PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXW7	2	KLF2	3	enzymatic study, affinity chromatography technology	Wang R (2013), Wang R (2013)	2
WWP1	3	KLF2	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Conkright MD (2001), Conkright MD (2001), Zhang X (2004)	3
CREBBP	29	PSME3	0	enzymatic study	Liu J (2013)	1
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
GATA6	4	KLF2	3	two hybrid	Conkright MD (2001)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
KLF2	3	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Xie P (2011), Xie P (2011), Xie P (2011)	3
GATA5	0	KLF2	3	two hybrid	Conkright MD (2001)	1
KLF2	3	PSME3	0	affinity chromatography technology, pull down, enzymatic study	Sun J (2016), Sun J (2016), Sun J (2016)	3
GATA6	4	EP300	36	affinity chromatography technology	Wada H (2000)	1
GSK3B	1	KLF2	3	enzymatic study	Wang R (2013)	1
SMURF1	4	PSME3	0	two hybrid, affinity chromatography technology, pull down	Nie J (2010), Nie J (2010), Nie J (2010)	3
CREBBP	29	KLF2	3	imaging technique	Allen KL (2011)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
KLF2	3	KAT2B	2	pull down, affinity chromatography technology	Das H (2006), Das H (2006)	2
ELAVL1	0	GSK3B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
ELAVL1	0	KLF2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EP300	36	KLF2	3	imaging technique, pull down, affinity chromatography technology	Allen KL (2011), SenBanerjee S (2004), SenBanerjee S (2004)	3