PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
TP53	0	TOR1AIP2	2	affinity chromatography technology	Fogeron ML (2013)	1
SRPK1	2	UBD	0	enzymatic study	Varjosalo M (2013)	1
UBD	0	TOR1AIP2	2	affinity chromatography technology	Buchsbaum S (2012)	1
UBD	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Nguyen NT (2016), Nguyen NT (2016)	2
NUB1	2	UBD	0	affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Hipp MS (2004), Hipp MS (2004), Rani N (2012), Rani N (2012), Schmidtke G (2006), Schmidtke G (2006), Theng SS (2014), Theng SS (2014)	8
AIPL1	3	UBD	0	affinity chromatography technology	Bett JS (2012)	1
UBD	0	HDAC6	0	pull down, unspecified method, affinity chromatography technology, imaging technique	Kalveram B (2008), Hard RL (2010), Theng SS (2014), Theng SS (2014)	4
UBD	0	EEF1A1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Yu X (2012), Yu X (2012), Yu X (2012)	3
AIPL1	3	NUB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Akey DT (2002), Akey DT (2002), Bett JS (2012), Kanaya K (2004), Kanaya K (2004), Kanaya K (2004), Akey DT (2004)	7
UBD	0	PSMA6	1	affinity chromatography technology, affinity chromatography technology	Buchsbaum S (2011), Schmidtke G (2006)	2
SQSTM1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Yan J (2013), Yan J (2013), Chen Q (2015)	4
PSMC3	0	PSMD4	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NUB1	2	PSMD4	1	pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kamitani T (2001), Rani N (2012), Rani N (2012), Rani N (2012), Tanji K (2005), Tanji K (2005), Jeong YY (2016), Jeong YY (2016)	8
UBA6	4	UBE2Z	0	enzymatic study, enzymatic study, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study	Gavin JM (2012), Aichem A (2010), Aichem A (2010), Jin J (2007), Huang DT (2009), Huang DT (2009), Aichem A (2014)	7
PSMB4	2	UBD	0	affinity chromatography technology	Schmidtke G (2006)	1
PSMA6	1	PSMD4	1	biochemical, biochemical, biochemical	Hendil KB (2009), Havugimana PC (2012), Wan C (2015)	3
PSMA6	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Cohen-Kaplan V (2016), Cohen-Kaplan V (2016), Cohen-Kaplan V (2016)	3
UBD	0	MAD2L1	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Liu YC (1999), Liu YC (1999), Liu YC (1999), Ren J (2006), Ren J (2006), Theng SS (2014), Theng SS (2014), Theng SS (2014)	8
AIPL1	3	UBA6	4	affinity chromatography technology	Bett JS (2012)	1
UBD	0	UBE2Z	0	two hybrid	Aichem A (2010)	1
USP16	0	UBD	0	unspecified method	Hard RL (2010)	1
SRPK1	2	TP53	0	two hybrid, pull down, affinity chromatography technology	Peidis P (2011), Peidis P (2011), Peidis P (2011)	3
PSMD4	1	SQSTM1	0	affinity chromatography technology	Seibenhener ML (2004)	1
HDAC6	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Choi SJ (2016), Choi SJ (2016)	2
SRPK2	1	UBD	0	enzymatic study	Varjosalo M (2013)	1
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
MAPK8IP2	5	UBD	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
UBA6	4	UBD	0	pull down, enzymatic study, two hybrid, affinity chromatography technology, imaging technique	Gavin JM (2012), Gavin JM (2012), Aichem A (2010), Theng SS (2014), Theng SS (2014)	5
TP53	0	UBD	0	affinity chromatography technology, affinity chromatography technology	Li T (2011), Theng SS (2014)	2
PSMC3	0	TP53	0	affinity chromatography technology	Kulikov R (2010)	1
PSMB4	2	NUB1	2	affinity chromatography technology	Schmidtke G (2006)	1
HDAC6	0	EEF1A1	0	affinity chromatography technology	Watson GW (2016)	1
PSMC3	0	PSMA6	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PSMB4	2	PSMD4	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
PSMA6	1	PSMB4	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
EEF1A1	0	PSMA6	1	biochemical	Havugimana PC (2012)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
PSMD4	1	UBD	0	two hybrid, pull down, pull down	Rani N (2012), Rani N (2012), Rani N (2012)	3
EEF1A1	0	PSMB4	2	biochemical	Havugimana PC (2012)	1
TP53	0	NUB1	2	affinity chromatography technology, affinity chromatography technology	Liu G (2010), Liu G (2010)	2
TP53	0	PSMD4	1	affinity chromatography technology, pull down	Kulikov R (2010), Sparks A (2014)	2
UBD	0	PSMC3	0	affinity chromatography technology	Buchsbaum S (2011)	1
UBE2Z	0	UBA1	1	enzymatic study, enzymatic study	Bialas J (2015), Huguenin-Dezot N (2016)	2
UBA1	1	UBD	0	affinity chromatography technology	Rani N (2012)	1
UBD	0	LRRFIP2	2	affinity chromatography technology	Buchsbaum S (2012)	1
PSMC3	0	PSMB4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBD	0	SQSTM1	0	affinity chromatography technology, imaging technique	Theng SS (2014), Theng SS (2014)	2