PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EED	1	STAG1	7	affinity chromatography technology	Cao Q (2014)	1
SMC1A	15	RAD21	3	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gregson HC (2001), Austin C (2009), Gandhi R (2006), Panigrahi AK (2011), Panigrahi AK (2011), Panigrahi AK (2011), Holzmann J (2011), Hauf S (2005), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	13
PDS5A	5	STAG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Kueng S (2006), Losada A (2005)	4
SMC3	16	PDS5A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Bauerschmidt C (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Schmitz J (2007), Losada A (2005), Losada A (2005), Nishiyama T (2010), Wan C (2015)	9
SIGLECL1	0	STAG1	7	affinity chromatography technology	Huttlin EL (2017)	1
EED	1	SMC1A	15	affinity chromatography technology	Cao Q (2014)	1
SMC3	16	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2005), Losada A (2005), Brough R (2012), Wan C (2015), Hein MY (2015)	9
PDS5B	3	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2005), Wan C (2015), Hein MY (2015)	5
USP37	1	SMC3	16	bioid, affinity chromatography technology	Yeh C (2015), Yeh C (2015)	2
WAPL	1	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Hein MY (2015), Hein MY (2015)	4
HDAC11	0	SMC1A	15	affinity chromatography technology	Joshi P (2013)	1
FOXL1	0	SMC1A	15	affinity chromatography technology	Li X (2015)	1
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
CDCA5	0	RAD21	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Rankin S (2005), Nishiyama T (2010), Zhang N (2011), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
FOXL1	0	STAG1	7	affinity chromatography technology	Li X (2015)	1
WAPL	1	STAG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Kueng S (2006), Hein MY (2015)	4
TRMT13	2	STAG1	7	affinity chromatography technology	Huttlin EL (2017)	1
CD83	0	PDS5A	5	affinity chromatography technology	Huttlin EL (2017)	1
PDS5A	5	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2005), Wan C (2015), Hein MY (2015)	5
EED	1	PDS5A	5	affinity chromatography technology	Cao Q (2014)	1
RAD21	3	SMC3	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim HS (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2005), Losada A (2000), Panigrahi AK (2011), Panigrahi AK (2011), Kang H (2011), Holzmann J (2011), Hauf S (2005), Havugimana PC (2012), Seitan VC (2006), Nishiyama T (2010), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	20
WFDC5	0	PDS5B	3	affinity chromatography technology, affinity chromatography technology	Gandhi R (2006), Gandhi R (2006)	2
WFDC5	0	PDS5A	5	affinity chromatography technology, affinity chromatography technology	Gandhi R (2006), Gandhi R (2006)	2
CDCA5	0	SMC1B	1	affinity chromatography technology	Huttlin EL (2015)	1
SNW1	0	WAPL	1	affinity chromatography technology	Lleres D (2010)	1
SMC3	16	WAPL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmitz J (2007), Hutchins JR (2010), Nishiyama T (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015), Hein MY (2015)	9
TMEM206	5	STAG1	7	affinity chromatography technology	Huttlin EL (2017)	1
PDS5A	5	PDS5B	3	affinity chromatography technology, biochemical	Gandhi R (2006), Wan C (2015)	2
HDAC11	0	SNW1	0	affinity chromatography technology	Joshi P (2013)	1
CDCA5	0	STAG1	7	affinity chromatography technology	Hein MY (2015)	1
CDCA5	0	PDS5B	3	pull down, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Nishiyama T (2010), Hein MY (2015)	3
STAG1	7	TERF1	1	affinity chromatography technology	Canudas S (2007)	1
SNW1	0	SMC1A	15	affinity chromatography technology	Lleres D (2010)	1
STAG1	7	RAD21	3	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Gandhi R (2006), Canudas S (2007), Losada A (2000), Panigrahi AK (2011), Panigrahi AK (2011), Holzmann J (2011), Hauf S (2005), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
USP37	1	STAG1	7	bioid	Yeh C (2015)	1
EPHA1	5	STAG1	7	affinity chromatography technology	Huttlin EL (2017)	1
STAG1	7	SMC1B	1	biochemical	Wan C (2015)	1
KIF20B	3	STAG1	7	affinity chromatography technology	Hein MY (2015)	1
GPR183	1	STAG1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDCA5	0	SMC3	16	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Rankin S (2005), Schmitz J (2007), Schmitz J (2007), Nishiyama T (2010), Nishiyama T (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
SMC1B	1	RAD21	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
CD274	2	STAG1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALM1	0	STAG1	7	pull down	Shen X (2005)	1
SIGLECL1	0	PDS5A	5	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	STAG1	7	affinity chromatography technology	Lleres D (2010)	1
SMC3	16	WFDC5	0	affinity chromatography technology	Bauerschmidt C (2010)	1
CD83	0	STAG1	7	affinity chromatography technology	Huttlin EL (2017)	1
STAG1	7	EXOSC9	2	biochemical	Wan C (2015)	1
PDS5B	3	RAD21	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gandhi R (2006), Losada A (2005), Panigrahi AK (2011), Brough R (2012), Hein MY (2015), Huttlin EL (2017)	6
SMC1A	15	WFDC5	0	affinity chromatography technology, affinity chromatography technology	Gandhi R (2006), Gandhi R (2006)	2
SMC1A	15	SMC3	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (2002), Lee J (2003), Lee J (2003), Schmiesing JA (1998), Gregson HC (2001), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2000), Kang H (2011), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	15
EED	1	RAD21	3	affinity chromatography technology	Cao Q (2014)	1
CDCA5	0	WAPL	1	affinity chromatography technology	Hein MY (2015)	1
FOXL1	0	PDS5A	5	affinity chromatography technology	Li X (2015)	1
TP73	2	STAG1	7	affinity chromatography technology	Lunardi A (2010)	1
STAG1	7	SMC1A	15	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Gandhi R (2006), Losada A (2000), Wan C (2015), Hein MY (2015)	6
STAG1	7	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Kueng S (2006), Kueng S (2006), Losada A (2005), Wan C (2015)	4
CD274	2	PDS5B	3	affinity chromatography technology	Huttlin EL (2015)	1
WAPL	1	PDS5A	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Nishiyama T (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015)	7
HDAC11	0	SMC3	16	affinity chromatography technology	Joshi P (2013)	1
FOXL1	0	SMC3	16	affinity chromatography technology	Li X (2015)	1
WFDC5	0	RAD21	3	affinity chromatography technology	Gandhi R (2006)	1
CDCA5	0	PDS5A	5	pull down, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Nishiyama T (2010), Hein MY (2015)	3
WAPL	1	RAD21	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Panigrahi AK (2011), Panigrahi AK (2011), Kueng S (2006), Kueng S (2006), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	8
PNKD	2	STAG1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAG1	7	WFDC5	0	pull down	Gandhi R (2006)	1
USP37	1	RAD21	3	bioid, affinity chromatography technology	Yeh C (2015), Yeh C (2015)	2
STAG1	7	TINF2	1	affinity chromatography technology	Canudas S (2007)	1
RAD21	3	SNW1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Lleres D (2010)	2
USP37	1	EXOSC9	2	bioid	Yeh C (2015)	1
EED	1	PDS5B	3	affinity chromatography technology	Cao Q (2014)	1
USP37	1	WAPL	1	bioid, affinity chromatography technology, affinity chromatography technology	Yeh C (2015), Yeh C (2015), Yeh C (2015)	3
SNW1	0	SMC3	16	affinity chromatography technology	Lleres D (2010)	1
STAG1	7	SMC3	16	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Kueng S (2006), Kueng S (2006), Gandhi R (2006), Schmitz J (2007), Losada A (2005), Canudas S (2007), Losada A (2000), Losada A (2000), Wan C (2015), Hein MY (2015)	12
PTGER3	2	STAG1	7	affinity chromatography technology	Huttlin EL (2015)	1
CDCA5	0	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Elbatsh AM (2016)	4
SMC1B	1	SMC3	16	biochemical, affinity chromatography technology	Wan C (2015), Lee J (2003)	2
PDS5A	5	RAD21	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2005), Panigrahi AK (2011), Panigrahi AK (2011), Hein MY (2015), Huttlin EL (2017)	7
EED	1	SMC3	16	affinity chromatography technology	Cao Q (2014)	1
USP37	1	SMC1A	15	bioid	Yeh C (2015)	1
WAPL	1	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015)	5
HDAC11	0	STAG1	7	affinity chromatography technology	Joshi P (2013)	1