PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HUWE1	22	OLA1	2	affinity chromatography technology	Thompson JW (2014)	1
CUL3	17	MEPCE	1	affinity chromatography technology	Bennett EJ (2010)	1
HUWE1	22	LSM4	1	biochemical	Havugimana PC (2012)	1
ALYREF	0	LSM6	0	affinity chromatography technology	Boldt K (2016)	1
PPIH	1	LSM4	1	affinity chromatography technology	Boldt K (2016)	1
MEPCE	1	HNRNPD	3	affinity chromatography technology	Jeronimo C (2007)	1
CUL3	17	ALYREF	0	affinity chromatography technology	Bennett EJ (2010)	1
USP15	4	PRPF31	0	affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Das T (2017), Das T (2017)	3
CUL3	17	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	SNU13	0	affinity chromatography technology	Humphries JD (2009)	1
USP4	3	PRPF3	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Sowa ME (2009), Song EJ (2010), Song EJ (2010), Song EJ (2010), Song EJ (2010)	5
SART3	2	RPL26L1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CUL3	17	SART3	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	BAG2	0	affinity chromatography technology	Bennett EJ (2010)	1
USP15	4	PRPF3	3	affinity chromatography technology	Sowa ME (2009)	1
LSM6	0	PRPF31	0	affinity chromatography technology	Huttlin EL (2017)	1
RPL32	0	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
OLA1	2	LSM8	0	affinity chromatography technology	Boldt K (2016)	1
PPIH	1	LSM8	0	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	PPIH	1	affinity chromatography technology	Cox JL (2013)	1
VCAM1	2	PCMT1	1	affinity chromatography technology	Humphries JD (2009)	1
LSM4	1	LSM8	0	affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology	Eystathioy T (2002), Havugimana PC (2012), Lehner B (2004), Lehner B (2004), Boldt K (2016)	5
UBC	7	PPIH	1	affinity chromatography technology	Matsumoto M (2005)	1
FN1	17	BAG2	0	affinity chromatography technology	Humphries JD (2009)	1
SNU13	0	PRPF3	3	two hybrid, two hybrid, affinity chromatography technology	Liu S (2006), Liu S (2006), Huttlin EL (2017)	3
PRPF3	3	OLA1	2	affinity chromatography technology	Boldt K (2016)	1
SART3	2	PRPF31	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Das T (2017), Huttlin EL (2017)	3
USP4	3	MEPCE	1	affinity chromatography technology	Sowa ME (2009)	1
N4BP2L2	3	PPIH	1	two hybrid	Rolland T (2014)	1
CUL3	17	PRPF31	0	affinity chromatography technology	Bennett EJ (2010)	1
VCAM1	2	UBC	7	affinity chromatography technology	Humphries JD (2009)	1
RPL32	0	LSM8	0	affinity chromatography technology	Boldt K (2016)	1
SART3	2	USP4	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Song EJ (2010), Song EJ (2010), Song EJ (2010), Song EJ (2010), Zhao B (2012), Park JK (2016), Park JK (2016), Das T (2017), Das T (2017), Kwon SK (2017)	11
USP15	4	LSM8	0	affinity chromatography technology	Sowa ME (2009)	1
USP4	3	LSM4	1	affinity chromatography technology	Sowa ME (2009)	1
PPIH	1	OLA1	2	affinity chromatography technology	Boldt K (2016)	1
UBC	7	BAG2	0	affinity chromatography technology	Matsumoto M (2005)	1
SART3	2	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
CUL3	17	PCMT1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	WDR1	3	affinity chromatography technology	Wimuttisuk W (2014)	1
USP4	3	LSM8	0	affinity chromatography technology	Sowa ME (2009)	1
USP15	4	LSM4	1	affinity chromatography technology	Sowa ME (2009)	1
PRPF4	3	RPL32	0	affinity chromatography technology	Boldt K (2016)	1
MEPCE	1	PRPF3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Li S (2014), Huttlin EL (2017)	3
MEPCE	1	LSM4	1	affinity chromatography technology	Jeronimo C (2007)	1
SART3	2	LSM4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Boldt K (2016)	3
USP15	4	PRPF4	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009)	2
HNRNPD	3	PPIH	1	affinity chromatography technology	Hein MY (2015)	1
PRPF3	3	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
PPIH	1	PRPF3	3	two hybrid, two hybrid, affinity chromatography technology	Liu S (2006), Liu S (2006), Boldt K (2016)	3
PAXIP1	1	ALYREF	0	affinity chromatography technology	Woods NT (2012)	1
PRPF4	3	MEPCE	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Jeronimo C (2007)	2
RPL32	0	LSM4	1	affinity chromatography technology	Boldt K (2016)	1
SART3	2	UBC	7	affinity chromatography technology	Timani KA (2014)	1
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
MEPCE	1	PRPF31	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
USP4	3	LSM6	0	affinity chromatography technology	Sowa ME (2009)	1
PPIH	1	RPL32	0	affinity chromatography technology	Boldt K (2016)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
PRPF3	3	LSM8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
FN1	17	ALYREF	0	affinity chromatography technology	Humphries JD (2009)	1
SOX2	4	LSM8	0	affinity chromatography technology	Cox JL (2013)	1
USP4	3	HUWE1	22	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang X (2011), Zhang X (2011), Zhang X (2011)	3
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
PCMT1	1	PPIH	1	biochemical	Havugimana PC (2012)	1
VCAM1	2	PPIH	1	affinity chromatography technology	Humphries JD (2009)	1
PRPF4	3	N4BP2L2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
SOX2	4	MEPCE	1	affinity chromatography technology	Cox JL (2013)	1
LSM6	0	PRPF3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PRPF3	3	LSM4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PRPF4	3	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
ITGA4	4	PCMT1	1	affinity chromatography technology	Byron A (2012)	1
SOX2	4	LSM6	0	affinity chromatography technology	Cox JL (2013)	1
LSM4	1	LSM6	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Eystathioy T (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
METTL18	4	PPIH	1	affinity chromatography technology	Cloutier P (2013)	1
RPL32	0	SART3	2	affinity chromatography technology	Boldt K (2016)	1
METTL18	4	PRPF4	3	affinity chromatography technology	Cloutier P (2013)	1
USP15	4	PPIH	1	affinity chromatography technology	Sowa ME (2009)	1
PRPF4	3	PRPF3	3	affinity chromatography technology, two hybrid, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Liu S (2006), Liu S (2006), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	8
SART3	2	LSM8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Boldt K (2016)	3
OLA1	2	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
RPL26L1	1	LSM4	1	affinity chromatography technology	Boldt K (2016)	1
PPIH	1	LSM6	0	affinity chromatography technology	Boldt K (2016)	1
VCAM1	2	ALYREF	0	affinity chromatography technology	Humphries JD (2009)	1
B9D2	0	PPIH	1	bioid	Gupta GD (2015)	1
RPL26L1	1	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
FN1	17	PPIH	1	affinity chromatography technology	Humphries JD (2009)	1
CUL3	17	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
LSM6	0	MEPCE	1	affinity chromatography technology	Huttlin EL (2017)	1
WDR1	3	PPIH	1	biochemical	Wan C (2015)	1
7515	0	PPIH	1	affinity chromatography technology	Hein MY (2015)	1
MEPCE	1	ALYREF	0	affinity chromatography technology	Jeronimo C (2007)	1
FN1	17	HNRNPD	3	affinity chromatography technology	Humphries JD (2009)	1
PPIH	1	PPIH	1	two hybrid	Liu S (2006)	1
USP15	4	LSM6	0	affinity chromatography technology	Sowa ME (2009)	1
USP4	3	PRPF4	3	affinity chromatography technology	Sowa ME (2009)	1
PPIH	1	PRPF31	0	two hybrid, two hybrid	Liu S (2006), Liu S (2006)	2
SOX2	4	SART3	2	affinity chromatography technology	Cox JL (2013)	1
RPL26L1	1	RPL32	0	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	OLA1	2	affinity chromatography technology	Cox JL (2013)	1
SOX2	4	BAG2	0	affinity chromatography technology	Cox JL (2013)	1
MEPCE	1	PPIH	1	affinity chromatography technology	Jeronimo C (2007)	1
FN1	17	UBC	7	affinity chromatography technology	Humphries JD (2009)	1
SART3	2	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Sowa ME (2009), Long L (2014), Long L (2014), Long L (2014), Timani KA (2014), Park JK (2016), Zhang Q (2016), Zhang Q (2016), Das T (2017), Das T (2017), Das T (2017), Das T (2017), Huttlin EL (2017)	13
FN1	17	PRPF4	3	affinity chromatography technology	Humphries JD (2009)	1
RPL26L1	1	LSM8	0	affinity chromatography technology	Boldt K (2016)	1
CUL3	17	RPL26L1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	PRPF4	3	affinity chromatography technology	Bennett EJ (2010)	1
PRPF4	3	OLA1	2	affinity chromatography technology	Boldt K (2016)	1
VCAM1	2	ITGA4	4	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Byron A (2012)	2
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
FN1	17	USP15	4	affinity chromatography technology	Humphries JD (2009)	1
PPIH	1	BAG2	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
USP4	3	PRPF31	0	affinity chromatography technology	Sowa ME (2009)	1
SNU13	0	PRPF4	3	two hybrid, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Liu S (2006), Liu S (2006), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
SART3	2	LSM6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Boldt K (2016)	3
USP15	4	MEPCE	1	affinity chromatography technology	Sowa ME (2009)	1
CUL3	17	PPIH	1	affinity chromatography technology	Bennett EJ (2010)	1
VCAM1	2	HNRNPD	3	affinity chromatography technology	Humphries JD (2009)	1
PRPF4	3	LSM6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Boldt K (2016)	3
USP4	3	PPIH	1	affinity chromatography technology	Sowa ME (2009)	1
ITGA4	4	HNRNPD	3	affinity chromatography technology	Byron A (2012)	1
UBC	7	PCMT1	1	affinity chromatography technology	Matsumoto M (2005)	1
ITGA4	4	PPIH	1	affinity chromatography technology	Byron A (2012)	1
MEPCE	1	SNU13	0	affinity chromatography technology	Jeronimo C (2007)	1
HUWE1	22	PPIH	1	affinity chromatography technology	Thompson JW (2014)	1
SART3	2	MEPCE	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Jeronimo C (2007), Li S (2014), Huttlin EL (2017)	4
PRPF4	3	PPIH	1	affinity chromatography technology, two hybrid, two hybrid, biochemical, two hybrid, two hybrid, affinity chromatography technology	Sowa ME (2009), Liu S (2006), Liu S (2006), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Boldt K (2016)	7
PPIH	1	ALYREF	0	affinity chromatography technology	Boldt K (2016)	1
ALYREF	0	LSM4	1	affinity chromatography technology	Boldt K (2016)	1
LSM6	0	LSM8	0	biochemical, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Lehner B (2004), Lehner B (2004), Huttlin EL (2017), Boldt K (2016)	5
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
PAXIP1	1	PPIH	1	affinity chromatography technology	Woods NT (2012)	1
PRPF3	3	PRPF31	0	two hybrid, two hybrid, biochemical, affinity chromatography technology	Liu S (2006), Liu S (2006), Wan C (2015), Huttlin EL (2017)	4
PRPF3	3	RPL32	0	affinity chromatography technology	Boldt K (2016)	1
SART3	2	PRPF3	3	fluorescent resonance energy transfe, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stanek D (2004), Sowa ME (2009), Song EJ (2010), Song EJ (2010), Huttlin EL (2017), Boldt K (2016)	6
UBC	7	PRPF4	3	affinity chromatography technology	Matsumoto M (2005)	1
SOX2	4	PRPF4	3	affinity chromatography technology	Cox JL (2013)	1
OLA1	2	LSM4	1	affinity chromatography technology	Boldt K (2016)	1
PPIH	1	ITPA	1	biochemical	Wan C (2015)	1
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
OLA1	2	RPL26L1	1	affinity chromatography technology	Boldt K (2016)	1
OLA1	2	SART3	2	affinity chromatography technology	Boldt K (2016)	1
ITGA4	4	SNU13	0	affinity chromatography technology	Byron A (2012)	1
SART3	2	PPIH	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Boldt K (2016)	2
HUWE1	22	USP15	4	affinity chromatography technology	Thompson JW (2014)	1
SOX2	4	USP15	4	affinity chromatography technology	Cox JL (2013)	1
PRPF4	3	LSM8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Boldt K (2016)	3
ALYREF	0	LSM8	0	affinity chromatography technology	Boldt K (2016)	1
SNU13	0	PRPF31	0	two hybrid, two hybrid, affinity chromatography technology	Liu S (2006), Liu S (2006), Bizarro J (2015)	3
PRPF3	3	RPL26L1	1	affinity chromatography technology	Boldt K (2016)	1
OLA1	2	PRPF31	0	affinity chromatography technology	Boldt K (2016)	1
UBC	7	ALYREF	0	affinity chromatography technology	Matsumoto M (2005)	1
ITGA4	4	ALYREF	0	affinity chromatography technology	Byron A (2012)	1
PPIH	1	RPL26L1	1	affinity chromatography technology	Boldt K (2016)	1
FN1	17	OLA1	2	affinity chromatography technology	Humphries JD (2009)	1
CUL3	17	HUWE1	22	affinity chromatography technology	Bennett EJ (2010)	1
ITGA4	4	UBC	7	affinity chromatography technology	Byron A (2012)	1
SNU13	0	PPIH	1	two hybrid, two hybrid	Liu S (2006), Liu S (2006)	2
PRPF4	3	LSM4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Boldt K (2016)	3
FN1	17	PCMT1	1	affinity chromatography technology	Humphries JD (2009)	1
VCAM1	2	SNU13	0	affinity chromatography technology	Humphries JD (2009)	1
SART3	2	PRPF4	3	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stanek D (2004), Sowa ME (2009), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	5
HUWE1	22	PCMT1	1	affinity chromatography technology	Thompson JW (2014)	1
WDR1	3	ITPA	1	biochemical	Wan C (2015)	1
PRPF4	3	PRPF31	0	affinity chromatography technology, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Liu S (2006), Liu S (2006), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
PRPF4	3	RPL26L1	1	affinity chromatography technology	Boldt K (2016)	1