PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
PPP1CC	2	GSK3A	1	affinity chromatography technology	St-Denis N (2016)	1
ASCC2	3	DEAF1	12	two hybrid	Stelzl U (2005)	1
IRF3	4	IRF7	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Au WC (2001), Au WC (2001), Higgs R (2008), Higgs R (2008)	4
LMO4	1	DEAF1	12	two hybrid	Sum EY (2002)	1
DEAF1	12	SP1	0	affinity chromatography technology, affinity chromatography technology	Syddall CM (2013), Syddall CM (2013)	2
CDKN1A	1	DEAF1	12	two hybrid	Vinayagam A (2011)	1
PIN1	0	DEAF1	12	two hybrid	Vinayagam A (2011)	1
SP1	0	SUB1	0	pull down, affinity chromatography technology	Ge H (1998), Syddall CM (2013)	2
CDC37	0	DEAF1	12	two hybrid	Vinayagam A (2011)	1
IRF7	2	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1
PPP1CC	2	DEAF1	12	two hybrid	Esteves SL (2012)	1
FHL1	1	DEAF1	12	two hybrid	Vinayagam A (2011)	1
SP3	4	SUB1	0	affinity chromatography technology	Syddall CM (2013)	1
PPP1CA	3	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji C (2002), Varjosalo M (2013), St-Denis N (2016)	3
CDKN2A	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Li DQ (2011), Li DQ (2011)	2
GSK3B	1	DEAF1	12	enzymatic study, affinity chromatography technology	Pilot-Storck F (2010), Pilot-Storck F (2010)	2
SP3	4	PPP1CC	2	affinity chromatography technology	Valin A (2013)	1
GSK3A	1	CREB1	1	enzymatic study	Li B (2003)	1
DEAF1	12	SUB1	0	affinity chromatography technology	Syddall CM (2013)	1
PPP1CC	2	GSK3B	1	affinity chromatography technology	St-Denis N (2016)	1
TK1	0	DEAF1	12	two hybrid	Vinayagam A (2011)	1
GSK3B	1	CREB1	1	enzymatic study	Li B (2003)	1
PPP1CA	3	DEAF1	12	two hybrid	Esteves SL (2012)	1
PPP1CA	3	GSK3A	1	affinity chromatography technology	St-Denis N (2016)	1
GSK3A	1	DEAF1	12	enzymatic study, affinity chromatography technology	Pilot-Storck F (2010), Pilot-Storck F (2010)	2
SP1	0	PIN1	0	affinity chromatography technology, affinity chromatography technology	Yang HC (2014), Yang HC (2014)	2
RAD23B	1	DEAF1	12	two hybrid	Vinayagam A (2011)	1
SP1	0	FHL1	1	affinity chromatography technology	Chuang JY (2012)	1
CREB1	1	DEAF1	12	affinity chromatography technology, affinity chromatography technology	Ordureau A (2013), Ordureau A (2013)	2
DEAF1	12	PELI2	5	two hybrid	Wang J (2011)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
HRAS	2	DEAF1	12	two hybrid	Vinayagam A (2011)	1
PPP1CA	3	CREB1	1	enzymatic study	Leone V (2010)	1
IRF3	4	PIN1	0	affinity chromatography technology, affinity chromatography technology	Saitoh T (2006), Saitoh T (2006)	2
GSK3B	1	LMO4	1	two hybrid	Vinayagam A (2011)	1
IRF3	4	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1
AIMP2	0	DEAF1	12	two hybrid	Vinayagam A (2011)	1
SP3	4	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Goto T (2006), Goto T (2006), Choi HS (2002), Choi HS (2002), Walker GE (2001), Walker GE (2001), Xu Q (2000), Tang S (2004), Kwon JH (2003), Syddall CM (2013), Syddall CM (2013), Syddall CM (2013)	12
DEAF1	12	SP3	4	affinity chromatography technology, affinity chromatography technology	Syddall CM (2013), Syddall CM (2013)	2
DEAF1	12	RIDA	0	two hybrid	Wang J (2011)	1
PPP1CC	2	CDKN2A	1	affinity chromatography technology	Flores-Delgado G (2007)	1
CDKN2A	1	DEAF1	12	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
BSPRY	2	DEAF1	12	affinity chromatography technology	Huttlin EL (2017)	1
PELI1	1	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1