PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
CDK6	0	CDKN2D	0	x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Brotherton DH (1998), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
CDKN2D	0	NR4A2	6	two hybrid	Rolland T (2014)	1
CDKN2D	0	APP	1	pull down	Olah J (2011)	1
CDKN2D	0	INCA1	1	two hybrid	Rolland T (2014)	1
CDKN2D	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Kehn K (2007), Kehn K (2007), Kehn K (2007), Kehn K (2007)	4
CDK4	2	CDKN2D	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Waaijers S (2013), Waaijers S (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	7
CDKN2D	0	TBC1D17	2	two hybrid	Rual JF (2005)	1
BRCA1	7	CDK4	2	pull down, enzymatic study, enzymatic study	Wang H (1997), Kehn K (2007), Miralem T (2003)	3
CDK4	2	APP	1	pull down	Olah J (2011)	1
CDKN2D	0	NR4A1	4	two hybrid	Rolland T (2014)	1
CDKN2D	0	IKZF3	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CDKN2D	0	C1orf94	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CDKN2D	0	HSD17B14	0	two hybrid	Rolland T (2014)	1