PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLK4	1	MTUS2	4	two hybrid	Rual JF (2005)	1
SASS6	1	FBXW5	6	affinity chromatography technology, affinity chromatography technology, enzymatic study	Puklowski A (2011), Puklowski A (2011), Puklowski A (2011)	3
PLK4	1	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP250	4	SPICE1	2	affinity chromatography technology	Fogeron ML (2013)	1
SDCCAG3	3	CHD3	19	two hybrid	Stelzl U (2005)	1
OFD1	3	NEDD1	1	bioid	Gupta GD (2015)	1
SASS6	1	ALMS1	13	bioid	Gupta GD (2015)	1
CEP192	5	PCNT	10	bioid	Firat-Karalar EN (2014)	1
CEP192	5	CEP131	9	bioid	Firat-Karalar EN (2014)	1
STIL	3	SDCCAG3	3	bioid	Gupta GD (2015)	1
CEP192	5	ALMS1	13	affinity chromatography technology, bioid	Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	2
CEP63	2	CSPP1	7	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
NEDD1	1	CCT2	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hein MY (2015)	2
SPICE1	2	CSPP1	7	bioid	Gupta GD (2015)	1
PLK4	1	MIB1	5	affinity chromatography technology, affinity chromatography technology	Cajanek L (2015), Cajanek L (2015)	2
CEP192	5	CEP350	4	bioid	Firat-Karalar EN (2014)	1
PLK4	1	TAX1BP3	1	two hybrid	Wang J (2011)	1
PLK4	1	PNPLA8	2	affinity chromatography technology	Hein MY (2015)	1
ARR3	0	PLK4	1	two hybrid	Rolland T (2014)	1
OFD1	3	SDCCAG3	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PLK4	1	CEP350	4	bioid	Firat-Karalar EN (2014)	1
PLK4	1	CEP128	1	bioid	Firat-Karalar EN (2014)	1
PLK4	1	USP54	5	bioid	Firat-Karalar EN (2014)	1
PLK4	1	PLK1	0	bioid	Firat-Karalar EN (2014)	1
PLK4	1	CSPP1	7	bioid	Firat-Karalar EN (2014)	1
PCNT	10	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
CEP152	2	CDK5RAP2	3	bioid, affinity chromatography technology	Firat-Karalar EN (2014), Firat-Karalar EN (2014)	2
CEP152	2	ALMS1	13	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
PLK4	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
SPICE1	2	NEDD1	1	bioid	Gupta GD (2015)	1
PLK4	1	TTK	4	bioid	Firat-Karalar EN (2014)	1
BTRC	1	CCT2	1	bioid	Coyaud E (2015)	1
CEP152	2	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
SPICE1	2	CEP85	5	bioid	Gupta GD (2015)	1
LZTS2	4	ELOA	3	affinity chromatography technology	Huttlin EL (2017)	1
SASS6	1	NEDD1	1	bioid	Gupta GD (2015)	1
CEP128	1	NEDD1	1	bioid	Gupta GD (2015)	1
PLK4	1	ATP9A	2	affinity chromatography technology	Hein MY (2015)	1
PLK4	1	SYNPO2	1	affinity chromatography technology	Hein MY (2015)	1
SFN	1	PLK4	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
CEP128	1	MIB1	5	bioid	Gupta GD (2015)	1
SASS6	1	CEP152	2	bioid	Gupta GD (2015)	1
SASS6	1	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	LZTS2	4	bioid	Gupta GD (2015)	1
CEP63	2	CEP131	9	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
PLK4	1	ALMS1	13	bioid	Firat-Karalar EN (2014)	1
PCNT	10	MIB1	5	affinity chromatography technology	Hein MY (2015)	1
CEP152	2	KIAA1671	0	bioid	Gupta GD (2015)	1
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
BTRC	1	CCT6A	1	bioid	Coyaud E (2015)	1
PLK4	1	CEP192	5	bioid	Firat-Karalar EN (2014)	1
CEP63	2	ALMS1	13	bioid	Firat-Karalar EN (2014)	1
CEP192	5	NEDD1	1	affinity chromatography technology, bioid	Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	2
PLK4	1	NEDD1	1	bioid	Firat-Karalar EN (2014)	1
SASS6	1	STIL	3	affinity chromatography technology, affinity chromatography technology, bioid	Arquint C (2012), Arquint C (2012), Gupta GD (2015)	3
PLK4	1	RBFOX1	1	affinity chromatography technology	Hein MY (2015)	1
OFD1	3	PLOD1	2	bioid	Gupta GD (2015)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
CEP192	5	KIAA1671	0	bioid	Firat-Karalar EN (2014)	1
PLK4	1	STIL	3	bioid	Firat-Karalar EN (2014)	1
CEP128	1	CEP192	5	bioid	Gupta GD (2015)	1
STIL	3	NEDD1	1	bioid	Gupta GD (2015)	1
STIL	3	OFD1	3	bioid	Gupta GD (2015)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
BTRC	1	NEDD1	1	bioid	Coyaud E (2015)	1
STIL	3	BTRC	1	bioid	Gupta GD (2015)	1
FBXW11	2	USP54	5	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2
KIF2A	3	CEP192	5	affinity chromatography technology	Hein MY (2015)	1
PLK4	1	OFD1	3	bioid	Firat-Karalar EN (2014)	1
PLK4	1	KIAA1671	0	bioid	Firat-Karalar EN (2014)	1
CEP192	5	CEP152	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
DUSP23	1	PLK4	1	affinity chromatography technology	St-Denis N (2016)	1
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
SDF4	1	KIAA1671	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP250	4	DOCK7	3	affinity chromatography technology	Fogeron ML (2013)	1
CEP152	2	PCNT	10	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	CSPP1	7	bioid	Gupta GD (2015)	1
CEP192	5	CDK5RAP2	3	bioid	Firat-Karalar EN (2014)	1
PLK4	1	FBXW11	2	bioid	Firat-Karalar EN (2014)	1
CEP63	2	CEP350	4	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
PLK4	1	PLK4	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
OFD1	3	KIAA1671	0	bioid	Gupta GD (2015)	1
CEP63	2	KIAA1671	0	bioid	Gupta GD (2015)	1
BTRC	1	OFD1	3	bioid	Coyaud E (2015)	1
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
NEDD1	1	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	KIAA1671	0	bioid	Gupta GD (2015)	1
OFD1	3	PLK1	0	affinity chromatography technology, two hybrid, bioid	Wang J (2011), Wang J (2011), Gupta GD (2015)	3
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP128	1	CEP131	9	bioid	Gupta GD (2015)	1
LZTS2	4	CEP131	9	affinity chromatography technology	Huttlin EL (2017)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
PLK4	1	PCNT	10	bioid	Firat-Karalar EN (2014)	1
PLK4	1	SDF4	1	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	DOCK7	3	affinity chromatography technology	Low TY (2014)	1
BTRC	1	USP54	5	bioid	Coyaud E (2015)	1
STIL	3	FBXW11	2	bioid	Gupta GD (2015)	1
C1orf109	1	LZTS2	4	two hybrid	Rolland T (2014)	1
PLK4	1	CEP131	9	bioid	Firat-Karalar EN (2014)	1
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PLK4	1	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
SPICE1	2	CEP131	9	bioid	Gupta GD (2015)	1
CEP128	1	CEP85	5	bioid	Gupta GD (2015)	1
CEP250	4	MAGED1	0	affinity chromatography technology	Fogeron ML (2013)	1
CEP250	4	LZTS2	4	affinity chromatography technology	Fogeron ML (2013)	1
STIL	3	MAGED1	0	bioid	Gupta GD (2015)	1
CEP152	2	NEDD1	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
BTRC	1	MAGED1	0	bioid	Coyaud E (2015)	1
OFD1	3	CEP350	4	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MTUS2	4	C1orf109	1	two hybrid	Rolland T (2014)	1
PLK4	1	CCT2	1	affinity chromatography technology	Hein MY (2015)	1
STIL	3	CEP85	5	bioid	Gupta GD (2015)	1
BTRC	1	ALMS1	13	bioid	Coyaud E (2015)	1
CEP192	5	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
CEP128	1	ALMS1	13	bioid	Gupta GD (2015)	1
CEP128	1	TTK	4	bioid	Gupta GD (2015)	1
PLK4	1	SDCCAG3	3	bioid	Firat-Karalar EN (2014)	1
CEP152	2	CEP350	4	bioid	Firat-Karalar EN (2014)	1
CEP192	5	CEP85	5	affinity chromatography technology, bioid	Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	2
CEP152	2	SDCCAG3	3	bioid	Gupta GD (2015)	1
CEP192	5	OFD1	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP63	2	TTK	4	bioid	Gupta GD (2015)	1
CEP128	1	CEP350	4	bioid	Gupta GD (2015)	1
PLK4	1	CCDC15	3	bioid	Firat-Karalar EN (2014)	1
PLK4	1	DOCK7	3	bioid	Firat-Karalar EN (2014)	1
PLK4	1	FAM46C	3	two hybrid	Rual JF (2005)	1
CEP128	1	USP54	5	bioid	Gupta GD (2015)	1
CEP192	5	CEP63	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
NEDD1	1	CCT6A	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hein MY (2015)	2
CEP63	2	OFD1	3	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
CEP250	4	CEP350	4	affinity chromatography technology	Fogeron ML (2013)	1
SPICE1	2	CEP350	4	bioid	Gupta GD (2015)	1
CHD3	19	PCNT	10	two hybrid, affinity chromatography technology, affinity chromatography technology	Sillibourne JE (2007), Sillibourne JE (2007), Sillibourne JE (2007)	3
ELOA	3	PLK4	1	two hybrid	Rolland T (2014)	1
CEP128	1	PLK1	0	bioid	Gupta GD (2015)	1
PLK4	1	MYCBP2	11	bioid	Firat-Karalar EN (2014)	1
BTRC	1	PLK4	1	affinity chromatography technology, affinity chromatography technology	Guderian G (2010), Guderian G (2010)	2
CEP63	2	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
PLK4	1	PTDSS1	1	affinity chromatography technology	Hein MY (2015)	1
PLK4	1	CEP250	4	bioid	Firat-Karalar EN (2014)	1
CEP250	4	SDCCAG3	3	affinity chromatography technology	Fogeron ML (2013)	1
CEP250	4	MIB1	5	affinity chromatography technology	Fogeron ML (2013)	1
MAGED1	0	PLK1	0	two hybrid	Stelzl U (2005)	1
CEP128	1	SDCCAG3	3	bioid	Gupta GD (2015)	1
TTK	4	KIF2A	3	affinity chromatography technology	Hein MY (2015)	1
PLK4	1	FAM83H	6	bioid	Firat-Karalar EN (2014)	1
SASS6	1	CEP131	9	bioid	Gupta GD (2015)	1
PLK4	1	CEP85	5	bioid	Firat-Karalar EN (2014)	1
CEP63	2	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
FBXW11	2	FAM83H	6	affinity chromatography technology	Low TY (2014)	1
SASS6	1	KIAA1671	0	bioid	Gupta GD (2015)	1
CEP152	2	TTK	4	bioid	Gupta GD (2015)	1
PCNT	10	OFD1	3	affinity chromatography technology	Hein MY (2015)	1
SPICE1	2	KIF2A	3	bioid	Gupta GD (2015)	1
OFD1	3	CSPP1	7	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PLK4	1	CEP152	2	bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015)	3
SASS6	1	SDCCAG3	3	bioid	Gupta GD (2015)	1
OFD1	3	MIB1	5	affinity chromatography technology	Hein MY (2015)	1
PLK4	1	SASS6	1	bioid	Firat-Karalar EN (2014)	1
PLK4	1	C1orf109	1	two hybrid	Rolland T (2014)	1
CDK5RAP2	3	PCNT	10	affinity chromatography technology, affinity chromatography technology	Wang Z (2010), Hein MY (2015)	2
PLK4	1	KIF2A	3	bioid	Firat-Karalar EN (2014)	1
PLOD1	2	PLK4	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	CCT6A	1	affinity chromatography technology	Low TY (2014)	1
SASS6	1	CEP192	5	bioid	Gupta GD (2015)	1
CEP63	2	PCNT	10	bioid	Firat-Karalar EN (2014)	1
CEP63	2	CEP152	2	bioid, bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	4
FBXW5	6	PLK4	1	affinity chromatography technology, affinity chromatography technology	Puklowski A (2011), Puklowski A (2011)	2
PLK4	1	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
CCT2	1	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
OFD1	3	CEP85	5	bioid	Gupta GD (2015)	1
SFN	1	MYCBP2	11	affinity chromatography technology	Benzinger A (2005)	1
PLK4	1	CEP63	2	bioid	Firat-Karalar EN (2014)	1
CEP152	2	CEP131	9	bioid	Firat-Karalar EN (2014)	1
PLK4	1	CCT6A	1	affinity chromatography technology	Hein MY (2015)	1
SDF4	1	FAM83H	6	affinity chromatography technology	Huttlin EL (2015)	1
PLK4	1	CDK5RAP2	3	bioid	Firat-Karalar EN (2014)	1
RBFOX1	1	LZTS2	4	two hybrid	Lim J (2006)	1
CEP152	2	OFD1	3	bioid	Gupta GD (2015)	1
CEP131	9	MIB1	5	affinity chromatography technology, pull down	Villumsen BH (2013), Villumsen BH (2013)	2