PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
OBSL1	9	CENPF	5	affinity chromatography technology	Hanson D (2014)	1
MYC	2	POLH	1	genetic interference	Toyoshima M (2012)	1
NFKBIA	0	CENPF	5	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	G3BP1	4	affinity chromatography technology	Tsai YC (2012)	1
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
SIRT7	1	CENPF	5	affinity chromatography technology	Tsai YC (2012)	1
FBXL5	3	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
FAM167A	1	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
NUP107	1	NUP133	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, biochemical, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Kaur S (2010), Zuccolo M (2007), Glavy JS (2007), Glavy JS (2007), Havugimana PC (2012), Whittle JR (2009), Wan C (2015), Kim DI (2014), Kim DI (2014), Kim DI (2014), Hein MY (2015), Boldt K (2016)	18
CUL7	4	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
ARRB2	5	CENPF	5	affinity chromatography technology	Xiao K (2007)	1
CUL7	4	NUP107	1	affinity chromatography technology	Hanson D (2014)	1
CCDC68	1	CENPF	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLH	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
CENPU	0	CENPF	5	affinity chromatography technology	Hein MY (2015)	1
FNTB	0	CENPF	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OBSL1	9	NUP107	1	affinity chromatography technology	Hanson D (2014)	1
COPS6	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
NANOG	0	CENPF	5	affinity chromatography technology	Oliviero G (2015)	1
ARRB2	5	NPM1	0	affinity chromatography technology	Xiao K (2007)	1
NPM1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Sato K (2004), Ertych N (2016)	2
CUL7	4	CENPF	5	affinity chromatography technology	Hanson D (2014)	1
BRCA1	7	TERF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballal RD (2009), Ballal RD (2009), Hill SJ (2014)	3
OBSL1	9	NUP133	4	affinity chromatography technology	Hanson D (2014)	1
IKBKG	0	ALK	8	pull down	Fenner BJ (2010)	1
SVIL	9	CENPF	5	two hybrid	Smith TC (2010)	1
SIRT7	1	CUL7	4	affinity chromatography technology	Tsai YC (2012)	1
TERF1	1	CENPF	5	affinity chromatography technology	Giannone RJ (2010)	1
SIRT7	1	NUP133	4	affinity chromatography technology	Tsai YC (2012)	1
G3BP1	4	CENPF	5	affinity chromatography technology	Hein MY (2015)	1
CENPF	5	CENPF	5	two hybrid	Zhu X (1995)	1
CENPF	5	NUP107	1	affinity chromatography technology	Zuccolo M (2007)	1
OBSL1	9	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
CCDC33	3	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	NDEL1	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	NUP107	1	affinity chromatography technology	Rodriguez J (2016)	1
TMA16	0	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
CENPF	5	NQO2	0	biochemical	Havugimana PC (2012)	1
NPM1	0	G3BP1	4	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	TERF1	1	affinity chromatography technology, affinity chromatography technology	Ballal RD (2009), Ballal RD (2009)	2
G3BP1	4	TMA16	0	affinity chromatography technology	Sowa ME (2009)	1
MYC	2	NUP133	4	affinity chromatography technology	Koch HB (2007)	1
EGLN3	0	MAP7D2	0	affinity chromatography technology	Rodriguez J (2016)	1
IKBKG	0	TCP10L	0	pull down	Fenner BJ (2010)	1
BRCA1	7	NUP107	1	affinity chromatography technology	Ertych N (2016)	1
EGLN3	0	BRCA1	7	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	GOPC	5	affinity chromatography technology	Rodriguez J (2016)	1
COPS6	0	CENPF	5	affinity chromatography technology	Bennett EJ (2010)	1
RNF166	0	CENPF	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPM1	0	CENPF	5	affinity chromatography technology	Crockett DK (2004)	1
SIRT7	1	NPM1	0	affinity chromatography technology	Tsai YC (2012)	1
MAP7D2	0	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
NDEL1	2	CENPF	5	two hybrid, affinity chromatography technology, two hybrid	Camargo LM (2007), Vergnolle MA (2007), Vergnolle MA (2007)	3
MYC	2	NQO2	0	genetic interference	Toyoshima M (2012)	1
ALK	8	CENPF	5	affinity chromatography technology	Crockett DK (2004)	1
COG6	1	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	MYC	2	affinity chromatography technology	Kim BY (2010)	1
POLH	1	CENPF	5	affinity chromatography technology	Hein MY (2015)	1
POLH	1	SIRT7	1	affinity chromatography technology	Hein MY (2015)	1
GOPC	5	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	NUP133	4	affinity chromatography technology	Rodriguez J (2016)	1
WASF3	3	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
CENPF	5	NUP133	4	affinity chromatography technology, affinity chromatography technology	Zuccolo M (2007), Zuccolo M (2007)	2
MYC	2	CENPF	5	affinity chromatography technology	Hein MY (2015)	1
ARRB2	5	NFKBIA	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Witherow DS (2004), Witherow DS (2004), Gao H (2004), Gao H (2004), Gao H (2004)	5
SIRT7	1	NUP107	1	affinity chromatography technology	Tsai YC (2012)	1
TERF2	2	CENPF	5	affinity chromatography technology	Giannone RJ (2010)	1
CDCA5	0	CENPF	5	affinity chromatography technology	Hein MY (2015)	1
TOP3B	5	CENPF	5	two hybrid	Kobayashi M (2001)	1
EGLN3	0	CENPF	5	affinity chromatography technology	Rodriguez J (2016)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
HECW2	13	CENPF	5	affinity chromatography technology	Lu L (2013)	1
EGLN3	0	NFKBIA	0	affinity chromatography technology	Rodriguez J (2016)	1
ESAM	3	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	NUP133	4	affinity chromatography technology	Ertych N (2016)	1
TCP10L	0	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	CENPF	5	affinity chromatography technology	Ertych N (2016)	1
FBXL5	3	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
IKBKG	0	TMA16	0	pull down	Fenner BJ (2010)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
IKBKG	0	CENPF	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	OBSL1	9	affinity chromatography technology	Rodriguez J (2016)	1
MZT1	1	CENPF	5	affinity chromatography technology	Hein MY (2015)	1