PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT6	2	RBBP4	3	affinity chromatography technology	Simeoni F (2013)	1
POLD3	0	POLA1	0	biochemical	Havugimana PC (2012)	1
PCNA	0	DNMT1	5	affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rountree MR (2000), Iida T (2002), Chuang LS (1997), Ha K (2011), Pichler G (2012), Pichler G (2012), Pichler G (2012), Hervouet E (2010), Hervouet E (2010), Cai Y (2014), Han J (2014), Hein MY (2015)	12
NR2C1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011), Cui S (2011)	3
DCP2	0	POLD3	0	affinity chromatography technology	Li S (2014)	1
POLD3	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NR2C1	0	POLD3	0	affinity chromatography technology	Cui S (2011)	1
DNMT1	5	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Cui S (2011), Cui S (2011), Cai Y (2014), Cai Y (2014), Cai Y (2014), Cai Y (2014)	6
PCNA	0	POLD2	2	pull down, pull down, far western blotting, biochemical, affinity chromatography technology, affinity chromatography technology	Lu X (2002), Lu X (2002), Lu X (2002), Shikata K (2001), Cazzalini O (2014), Hein MY (2015)	6
HDAC1	4	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2003), Yao YL (2003), Yao YL (2003), Mazumdar A (2001), Mazumdar A (2001), Yoo YG (2006), Liu XF (2004), Khaleque MA (2008), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016)	21
TAF2	1	XPO1	8	genetic interference	Horlbeck MA (2018)	1
NR2C1	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011), Cui S (2011)	3
USP8	7	POLD3	0	biochemical	Kristensen AR (2012)	1
HUS1	1	POLA1	0	genetic interference	Horlbeck MA (2018)	1
TP53	0	DNMT1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Palii SS (2008), Zhang H (2013), Zhang H (2013)	3
TRIM14	1	RBBP4	3	bioid	Tan P (2017)	1
XPO1	8	POLD3	0	affinity chromatography technology	Kirli K (2015)	1
MTA1	3	POLD3	0	affinity chromatography technology	Cui S (2011)	1
MBD3L2	0	RBBP4	3	pull down	Jin SG (2005)	1
POLD3	0	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
TP53	0	POLD3	0	genetic interference	Xie L (2013)	1
RBBP4	3	POLD3	0	affinity chromatography technology	Cui S (2011)	1
MCM3	2	RBBP4	3	affinity chromatography technology	Mulvaney KM (2016)	1
POLD3	0	POLD2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Pohler JR (2005), Shikata K (2001), Huttlin EL (2017)	3
POLA1	0	PCNA	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
POLD3	0	MAD2L2	0	affinity chromatography technology	Kim MS (2013)	1
TRIM14	1	AHSA1	0	bioid	Tan P (2017)	1
POLD4	0	PCNA	0	pull down, far western blotting, pull down	Li H (2006), Li H (2006), Terai K (2013)	3
PCNA	0	REV1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Pozo FM (2011), Pozo FM (2011), Qin Z (2013), Shim HS (2015)	4
NR2C1	0	DNMT1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011), Cui S (2011)	3
POLD1	5	TAF2	1	genetic interference	Horlbeck MA (2018)	1
MBD3L2	0	CHD4	22	pull down	Jin SG (2005)	1
MBD3L2	0	HDAC1	4	pull down	Jin SG (2005)	1
TSEN2	5	USP8	7	biochemical	Kristensen AR (2012)	1
TRIM14	1	POLD3	0	bioid	Tan P (2017)	1
CHD4	22	RBBP4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Wan C (2015), Hauri S (2016)	9
SPRTN	0	POLD1	5	affinity chromatography technology, affinity chromatography technology	Kim MS (2013), Kim MS (2013)	2
PCNA	0	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Naryzhny SN (2005), Naryzhny SN (2004), Ogi T (2010), Shikata K (2001), Shikata K (2001), Xie B (2002), Li H (2006), Park JM (2014), Han J (2014), Hein MY (2015)	11
TP53	0	MTA1	3	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yao YL (2003), Li DQ (2010), Moon HE (2007), Moon HE (2007), Li DQ (2009), Li DQ (2009)	6
POLD4	0	POLD1	5	pull down, pull down, affinity chromatography technology	Li H (2006), Li H (2006), Hein MY (2015)	3
STXBP4	0	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
POLA1	0	MCM3	2	biochemical	Havugimana PC (2012)	1
POLD3	0	POLD1	5	affinity chromatography technology, affinity chromatography technology	Shikata K (2001), Hein MY (2015)	2
CACTIN	3	HUS1	1	genetic interference	Horlbeck MA (2018)	1
SPRTN	0	POLD4	0	affinity chromatography technology	Kim MS (2013)	1
CACTIN	3	POLD3	0	genetic interference	Horlbeck MA (2018)	1
MCM3	2	TIMELESS	8	affinity chromatography technology, genetic interference	Huttlin EL (2017), Horlbeck MA (2018)	2
SPRTN	0	POLD3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ghosal G (2012), Ghosal G (2012), Kim MS (2013), Kim MS (2013), Kim MS (2013)	5
TSEN2	5	POLD1	5	biochemical	Kristensen AR (2012)	1
MED10	0	POLD3	0	genetic interference	Horlbeck MA (2018)	1
DNMT1	5	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Cui S (2011), Cui S (2011), Cai Y (2014), Cai Y (2014), Wan C (2015)	5
MTA1	3	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Xue Y (1998), Cui S (2011), Cui S (2011), Chudnovsky Y (2014), Wan C (2015)	6
POLD3	0	TAF2	1	genetic interference	Horlbeck MA (2018)	1
POLD4	0	POLD3	0	pull down	Li H (2006)	1
XPO1	8	POLD1	5	affinity chromatography technology	Kirli K (2015)	1
SIRT6	2	POLD3	0	affinity chromatography technology	Simeoni F (2013)	1
POLA1	0	TP53	0	affinity chromatography technology	Melle C (2002)	1
HUS1	1	PCNA	0	two hybrid, two hybrid, affinity chromatography technology	Komatsu K (2000), Komatsu K (2000), Komatsu K (2000)	3
POLD1	5	MCM3	2	biochemical	Havugimana PC (2012)	1
TIMELESS	8	TSEN2	5	genetic interference	Horlbeck MA (2018)	1
POLD3	0	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, unspecified method, two hybrid, far western blotting, fluorescent resonance energy transfe, affinity chromatography technology	Ducoux M (2001), Ohta S (2002), Pohler JR (2005), Shikata K (2001), Shikata K (2001), Bruning JB (2004), Plosky BS (2006), Li H (2006), Nicolae CM (2014), Hein MY (2015)	10
HDAC1	4	HUS1	1	two hybrid, pull down, affinity chromatography technology	Cai RL (2000), Cai RL (2000), Cai RL (2000)	3
HUS1	1	POLD1	5	genetic interference	Horlbeck MA (2018)	1
TP53	0	STXBP4	0	genetic interference	Xie L (2013)	1
HUS1	1	POLD3	0	genetic interference	Horlbeck MA (2018)	1
MTA1	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Cui S (2011), Cui S (2011), Rolland T (2014), Huttlin EL (2015), Alqarni SS (2014), Alqarni SS (2014), Alqarni SS (2014), Wan C (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016), Millard CJ (2016), Hauri S (2016)	15
MBD3L2	0	POLD3	0	pull down	Jin SG (2005)	1
POLD3	0	MCM3	2	biochemical	Havugimana PC (2012)	1
POLD2	2	POLD1	5	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Li H (2006), Li H (2006), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
HDAC1	4	POLD3	0	affinity chromatography technology	Cui S (2011)	1
SIRT6	2	POLD2	2	affinity chromatography technology	Simeoni F (2013)	1
REV1	1	TP53	0	affinity chromatography technology	Shim HS (2015)	1
NR2C1	0	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011), Cui S (2011)	3
AHSA1	0	POLD3	0	affinity chromatography technology	Wolfgeher D (2015)	1
TIMELESS	8	PCNA	0	affinity chromatography technology	Yang XH (2008)	1
DNMT1	5	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011)	2
HDAC1	4	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), Grozinger CM (1999), Tong JK (1998), Tong JK (1998), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Terhune SS (2010), Polo SE (2010), Xue Y (1998), Xue Y (1998), Xue Y (1998), Kwintkiewicz J (2011), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Quan J (2014), Wan C (2015), Hein MY (2015), Weiss K (2016), Huttlin EL (2017)	28
MAD2L2	0	REV1	1	two hybrid, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, pull down	Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Pozo FM (2011), Ohashi E (2004), Hashimoto K (2012), Sharma S (2012), Hara K (2010), Masuda Y (2003), Tissier A (2004), Chun AC (2013), Pustovalova Y (2012), Kikuchi S (2012), Kikuchi S (2012)	15
XPO1	8	POLD2	2	affinity chromatography technology	Kirli K (2015)	1
HUS1	1	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SIRT6	2	CHD4	22	affinity chromatography technology	Simeoni F (2013)	1
POLD3	0	POLD3	0	genetic interference	Horlbeck MA (2018)	1
TP53	0	RBBP4	3	affinity chromatography technology	Fogeron ML (2013)	1
PCNA	0	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Milutinovic S (2002), Milutinovic S (2002), Naryzhny SN (2004)	3
TSEN2	5	POLD3	0	biochemical	Kristensen AR (2012)	1
DNMT1	5	POLD3	0	affinity chromatography technology	Cui S (2011)	1
SIRT6	2	HDAC1	4	affinity chromatography technology	Simeoni F (2013)	1
DNMT1	5	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Robertson KD (2000), Achour M (2008), Achour M (2008), Kimura H (2003), Zhang Q (2005), Myant K (2008), Schnekenburger M (2007), Kang KA (2012), Cui S (2011), Cui S (2011), Hervouet E (2010), Cai Y (2014), Cai Y (2014), Yuan K (2016), Yuan K (2016)	15
CACTIN	3	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
CHD4	22	POLD3	0	affinity chromatography technology	Cui S (2011)	1
CACTIN	3	XPO1	8	genetic interference	Horlbeck MA (2018)	1
NR2C1	0	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Cui S (2011), Cui S (2011)	3
POLD3	0	REV1	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Kim MS (2013), Kim MS (2013), Pustovalova Y (2016), Pustovalova Y (2016)	4
POLD4	0	POLD2	2	pull down, pull down, affinity chromatography technology	Li H (2006), Li H (2006), Huttlin EL (2017)	3
FAF2	4	POLD3	0	affinity chromatography technology	Raman M (2015)	1
MBD3L2	0	MTA1	3	pull down	Jin SG (2005)	1
AHSA1	0	APP	1	pull down	Olah J (2011)	1
POLD3	0	STXBP4	0	genetic interference	Horlbeck MA (2018)	1
SPRTN	0	POLD2	2	affinity chromatography technology, affinity chromatography technology	Kim MS (2013), Kim MS (2013)	2
SPRTN	0	PCNA	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Machida Y (2012), Machida Y (2012), Davis EJ (2012), Davis EJ (2012), Juhasz S (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Juhasz S (2012), Centore RC (2012)	16