PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAGOH	0	FYTTD1	2	affinity chromatography technology	Singh G (2012)	1
RAN	1	TNPO1	1	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Chook YM (1999), Shamsher MK (2002), Kutay U (2000), Lipowsky G (2000), Havugimana PC (2012), Wan C (2015)	6
NXF1	0	NUP205	3	affinity chromatography technology, affinity chromatography technology	Bachi A (2000), Castello A (2012)	2
KPNB1	3	NUP153	1	pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakielny S (1999), Nakielny S (1999), Kehlenbach RH (2000), Ben-Efraim I (2001), Walther TC (2003), Ciciarello M (2010), Hein MY (2015), Hein MY (2015)	8
MAGOH	0	NXF1	0	pull down, affinity chromatography technology	Kataoka N (2001), Kataoka N (2001)	2
DHX9	3	SRSF7	0	biochemical	Havugimana PC (2012)	1
DHX15	5	RBM15	7	biochemical	Wan C (2015)	1
KPNB1	3	RAE1	0	pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Blower MD (2005), Blower MD (2005), Blower MD (2005), Wan C (2015), Hein MY (2015)	5
RAN	1	TNPO2	10	pull down	Shamsher MK (2002)	1
MAGOH	0	DHX15	5	affinity chromatography technology	Singh G (2012)	1
TP53BP2	5	NXF1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Castello A (2012)	2
MAGOH	0	CASC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh G (2012), Huttlin EL (2015), Huttlin EL (2017)	3
NXF1	0	DHX9	3	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Tang H (2000), Tang H (2000), Havugimana PC (2012), Castello A (2012)	4
NXF1	0	SRSF7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai MC (2004), Huang Y (2004), Castello A (2012)	3
NXF1	0	U2AF1	0	two hybrid, pull down	Zolotukhin AS (2002), Zolotukhin AS (2002)	2
MAGOH	0	SRSF7	0	affinity chromatography technology	Singh G (2012)	1
RAN	1	NXF1	0	pull down, pull down	Shamsher MK (2002), Katahira J (1999)	2
DHX9	3	NCL	1	affinity chromatography technology, affinity chromatography technology	Chu L (2012), Salvetti A (2016)	2
HP1BP3	2	KPNB1	3	affinity chromatography technology	Huttlin EL (2017)	1
KPNB1	3	NUP214	3	affinity chromatography technology	Hein MY (2015)	1
LUC7L3	2	NXF1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Castello A (2012)	2
KPNB1	3	IPO4	9	biochemical	Wan C (2015)	1
DHX15	5	NXF1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Castello A (2012)	2
NUP153	1	RAE1	0	affinity chromatography technology	Hein MY (2015)	1
TNPO2	10	NXF1	0	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Shamsher MK (2002), Shamsher MK (2002), Shamsher MK (2002), Castello A (2012)	4
RAN	1	NUP62	1	affinity chromatography technology	Huttlin EL (2017)	1
RAN	1	U2AF1	0	biochemical	Havugimana PC (2012)	1
HP1BP3	2	NXF1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Castello A (2012)	2
NUP62	1	NUP153	1	pull down, affinity chromatography technology	Stochaj U (2006), Stochaj U (2006)	2
RAE1	0	NUP62	1	affinity chromatography technology	Sowa ME (2009)	1
NUP153	1	NUP214	3	affinity chromatography technology	Hein MY (2015)	1
RBM15B	4	RBM15	7	affinity chromatography technology, affinity chromatography technology	Uranishi H (2009), Huttlin EL (2017)	2
NCL	1	NXF1	0	affinity chromatography technology, affinity chromatography technology	Salvetti A (2016), Salvetti A (2016)	2
NUP98	5	RAE1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Pritchard CE (1999), Pritchard CE (1999), Wong RW (2008), Sowa ME (2009), Ren Y (2010), Blower MD (2005), Wong RW (2006), Funasaka T (2011), Funasaka T (2011), Funasaka T (2011), Quan B (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Salsi V (2016)	15
NUTF2	0	NUP153	1	pull down	Cushman I (2004)	1
NXF1	0	SRSF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lai MC (2004), Lai MC (2004), Huang Y (2004), Wang J (2011), Castello A (2012)	5
NUP62	1	NCL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Padilla PI (2008), Padilla PI (2004), Padilla PI (2004)	3
DHX15	5	SRSF7	0	biochemical	Havugimana PC (2012)	1
LUC7L3	2	SRSF1	0	two hybrid	Umehara H (2003)	1
NXF1	0	RAE1	0	affinity chromatography technology, affinity chromatography technology	Bachi A (2000), Bachi A (2000)	2
NUP214	3	NXF1	0	pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology	Herold A (2000), Schmitt I (2001), Katahira J (1999), Katahira J (1999), Herold A (2000), Huttlin EL (2017)	6
RANBP2	9	KPNB1	3	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yaseen NR (1999), Delphin C (1997), Ben-Efraim I (2001), Walther TC (2003), Chi NC (1996), Chi NC (1996), Hein MY (2015)	7
KPNB1	3	NUTF2	0	pull down	Percipalle P (1997)	1
RBM15B	4	NXF1	0	affinity chromatography technology, pull down	Uranishi H (2009), Uranishi H (2009)	2
MAGOH	0	SRSF1	0	affinity chromatography technology	Singh G (2012)	1
TNPO2	10	NUP98	5	pull down, pull down	Fontoura BM (2000), Fontoura BM (2000)	2
DDX19A	0	NUP62	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IPO11	0	RAN	1	two hybrid, pull down, pull down	Plafker SM (2000), Plafker SM (2000), Plafker SM (2004)	3
NUP153	1	NUP205	3	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	IMPA1	0	pull down, pull down	Zhang ZC (2011), Zhang ZC (2011)	2
RANBP2	9	NUP214	3	affinity chromatography technology	Yokoyama N (1995)	1
SRSF1	0	U2AF1	0	pull down, two hybrid, biochemical, two hybrid	Xiao SH (1998), Zhang WJ (1996), Havugimana PC (2012), Wang J (2011)	4
NXF1	0	KPNB1	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Zhang ZC (2011), Zhang ZC (2011), Bachi A (2000), Hein MY (2015)	4
RAN	1	TPR	5	biochemical	Havugimana PC (2012)	1
DHX15	5	RBM15B	4	biochemical	Wan C (2015)	1
MAGOH	0	RAN	1	affinity chromatography technology	Singh G (2012)	1
TPR	5	NUP98	5	affinity chromatography technology, pull down, pull down	Hase ME (2003), Fontoura BM (2001), Fontoura BM (2001)	3
RAE1	0	NUP214	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
NXF1	0	NXT1	0	two hybrid, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical, affinity chromatography technology	Rual JF (2005), Suyama M (2000), Matzat LH (2008), Fribourg S (2001), Levesque L (2006), Wan C (2015), Huttlin EL (2017)	7
NCL	1	DHX15	5	affinity chromatography technology	Salvetti A (2016)	1
NUP153	1	NUP98	5	affinity chromatography technology	Hein MY (2015)	1
TPR	5	NUP205	3	affinity chromatography technology	Hase ME (2003)	1
KPNB1	3	NCL	1	biochemical	Wan C (2015)	1
SRSF7	0	U2AF1	0	biochemical	Havugimana PC (2012)	1
LUC7L3	2	SRSF7	0	biochemical, genetic interference	Havugimana PC (2012), Horlbeck MA (2018)	2
DHX9	3	RANBP2	9	biochemical	Havugimana PC (2012)	1
RPGRIP1L	2	TP53BP2	5	bioid	Gupta GD (2015)	1
NXF1	0	NUTF2	0	pull down, affinity chromatography technology	Katahira J (1999), Castello A (2012)	2
RPGRIP1L	2	RBM15	7	bioid	Gupta GD (2015)	1
RAN	1	NUP214	3	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	NUP98	5	pull down, affinity chromatography technology, pull down, pull down	Schmitt I (2001), Bachi A (2000), Levesque L (2006), Herold A (2000)	4
NUTF2	0	RAN	1	pull down, x-ray crystallography, affinity chromatography technology, pull down, biochemical, two hybrid, biochemical, affinity chromatography technology	Cushman I (2004), Stewart M (1998), Bompard G (2010), Katahira J (1999), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	8
NUP62	1	NUTF2	0	pull down, pull down, two hybrid, pull down	Hu T (1996), Paschal BM (1995), Rolland T (2014), Stochaj U (2006)	4
TPR	5	NUP153	1	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Hase ME (2003), Hase ME (2003), Hase ME (2003), Hein MY (2015)	4
KPNB1	3	NUP62	1	pull down, pull down, affinity chromatography technology	Ben-Efraim I (2001), Percipalle P (1997), Walther TC (2003)	3
NUP62	1	NUP214	3	pull down, biochemical	Stochaj U (2006), Wan C (2015)	2
DHX15	5	RANBP2	9	biochemical	Havugimana PC (2012)	1
NCL	1	U2AF1	0	affinity chromatography technology	Salvetti A (2016)	1
NXF1	0	RANBP2	9	affinity chromatography technology, pull down, biochemical	Bachi A (2000), Levesque L (2006), Wan C (2015)	3
NUP153	1	RAN	1	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Nakielny S (1999), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
NXF1	0	CASC3	0	affinity chromatography technology, affinity chromatography technology	Castello A (2012), Huttlin EL (2017)	2
NXF1	0	RPGRIP1L	2	affinity chromatography technology, bioid	Castello A (2012), Gupta GD (2015)	2
RBM15	7	NXF1	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Uranishi H (2009), Uranishi H (2009), Lindtner S (2006), Lindtner S (2006)	4
DDX19A	0	NXF1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Castello A (2012)	2
NXF1	0	TNPO1	1	pull down, pull down	Zhang ZC (2011), Zhang ZC (2011)	2
NUP62	1	RANBP2	9	pull down, affinity chromatography technology	Stochaj U (2006), Stochaj U (2006)	2
NXF1	0	IPO11	0	pull down, pull down, affinity chromatography technology	Zhang ZC (2011), Zhang ZC (2011), Castello A (2012)	3
DHX9	3	SRSF1	0	biochemical	Havugimana PC (2012)	1
SRSF7	0	SRSF1	0	biochemical	Wan C (2015)	1
KPNB1	3	RAN	1	far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Kutay U (1997), Percipalle P (1997), Plafker K (2000), Ciciarello M (2010), Hieda M (1999), Hieda M (1999), Kutay U (2000), Kutay U (2000), Chi NC (1996), Chi NC (1996), Lipowsky G (2000), Chi NC (1997), Havugimana PC (2012), Goerlich D (1997), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	17
DHX9	3	U2AF1	0	biochemical	Havugimana PC (2012)	1
DHX15	5	SRSF1	0	biochemical	Havugimana PC (2012)	1
NXF1	0	NUP62	1	pull down, pull down, two hybrid, pull down, two hybrid	Levesque L (2006), Levesque L (2006), Rolland T (2014), Herold A (2000), Yu H (2011)	5
RANBP2	9	RAN	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Yaseen NR (1999), Liu C (2010), Yokoyama N (1995), Yokoyama N (1995), Wang J (2011), Nishitani H (2001), Wan C (2015), Huttlin EL (2017)	8
HP1BP3	2	SRSF7	0	biochemical	Havugimana PC (2012)	1
DDX19A	0	NUP214	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	IPO4	9	pull down, pull down	Zhang ZC (2011), Zhang ZC (2011)	2
NUP153	1	TNPO1	1	affinity chromatography technology	Hein MY (2015)	1
TNPO1	1	NUP98	5	pull down, biochemical	Bonifaci N (1997), Wan C (2015)	2
TNPO1	1	IPO4	9	biochemical	Kristensen AR (2012)	1
FYTTD1	2	NCL	1	affinity chromatography technology	Hautbergue GM (2009)	1
NXF1	0	NUP153	1	pull down, affinity chromatography technology	Herold A (2000), Hein MY (2015)	2
FYTTD1	2	NXF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hautbergue GM (2009), Hautbergue GM (2009), Hautbergue GM (2009), Castello A (2012)	4
NXF1	0	NXF1	0	pull down, pull down	Matzat LH (2008), Katahira J (1999)	2
NXF1	0	TPR	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NUP98	5	KPNB1	3	pull down, pull down, pull down, biochemical, affinity chromatography technology	Moroianu J (1997), Bonifaci N (1997), Schmidt HB (2015), Wan C (2015), Hein MY (2015)	5
ELAVL4	5	NXF1	0	affinity chromatography technology, pull down	Saito K (2004), Saito K (2004)	2
RANBP2	9	NUP153	1	affinity chromatography technology, affinity chromatography technology	Yokoyama N (1995), Hein MY (2015)	2
KPNB1	3	NUP205	3	affinity chromatography technology	Hein MY (2015)	1