Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CACNG3 10368 GABAPENTIN CHEMBL940 modulator ChemblInteractions
CACNG3 10368 GABAPENTIN ENACARBIL CHEMBL1628502 modulator ChemblInteractions
CACNG3 10368 IMAGABALIN CHEMBL2103836 modulator ChemblInteractions
CACNG3 10368 PREGABALIN CHEMBL1059 modulator ChemblInteractions
CACNG3 10368 ATAGABALIN CHEMBL593430 modulator ChemblInteractions
CACNG3 10368 BEPRIDIL HYDROCHLORIDE CHEMBL1200382 blocker ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CACNG3 rs1859204 TT antipsychotics efficacy yes Patients with the TT genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the CC genotype. No significant association was seen when comparing the CT vs TT genotype. Significance was set at p<3.45E-6. Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype CC. 30032160 1449753391