PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNCA	0	CDC42EP2	0	pull down	Schnack C (2008)	1
CDC42	3	CDC42EP2	0	pull down, pull down, two hybrid, two hybrid, two hybrid, two hybrid	Hirsch DS (2001), Joberty G (1999), Joberty G (1999), Bandyopadhyay S (2010), Wang J (2011), Rolland T (2014)	6
CDC42EP2	0	RHOQ	0	pull down, two hybrid	Joberty G (1999), Joberty G (1999)	2
CDC42EP2	0	SEPT6	0	pull down	Joberty G (2001)	1
CDC42EP2	0	NME7	0	two hybrid	Rolland T (2014)	1
SEPT6	0	SEPT7	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
CDC42EP2	0	SEPT7	0	pull down	Joberty G (2001)	1
ARHGAP26	3	CDC42	3	enzymatic study	Shibata H (2001)	1
CDC42EP2	0	ARHGAP26	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2