PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NEDD4L	3	NPC2	0	two hybrid, affinity chromatography technology	Araki N (2009), Araki N (2009)	2
SLC9A3R2	8	NPC2	0	biochemical	Havugimana PC (2012)	1
ERRFI1	1	NPC2	0	two hybrid	Ying H (2010)	1
USP4	3	NPC2	0	two hybrid	Zhao B (2012)	1
DHDDS	5	NPC2	0	two hybrid, pull down	Kharel Y (2004), Kharel Y (2004)	2
PAXIP1	1	NPC2	0	two hybrid	Woods NT (2012)	1
ECT2	2	NPC2	0	two hybrid	Woods NT (2012)	1
TRIM14	1	NPC2	0	two hybrid	Tan P (2017)	1
NPC2	0	HK3	3	affinity chromatography technology	Huttlin EL (2017)	1
LRP1	25	NPC2	0	affinity chromatography technology	Huttlin EL (2017)	1
DEFA1	0	NPC2	0	affinity chromatography technology	Huttlin EL (2017)	1
NPC2	0	NME2	0	affinity chromatography technology	Huttlin EL (2017)	1
NPC2	0	CFB	1	affinity chromatography technology	Huttlin EL (2017)	1
NPC2	0	TTR	0	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R2	8	NUDT19	2	biochemical	Havugimana PC (2012)	1
NPC2	0	283458	0	affinity chromatography technology	Huttlin EL (2017)	1
NDUFV2	0	NPC2	0	biochemical	Havugimana PC (2012)	1
PSG1	0	NPC2	0	affinity chromatography technology	Huttlin EL (2017)	1
LDB3	2	NPC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPC2	0	NUDT19	2	biochemical	Havugimana PC (2012)	1
LIG4	0	NPC2	0	two hybrid	Woods NT (2012)	1
RRAGA	1	NPC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	NPC2	0	two hybrid	Woods NT (2012)	1
CFB	1	NME2	0	affinity chromatography technology	Huttlin EL (2017)	1
BARD1	4	NPC2	0	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
NPC2	0	IRGQ	0	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
TMPRSS11B	0	NPC2	0	affinity chromatography technology	Huttlin EL (2017)	1