PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM23	3	TRAIP	0	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), Banka PA (2015), DiBello A (2016)	6
USP2	0	PCNA	0	enzymatic study	Masuda Y (2012)	1
USP2	0	TRAIP	0	two hybrid	Hayes SD (2012)	1
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
TNFRSF1B	4	TRAF3	1	pull down, affinity chromatography technology	Mosialos G (1995), Mosialos G (1995)	2
TBK1	1	CYLD	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Friedman CS (2008), Genin P (2015), Genin P (2015)	3
TBK1	1	APP	1	pull down	Olah J (2011)	1
CYLD	2	TRAIP	0	two hybrid, far western blotting	Regamey A (2003), Regamey A (2003)	2
UBE2U	0	RNF114	0	two hybrid	van Wijk SJ (2009)	1
TNFRSF1B	4	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TRAIP	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
TRIM41	6	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
TRIM23	3	TRAF1	0	two hybrid	Rolland T (2014)	1
TRAF1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
TRAIP	0	UBE2D2	0	pull down	Besse A (2007)	1
TRAIP	0	MAP3K7	2	affinity chromatography technology	Kong QZ (2016)	1
SYK	3	TRAIP	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Q (2009), Zhou Q (2009), Zhou Q (2009)	3
RNF4	1	TRAIP	0	two hybrid	Woodsmith J (2012)	1
UBE2Z	0	TRAIP	0	two hybrid	Markson G (2009)	1
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
RAD21	3	PCNA	0	affinity chromatography technology, biochemical, biochemical	Panigrahi AK (2011), Havugimana PC (2012), Wan C (2015)	3
SYK	3	TBK1	1	affinity chromatography technology	Lin YC (2013)	1
TRAIP	0	FLII	11	two hybrid, pull down	Wilson SA (1998), Wilson SA (1998)	2
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
UBE2K	0	TRAIP	0	two hybrid	Markson G (2009)	1
TRAIP	0	TBK1	1	affinity chromatography technology	Zhang M (2012)	1
MAP3K7	2	TRAF5	1	affinity chromatography technology	Hong S (2007)	1
RNF20	9	TRAIP	0	affinity chromatography technology, affinity chromatography technology	Soo Lee N (2016), Soo Lee N (2016)	2
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TSG101	1	TRAIP	0	two hybrid	Markson G (2009)	1
UBE2H	3	RNF114	0	two hybrid	Markson G (2009)	1
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
SYK	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamada T (2001), Lin YC (2013), Wu NL (2014)	3
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
TRAF5	1	TBK1	1	affinity chromatography technology, pull down	Fang R (2017), Fang R (2017)	2
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
TRAIP	0	APP	1	pull down	Olah J (2011)	1
RNF40	11	TRAIP	0	affinity chromatography technology, affinity chromatography technology	Soo Lee N (2016), Soo Lee N (2016)	2
TRAF1	0	MAPRE2	0	two hybrid	Rolland T (2014)	1
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
TRIM23	3	UBE2D2	0	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
UBE2H	3	RNF4	1	two hybrid	Markson G (2009)	1
TRAIP	0	TRIM41	6	two hybrid	Woodsmith J (2012)	1
UBE2H	3	TRAIP	0	two hybrid	Markson G (2009)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
TRAIP	0	TRAF1	0	two hybrid, pull down, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007)	3
UBE2D1	0	RNF4	1	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Plechanovova A (2011), Plechanovova A (2011), Tatham MH (2008), Tatham MH (2013), Yang YC (2013), Groocock LM (2014), Rojas-Fernandez A (2014), Guo L (2014), Xu Y (2014), Lecona E (2016), DiBello A (2016)	13
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF8	2	TRAF2	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Aizawa S (1997), Aizawa S (1997), Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Horie R (2002), Huttlin EL (2017)	7
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
RNF20	9	RNF40	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhang F (2011), Jaeaeskelaeinen T (2011), Jaeaeskelaeinen T (2011), Moyal L (2011), Moyal L (2011), Zhu B (2005), Kim J (2009), Bedi U (2015), Klement K (2014), Duan Y (2016), Duan Y (2016), Foglizzo M (2016)	12
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RNF4	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Tan B (2015), Tan B (2015)	2
UBE2D3	1	PCNA	0	enzymatic study	Hibbert RG (2012)	1
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
TRAIP	0	TRAIP	0	enzymatic study, affinity chromatography technology, pull down	Besse A (2007), Park IS (2015), Park IS (2015)	3
UBE2D3	1	UBOX5	4	two hybrid, pull down	Markson G (2009), Hatakeyama S (2001)	2
TNFRSF8	2	TRAF5	1	pull down, affinity chromatography technology, pull down	Aizawa S (1997), Aizawa S (1997), Mizushima S (1998)	3
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
TRAF6	0	TNFRSF1B	4	affinity chromatography technology	Khursigara G (1999)	1
SYK	3	TRAF3	1	affinity chromatography technology	Lin YC (2013)	1
USP2	0	UBOX5	4	two hybrid	Hayes SD (2012)	1
UBE2H	3	TRIM23	3	two hybrid	Markson G (2009)	1
TRAIP	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Besse A (2007), Zhang M (2012)	2
TRAIP	0	UBE2D1	0	pull down	Besse A (2007)	1
UBE2U	0	TRIM23	3	two hybrid	Markson G (2009)	1
RAD21	3	TRAIP	0	affinity chromatography technology	Panigrahi AK (2011)	1
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
PCNA	0	POLK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Ogi T (2010), Ogi T (2010), Jones MJ (2011), Boehm EM (2016)	5
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
UBE2U	0	TRAIP	0	two hybrid	van Wijk SJ (2009)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
USP2	0	TRIM23	3	two hybrid	Hayes SD (2012)	1
PCNA	0	RNF20	9	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), DiBello A (2016)	5
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
PCNA	0	TRAIP	0	affinity chromatography technology, pull down, x-ray crystallography	Hoffmann S (2016), Hoffmann S (2016), Hoffmann S (2016)	3
TRAIP	0	UBE2D3	1	pull down	Besse A (2007)	1
TNFRSF8	2	TRAF3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
SYK	3	MAP3K7	2	affinity chromatography technology	Lin YC (2013)	1
TRAIP	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
POLH	1	PCNA	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology	Haracska L (2001), Haracska L (2001), Kannouche PL (2004), Bienko M (2010), Bienko M (2010), Bienko M (2010), Bienko M (2010), Jung YS (2011), Zlatanou A (2011), Plosky BS (2006), Vidal AE (2004), Sekimoto T (2010), Hibbert RG (2012), Mosbech A (2012), Durando M (2013), Qin Z (2013), Fu D (2013), Fu D (2013), Sekimoto T (2010), Sekimoto T (2010), Sekimoto T (2010), Ahmed-Seghir S (2015), Inoue A (2014), Hedglin M (2016), Hedglin M (2016), Dai X (2016), Guan J (2017)	27
UBE2D1	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRAIP	0	POLK	0	two hybrid	Wallace HA (2014)	1
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
MAGEF1	3	TRAIP	0	two hybrid	Kozakova L (2015)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
SYK	3	APP	1	pull down	Olah J (2011)	1
TRIM23	3	UBE2D3	1	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
TRIM23	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017)	4
TSG101	1	TRIM23	3	two hybrid	Markson G (2009)	1
TNFRSF8	2	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
POLH	1	APP	1	pull down	Olah J (2011)	1
TRAIP	0	MAPRE2	0	two hybrid	Rolland T (2014)	1
UBE2H	3	UBOX5	4	two hybrid	Markson G (2009)	1
TRIM41	6	UBE2D2	0	pull down	Chen D (2007)	1
TRAIP	0	UIMC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Soo Lee N (2016), Soo Lee N (2016), Soo Lee N (2016)	3
UBE2K	0	RNF4	1	two hybrid	Markson G (2009)	1
UBE2D2	0	UBOX5	4	two hybrid	Markson G (2009)	1
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
UBE2K	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRAIP	0	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007), Park ES (2015)	4
MAPRE2	0	APP	1	pull down	Olah J (2011)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
TRAIP	0	TRAF5	1	affinity chromatography technology	Besse A (2007)	1
CYLD	2	PCNA	0	affinity chromatography technology	Elliott PR (2016)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
UBE2K	0	RNF114	0	two hybrid	Markson G (2009)	1
TRAIP	0	POLH	1	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Wallace HA (2014), Wallace HA (2014), Wallace HA (2014), Wallace HA (2014)	4
TNFRSF8	2	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
USP2	0	TBK1	1	affinity chromatography technology	Zhang L (2014)	1