PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MTA3	3	RCOR3	0	affinity chromatography technology	Bantscheff M (2011)	1
FBXO7	1	HMG20B	2	enzymatic study	Teixeira FR (2016)	1
RCOR1	0	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Battaglioli E (2002), Gu H (2005), Pflum MK (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Cetinkaya C (2007), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	15
MTA3	3	HMG20A	0	affinity chromatography technology	Bantscheff M (2011)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
HDAC2	1	RCOR2	3	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013)	2
HMG20B	2	KIF4A	2	affinity chromatography technology, two hybrid, two hybrid, pull down	Lee YM (2003), Lee YM (2003), Lee YM (2003), Lee YM (2003)	4
BRCA2	6	HMG20B	2	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marmorstein LY (2001), Marmorstein LY (2001), Marmorstein LY (2001), Marmorstein LY (2001), Marmorstein LY (2001), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Lee M (2011), Lee M (2011)	10
HDAC1	4	RCOR2	3	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
SNAI1	1	KDM1A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin T (2010), Lin T (2010), Lin Y (2010), Lin Y (2010), Lin Y (2010), Lin Y (2010), Wu ZQ (2012), Lin Y (2010), Huttlin EL (2015), Rivero S (2015)	10
SF3A2	1	HMG20B	2	affinity chromatography technology	Will CL (2002)	1
TRAF1	0	SYCE1	0	two hybrid	Rolland T (2014)	1
HMG20A	0	RCOR2	3	affinity chromatography technology	Huttlin EL (2017)	1
HMG20B	2	TACC2	4	two hybrid	Stelzl U (2005)	1
MTA3	3	RCOR1	0	affinity chromatography technology	Bantscheff M (2011)	1
XPO1	8	FBXO7	1	pull down	Nelson DE (2011)	1
HDAC1	4	RCOR3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
HMG20B	2	TFIP11	5	two hybrid	Rolland T (2014)	1
NKX3-1	2	HMG20B	2	two hybrid	Wang X (2008)	1
HMG20B	2	CCDC85B	0	two hybrid	Rual JF (2005)	1
HMG20B	2	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMG20B	2	CCDC136	1	two hybrid	Rolland T (2014)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
LLGL2	4	RCOR1	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	HMG20A	0	enzymatic study	Teixeira FR (2016)	1
CCDC102B	0	FBXO7	1	affinity chromatography technology	Huttlin EL (2017)	1
MTA3	3	GSE1	14	affinity chromatography technology	Bantscheff M (2011)	1
SNAI1	1	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	VIM	0	affinity chromatography technology	Kirli K (2015)	1
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
KIF4A	2	APP	1	pull down	Olah J (2011)	1
HMG20A	0	CCDC136	1	two hybrid	Rolland T (2014)	1
SNAI1	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peinado H (2004), Peinado H (2004), Kim Y (2010), Tong ZT (2012), Tong ZT (2012), Hsu DS (2014)	6
KRT38	4	KDM1A	2	two hybrid	Rolland T (2014)	1
KIF4A	2	BRCA2	6	affinity chromatography technology	Wu G (2008)	1
HNRNPL	3	USP15	4	affinity chromatography technology	Fei T (2017)	1
HDAC1	4	HMG20B	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
SNAI1	1	HMG20B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RCOR3	0	APP	1	pull down	Olah J (2011)	1
HMG20B	2	APP	1	pull down	Olah J (2011)	1
LLGL2	4	HMG20B	2	affinity chromatography technology	Huttlin EL (2017)	1
HDAC2	1	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013)	2
HDAC2	1	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017), Rivero S (2015)	5
MTA3	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Kwintkiewicz J (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
HMG20B	2	PHF21A	4	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Iwase S (2004), Hakimi MA (2002), Huttlin EL (2015), Huttlin EL (2017)	7
HNRNPL	3	RCOR3	0	affinity chromatography technology	Fei T (2017)	1
SNAI1	1	RCOR1	0	pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology	Lin T (2010), Baron R (2011), Baron R (2011), Huttlin EL (2015), Huttlin EL (2017)	5
LLGL2	4	HMG20A	0	affinity chromatography technology	Huttlin EL (2017)	1
HMG20A	0	PHF21A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	4
LLGL2	4	RCOR3	0	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
HMG20A	0	GSE1	14	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HMG20B	2	TRAF1	0	two hybrid	Yu H (2011)	1
RCOR1	0	HMG20B	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Huttlin EL (2015), Huttlin EL (2017)	6
SNAI1	1	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMG20A	0	RCOR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	4
KDM1A	2	RBPJ	1	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Li X (2015)	2
PHF21A	4	HDAC1	4	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	5
SNAI1	1	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Rivero S (2015)	3
TFIP11	5	RCOR3	0	two hybrid	Rolland T (2014)	1
KRT38	4	HMG20B	2	two hybrid	Rolland T (2014)	1
XPO1	8	HMG20B	2	affinity chromatography technology	Kirli K (2015)	1
GSE1	14	RCOR3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
KDM1A	2	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Bantscheff M (2011), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	6
HMG20B	2	VIM	0	two hybrid, biochemical	Stelzl U (2005), Havugimana PC (2012)	2
KDM1A	2	XPO1	8	genetic interference	Horlbeck MA (2018)	1
HMG20B	2	SYCE1	0	two hybrid	Rolland T (2014)	1
HDAC2	1	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, genetic interference	Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Tong JK (1998), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Wang Y (2009), Li Q (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Wong AS (2016)	17
RBPJ	1	PHF21A	4	affinity chromatography technology	Li X (2015)	1
RBPJ	1	HMG20B	2	affinity chromatography technology	Li X (2015)	1
XPO1	8	RBPJ	1	affinity chromatography technology	Kirli K (2015)	1
CCDC102B	0	SYCE1	0	two hybrid	Rolland T (2014)	1
HMG20B	2	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMG20B	2	CCDC102B	0	two hybrid	Rolland T (2014)	1
KDM1A	2	MTA3	3	affinity chromatography technology, pull down, affinity chromatography technology	Wang Y (2009), Wang Y (2009), Li Q (2011)	3
KRT15	2	HMG20B	2	two hybrid	Rolland T (2014)	1
PHF21A	4	HDAC2	1	biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Hakimi MA (2003), Joshi P (2013)	4
RBPJ	1	APP	1	pull down	Olah J (2011)	1
RBPJ	1	HDAC2	1	affinity chromatography technology	Li X (2015)	1
HDAC2	1	HMG20B	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2002), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Huttlin EL (2017)	9
KRT15	2	RCOR3	0	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
HMG20A	0	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HDAC1	4	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
HMG20B	2	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2003), Shi YJ (2005), Lee MG (2005), Hakimi MA (2002), Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017)	10
SNAI1	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peinado H (2004), Peinado H (2004), Lin T (2010), Tong ZT (2012), Tong ZT (2012), Wu ZQ (2012), Hsu DS (2014), Yuan K (2016), Yuan K (2016)	9
RCOR1	0	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Battaglioli E (2002), Humphrey GW (2001), Humphrey GW (2001), Bantscheff M (2011), Joshi P (2013)	8
LLGL2	4	GSE1	14	affinity chromatography technology	Huttlin EL (2017)	1
PHF21A	4	RCOR1	0	biochemical, pull down, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Boldt K (2016)	3
RCOR3	0	CCDC102B	0	two hybrid	Rolland T (2014)	1
TRAF1	0	PHF21A	4	two hybrid	Rolland T (2014)	1
HMG20B	2	USP15	4	biochemical	Havugimana PC (2012)	1
LLGL2	4	PHF21A	4	affinity chromatography technology	Hein MY (2015)	1
HMG20B	2	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Ceballos-Chavez M (2012), Ceballos-Chavez M (2012)	5
HMG20B	2	RCOR2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMG20B	2	HNRNPL	3	two hybrid	Stelzl U (2005)	1
HNRNPL	3	MTA3	3	affinity chromatography technology	Fei T (2017)	1
HDAC1	4	NKX3-1	2	affinity chromatography technology, affinity chromatography technology	Lei Q (2006), Lei Q (2006)	2
HMG20B	2	POLR3H	0	biochemical	Havugimana PC (2012)	1
PHF21A	4	KDM1A	2	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Hakimi MA (2003), Shi YJ (2005), Lee MG (2005), Boldt K (2016)	6
MTA3	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Fujita N (2003), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	5
KDM1A	2	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Lee MG (2005), Bantscheff M (2011)	3
MTA3	3	HMG20B	2	affinity chromatography technology	Bantscheff M (2011)	1
HDAC1	4	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
HDAC1	4	VIM	0	affinity chromatography technology	Terhune SS (2010)	1
VIM	0	APP	1	pull down	Olah J (2011)	1
HDAC2	1	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Bantscheff M (2011), Joshi P (2013)	3