PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCND3	1	CDK4	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Arsenijevic T (2004), Lin J (2001), Zhang Q (1999), Datta NS (1998), Garcia-Morales P (2006), Bockstaele L (2006), Ramachandran N (2004), Wang J (2011), Lodewick J (2013), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Hein MY (2015), Huttlin EL (2017)	15
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
RBL1	1	CCNA2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dyson N (1993), Joaquin M (2002), Gibbs E (1996), Schulman BA (1998), Schulman BA (1998), Huttlin EL (2015), Huttlin EL (2017)	7
CDK4	2	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Kehn K (2004), Kehn K (2004), Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017), Denicourt C (2008), Ivanov AA (2017)	8
CDKN1C	0	CCNE2	2	two hybrid	Zariwala M (1998)	1
RBL1	1	CDKN1C	0	affinity chromatography technology	Joaquin M (2003)	1
CDK4	2	RBL1	1	enzymatic study	Anders L (2011)	1
CCND2	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017)	3
CCNA2	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Higashi H (1996), Knudsen ES (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Nakanishi M (1999)	7
CDK3	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDKN1C	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhao R (2013), Zhao R (2013), Zhao R (2013)	3
CDK6	0	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Sugimoto M (1999), Lin J (2001), Sweeney KJ (1997), Ruas M (2007), Shu F (2007), Ramachandran N (2004), Ghiani C (2001)	7
CCNA2	1	CDKN1C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CDKN1C	0	LIMK1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Yokoo T (2003), Yokoo T (2003), Yokoo T (2003)	3
CCNE2	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gudas JM (1999), Lauper N (1998), Zariwala M (1998), Zariwala M (1998), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
CDK1	0	CDK3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK3	0	CDKN1C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
SKP2	2	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Lin HK (2009), Lin HK (2009), Lin HK (2009), Lin HK (2009), Lin HK (2009), Roe JS (2011), Gao D (2009), Gao D (2009), Chan CH (2013)	9
CDK4	2	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Serrano M (1993), Xiong Y (1993), Takasaki Y (2001)	3
SKP2	2	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Bashir T (2010), Rosner M (2009), Rosner M (2004), Zhang H (1995), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
CCND3	1	CDKN1C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBL1	1	MYBL2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Joaquin M (2003), Joaquin M (2002), Joaquin M (2002), Schmit F (2007)	4
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
MYOD1	0	CDK4	2	pull down, pull down, two hybrid	Zhang JM (1999), Zhang JM (1999), Zhang JM (1999)	3
CDK1	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
TP53	0	CCND1	1	affinity chromatography technology	Yang P (2016)	1
CCNA2	1	CDK6	0	affinity chromatography technology	Datta NS (1998)	1
COPS5	0	CDK2	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Chun Y (2013)	2
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
CCND2	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Moorthamer M (1999), Sweeney KJ (1997), Jiang W (1998), Welcker M (1998)	4
FBXL12	1	CDKN1C	0	affinity chromatography technology	Kim M (2008)	1
TP53	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SKP2	2	RB1	2	affinity chromatography technology, affinity chromatography technology	Ji P (2004), Ji P (2004)	2
CDK6	0	RBL1	1	enzymatic study	Anders L (2011)	1
CDKN1C	0	CDK4	2	pull down, affinity chromatography technology	Reynaud EG (2000), Reynaud EG (2000)	2
CCND3	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Bockstaele L (2006), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5
PCNA	0	CCNE2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RB1	2	CDKN1C	0	pull down	Nakanishi M (1999)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
CDK4	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nair JS (2009), Takaki T (2004), Deep G (2006), Kehn K (2004), Scholz A (2003), Gladden AB (2003), Mori S (1999), Higashi H (1996), Musgrove EA (1996), Sarmento LM (2005), Kim KS (2002), Li J (2002), Garcia-Morales P (2006), Tsai CH (2009), Miralem T (2003), Toji S (2004), Halder SK (2005), Dynlacht BD (1997), Mandal M (1998), Voit R (1999), Annicotte JS (2006), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Kitagawa M (1996), Anders L (2011), Gaiddon C (2003), Seo DW (2006), Kabuta T (2013), Lee B (2006), Kossatz U (2006), Zarkowska T (1997), Nakanishi M (1999), Iyer NG (2007), Guidoboni M (2005), Barbash O (2009), Wang C (2001), Denicourt C (2008), Pan W (2001)	39
SKP2	2	MYBL2	2	affinity chromatography technology	Charrasse S (2000)	1
CCND2	2	CDKN1C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	CDKN1C	0	affinity chromatography technology, affinity chromatography technology	Guo H (2016), Guo H (2016)	2
RB1	2	CCND3	1	two hybrid, affinity chromatography technology, pull down	Stern MD (2007), Bockstaele L (2006), Jaenicke RU (1996)	3
CDK6	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Garcia-Morales P (2006), Aprelikova O (1995), Yarbrough WG (1999), Dynlacht BD (1997), Jiang W (1998), Anders L (2011), Nakanishi M (1999), Iyer NG (2007)	8
CDKN1C	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kamura T (2003), Calvisi DF (2009), Kamura T (2003)	3
CCND1	1	RB1	2	pull down, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Siegert JL (2000), Siegert JL (2000), Dowdy SF (1993), Chan HM (2001), Dasgupta P (2004), Dasgupta P (2004), Sweeney KJ (1997), Higashi H (1996), Musgrove EA (1996), Yarbrough WG (1999), Connell-Crowley L (1997), Kitagawa M (1996), Poon RY (1996), Gaiddon C (2003), Zarkowska T (1997), Nakanishi M (1999), Welcker M (1998)	17
CDK1	0	CDKN1C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK4	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
MYBL2	2	CDKN1C	0	pull down, affinity chromatography technology	Joaquin M (2003), Joaquin M (2003)	2
CDKN1C	0	CDKN1C	0	pull down, affinity chromatography technology	Reynaud EG (2000), Reynaud EG (2000)	2
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
TP53	0	CDKN1C	0	affinity chromatography technology	Kikuchi J (2003)	1
CCND1	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Higashi H (1996), Higashi H (1996), Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	6
CDKN1C	0	PCNA	0	two hybrid, affinity chromatography technology, pull down	Watanabe H (1998), Watanabe H (1998), Watanabe H (1998)	3
CDK3	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
COPS5	0	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
MYOD1	0	CDKN1C	0	affinity chromatography technology, affinity chromatography technology, pull down	Reynaud EG (2000), Reynaud EG (2000), Reynaud EG (2000)	3
CDK1	0	TP53	0	enzymatic study, affinity chromatography technology	Luciani MG (2000), Ababneh M (2001)	2
CCND3	1	PCNA	0	pull down	Matsuoka S (1994)	1
CCND1	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Zhang H (1993), Hein MY (2015), Huttlin EL (2017)	4
CCND1	1	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology	Matsuoka S (1994), Xiong Y (1993), Zhang H (1993)	3
TP53	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNA2	1	TP53	0	pull down	Luciani MG (2000)	1
CDK1	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Lees JA (1991), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Knudsen ES (1997), Pan W (2001)	8
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
CDK2	0	CDKN1C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCND3	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CDK3	0	RB1	2	enzymatic study, enzymatic study	Connell-Crowley L (1997), Ren S (2004)	2
CDK4	2	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugimoto M (1999), Sugimoto M (1999), Serrano M (1993), Lin J (2001), Taules M (1998), Cariou S (2000), Coleman KG (1997), Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Diehl JA (1997), Okabe H (2007), Bustany S (2011), Gladden AB (2003), Sweeney KJ (1997), Musgrove EA (1996), Vlach J (1996), Garcia-Morales P (2006), Bindra RS (2002), Ruas M (2007), Poon RY (1996), Ramachandran N (2004), Larrea MD (2009), Waaijers S (2013), Mallampalli RK (2013), Rolland T (2014), Chen TC (2014), Barbash O (2009), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Ghiani C (2001), Ito H (2016), Huttlin EL (2017), Roessig L (2001), Qie S (2017)	35
CDK2	0	MYBL2	2	enzymatic study, enzymatic study, enzymatic study	Mueller-Tidow C (2001), Bartsch O (1999), Johnson TK (1999)	3
CDK6	0	CCND3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Lin J (2001), Meyerson M (1994), Datta NS (1998), Bockstaele L (2006), Shu F (2007), Ramachandran N (2004), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	11
COPS5	0	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK6	0	CDKN1C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDKN1C	0	CCND1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Reynaud EG (2000), Huttlin EL (2017), Reynaud EG (2000), Reynaud EG (2000)	4
COPS5	0	CCNA2	1	affinity chromatography technology	Bennett EJ (2010)	1
CDK3	0	CCNE2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Zariwala M (1998), Huttlin EL (2015), Huttlin EL (2017)	3
CCNA2	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Huttlin EL (2015), Huttlin EL (2017)	3
CDK2	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
MYOD1	0	RB1	2	pull down, pull down, affinity chromatography technology	Mal A (2001), Gu W (1993), Gu W (1993)	3
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1