Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IGF2BP2 rs1470579 AC + CC repaglinide "dosage","efficacy" yes The parameters that showed decreased response were FPG(fasting plasma glucose) and PPG(postprandial plasma glucose). The authors noted that the C allele frequency was higher in the Type 2 Diabetes patients than in the healthy controls when the entire trial population of 350 patients and 207 controls was assayed (C freq = 0.3029 vs 0.2464) . The subset of patients treated with repaglinide all had the same CYP2C8 genotypes(with respect to *3- but exact genotypes not given) and SLCO1B1 genotypes(with respect to *1B,*5 and *15, but exact genotypes not given) . Genotypes AC + CC are associated with decreased response to repaglinide in people with Diabetes Mellitus, Type 2 as compared to genotype AA. 20523342 981502261
IGF2BP2 rs4402960 GT + TT repaglinide "dosage","efficacy" yes The parameter that showed enhanced response was PINS(postprandial serum insulin) . The authors noted that the T allele frequency was higher in the Type 2 Diabetes patients than in the healthy controls when the entire trial population of 350 patients and 207 controls was assayed (T freq = 0.2714 vs 0.2126) . The subset of patients treated with repaglinide all had the same CYP2C8 genotypes(with respect to *3- but exact genotypes not given) and SLCO1B1 genotypes(with respect to *1B,*5 and *15, but exact genotypes not given) . Genotypes GT + TT are associated with increased response to repaglinide in people with Diabetes Mellitus, Type 2 as compared to genotype GG. 20523342 981502270