PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	UBE2N	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Joch M (2007), Olzmann JA (2007), Chaugule VK (2011), Sha D (2010), Lim GG (2013), Durcan TM (2011), McKeon JE (2014), Sha D (2010)	8
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
BAG3	4	HSF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014), Boldt K (2016)	6
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
HSPA1A	0	AR	3	affinity chromatography technology, affinity chromatography technology	Veldscholte J (1992), Ni L (2010)	2
LRRK2	5	MAPT	1	affinity chromatography technology, enzymatic study	Kawakami F (2012), Kawakami F (2012)	2
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
ATXN3	2	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016)	5
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
UBE2D2	0	STUB1	4	pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down	Demand J (2001), Soss SE (2011), Shimura H (2004), Esser C (2005), Kalia LV (2011), Xie P (2009), Grelle G (2006), Westhoff B (2005), Hatakeyama S (2004), Dolan PJ (2010), Tsukahara F (2010), Chen Z (2013), Dreiseidler M (2012), Zhang H (2015), Liu X (2017), Liu X (2017), Blessing NA (2017)	17
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
HSPA8	4	BAG2	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Takayama S (1999), Takayama S (1999), Takayama S (1999), Arndt V (2005), Arndt V (2005), Hegele A (2012), Hegele A (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	10
TP53	0	BAG1	1	genetic interference	Matsuzawa S (1998)	1
RAF1	3	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giommarelli C (2010), Zhu J (2005), Zhu J (2005), Zhu J (2005)	4
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
ESR1	0	TRAF6	0	affinity chromatography technology	Robinson LJ (2009)	1
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
PTEN	24	HSPA8	4	affinity chromatography technology, pull down	Maddika S (2011), Verrastro I (2015)	2
EGFR	5	PRKCZ	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ATXN1	2	HSPA8	4	affinity chromatography technology	Choi JY (2007)	1
ERN1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Qiu Q (2013), Qiu Q (2013)	2
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
EGFR	5	HSPA1B	1	imaging technique	Chen TC (2014)	1
CFTR	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meacham GC (1999), Younger JM (2004), Fuller W (2000), Rubenstein RC (2000), Matsumura Y (2011), Goldstein RF (2007), Goldstein RF (2007), Meacham GC (2001), Meacham GC (2001), Wang X (2006), Matsumura Y (2013), Zaman K (2006), Pankow S (2015)	13
UBE2V1	0	STUB1	4	pull down, pull down, pull down, biochemical, affinity chromatography technology, pull down	Zhang M (2005), Yang M (2011), Windheim M (2008), Havugimana PC (2012), Zhang M (2005), Zhang M (2005)	6
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
AR	3	RAF1	3	biochemical	Kupfer SR (1993)	1
ESR1	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tarallo R (2011), Cho J (2005), Cho J (2005)	3
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
CFTR	5	BAG2	0	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
HSP90AA1	7	CFTR	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fuller W (2000), Goldstein RF (2007), Goldstein RF (2007), Sun F (2008), Wang X (2006)	5
CFTR	5	BAG3	4	affinity chromatography technology	Pankow S (2015)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
HSP90AA1	7	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hogenesch JB (1997), Qian DZ (2006), Kong X (2006), Kubo T (2004), Zhou J (2004), Fu B (2007), Choi YK (2010), Choi YK (2010), Lee JM (2011), Liu YV (2007), Liu YV (2007), Katschinski DM (2004), Katschinski DM (2004), Katschinski DM (2004), Trisciuoglio D (2010), Trisciuoglio D (2010), Ueda K (2008), Sun H (2013), Kawanami D (2009), Prince TL (2015), Prince TL (2015), Isaacs JS (2004), Lee SH (2015)	23
HSPA1A	0	MAP3K5	1	pull down, affinity chromatography technology	Park HS (2002), Park HS (2002)	2
STUB1	4	SRC	2	pull down, affinity chromatography technology, imaging technique, enzymatic study	Yang M (2011), Yang M (2011), Yang M (2011), Yang M (2011)	4
LRRK2	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2008), Sen S (2009), Daechsel JC (2007), Rudenko IN (2017)	4
NR3C1	2	SRC	2	unspecified method	Suino-Powell K (2008)	1
ATCAY	6	STUB1	4	two hybrid, enzymatic study, pull down, unspecified method	Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006)	4
STUB1	4	NR3C1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Connell P (2001), Schuelke JP (2010), Mata-Greenwood E (2013), Connell P (2001)	4
STUB1	4	MYOCD	4	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, enzymatic study	Xie P (2009), Xie P (2009), Xie P (2009), Xie P (2009), Xie P (2009)	5
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
MAPT	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Petrucelli L (2004)	2
IRF1	0	HSP90AA1	7	affinity chromatography technology	Gao B (2013)	1
HIF1A	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kong X (2006), Qian DZ (2006), Kong X (2006), Zhou J (2004), Zhou J (2004), van de Sluis B (2009), Luo W (2010), Luo W (2010), Luo W (2010), Bento CF (2010), Katschinski DM (2004), Sun H (2013)	12
BAG3	4	STUB1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Hein MY (2015)	4
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
PTEN	24	EGFR	5	affinity chromatography technology	Zheng J (2016)	1
STUB1	4	NOS1	4	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Peng HM (2004), Peng HM (2004), Clapp KM (2010), Clapp KM (2012)	4
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
SMAD1	0	STUB1	4	affinity chromatography technology, x-ray crystallography, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang L (2011), Wang L (2011), Wang L (2011), Li L (2004), Li L (2004), Li L (2004), Li L (2004), Shimamoto S (2013), Shimamoto S (2013)	9
HSPA1A	0	BAG1	1	pull down	Shatkina L (2003)	1
ESR1	0	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fan M (2005), Tateishi Y (2004), Tateishi Y (2004), Tateishi Y (2004), Berry NB (2008), Dhamad AE (2016)	6
PRMT5	3	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, protein complementation assay	Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016)	5
ATXN3	2	HSPA8	4	affinity chromatography technology	Kristensen LV (2018)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
TP53	0	BAG2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014), Horikawa I (2014), Yue X (2016)	4
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
HIF1A	1	HSPA8	4	affinity chromatography technology	Ferreira JV (2013)	1
BAG1	1	AR	3	pull down, pull down, affinity chromatography technology	Shatkina L (2003), Knee DA (2001), Froesch BA (1998)	3
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
EGFR	5	HSPA1A	0	protein complementation assay, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013)	5
STUB1	4	CYP3A4	1	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Pabarcus MK (2009), Wang Y (2011), Wang Y (2015), Wang Y (2015)	4
STUB1	4	STUB1	4	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down	Xu Z (2008), Hampe C (2006), Tateishi Y (2004), Murata S (2001), Graf C (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Arndt V (2005), Plechanovova A (2012), Tatham MH (2013), Matsumura Y (2013), Spooner RA (2008), Heimdal K (2014), Zhang H (2015), Narayan V (2015), Kim HT (2007), Liu X (2017), Blessing NA (2017), Kopp Y (2017), Kopp Y (2017), Pakdaman Y (2017), Pakdaman Y (2017)	23
STUB1	4	UBE2W	0	pull down, pull down, enzymatic study, pull down	Soss SE (2011), Tatham MH (2013), Scaglione KM (2011), Blessing NA (2017)	4
MAP3K5	1	RAF1	3	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Chen J (2001), Chen J (2001), Ivanov AA (2017)	3
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
HSPA1A	0	BAG2	0	affinity chromatography technology	Schoenbuehler B (2016)	1
EGFR	5	BAG2	0	affinity chromatography technology	Foerster S (2013)	1
MYC	2	RAF1	3	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Alexandrov I (1997), Koch HB (2007), Ivanov AA (2017)	3
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
UBC	7	BAG2	0	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
HSP90AA1	7	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Woodford MR (2016)	2
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
ATXN3	2	HSP90AA1	7	affinity chromatography technology	Liu H (2016)	1
STUB1	4	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kutuzov MA (2007), Hwang JR (2005), Gao Y (2010), Gao Y (2010)	4
RAF1	3	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	PSMD4	1	protein complementation assay	Deribe YL (2009)	1
MYOCD	4	HSP90AA1	7	affinity chromatography technology	Xie P (2009)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
TRAF6	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Sun H (2013), Sun H (2013), Sun H (2013), Rezaeian AH (2017), Rezaeian AH (2017)	5
MYC	2	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IRF1	0	HSPA1A	0	affinity chromatography technology	Gao B (2013)	1
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
MYC	2	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paul I (2012), Paul I (2012), Paul I (2012), Huang H (2017)	4
ATXN3	2	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Scaglione KM (2011), Scaglione KM (2011), Scaglione KM (2011), Todi SV (2010), Todi SV (2010), Gao XC (2011), Todi SV (2009), Kristensen LV (2018), Kristensen LV (2018)	9
MYC	2	HSPA1A	0	affinity chromatography technology	Agrawal P (2010)	1
ESR1	0	PRKCZ	5	affinity chromatography technology	Yi P (2008)	1
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
RAF1	3	BAG1	1	pull down, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Wang HG (1996), Wang HG (1996), Wang HG (1996), Wang HG (1996), Song J (2001), Song J (2001)	6
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
ERBB2	6	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Citri A (2002), Jung Y (2007), Suzuki T (2011)	3
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
BAG3	4	BAG2	0	affinity chromatography technology	Chen Y (2013)	1
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
CFTR	5	TP53	0	affinity chromatography technology	Pankow S (2015)	1
HSPA8	4	BAG3	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Takayama S (1999), Takayama S (1999), Takayama S (1999), Gentilella A (2011), Hishiya A (2011), Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Hein MY (2015)	11
NR3C1	2	BAG1	1	pull down, pull down, affinity chromatography technology	Kullmann M (1998), Schneikert J (2000), Mata-Greenwood E (2013)	3
PTEN	24	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
UBE2W	0	MAPT	1	x-ray crystallography	Vittal V (2015)	1
TP53	0	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Akakura S (2001), Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994), Karras GI (2017)	7
ERN1	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu X (2014), Zhu X (2014), Zhu X (2014), Zhu X (2014)	4
TP53	0	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF6	0	MAPT	1	enzymatic study	Babu JR (2005)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
HSP90AA1	7	LRRK2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ding X (2009), Ding X (2009), Nichols RJ (2010), Zach S (2010), Daechsel JC (2007), Wang L (2008), Sen S (2009), Rudenko IN (2012), Gloeckner CJ (2006), Imai Y (2015)	10
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
MAP3K5	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Gao Y (2010), Gao Y (2010)	2
CFTR	5	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
HSP90AA1	7	PRMT5	3	affinity chromatography technology	Maloney A (2007)	1
ERBB2	6	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Xu W (2002), Jung Y (2007), Jung Y (2007), Zhou P (2003), Zhou P (2003), Li X (2007), Li X (2007), Xu W (2002), Bisaro B (2016)	9
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
TRAF6	0	PRKCZ	5	affinity chromatography technology	Sanz L (2000)	1
HSP90AA1	7	HSF1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Hu Y (2003), Nair SC (1996), Guo Y (2001), Bento CF (2010), Wang X (2006), Rao R (2012), Fu Q (2008), Prince TL (2015), Prince TL (2015)	9
HSF1	1	HSPA4	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Abravaya K (1992), Dai Q (2003), Dai Q (2003)	4
ATXN1	2	HSPA4	3	affinity chromatography technology	Choi JY (2007)	1
ESR1	0	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nair SC (1996), Tateishi Y (2004), Suzuki T (2011), Azuma K (2004), Azuma K (2004), Nalvarte I (2010), Dhamad AE (2016)	7
LRRK2	5	PRKCZ	5	enzymatic study	Zach S (2010)	1
ATXN3	2	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Kristensen LV (2018), Kristensen LV (2018)	2
TP53	0	ERN1	1	affinity chromatography technology	Namba T (2015)	1
PRKCZ	5	HSP90AA1	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Taipale M (2012), Taipale M (2012)	3
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
PRKCZ	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Seibenhener ML (1999), Seibenhener ML (1999)	2
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
ATXN1	2	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Al-Ramahi I (2006), Al-Ramahi I (2006), Choi JY (2007), Choi JY (2007)	4
UBE2D2	0	RAF1	3	enzymatic study	Demand J (2001)	1
CYP3A4	1	HSPA8	4	affinity chromatography technology	Wang Y (2015)	1
MAPT	1	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elliott E (2007), Shimura H (2004), Huttlin EL (2017)	3
CFTR	5	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goldstein RF (2007), Goldstein RF (2007), Sun F (2008), Schmidt BZ (2009), Rosser MF (2008), Pankow S (2015)	6
STUB1	4	UBE2D3	1	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Murata S (2001), Soss SE (2011), Page RC (2012), Parsons JL (2009), Stankiewicz M (2010), Gao XC (2011), Kundrat L (2010), Kundrat L (2010), Tsukahara F (2010), Todi SV (2010), Smith MC (2013), Ronnebaum SM (2013), Seki T (2013), Heimdal K (2014), Todi SV (2009), Yuan L (2015), Kim JH (2017), Blessing NA (2017), Pakdaman Y (2017)	19
HSF1	1	HSPA8	4	pull down, pull down, affinity chromatography technology	Nunes SL (1995), Kim SA (2005), Huttlin EL (2017)	3
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
PPARG	0	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kim JH (2017), Kim JH (2017), Kim JH (2017), Kim JH (2017)	4
HSPA1A	0	NR3C1	2	pull down	Kanelakis KC (2002)	1
SRC	2	ESR1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, imaging technique, imaging technique, imaging technique, pull down, imaging technique, imaging technique, affinity chromatography technology, two hybrid	Migliaccio A (2000), Teo AK (2001), Slentz-Kesler K (2000), Bourdoncle A (2005), Jaber BM (2004), Jaber BM (2004), Ku TK (2007), Cabodi S (2004), Monroe DG (2003), Hitosugi T (2007), Zwart W (2007), Zwart W (2007), Zwart W (2007), Yoshimaru T (2013), Yoshimaru T (2013), Zhang H (2006), Zhang H (2006), Zhang H (2006), Endler A (2012), Endler A (2012)	20
HIF1A	1	SRC	2	imaging technique, affinity chromatography technology	Gray MJ (2005), Ruas JL (2005)	2
NR3C1	2	RAF1	3	affinity chromatography technology	Widen C (2000)	1
RAF1	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu J (2005), Zhu J (2005), Zhu J (2005), da Rocha Dias S (2005)	4
ESR1	0	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Dhamad AE (2016), Dhamad AE (2016)	2
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
UBE2D2	0	MAPT	1	enzymatic study	Shimura H (2004)	1
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
SRC	2	AR	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Migliaccio A (2000), Unni E (2004), Powell SM (2004), Dotzlaw H (2003)	4
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
STUB1	4	HSF1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down	Kim SA (2005), Dai Q (2003), Shimamoto S (2013), Shimamoto S (2013), Kim SA (2005)	5
STUB1	4	BAG2	0	pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai Q (2005), Dai Q (2005), Arndt V (2005), Arndt V (2005), Arndt V (2005), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	9
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
PTEN	24	ESR1	0	pull down	Lin HK (2004)	1
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
HSPA1A	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994)	5
ESR1	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fan M (2005), Tateishi Y (2004), Ambrosino C (2010), Tarallo R (2011), Gebauer M (1998), Dhamad AE (2016), Dhamad AE (2016)	7
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
ESR1	0	BAG1	1	pull down, affinity chromatography technology, affinity chromatography technology	Zeiner M (1995), Tateishi Y (2004), Berry NB (2008)	3
RAF1	3	PRKCZ	5	affinity chromatography technology, affinity chromatography technology, pull down	Van Der Hoeven PC (2000), Van Der Hoeven PC (2000), Van Der Hoeven PC (2000)	3
PRKN	1	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Zanon A (2013)	4
TP53	0	PRMT5	3	affinity chromatography technology	Horikawa I (2014)	1
STUB1	4	CFTR	5	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Younger JM (2004), Summers DW (2009), Ren HY (2011), Meacham GC (2001), Schmidt BZ (2009), Alberti S (2004)	6
HSP90AA1	7	AR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Veldscholte J (1992), Nemoto T (1992), Zoubeidi A (2007), DaSilva J (2009), Chymkowitch P (2011), Gibbs A (2009), Wolf SS (2007), Luo J (2015), Kwegyir-Afful AK (2015), Ni L (2010), McClurg UL (2016)	11
PRKN	1	UBE2V1	0	pull down, pull down, pull down, affinity chromatography technology	Chaugule VK (2011), Durcan TM (2011), Sha D (2010), Sha D (2010)	4
ESR1	0	ERBB2	6	affinity chromatography technology	Yang Z (2004)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
MYC	2	HIF1A	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Koshiji M (2004), Koshiji M (2004), Ivanov AA (2017)	3
LRRK2	5	PRKN	1	affinity chromatography technology, affinity chromatography technology	Smith WW (2005), Smith WW (2005)	2
PRKN	1	ATXN3	2	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography	Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Bai JJ (2013)	7
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
BAG3	4	UBE2N	1	affinity chromatography technology	Chen Y (2013)	1
PTEN	24	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ahmed SF (2012), Ahmed SF (2012), Ahmed SF (2012), Yuan L (2015)	4
IRF1	0	STUB1	4	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study	Narayan V (2011), Narayan V (2011), Narayan V (2011), Narayan V (2011), Landre V (2013), Landre V (2013), Gao B (2013), Narayan V (2015), Landre V (2017)	9
UBE2D1	0	HIF1A	1	enzymatic study	Miller F (2005)	1
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
AR	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, unspecified method, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	DaSilva J (2009), Chymkowitch P (2011), Chymkowitch P (2011), Rees I (2006), He B (2004), He B (2004), Schuelke JP (2010), McClurg UL (2016), Wang J (2016), Wang J (2016), Wang J (2016)	11
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
MAPT	1	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Dickey CA (2008), Hatakeyama S (2004), Hatakeyama S (2004), Hatakeyama S (2004), Petrucelli L (2004), Dolan PJ (2010), Dolan PJ (2010), Shimura H (2004), Shimura H (2004), Shimura H (2004), Dickey CA (2007), Sakagami Y (2013), Ozdemir AY (2013), Grelle G (2006), Grelle G (2006)	15
EGFR	5	MAPT	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
BAG3	4	ATXN3	2	affinity chromatography technology	Chen Y (2013)	1
CFTR	5	HSPA1B	1	affinity chromatography technology	Pankow S (2015)	1
PRKN	1	HSPA8	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2003), Zanon A (2013)	4
ERN1	1	MAP3K5	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Nishitoh H (2002), Chen TC (2014), Zeng T (2015)	3
STUB1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Xu Z (2008), Xia T (2007), Jiang J (2001), Graf C (2010), Soss SE (2011), Pabarcus MK (2009), Wang Y (2011), Summers DW (2009), Clapp KM (2010), Wang L (2011), Ren HY (2011), Urushitani M (2004), Plechanovova A (2012), Al-Ramahi I (2006), Germano S (2006), Alberti S (2004), Peng HM (2004), Qian SB (2009), Yang M (2011), Lee H (2006), Windheim M (2008), Tsukahara F (2010), Zhou P (2003), Chymkowitch P (2011), Shimamoto S (2013), Spooner RA (2008), Zhang M (2005), Uchiki T (2009), Wang Y (2011), Wang Y (2015), Narayan V (2015), Clapp KM (2012), Kim HT (2007), McClurg UL (2016), Blessing NA (2017), Landre V (2017), Kopp Y (2017)	37
BAG1	1	BAG3	4	biochemical	Havugimana PC (2012)	1
HIF1A	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Luo W (2010), Luo W (2010), Luo W (2010), Luo W (2010)	4
RAF1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stancato LF (1993), Dogan T (2008), Mollapour M (2010), Du J (2006), Maloney A (2007), Fiskus W (2007), Giommarelli C (2010), Arlander SJ (2006), ONeill E (2004), Taipale M (2012), Zhu J (2005), Schneider C (1996), Mollapour M (2014), Atabakhsh E (2012), Mitra S (2016)	15
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
TP53	0	PSMD4	1	affinity chromatography technology, pull down	Kulikov R (2010), Sparks A (2014)	2
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
MAPT	1	HSPA1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012), Ozdemir AY (2013)	4
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
LRRK2	5	HIF1A	1	enzymatic study	Lin A (2016)	1
CFTR	5	BAG1	1	affinity chromatography technology	Mendes F (2012)	1
LRRK2	5	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ho DH (2015), Ho DH (2015), Ho DH (2015)	3
MAPT	1	BAG1	1	affinity chromatography technology, pull down, affinity chromatography technology	Elliott E (2007), Elliott E (2007), Elliott E (2007)	3
EGFR	5	NR3C1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
RAF1	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study	Dogan T (2008), Dogan T (2008), Alberti S (2004), Westhoff B (2005), Dreiseidler M (2012)	5
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
PPARG	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu Y (2016), Xu Y (2016), Xu Y (2016)	3
STUB1	4	HSPA1B	1	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Taipale M (2014), Taipale M (2014), Grelle G (2006), Grelle G (2006)	4
SRC	2	RAF1	3	affinity chromatography technology, pull down	Cleghon V (1994), Cleghon V (1994)	2
PSMD4	1	PRKN	1	pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Safadi SS (2010), Uchiki T (2009), Sakata E (2003), Safadi SS (2011), Um JW (2010), Um JW (2010), Kim HT (2012), Beasley SA (2012), Sarraf SA (2013), Sarraf SA (2013)	10
PTEN	24	UBE2D1	0	genetic interference	Vizeacoumar FJ (2013)	1
MYC	2	ERN1	1	genetic interference	Zhou Z (2014)	1
PPARG	0	UBC	7	enzymatic study	Hou Y (2012)	1
MYOCD	4	HSPA4	3	affinity chromatography technology	Xie P (2009)	1
HSP90AA1	7	BAG2	0	affinity chromatography technology	Gano JJ (2010)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
BAG1	1	STUB1	4	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Demand J (2001), Tateishi Y (2004), Tsukahara F (2010), Arndt V (2005), Taipale M (2014), Taipale M (2014), Narayan V (2015)	7
PTEN	24	HSP90AA1	7	affinity chromatography technology, genetic interference	Maddika S (2011), Shen JP (2017)	2
PSMD4	1	HSPA4	3	affinity chromatography technology	Andersen KM (2009)	1
PTEN	24	AR	3	pull down, affinity chromatography technology	Lin HK (2004), Lin HK (2004)	2
LRRK2	5	HSPA4	3	affinity chromatography technology	Sen S (2009)	1
BAG3	4	HSP90AA1	7	affinity chromatography technology	Chen Y (2013)	1
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
SRC	2	MAPT	1	enzymatic study	Bhaskar K (2005)	1
HSP90AA1	7	MAP3K5	1	affinity chromatography technology	Taipale M (2012)	1
MAPT	1	UBC	7	affinity chromatography technology	Mesco ER (1991)	1
BAG3	4	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2000), Antoku K (2001), Chen Y (2013), Hein MY (2015)	4
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TP53	0	HSPA1B	1	affinity chromatography technology, imaging technique	Horikawa I (2014), Chen TC (2014)	2
HSPA4	3	NR3C1	2	affinity chromatography technology	Moraes LA (2005)	1
LRRK2	5	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ko HS (2009), Ko HS (2009), Ding X (2009), Ding X (2009), Rudenko IN (2017), Rudenko IN (2017)	6
PTEN	24	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Freeman DJ (2003), Freeman DJ (2003), Zhou M (2003), Zhou M (2003), Hong SW (2013), Li Y (2008)	6
NOS1	4	HSPA4	3	affinity chromatography technology	Peng HM (2004)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
ERN1	1	HSP90AA1	7	affinity chromatography technology, pull down	Marcu MG (2002), Marcu MG (2002)	2
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
MAPT	1	HSPA4	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Petrucelli L (2004), Kawakami F (2011), Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012)	5
PTEN	24	HSPA1A	0	affinity chromatography technology	Maddika S (2011)	1
BAG2	0	HSPA4	3	pull down	Dai Q (2005)	1
HSF1	1	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Shi Y (1998), Shi Y (1998), Shi Y (1998), Zhou X (1998), Hu Y (2011)	5
BAG1	1	HSPA8	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, two hybrid, pull down, affinity chromatography technology	Takayama S (1997), Takayama S (1999), Takayama S (1999), Takayama S (1997), Takayama S (1997), Elliott E (2007), Alberti S (2002), Tsukahara F (2010), Brive L (2001), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Townsend PA (2004), Sharp A (2009), Sharp A (2009), Sondermann H (2001), Gebauer M (1998), Rolland T (2014), Mock JY (2015), Karras GI (2017)	20
NR3C1	2	HSP90AA1	7	imaging technique, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down	Jibard N (1999), Hulkko SM (2000), Kanelakis KC (2002), Hecht K (1997), de Castro M (1996), van den Berg JD (1996), Stancato LF (1996), Kovacs JJ (2005), Silverstein AM (1997), Gradin K (1994), Gano JJ (2010), Miyamoto-Sato E (2010), Mollapour M (2014), Moraes LA (2005), Wochnik GM (2004), Woodford MR (2016), Lievens S (2016), McGuire J (1994)	18
BAG1	1	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Takayama S (1997), Kalia SK (2004), Gamerdinger M (2009), Gamerdinger M (2009), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Takahashi N (2001), Deeg S (2010), Song J (2001), Song J (2001)	11
ATXN1	2	HSPA1A	0	two hybrid	Lim J (2006)	1
SMAD1	0	UBC	7	two hybrid	Guo X (2001)	1
PRKN	1	BAG2	0	affinity chromatography technology	Zanon A (2013)	1
CFTR	5	PSMD4	1	affinity chromatography technology	Pankow S (2015)	1
PSMD4	1	STUB1	4	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, biochemical	Connell P (2001), Scaglione KM (2011), Uchiki T (2009), Kim HT (2012), Connell P (2001), Wan C (2015)	6
STUB1	4	PRKCZ	5	pull down, affinity chromatography technology, imaging technique, enzymatic study	Yang M (2011), Yang M (2011), Yang M (2011), Yang M (2011)	4
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
CYP3A4	1	UBE2D1	0	affinity chromatography technology	Wang Y (2015)	1