PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RCBTB2	1	RCBTB1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
DTL	0	UBE2E3	0	affinity chromatography technology	Shibata E (2011)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
HNRNPL	3	TBL1X	1	affinity chromatography technology	Fei T (2017)	1
UBE2E3	0	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2E3	0	CUL4A	2	pull down	Plafker KS (2009)	1
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
UBC	7	RNF25	1	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	KLHL42	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cummings CM (2009), Cummings CM (2009), Bennett EJ (2010), Plafker KS (2009), Olma MH (2009), Wimuttisuk W (2014), Huttlin EL (2017)	7
MARCH5	0	UBE2E3	0	pull down	Nakamura N (2006)	1
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
CUL4A	2	MDM2	2	affinity chromatography technology, affinity chromatography technology	Banks D (2006), Latini P (2011)	2
HNRNPL	3	UBE2E3	0	affinity chromatography technology	Fei T (2017)	1
BRCA1	7	RANGAP1	4	affinity chromatography technology	Ertych N (2016)	1
UBE2E3	0	TRIM2	1	two hybrid	Markson G (2009)	1
CCDC121	0	UBE2E3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1	2	TRIM32	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
CUL3	17	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
PCGF3	0	RNF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Woodsmith J (2012), Woodsmith J (2012), Cao Q (2014), Taherbhoy AM (2015), Taherbhoy AM (2015), Hauri S (2016), Hauri S (2016)	9
TBL1XR1	23	UBE2E3	0	affinity chromatography technology	Choi HK (2008)	1
UBE2E3	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
RNF185	1	UBB	4	affinity chromatography technology	Iioka H (2007)	1
CSNK2A2	1	FBRS	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
UBE2E3	0	ZNRF1	1	two hybrid	Markson G (2009)	1
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
UBE2E3	0	RNF43	5	two hybrid	van Wijk SJ (2009)	1
UBE2E3	0	USP15	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E3	0	RNF185	1	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
STUB1	4	UBE2E3	0	pull down	Soss SE (2011)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Bennett EJ (2010), Sertic S (2013), Rossi M (2013), Jin J (2006), Shibata E (2011), Higa LA (2006)	7
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
PRKN	1	CUL1	7	affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	3
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
UBE2E3	0	CSNK2A2	1	affinity chromatography technology	Huttlin EL (2017)	1
DET1	2	MDM2	2	affinity chromatography technology	Pick E (2007)	1
HERC4	0	UBC	7	enzymatic study	Sheng Y (2012)	1
RDH12	0	UBE2E3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
RNF11	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
ARIH2	4	TRIM27	2	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TARDBP	4	affinity chromatography technology	Scholz CC (2016)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
RNF13	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
SIAH1	2	UBE2E3	0	two hybrid	Matsuzawa SI (2001)	1
UBE2E3	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2E3	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
UBE2E3	0	PECR	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
DET1	2	UBE2E3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Huttlin EL (2017)	4
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
CUL4A	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Pick E (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006)	7
UBE2E3	0	CNOT4	4	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Winkler GS (2004), Albert TK (2002)	3
TOPORS	6	UBC	7	enzymatic study	Rajendra R (2004)	1
TBL1X	1	SIAH1	2	affinity chromatography technology	Matsuzawa SI (2001)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
RNF181	0	UBC	7	enzymatic study	Pedersen SM (2015)	1
UBE2E3	0	RNF13	0	two hybrid	van Wijk SJ (2009)	1
ATXN1	2	DZIP3	6	two hybrid, affinity chromatography technology, enzymatic study	Lim J (2006), Yoon JH (2013), Yoon JH (2013)	3
PJA1	1	USP7	14	enzymatic study, affinity chromatography technology	Loch CM (2012), Huttlin EL (2017)	2
FBXO25	1	RBX1	2	affinity chromatography technology	Maragno AL (2006)	1
RNF11	0	USP7	14	affinity chromatography technology	Poulsen SL (2013)	1
RC3H2	5	UBC	7	enzymatic study	Zhang Q (2015)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
PCGF3	0	CSNK2A2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
UBE2E3	0	ZNRF4	1	two hybrid	van Wijk SJ (2009)	1
DTX3	4	CHFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1	2	USP7	14	two hybrid, affinity chromatography technology	Hong S (2002), Hong S (2002)	2
DDB1	6	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Angers S (2006), Behrends C (2010), Pick E (2007), Pick E (2007), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Jin J (2006), Wan C (2015)	10
HTT	14	MID1	1	unspecified method	Krauss S (2013)	1
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
CUL1	7	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE2E3	0	DDB1	6	affinity chromatography technology	Pick E (2007)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
UBE2E3	0	UFM1	0	two hybrid	van Wijk SJ (2009)	1
DDA1	1	UBE2E3	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007)	3
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
UBE2E3	0	RNF10	0	two hybrid, affinity chromatography technology	Markson G (2009), Huttlin EL (2017)	2
MDM2	2	DDB1	6	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Jacob AG (2014)	2
HNRNPL	3	RNF4	1	affinity chromatography technology	Fei T (2017)	1
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
UBE2E3	0	KLHL42	1	pull down	Plafker KS (2009)	1
CUL1	7	RCBTB1	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2E3	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
HNRNPL	3	TBL1XR1	23	affinity chromatography technology	Fei T (2017)	1
USP7	14	UBB	4	x-ray crystallography	Rouge L (2016)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E3	0	DTX3	4	two hybrid	Markson G (2009)	1
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
UBE2E3	0	CHFR	5	two hybrid	Markson G (2009)	1
CUL4A	2	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
ATXN1	2	UBE2E3	0	two hybrid	Lim J (2006)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
TBL1X	1	UBE2E3	0	affinity chromatography technology	Choi HK (2008)	1
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
HNRNPL	3	USP15	4	affinity chromatography technology	Fei T (2017)	1
FBXO25	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
TARDBP	4	RNF10	0	affinity chromatography technology	Freibaum BD (2010)	1
TARDBP	4	RNF2	1	two hybrid	Hans F (2014)	1
UBE2E3	0	RNF5	0	two hybrid, two hybrid, two hybrid	Markson G (2009), Plafker SM (2004), Rolland T (2014)	3
USP7	14	RNF2	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), Gao Z (2012), Cao Q (2014), Lecona E (2015), Lecona E (2015), Hein MY (2015)	12
UBE2E3	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
CUL3	17	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furukawa M (2005), Cullinan SB (2004), Cullinan SB (2004)	3
HTT	14	SIAH1	2	affinity chromatography technology	Bae BI (2006)	1
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
HNRNPL	3	CUL4A	2	affinity chromatography technology	Fei T (2017)	1
UBE2E3	0	CADPS2	0	two hybrid	van Wijk SJ (2009)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
UBE2E3	0	MUL1	1	two hybrid, two hybrid	van Wijk SJ (2009), Ambivero CT (2014)	2
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
RNF2	1	FBRS	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014), Hein MY (2015), Hauri S (2016)	4
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
UBE2E3	0	UBE2E3	0	enzymatic study, enzymatic study	Plafker KS (2010), David Y (2010)	2
MDM2	2	RNF10	0	two hybrid	Woodsmith J (2012)	1
TOPORS	6	RANGAP1	4	affinity chromatography technology	Pungaliya P (2007)	1
1820	0	UBC	7	affinity chromatography technology	Fukuyo Y (2011)	1
UBE2E3	0	RNF25	1	two hybrid, two hybrid, pull down, enzymatic study, pull down, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Nguyen L (2014), Nguyen L (2014), Li S (2015), Huttlin EL (2017)	6
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
1820	0	UBE2E3	0	affinity chromatography technology, two hybrid	Fukuyo Y (2004), Fukuyo Y (2004)	2
RNF185	1	UBC	7	affinity chromatography technology	Iioka H (2007)	1
DTL	0	MDM2	2	affinity chromatography technology	Banks D (2006)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
RNF4	1	TARDBP	4	imaging technique	Guo L (2014)	1
DET1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Pick E (2007), Pick E (2007), Jin J (2006), Huttlin EL (2017)	8
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
MID2	1	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
HTT	14	ITCH	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014), Chhangani D (2014)	3
TRIM45	1	UBE2E3	0	two hybrid	Napolitano LM (2011)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
HNRNPL	3	BARD1	4	affinity chromatography technology	Fei T (2017)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
TOPORS	6	HNRNPL	3	affinity chromatography technology	Pungaliya P (2007)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
NEDD4L	3	UBE2E3	0	pull down, pull down	Sheng Y (2012), Todaro DR (2017)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
UBE2E3	0	RNF8	2	two hybrid, pull down	Ito K (2001), Ito K (2001)	2
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	UBE2E3	0	pull down	Sheng Y (2012)	1
CUL3	17	TARDBP	4	affinity chromatography technology	Bennett EJ (2010)	1
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
DDB1	6	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Jin J (2006), Jin J (2006), Higa LA (2006), Rossi M (2013), Shibata E (2011), Higa LA (2006), Higa LA (2006)	8
MDM2	2	UBE2E3	0	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
UBE2E3	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
DTX3L	1	ITCH	1	affinity chromatography technology, pull down, pull down	Holleman J (2014), Holleman J (2014), Holleman J (2014)	3
UBE2E3	0	MID1	1	two hybrid, two hybrid, two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014)	4
HNRNPL	3	RNF165	0	affinity chromatography technology	Fei T (2017)	1
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
OTUB1	0	UBE2E3	0	affinity chromatography technology, affinity chromatography technology	Scholz CC (2016), Huttlin EL (2017)	2
UBE2E3	0	PCGF3	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	MID2	1	affinity chromatography technology	Fei T (2017)	1
IPO11	0	UBE2E3	0	two hybrid, pull down, pull down	Plafker SM (2004), Plafker SM (2004), Plafker SM (2004)	3
HNRNPL	3	PCGF3	0	affinity chromatography technology	Fei T (2017)	1
WWP2	7	UBE2E3	0	pull down	Sheng Y (2012)	1
PRKN	1	TARDBP	4	imaging technique, affinity chromatography technology	Hebron M (2013), Zhu X (2017)	2
FSD1	3	UBE2E3	0	affinity chromatography technology	Huttlin EL (2015)	1
UBE2E3	0	RANGAP1	4	enzymatic study	Okuma T (1999)	1
UBA1	1	UBE2E3	0	enzymatic study, pull down	Tokgoez Z (2012), Jin J (2007)	2
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
MDM2	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
RFWD3	5	MDM2	2	pull down, affinity chromatography technology	Fu X (2010), Fu X (2010)	2
UBE2E3	0	ARIH2	4	two hybrid	Markson G (2009)	1
UBE2E3	0	RNF150	2	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	UBE2E3	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
UBE2E3	0	RNF166	0	two hybrid	Markson G (2009)	1
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
UBE2E3	0	RNF14	2	two hybrid, two hybrid, pull down	Ito K (2001), Markson G (2009), Ito K (2001)	3
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
TRIM27	2	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
CSNK2A2	1	RING1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
CUL1	7	WWP2	7	affinity chromatography technology	Bennett EJ (2010)	1
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
RNF165	0	UBC	7	enzymatic study, x-ray crystallography, pull down	Wright JD (2016), Wright JD (2016), Wright JD (2016)	3
ATXN1	2	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Al-Ramahi I (2006), Al-Ramahi I (2006), Choi JY (2007), Choi JY (2007)	4
HNRNPL	3	WWP2	7	affinity chromatography technology	Fei T (2017)	1
USP7	14	RNF220	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Lim J (2006), Ma P (2014), Ma P (2014)	4
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E3	0	RFWD3	5	two hybrid	Markson G (2009)	1
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
MDM2	2	ARIH2	4	affinity chromatography technology, affinity chromatography technology	Bae S (2012), Bae S (2012)	2
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
RNF115	1	UBC	7	two hybrid, pull down, protein complementation assay, pull down	Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008)	4
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
ETV5	0	UBE2E3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPRY2	4	MID2	1	two hybrid	Rolland T (2014)	1
1820	0	PCGF3	0	affinity chromatography technology	Boldt K (2016)	1
DTL	0	RBX1	2	affinity chromatography technology	Shibata E (2011)	1
PRKN	1	UBE2E3	0	pull down	Kazlauskaite A (2014)	1
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
RNF2	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
DDB1	6	UBA1	1	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
HTT	14	UBE2E3	0	two hybrid	Suter B (2013)	1
BRCA1	7	NFE2L2	1	affinity chromatography technology, affinity chromatography technology	Gorrini C (2013), Gorrini C (2013)	2
DDA1	1	DTL	0	affinity chromatography technology	Olma MH (2009)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
TRIM27	2	RBX1	2	two hybrid	Woodsmith J (2012)	1
RING1	2	FBRS	5	affinity chromatography technology	Hauri S (2016)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
UBE2E3	0	RNF2	1	two hybrid	Markson G (2009)	1
RNF2	1	CSNK2A2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
CSNK2A2	1	RNF111	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
USP7	14	RING1	2	affinity chromatography technology, pull down, affinity chromatography technology	Maertens GN (2010), de Bie P (2010), Hein MY (2015)	3
UBE2E3	0	RNF220	2	affinity chromatography technology	Huttlin EL (2017)	1
DZIP3	6	PCGF3	0	two hybrid	Woodsmith J (2012)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
CUL3	17	RCBTB1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bennett EJ (2010), Plafker KS (2009), Plafker KS (2009), Plafker KS (2009)	4
UBE2E3	0	RCBTB2	1	pull down, affinity chromatography technology	Plafker KS (2009), Huttlin EL (2017)	2
UBE2E3	0	DZIP3	6	two hybrid	Markson G (2009)	1
UBE2E3	0	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
UBE2E3	0	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
DET1	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Huttlin EL (2017)	5
TRIM37	7	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
UBE2E3	0	RNF115	1	two hybrid	van Wijk SJ (2009)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TBL1X	1	TBL1XR1	23	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Perissi V (2008), Choi HK (2008), Bantscheff M (2011), Lan X (2016)	4
PJA1	1	OTUB1	0	enzymatic study	Loch CM (2012)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
TRIM38	3	UBE2E3	0	two hybrid	Napolitano LM (2011)	1
ETV5	0	DET1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	RCBTB2	1	pull down	Plafker KS (2009)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
CSNK2A2	1	MDM2	2	enzymatic study	Goetz C (1999)	1
MDM2	2	USP15	4	pull down	Liu WT (2016)	1
ARIH2	4	UBC	7	enzymatic study	Marteijn JA (2009)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
UBE2E3	0	TRIM39	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2E3	0	RCBTB1	1	pull down	Plafker KS (2009)	1
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
UBE2E3	0	RING1	2	two hybrid	Markson G (2009)	1
DET1	2	RNF14	2	affinity chromatography technology	Pick E (2007)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
DET1	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Olma MH (2009), Pick E (2007), Huttlin EL (2017)	6
UBE2E3	0	RNF130	0	two hybrid	van Wijk SJ (2009)	1
RNF4	1	NFE2L2	1	affinity chromatography technology	Malloy MT (2013)	1
HNRNPL	3	RNF130	0	affinity chromatography technology	Fei T (2017)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
UBE2E3	0	SPOP	1	pull down	Plafker KS (2009)	1
PCGF3	0	USP7	14	affinity chromatography technology	Gao Z (2012)	1
UBE2E3	0	FBRS	5	affinity chromatography technology	Huttlin EL (2017)	1
UFM1	0	RANGAP1	4	biochemical	Kristensen AR (2012)	1
PCGF3	0	FBRS	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Boldt K (2016), Hauri S (2016)	3
TRIM32	2	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
UBE2E3	0	NFE2L2	1	pull down, affinity chromatography technology	Plafker KS (2010), Plafker KS (2010)	2
FBXO25	1	UBE2E3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NKD2	1	RNF25	1	affinity chromatography technology	Ding W (2008)	1
UBE2E3	0	RMND5B	0	two hybrid	van Wijk SJ (2009)	1
RNF2	1	TBL1XR1	23	affinity chromatography technology	Cao Q (2014)	1
TARDBP	4	UBE2E3	0	two hybrid, affinity chromatography technology	Hans F (2014), Hans F (2014)	2
BRCA1	7	TARDBP	4	affinity chromatography technology	Goina E (2008)	1
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
RC3H2	5	UBE2E3	0	pull down	Zhang Q (2015)	1
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
SPRY2	4	UBE2E3	0	affinity chromatography technology	Huttlin EL (2015)	1
DDA1	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
PCGF3	0	RING1	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Woodsmith J (2012), Hauri S (2016), Hauri S (2016)	4
RNF4	1	ATXN1	2	imaging technique, enzymatic study	Guo L (2014), Guo L (2014)	2
UBE2E3	0	MKRN3	2	two hybrid	Markson G (2009)	1
IPO11	0	RANGAP1	4	biochemical	Kristensen AR (2012)	1
RBX1	2	UBE2E3	0	pull down	Pick E (2007)	1
BARD1	4	UBE2E3	0	pull down	David Y (2011)	1
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
TRIM50	1	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
USP7	14	CHFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oh YM (2007), Oh YM (2009), Oh YM (2009)	3
HNRNPL	3	NEDD4L	3	affinity chromatography technology	Fei T (2017)	1
PRKN	1	MARCH5	0	affinity chromatography technology	Sarraf SA (2013)	1
NFE2L2	1	UBC	7	affinity chromatography technology	Su C (2015)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
UBE2E3	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	TRIM38	3	two hybrid	Suter B (2013)	1
CUL3	17	TRIM32	2	affinity chromatography technology	Wimuttisuk W (2014)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
RNF130	0	UBC	7	enzymatic study	Guais A (2006)	1
NKD2	1	UBE2E3	0	affinity chromatography technology	Huttlin EL (2015)	1
DET1	2	RBX1	2	affinity chromatography technology	Wertz IE (2004)	1
HERC4	0	UBE2E3	0	pull down	Sheng Y (2012)	1
SPOP	1	CUL3	17	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li C (2011), Cummings CM (2009), Choo YY (2011), Choo YY (2012), Plafker KS (2009), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wimuttisuk W (2014), Theurillat JP (2014), Sakaue T (2017)	11
UBE2E3	0	RNF11	0	two hybrid	Markson G (2009)	1
PJA1	1	UBE2E3	0	pull down	Loch CM (2011)	1
BRCA1	7	ETV5	0	fluorescent resonance energy transfe	Coene ED (2011)	1
WWP2	7	USP15	4	affinity chromatography technology	Chaudhary N (2014)	1
UBE2E3	0	CUL3	17	pull down	Plafker KS (2009)	1
RNF4	1	UBC	7	enzymatic study, enzymatic study	Groocock LM (2014), Branigan E (2015)	2
UBE2E3	0	CUL1	7	pull down	Plafker KS (2009)	1
RNF2	1	RANGAP1	4	affinity chromatography technology	Cao Q (2014)	1