)	1
NEK6	2	SLC1A5	1	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	MCM7	5	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	GCN1	6	affinity chromatography technology	Ewing RM (2007)	1
PRDX3	3	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEK6	2	CDC37	0	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	XPO5	2	affinity chromatography technology	Ewing RM (2007)	1
HNRNPL	3	XIAP	0	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	HSD17B14	0	affinity chromatography technology	Fei T (2017)	1
NEK6	2	ARHGAP33	2	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
IKZF1	2	IKZF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (1999), Hung KH (2016), Hung KH (2016), Huttlin EL (2017)	4
AES	2	NEK6	2	two hybrid	Rolland T (2014)	1
NFATC1	12	NEK7	0	affinity chromatography technology	Gabriel CH (2016)	1
NEK6	2	KDELR1	1	affinity chromatography technology	Ewing RM (2007)	1
LNX1	7	PAK6	0	affinity chromatography technology	Wolting CD (2011)	1
HNRNPL	3	HACD3	2	affinity chromatography technology	Fei T (2017)	1
NEK6	2	CCAR2	9	affinity chromatography technology	Ewing RM (2007)	1
EML2	2	EML3	1	affinity chromatography technology	Richards MW (2015)	1
MCM7	5	TRIM27	2	two hybrid	Rolland T (2014)	1
TNK2	7	CDC37	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Mahendrarajah N (2017)	2
NEK6	2	NEK9	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Belham C (2003), Belham C (2003), Roig J (2002), Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010), Huttlin EL (2015), Huttlin EL (2017)	9
TRIM23	3	FAM208B	4	two hybrid	Rolland T (2014)	1
NEK6	2	PSMD2	2	affinity chromatography technology	Ewing RM (2007)	1
HNRNPL	3	NEK9	1	affinity chromatography technology	Fei T (2017)	1
NEK6	2	CCDC85B	0	two hybrid	Rual JF (2005)	1
CCDC85B	0	LNX1	7	two hybrid	Rual JF (2005)	1
CDC42	3	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
NEK6	2	USP9X	15	affinity chromatography technology	Ewing RM (2007)	1
RUVBL2	4	LNX1	7	two hybrid	Rolland T (2014)	1
TNK2	7	CDC42	3	affinity chromatography technology, two hybrid, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Kato-Stankiewicz J (2001), Bandyopadhyay S (2010), Lin Q (2010), Mott HR (1999), Mott HR (1999), Gu Y (2004), Gu Y (2004), Owen D (2000), Govind S (2001), Jones S (2014), Jones S (2014), Urena JM (2005), Urena JM (2005), Tetley GJN (2017), Tetley GJN (2017)	15
NEK6	2	CDC42	3	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
LAMP2	0	MCM7	5	biochemical	Havugimana PC (2012)	1
TRIM23	3	LNX1	7	two hybrid	Rual JF (2005)	1
TRIM23	3	NEK6	2	two hybrid	Rolland T (2014)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
NEK6	2	CCDC36	1	two hybrid	Rolland T (2014)	1
AES	2	KRT40	0	two hybrid	Rolland T (2014)	1
NEK6	2	LZTS2	4	two hybrid	Rolland T (2014)	1
NEK6	2	RPS7	0	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
NEK6	2	LRPPRC	7	affinity chromatography technology	Ewing RM (2007)	1
LAMP3	1	NEK7	0	affinity chromatography technology	Huttlin EL (2017)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
LAMP2	0	NEK6	2	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	NFATC1	12	affinity chromatography technology	Fei T (2017)	1
NEK6	2	MYO1C	5	affinity chromatography technology	Ewing RM (2007)	1
IL13RA2	0	NEK7	0	affinity chromatography technology	Huttlin EL (2017)	1
RUVBL2	4	IPO4	9	biochemical	Wan C (2015)	1
CDC42	3	XIAP	0	affinity chromatography technology, pull down, enzymatic study, pull down	Murali A (2017), Murali A (2017), Murali A (2017), Murali A (2017)	4
LAMP3	1	NEK6	2	affinity chromatography technology	Huttlin EL (2017)	1
ANKRA2	0	CCAR2	9	affinity chromatography technology	Nie J (2015)	1
NEK6	2	SMC3	16	affinity chromatography technology	Ewing RM (2007)	1
LNX1	7	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017)	2
NEK6	2	INCA1	1	two hybrid	Rolland T (2014)	1
NEK6	2	LNX1	7	two hybrid	Rolland T (2014)	1
NEK9	1	DYNLL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), So J (2015), Hein MY (2015), Boldt K (2016)	4
TRIM27	2	PRAM1	4	affinity chromatography technology, two hybrid, two hybrid	Cao T (1998), Cao T (1998), Rolland T (2014)	3
AES	2	TRIM27	2	two hybrid	Rolland T (2014)	1
PHF1	1	HSD17B14	0	two hybrid	Rolland T (2014)	1
NEK6	2	CIR1	1	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
NEK6	2	EML3	1	affinity chromatography technology	Ewing RM (2007)	1
NEK6	2	RELB	1	two hybrid, pull down, affinity chromatography technology	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
NEK6	2	NUP93	5	affinity chromatography technology	Ewing RM (2007)	1
HNRNPL	3	LRPPRC	7	affinity chromatography technology	Fei T (2017)	1
CDC42	3	PAK6	0	pull down, two hybrid	Lee SR (2002), Bandyopadhyay S (2010)	2
TRIM23	3	PHF1	1	two hybrid	Rolland T (2014)	1
TRIM27	2	NEK6	2	two hybrid	Rolland T (2014)	1
DERA	1	NEK6	2	biochemical	Havugimana PC (2012)	1
HNRNPL	3	LZTS2	4	affinity chromatography technology	Fei T (2017)	1
NEK6	2	PTN	0	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
DYNLL1	0	NEK7	0	affinity chromatography technology	Boldt K (2016)	1
NEK6	2	ANKRA2	0	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
MCM7	5	PSMD2	2	biochemical	Wan C (2015)	1
CDC42	3	PRDX3	3	affinity chromatography technology	Hein MY (2015)	1
NFATC1	12	SMC3	16	affinity chromatography technology	Li X (2015)	1
AES	2	TCF4	26	two hybrid	Rolland T (2014)	1
NEK6	2	NECAB2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2