PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
KLF1	1	UBC	7	x-ray crystallography	Raiola L (2013)	1
CREBBP	29	SMARCB1	1	biochemical, affinity chromatography technology	Cho H (1998), Cho H (1998)	2
KLF1	1	FLI1	2	affinity chromatography technology, pull down	Starck J (2003), Starck J (2003)	2
SIN3A	13	SMARCC1	5	pull down, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Kuzmichev A (2002), Nakamura T (2002)	3
SMARCB1	1	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Wang W (1996), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Medjkane S (2004), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	9
KLF1	1	SIN3A	13	affinity chromatography technology	Chen X (2004)	1
SMARCA4	19	SMARCC1	5	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sif S (2001), Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Inayoshi Y (2006), Inayoshi Y (2006), Pal S (2003), Pal S (2003), Bultman SJ (2005), Nagl NG (2005), Mahajan MC (2005), Trotter KW (2008), Dallas PB (1998), Tando T (2010), Tando T (2010), Bartlett C (2011), Bartlett C (2011), Oh J (2008), Oh J (2008), Havugimana PC (2012), Wan C (2015)	25
HDAC1	4	SMARCC1	5	biochemical	Havugimana PC (2012)	1
HDAC1	4	SMARCD1	5	biochemical	Havugimana PC (2012)	1
UBC	7	GTF2H1	0	pull down	Zhu Q (2004)	1
KLF1	1	CSNK2A1	15	pull down, enzymatic study	Ouyang L (1998), Ouyang L (1998)	2
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
SMARCE1	1	SMARCD1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
ARID1A	16	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Nagl NG (2005), Wang X (2004), Havugimana PC (2012), Wan C (2015), Dallas PB (1998)	7
CSNK2A1	15	SMARCC2	9	enzymatic study	Zhang M (2011)	1
KLF1	1	SMARCD1	5	pull down	Kadam S (2000)	1
SMARCE1	1	ARID1A	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
SMARCC2	9	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Nagl NG (2005), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	10
SMARCD1	5	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
SMARCD1	5	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Mak AB (2010), Oh J (2008), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
SIN3A	13	SMARCE1	1	pull down	Pal S (2003)	1
KLF1	1	SMARCB1	1	pull down	Kadam S (2000)	1
KLF1	1	SMARCC1	5	pull down	Kadam S (2000)	1
KLF1	1	SMARCE1	1	pull down	Kadam S (2000)	1
SMARCD1	5	SMARCB1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ito T (2008), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
CSNK2A1	15	HDAC1	4	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Pflum MK (2001), Cai R (2001), Sun JM (2007), Zhang M (2011), Joshi P (2013)	5
SMARCC2	9	HDAC1	4	affinity chromatography technology	Battaglioli E (2002)	1
KLF1	1	SMARCA4	19	pull down	Kadam S (2000)	1
CREBBP	29	CSNK2A1	15	pull down, far western blotting, affinity chromatography technology	Yamaguchi Y (1998), Yamaguchi Y (1998), Jung SY (2005)	3
SIN3A	13	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sun JM (2007), Sun JM (2007), Havugimana PC (2012), Wan C (2015)	4
SMARCA4	19	ARID1A	16	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Pal S (2003), Bultman SJ (2005), Wang X (2004), Trotter KW (2008), Tando T (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998)	10
SMARCB1	1	HDAC1	4	biochemical	Sif S (2001)	1
CREBBP	29	CSNK2A2	1	affinity chromatography technology	Jung SY (2005)	1
ARID1A	16	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
SMARCE1	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Lai D (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
KLF1	1	GTF2H1	0	pull down, x-ray crystallography	Mas C (2011), Mas C (2011)	2
SMARCA4	19	CREBBP	29	genetic interference	DiRenzo J (2000)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
SMARCE1	1	HDAC1	4	affinity chromatography technology	Battaglioli E (2002)	1
SMARCB1	1	SMARCC1	5	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sif S (2001), Wang W (1996), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Foster KS (2006), Foster KS (2006), Medjkane S (2004), Sif S (1998), Dallas PB (1998), Bartlett C (2011), Havugimana PC (2012), Wan C (2015)	15
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
KLF1	1	SMARCC2	9	pull down	Kadam S (2000)	1
CREBBP	29	KLF1	1	enzymatic study, pull down	Zhang W (2001), Mas C (2011)	2
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
CSNK2A2	1	SIN3A	13	biochemical	Wan C (2015)	1
SMARCB1	1	SMARCA4	19	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, genetic interference, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Sullivan EK (2001), Wang W (1996), Wang W (1996), Otsuki T (2001), Zhao K (1998), Reyes JC (1997), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Gong F (2008), Medjkane S (2004), Ito T (2008), Sif S (1998), Dallas PB (1998), Tando T (2010), Bakshi R (2010), Bakshi R (2010), Mahmoudi T (2006), Mahmoudi T (2006), Bartlett C (2011), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Shen JP (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	30
SIN3A	13	SMARCC2	9	affinity chromatography technology	Nakamura T (2002)	1
SMARCB1	1	ARID1A	16	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical	Kato H (2002), Wang W (1996), Ryme J (2009), Havugimana PC (2012), Wan C (2015)	5
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
SMARCD1	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Pal S (2003), Ito T (2008), Tando T (2010), Mak AB (2010), Oh J (2008), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
SMARCA4	19	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Zhao K (1998), Hu K (2006), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Battaglioli E (2002), ONeill DW (2000), Tando T (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	18
SMARCB1	1	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
KLF1	1	HDAC1	4	pull down, pull down	Chen X (2004), Chen X (2001)	2
KLF1	1	ARID1A	16	pull down	Kadam S (2000)	1
SMARCD1	5	ARID1A	16	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
CSNK2A2	1	KLF1	1	enzymatic study, pull down	Ouyang L (1998), Ouyang L (1998)	2
SMARCA4	19	SIN3A	13	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sif S (2001), Sif S (2001), Kuzmichev A (2002), Kuzmichev A (2002), Qiu Z (2008), Xu Z (2006), Pal S (2003), Pal S (2003)	8
SMARCE1	1	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Chen J (2005), Keppler BR (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	15
SMARCA4	19	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Trotter KW (2008), Tando T (2010), Mak AB (2010), Nishimoto N (2012), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	15
KLF1	1	EP300	36	pull down	Mas C (2011)	1
SMARCB1	1	SIN3A	13	biochemical, pull down, affinity chromatography technology	Sif S (2001), Pal S (2003), Nakamura T (2002)	3