PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ECT2	2	UNC13B	8	affinity chromatography technology	Woods NT (2012)	1
WDR48	2	UNC13B	8	affinity chromatography technology	Sowa ME (2009)	1
CLK1	1	UNC13B	8	enzymatic study	Lipp JJ (2015)	1
UNC13B	8	STX1A	2	two hybrid, biochemical	Betz A (1997), Betz A (1997)	2
BARD1	4	UNC13B	8	affinity chromatography technology	Woods NT (2012)	1
UNC13B	8	SPTBN2	11	two hybrid, pull down	Sakaguchi G (1998), Sakaguchi G (1998)	2
UNC13B	8	RAB27A	0	affinity chromatography technology	Boggio E (2013)	1
CCDC40	6	UNC13B	8	affinity chromatography technology	Huttlin EL (2017)	1
PTPN4	0	UNC13B	8	affinity chromatography technology	Li X (2016)	1
UNC13B	8	STX1B	2	two hybrid, biochemical	Betz A (1997), Betz A (1997)	2
SNAP25	8	STX1A	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Dulubova I (1999), McMahon HT (1995), Gonelle-Gispert C (2000), Gonelle-Gispert C (2000), Ilardi JM (1999), Li Y (2001), Ravichandran V (1996), Chapman ER (1994), Chapman ER (1994), Chen X (2002), Steegmaier M (1998), Darios F (2010)	14
RPH3AL	1	UNC13B	8	pull down	Cheviet S (2004)	1
UNC13B	8	VAMP2	3	biochemical	Betz A (1997)	1
RAB27A	0	RPH3AL	1	pull down	Cheviet S (2004)	1
UBXN10	2	UNC13B	8	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
UNC13B	8	SNAP25	8	biochemical	Betz A (1997)	1
SNAP25	8	VAMP2	3	affinity chromatography technology, pull down, two hybrid, far western blotting, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Li Y (2001), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002), Zhang Q (2012), Zhang Q (2012)	7
DIRAS2	0	UNC13B	8	affinity chromatography technology	Huttlin EL (2017)	1
UNC13B	8	DOC2A	2	two hybrid, pull down, pull down, biochemical, pull down	Orita S (1997), Orita S (1997), Orita S (1997), Orita S (1997), Mochida S (1998)	5
UNC13B	8	RIMS1	6	two hybrid, pull down, pull down, affinity chromatography technology	Betz A (2001), Betz A (2001), Betz A (2001), Ohtsuka T (2002)	4
STX1A	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, far western blotting, x-ray crystallography	Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Margittai M (1999), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002)	8
STX1B	2	VAMP2	3	two hybrid	Perez-Branguli F (2002)	1