PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RACK1	2	PRKCE	6	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Liedtke CM (2002), Liedtke CM (2002), Liedtke CM (2002), Liedtke CM (2002)	4
ADRB2	0	ELOC	0	affinity chromatography technology	Xie L (2009)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
TBXA2R	1	GNB1	4	fluorescent resonance energy transfe, pull down	Gales C (2005), Manganello JM (2003)	2
TP63	0	RACK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Fomenkov A (2003), Fomenkov A (2004), Fomenkov A (2004), Fomenkov A (2004)	4
RACK1	2	STAT1	1	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2001), Usacheva A (2001)	3
SRC	2	RACK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang BY (1998), Chang BY (1998), Chang BY (1998), Chang BY (1998), Chen S (2008)	5
TP73	2	RACK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Ozaki T (2003), Ozaki T (2003), Ozaki T (2003), Ozaki T (2003)	4
TRIM45	1	RACK1	2	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sato T (2014), Sato T (2014), Sato T (2014), Sato T (2014)	4
RACK1	2	FYN	1	affinity chromatography technology, pull down, affinity chromatography technology	Yaka R (2003), Yaka R (2002), Yaka R (2002)	3
IFNAR2	1	RACK1	2	pull down, two hybrid, pull down, affinity chromatography technology	Usacheva A (2001), Croze E (2000), Croze E (2000), Croze E (2000)	4
VHL	0	AR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen S (2013), Chen S (2013), Wang J (2014), Wang J (2014)	4
ITGB2	4	RACK1	2	two hybrid, pull down, affinity chromatography technology	Liliental J (1998), Liliental J (1998), Liliental J (1998)	3
RACK1	2	JAK1	6	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2003), Renga B (2012)	3
RACK1	2	ELOC	0	affinity chromatography technology, pull down, affinity chromatography technology	Subauste MC (2009), Liu YV (2007), Liu YV (2007)	3
ADRB2	0	VHL	0	affinity chromatography technology	Xie L (2009)	1
ADRB2	0	SRC	2	affinity chromatography technology	Cao W (2000)	1
PRKCE	6	STAT1	1	affinity chromatography technology, affinity chromatography technology	Cheng MB (2010), Cheng MB (2010)	2
NSMAF	5	RACK1	2	two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Tcherkasowa AE (2002), Tcherkasowa AE (2002), Tcherkasowa AE (2002), Tcherkasowa AE (2002), Tcherkasowa AE (2002)	5
RACK1	2	EED	1	two hybrid, two hybrid, imaging technique, affinity chromatography technology	Philipp S (2010), Philipp S (2010), Philipp S (2010), Philipp S (2010)	4
HIF1A	1	RACK1	2	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baek JH (2007), Liu YV (2007), Liu YV (2007), Liu YV (2007), Sun H (2013), Amir S (2009), Kuo YC (2015), Lee SH (2015)	8
SRC	2	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olayioye MA (1999), Cirri P (1997), Chang YJ (2004), Chang YJ (2004)	4
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
HABP4	1	RACK1	2	two hybrid, two hybrid, pull down, two hybrid	Nery FC (2004), Nery FC (2004), Nery FC (2004), Nery FC (2006)	4
IFNAR2	1	JAK1	6	pull down, affinity chromatography technology, affinity chromatography technology	Usacheva A (2002), Malakhova OA (2006), Malakhova OA (2006)	3
TBXA2R	1	RACK1	2	two hybrid, pull down, affinity chromatography technology	Parent A (2008), Parent A (2008), Parent A (2008)	3
ADRB2	0	GNB1	4	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Roy SJ (2013)	3
CSF2RB	6	PRKCB	4	affinity chromatography technology	Geijsen N (1999)	1
EED	1	AR	3	affinity chromatography technology	Cao Q (2014)	1
PRKCB	4	RACK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ron D (1999), Ron D (1999), Chen S (2008), Sato T (2014), Sato T (2014), Sato T (2014)	6
IGF1R	5	RACK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hermanto U (2002), He X (2011), He X (2011)	3
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
CSF2RB	6	RACK1	2	two hybrid, affinity chromatography technology, pull down	Geijsen N (1999), Geijsen N (1999), Geijsen N (1999)	3
RACK1	2	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Chen S (2008), Knezevic N (2009)	3
RACK1	2	LARP4B	5	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Angenstein F (2002), Wang J (2011), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
IFNAR2	1	STAT1	1	pull down, pull down	Li X (1997), Usacheva A (2001)	2
ADRB2	0	RACK1	2	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Kittanakom S (2014), Kittanakom S (2014), Kittanakom S (2014)	4
HIF1A	1	SRC	2	imaging technique, affinity chromatography technology	Gray MJ (2005), Ruas JL (2005)	2
PTOV1	3	RACK1	2	two hybrid, affinity chromatography technology, pull down, pull down, imaging technique	Marques N (2013), Marques N (2013), Marques N (2013), Marques N (2013), Marques N (2013)	5
RACK1	2	DYNLL1	0	two hybrid, affinity chromatography technology, pull down, biochemical	Zhang W (2008), Zhang W (2008), Zhang W (2008), Kristensen AR (2012)	4
SRC	2	AR	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Migliaccio A (2000), Unni E (2004), Powell SM (2004), Dotzlaw H (2003)	4
SRC	2	PDE4D	4	far western blotting	Beard MB (1999)	1
PDE4D	4	RACK1	2	two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down	Yarwood SJ (1999), Yarwood SJ (1999), Yarwood SJ (1999), Steele MR (2001), Steele MR (2001), Li X (2009), Bolger GB (2002), Bolger GB (2002)	8
EED	1	DYNLL1	0	affinity chromatography technology	Cao Q (2014)	1
CSF2RB	6	JAK1	6	affinity chromatography technology	Lei JT (2011)	1
PRKCB	4	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
HIF1A	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baek JH (2007), Hubbi ME (2011), Liu YV (2007), Luo W (2010), Liu YV (2007), Russell RC (2008)	6
AR	3	RACK1	2	two hybrid, affinity chromatography technology, pull down	Rigas AC (2003), Rigas AC (2003), Rigas AC (2003)	3
TP73	2	HIF1A	1	affinity chromatography technology	Amelio I (2015)	1
VHL	0	RACK1	2	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	He X (2011), He X (2011), He X (2011), He X (2011)	4
RACK1	2	PTPRM	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Hellberg CB (2002), Mourton T (2001), Mourton T (2001)	3
JAK1	6	STAT1	1	affinity chromatography technology, affinity chromatography technology	Andl CD (2004), Chang YJ (2004)	2
PRKCE	6	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
FYN	1	PDE4D	4	far western blotting	Beard MB (1999)	1
JAK1	6	IGF1R	5	pull down	Gual P (1998)	1
GNB1	4	FYN	1	affinity chromatography technology	Knezevic N (2009)	1
RACK1	2	AGTRAP	1	pull down, affinity chromatography technology, two hybrid	Wang W (2002), Wang W (2002), Wang W (2002)	3
TP63	0	HIF1A	1	affinity chromatography technology	Senoo M (2002)	1
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
EIF6	2	RACK1	2	affinity chromatography technology, pull down, two hybrid	Ceci M (2003), Ceci M (2003), Ceci M (2003)	3