PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GNB5	2	RPA1	0	two hybrid	Wang J (2011)	1
MCM2	3	CCT6B	2	affinity chromatography technology	Drissi R (2015)	1
TCP1	0	CCT2	1	affinity chromatography technology, biochemical, biochemical, biochemical, biochemical	Gingras AC (2005), Imai Y (2003), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
GNG2	0	GNB5	2	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Snow BE (1999), Howlett AC (2009), Zhou JY (2003)	3
PFDN5	0	RPA1	0	biochemical	Kristensen AR (2012)	1
MCM2	3	TCP1	0	affinity chromatography technology	Drissi R (2015)	1
CCT2	1	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CCT5	1	GNB5	2	affinity chromatography technology	Howlett AC (2009)	1
CCT2	1	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GNB5	2	CCT6B	2	affinity chromatography technology	Huttlin EL (2015)	1
GNB5	2	PSMD4	1	two hybrid	Wang J (2011)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	CCT2	1	affinity chromatography technology	Drissi R (2015)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
GNB5	2	DRD2	4	imaging technique, protein complementation assay	Octeau JC (2014), Octeau JC (2014)	2
ANXA7	0	GNB5	2	two hybrid	Vinayagam A (2011)	1
CCT5	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
COPS5	0	CCT2	1	affinity chromatography technology	Bennett EJ (2010)	1
GNB5	2	CCT2	1	affinity chromatography technology	Huttlin EL (2017)	1
PSMD4	1	APP	1	pull down	Olah J (2011)	1
CSNK2B	5	RPA1	0	two hybrid	Vinayagam A (2011)	1
CCT3	1	PDCL	2	affinity chromatography technology	Huttlin EL (2017)	1
CCT5	1	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TSC22D1	1	GNB5	2	two hybrid	Vinayagam A (2011)	1
MCM2	3	RGS7BP	0	affinity chromatography technology	Drissi R (2015)	1
GNG4	0	PDCL	2	affinity chromatography technology	Huttlin EL (2017)	1
TCP1	0	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CCT3	1	CCT6B	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
TCP1	0	CCT5	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
MCM2	3	CCT5	1	affinity chromatography technology	Drissi R (2015)	1
MTOR	14	GNG2	0	affinity chromatography technology, affinity chromatography technology	Robles-Molina E (2014), Robles-Molina E (2014)	2
GNG5	0	GNB5	2	two hybrid	Yan K (1996)	1
GNB5	2	CCT3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANXA7	0	CCT7	2	two hybrid	Vinayagam A (2011)	1
CCT2	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TCP1	0	CCT7	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
CCT3	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
ANXA7	0	RPA1	0	two hybrid	Vinayagam A (2011)	1
PSMD4	1	RPA1	0	affinity chromatography technology	Galanty Y (2012)	1
GNB5	2	MVD	2	two hybrid	Stelzl U (2005)	1
GNB5	2	GNG7	0	two hybrid, two hybrid, imaging technique	Yan K (1996), Yan K (1996), Chen TC (2014)	3
CCT7	2	PDCL	2	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	GNB5	2	two hybrid	Vinayagam A (2011)	1
CDKN1A	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abbas T (2008), Abbas T (2008), Gao J (2015)	3
GNG3	0	PDCL	2	affinity chromatography technology	Huttlin EL (2017)	1
RGS6	1	GNB5	2	pull down, affinity chromatography technology, affinity chromatography technology	Posner BA (1999), Snow BE (1999), Huttlin EL (2017)	3
CDKN1A	1	GNB5	2	two hybrid	Vinayagam A (2011)	1
GNB5	2	CCT7	2	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	CCT7	2	two hybrid	Vinayagam A (2011)	1
RPA1	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Drissi R (2015)	3
GNG13	0	GNB5	2	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Blake BL (2001), Blake BL (2001), Zhou JY (2003)	3
ELAVL1	0	E2F2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CCT2	1	CCT5	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
GNB5	2	PFDN5	0	affinity chromatography technology	Huttlin EL (2015)	1
ELAVL1	0	PDCL	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BNIP3L	1	GNB5	2	two hybrid	Vinayagam A (2011)	1
MCM2	3	APP	1	pull down	Olah J (2011)	1
CCT6B	2	CCT7	2	biochemical	Wan C (2015)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
GNG3	0	GNB5	2	two hybrid, fluorescent resonance energy transfe	Yan K (1996), Zhou JY (2003)	2
RGS7BP	0	GNB5	2	affinity chromatography technology, affinity chromatography technology	Drenan RM (2006), Masuho I (2011)	2
GNB5	2	COPS5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCT5	1	CCT3	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
PRPF40B	6	GNB5	2	affinity chromatography technology	Huttlin EL (2017)	1
GNB5	2	MCM2	3	two hybrid	Stelzl U (2005)	1
GNG4	0	GNB5	2	two hybrid	Yan K (1996)	1
E2F2	0	GNB5	2	two hybrid	Wang J (2011)	1
CUL4A	2	GNB5	2	affinity chromatography technology	Zha Z (2015)	1
ELAVL1	0	GNB5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
GNB5	2	APP	1	pull down	Olah J (2011)	1
GNB5	2	PDCL	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Howlett AC (2009), Huttlin EL (2015), Huttlin EL (2017)	3
RGS11	0	GNB5	2	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, fluorescent resonance energy transfe	Snow BE (1999), Snow BE (1998), Snow BE (1998), Snow BE (1998), Zhou JY (2003)	5
MCM2	3	CUL4A	2	affinity chromatography technology	Drissi R (2015)	1
PDCL	2	CCT5	1	pull down	Lukov GL (2005)	1
MCM2	3	CCT7	2	affinity chromatography technology	Drissi R (2015)	1
GNB5	2	TCP1	0	affinity chromatography technology	Huttlin EL (2015)	1
RGS9	0	GNB5	2	affinity chromatography technology, affinity chromatography technology	Masuho I (2011), Huttlin EL (2017)	2
GNB5	2	RGS7	4	pull down, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levay K (1999), Levay K (1999), Posner BA (1999), Snow BE (1999), Snow BE (1998), Howlett AC (2009), Huttlin EL (2015), Huttlin EL (2017)	8
USP38	2	GNB5	2	affinity chromatography technology	Huttlin EL (2015)	1
COPS5	0	TCP1	0	affinity chromatography technology	Bennett EJ (2010)	1
RPA1	0	ELAVL1	0	affinity chromatography technology	Marechal A (2014)	1
CCT7	2	APP	1	pull down	Olah J (2011)	1
CUL4A	2	CCT5	1	affinity chromatography technology	Bennett EJ (2010)	1
MTOR	14	GNB5	2	affinity chromatography technology	Robles-Molina E (2014)	1
CSNK2B	5	CDKN1A	1	pull down	Goetz C (2000)	1
ELAVL1	0	ANXA7	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PRPF40B	6	RGS9	0	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	CCT3	1	affinity chromatography technology	Drissi R (2015)	1
TCP1	0	CCT3	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
RGS7BP	0	RGS9	0	affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, affinity chromatography technology	Drenan RM (2006), Drenan RM (2006), Masuho I (2011), Masuho I (2011), Masuho I (2011)	5
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
CCT5	1	RGS7	4	affinity chromatography technology	Howlett AC (2009)	1