PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RTN4	4	SYT16	1	two hybrid	Rolland T (2014)	1
RHEB	2	RABAC1	0	two hybrid	Li Y (2007)	1
NDRG3	2	RABAC1	0	affinity chromatography technology	Kim JT (2012)	1
RAB1A	0	RABAC1	0	two hybrid, two hybrid	Rual JF (2005), Martincic I (1997)	2
RABAC1	0	TXN2	0	two hybrid	Wang J (2011)	1
TMEM128	0	RABAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
TXN2	0	VIM	0	two hybrid	Wang J (2011)	1
RAB33A	0	RABAC1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RABAC1	0	SGK1	4	two hybrid	Wang J (2011)	1
HRG	4	RABAC1	0	two hybrid	Wang J (2011)	1
FXR2	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
RAB5B	1	RABAC1	0	two hybrid	Wang J (2011)	1
RABAC1	0	PLEKHF2	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
NDRG1	2	NIF3L1	0	biochemical	Wan C (2015)	1
GOLT1B	0	RABAC1	0	affinity chromatography technology	Hein MY (2015)	1
RGS2	2	RIN3	2	two hybrid	Vinayagam A (2011)	1
CYP2A6	0	RABAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	SNCA	0	affinity chromatography technology	Dalfo E (2004)	1
RABAC1	0	VIM	0	two hybrid	Stelzl U (2005)	1
NDRG2	1	RABAC1	0	pull down, affinity chromatography technology, two hybrid	Kim JT (2012), Kim JT (2012), Kim JT (2012)	3
LMNA	2	RABAC1	0	two hybrid	Dittmer TA (2014)	1
LMNA	2	WDYHV1	0	two hybrid	Dittmer TA (2014)	1
NDRG2	1	NDRG1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TUBB2A	2	RIC8A	4	two hybrid	Stelzl U (2005)	1
LMNA	2	SPG21	0	two hybrid	Dittmer TA (2014)	1
RABAC1	0	MCF2L	4	two hybrid	Vinayagam A (2011)	1
RTN4	4	RABAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
SPG21	0	RTN4	4	two hybrid	Rual JF (2005)	1
NR3C2	4	RABAC1	0	two hybrid	Wang J (2011)	1
RAB5B	1	REEP5	1	two hybrid	Wang J (2011)	1
VIM	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
TMEM128	0	REEP5	1	affinity chromatography technology	Huttlin EL (2017)	1
RABAC1	0	TUBB2A	2	two hybrid	Stelzl U (2005)	1
LMNA	2	VAMP2	3	two hybrid	Dittmer TA (2014)	1
PLK1	0	RABAC1	0	two hybrid	Wang J (2011)	1
RABAC1	0	SNX11	3	two hybrid	Rolland T (2014)	1
RTN4	4	ZFYVE21	0	two hybrid	Rolland T (2014)	1
RABAC1	0	TRIM32	2	two hybrid	Rolland T (2014)	1
RABAC1	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RGS2	2	RABAC1	0	two hybrid	Vinayagam A (2011)	1
PLK1	0	SNCA	0	enzymatic study	Mbefo MK (2010)	1
RABAC1	0	CMTM3	0	two hybrid	Vinayagam A (2011)	1
RASD2	1	RABAC1	0	two hybrid	Venkatesan K (2009)	1
RABAC1	0	VAMP2	3	two hybrid, pull down	Martincic I (1997), Martincic I (1997)	2
RABAC1	0	VTA1	1	two hybrid	Rual JF (2005)	1
RABAC1	0	SNX15	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RABAC1	0	LNX1	7	two hybrid, two hybrid	Rual JF (2005), Wolting CD (2011)	2
RABAC1	0	NAT14	0	two hybrid	Vinayagam A (2011)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
CREB3	1	RABAC1	0	two hybrid	Wang J (2011)	1
RTN4	4	PLEKHF2	1	two hybrid	Rual JF (2005)	1
LMNA	2	RTN4	4	two hybrid	Dittmer TA (2014)	1
SGK1	4	NDRG1	2	enzymatic study	Garcia-Martinez JM (2009)	1
RABAC1	0	TNIP1	1	two hybrid	Wang J (2011)	1
MAD2L1	0	RABAC1	0	two hybrid	Wang J (2011)	1
NDRG1	2	RABAC1	0	affinity chromatography technology	Kim JT (2012)	1
RABAC1	0	RIN3	2	two hybrid	Vinayagam A (2011)	1
RAB3A	0	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dalfo E (2004), Dalfo E (2005), Dalfo E (2005)	3
RIN3	2	RAB5B	1	two hybrid, pull down	Kajiho H (2003), Kajiho H (2003)	2
RABAC1	0	RIC8A	4	two hybrid	Rolland T (2014)	1
FXR2	2	SNX1	2	affinity chromatography technology	Huttlin EL (2017)	1
RABAC1	0	REEP5	1	two hybrid, affinity chromatography technology	Vinayagam A (2011), Huttlin EL (2017)	2
RABAC1	0	WDYHV1	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
RGS2	2	REEP5	1	two hybrid	Vinayagam A (2011)	1
PBX3	4	RABAC1	0	two hybrid	Venkatesan K (2009)	1
RABAC1	0	RAB3A	0	two hybrid	Martincic I (1997)	1
SNX1	2	RTN4	4	two hybrid, biochemical	Rolland T (2014), Wan C (2015)	2
FXR2	2	RTN4	4	two hybrid	Rual JF (2005)	1
RAB5B	1	RAB1A	0	biochemical	Wan C (2015)	1
SNCA	0	FXR2	2	affinity chromatography technology	Hein MY (2015)	1
RABAC1	0	ZFYVE21	0	two hybrid	Rolland T (2014)	1
TRIM32	2	NDRG2	1	enzymatic study	Mokhonova EI (2015)	1
RABAC1	0	MIEF2	4	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RABAC1	0	NDRG4	4	two hybrid, affinity chromatography technology	Rolland T (2014), Kim JT (2012)	2
RABAC1	0	SYT16	1	two hybrid	Rolland T (2014)	1
RABAC1	0	SPG21	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SNX15	0	RTN4	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RABAC1	0	NIF3L1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RAB33A	0	RTN4	4	two hybrid	Rual JF (2005)	1
RAB5A	0	RAB1A	0	biochemical	Wan C (2015)	1
SNCA	0	RABAC1	0	pull down, affinity chromatography technology	Lee HJ (2011), Lee HJ (2011)	2
CREB3	1	RHEB	2	two hybrid	Yu H (2011)	1
LMNA	2	TMEM128	0	two hybrid	Dittmer TA (2014)	1
SNX1	2	RABAC1	0	two hybrid	Rolland T (2014)	1
RABAC1	0	RABAC1	0	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Venkatesan K (2009), Rolland T (2014)	5
LMNA	2	GOLT1B	0	two hybrid	Dittmer TA (2014)	1
RAB5A	0	RIN3	2	two hybrid	Kajiho H (2003)	1
RABAC1	0	DUSP12	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TMEM128	0	RTN4	4	affinity chromatography technology	Huttlin EL (2017)	1
RABAC1	0	SNX10	0	two hybrid	Rolland T (2014)	1
RABAC1	0	COQ8A	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RTN4	4	GOLT1B	0	affinity chromatography technology	Huttlin EL (2015)	1
RABAC1	0	WIPI2	5	two hybrid	Rolland T (2014)	1
RABAC1	0	RPS20	1	two hybrid	Wang J (2011)	1
REEP5	1	GOLT1B	0	affinity chromatography technology	Hein MY (2015)	1
NDRG1	2	RPS20	1	affinity chromatography technology	Tu LC (2007)	1
FXR2	2	RABAC1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RAB5A	0	RABAC1	0	two hybrid	Wang J (2011)	1
LMNA	2	CMTM3	0	two hybrid	Dittmer TA (2014)	1
RABAC1	0	FAM160A2	3	two hybrid	Rual JF (2005)	1