PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ABL1	9	CDKN1A	1	enzymatic study	Hukkelhoven E (2012)	1
COPS5	0	GNL3	3	affinity chromatography technology	Bennett EJ (2010)	1
CCND3	1	CDK4	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Arsenijevic T (2004), Lin J (2001), Zhang Q (1999), Datta NS (1998), Garcia-Morales P (2006), Bockstaele L (2006), Ramachandran N (2004), Wang J (2011), Lodewick J (2013), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Hein MY (2015), Huttlin EL (2017)	15
IGF1R	5	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Ewing RM (2007), Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010), Pozuelo-Rubio M (2010)	5
CKS2	0	CCNA1	3	pull down	Radulovic M (2010)	1
SKP2	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006)	5
CDK2	0	HSPA8	4	affinity chromatography technology	Neganova I (2011)	1
MYC	2	XPO1	8	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Kirli K (2015)	2
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
SKP2	2	WEE1	2	affinity chromatography technology	Watanabe N (2004)	1
VHL	0	PIN1	0	affinity chromatography technology	Ewing RM (2007)	1
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
RBX1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Ohta T (2001), Saiga T (2009), Rodier G (2008), Zhou W (2014), Zhou W (2014)	6
HSP90AA1	7	WEE1	2	genetic interference	Shen JP (2017)	1
UCHL1	1	COPS5	0	two hybrid, affinity chromatography technology	Caballero OL (2002), Caballero OL (2002)	2
DDB1	6	COPS6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009)	5
VCP	6	YWHAE	0	affinity chromatography technology	Yu CC (2013)	1
CCNE1	1	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Shanahan F (1999), Connor MK (2003), Connor MK (2003), Jeon Y (2007), Bustany S (2011), Xu X (1999), Xu X (1999), Datta NS (1998), Orend G (1998), Liu J (1997), Sheaff RJ (1997), Sheaff RJ (1997), Bresnahan WA (1996), Vlach J (1996), Vlach J (1997), Ciarallo S (2002), Ciarallo S (2002), Ciarallo S (2002), Chu I (2007), Chu I (2007), Chen J (1996), Levkau B (1998), Larrea MD (2009), Grimmler M (2007), Chen TC (2014), Qiu H (2016)	26
CUL1	7	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Michel JJ (1998)	2
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
CDKN1A	1	MAPK8	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Selma Dagtas A (2010), Selma Dagtas A (2010), Kim GY (2002)	3
CCNE2	2	CDKN1B	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Lauper N (1998), Zariwala M (1998), Zariwala M (1998)	3
CCNA2	1	SKP1	0	affinity chromatography technology	Hein MY (2015)	1
CDK1	0	UBE2I	0	enzymatic study, affinity chromatography technology	Tomasi ML (2012), Tomasi ML (2012)	2
CDKN1B	1	YWHAE	0	affinity chromatography technology, pull down	Sekimoto T (2004), Sekimoto T (2004)	2
CCNB1	3	HIST1H1B	4	enzymatic study, enzymatic study	Vazquez-Novelle MD (2010), Poon RY (1996)	2
CDK1	0	HSP90AA1	7	affinity chromatography technology	Garcia-Morales P (2007)	1
TSC1	4	RPS6KA1	3	affinity chromatography technology	Roux PP (2004)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
TSC2	17	RPS6KA1	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Roux PP (2004), Rolfe M (2005), Roux PP (2004), Roux PP (2004)	4
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
CDK4	2	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Kehn K (2004), Kehn K (2004), Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017), Denicourt C (2008), Ivanov AA (2017)	8
CDKN1B	1	SIRT6	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zhao G (2016), Zhao G (2016), Zhao G (2016), Zhao G (2016)	4
MYC	2	CUL1	7	affinity chromatography technology	von der Lehr N (2003)	1
WEE1	2	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Wang Y (2000), Jin J (2004)	3
KAT2B	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Ji W (2014)	2
COPS5	0	CKS1B	0	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Youn CK (2005), Porter LA (2003), Law BK (2002), Connor MK (2003), Naderi S (2005), Varshochi R (2005), Hsu SP (2008), McAndrew CW (2007), Peiretti A (2003), Peiretti A (2003), Haddad MM (1999), Xu X (1999), Xu X (1999), Radu M (2008), Mori S (1999), Schulman BA (1998), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Sheaff RJ (1997), Vlach J (1996), Vlach J (1996), Vlach J (1997), Liu S (2009), Rosner M (2004), Ciarallo S (2002), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Chu I (2007), Chu I (2007), Levkau B (1998), Levkau B (1998), Lacy ER (2005), Zhao J (1998), Seo DW (2006), Kossatz U (2006), Grimmler M (2007), Grimmler M (2007), Varjosalo M (2013), Varjosalo M (2013), Montagnoli A (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Lovisa S (2016), Qiu H (2016), Carrasco-Garcia E (2011), Huttlin EL (2017), Hu B (2017)	52
MYC	2	PSMB1	1	affinity chromatography technology	Koch HB (2007)	1
DDB1	6	UCHL1	1	affinity chromatography technology, affinity chromatography technology	Hussain S (2013), Hussain S (2013)	2
YWHAQ	0	HSPA8	4	affinity chromatography technology	Jin J (2004)	1
SGK1	4	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
CCNA2	1	CDK7	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Larochelle S (2006), Garrett S (2001), Huttlin EL (2015), Huttlin EL (2017)	4
CDKN1A	1	HIST1H1B	4	enzymatic study	Poon RY (1996)	1
HIST1H1A	0	DDB1	6	affinity chromatography technology, affinity chromatography technology	Kim K (2013), Kim K (2013)	2
CDKN1A	1	CCNA1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, imaging technique	Zheleva DI (2002), Ramachandran N (2004), Rohaly G (2005), Heron-Milhavet L (2006), Chen TC (2014)	5
HSP90AA1	7	SGK1	4	affinity chromatography technology	Taipale M (2012)	1
UBE3A	4	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Mishra A (2009), Mishra A (2009)	2
CDKN1B	1	XPO1	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ishida N (2002), Connor MK (2003), Connor MK (2003), Connor MK (2003), Qiu H (2016)	5
RBX1	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Pick E (2007), Lan L (2012), Tsai WB (2010), Hrecka K (2007), Okuda H (2001), Tai T (2006), Ahn J (2011), Gong B (2010), Lu Y (2012), Ohta A (2013), da Silva Almeida AC (2013), Delucia M (2013), Scott DC (2014), Camp ND (2012), Kim S (2014), Theurillat JP (2014), Kigoshi Y (2011), Pashkova N (2010), Beck J (2013), Pierce WK (2015), Wu K (2016), Parameswaran B (2015), Simo S (2013), Groisman R (2006), Marzahn MR (2016), Courtheoux T (2016), Hasanov E (2017), Ferretti LP (2016), Zhou X (2017), Kroenke J (2014), Mulvaney KM (2016)	31
CDK7	0	CDK2	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Drapkin R (1996), Cheng A (2005), Xu X (1999), Higashi H (1996), Aprelikova O (1995), Moisan A (2004), Larochelle S (2012), Larochelle S (2006), Larochelle S (2006), Garrett S (2001), Garrett S (2001), Lolli G (2004), Varjosalo M (2013), So J (2015)	14
UBE3A	4	YWHAE	0	two hybrid	Vinayagam A (2011)	1
PIN1	0	CDK2	0	pull down	Yeh ES (2006)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
CDKN1A	1	CKS2	0	affinity chromatography technology	Fogeron ML (2013)	1
PIN1	0	CCNE1	1	pull down, affinity chromatography technology	Yeh ES (2006), Yeh ES (2006)	2
KPNA1	5	NUP50	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CCNE1	1	SKP2	2	pull down, enzymatic study	Yeh KH (2001), Enchev RI (2012)	2
CDK2	0	STMN1	0	affinity chromatography technology	Neganova I (2011)	1
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
KAT2B	2	HIST1H1A	0	enzymatic study	Sakaguchi K (1998)	1
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
HSP90AA1	7	CDK4	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsutsumi S (2012), Wang H (2002), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Woodford MR (2016), Huttlin EL (2017)	7
SGK1	4	YWHAZ	1	affinity chromatography technology	Chun J (2004)	1
PAX5	7	KAT2B	2	affinity chromatography technology	Perearnau A (2017)	1
LYN	2	CDK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kharbanda S (1994), Kharbanda S (1994), Kharbanda S (1994), Pathan NI (1996)	4
CDK2	0	YWHAZ	1	affinity chromatography technology	Neganova I (2011)	1
HSP90AA1	7	LYN	2	affinity chromatography technology	Taipale M (2012)	1
CDKN1A	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang B (2010), Wang B (2010), Wang B (2010)	3
CCNA1	3	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, imaging technique	Sweeney C (1996), Yang R (1997), Yang R (1997), Mueller-Tidow C (2001), Brown NR (1999), Niida H (2005), Yam CH (2000), Wang H (2009), Narayanan R (2005), Harwell RM (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Peiretti A (2003), Pan ZQ (1993), Kim KS (2002), Lyapina SA (1998), Desai D (1995), Thomas DM (2004), Johnson LN (2002), Rohaly G (2005), Chen TC (2014)	22
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
SKP2	2	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique	Amador V (2007), Hwang CY (2007), Calvisi DF (2009), Bendjennat M (2003), Wu L (2012), Wu L (2012), Abbas T (2008), Ungermannova D (2005), Chen TC (2014)	9
GRB2	2	VCP	6	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
VCP	6	CDKN1B	1	affinity chromatography technology	Yu CC (2013)	1
HSPA8	4	CCND1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Truman AW (2012)	3
CCND2	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017)	3
UCHL1	1	HSPA8	4	affinity chromatography technology, pull down	Kabuta T (2008), Kabuta T (2008)	2
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
CDK3	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	CDK2	0	affinity chromatography technology	Bennett EJ (2010)	1
SKP2	2	CCNB1	3	affinity chromatography technology	Bashir T (2010)	1
COPS6	0	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK4	2	MYC	2	enzymatic study, two hybrid, fluorescent resonance energy transfe	Anders L (2011), Wang J (2011), Ivanov AA (2017)	3
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
CDK3	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDKN1B	1	GNL3	3	affinity chromatography technology, pull down, affinity chromatography technology	Hu B (2017), Hu B (2017), Hu B (2017)	3
MYC	2	KPNA4	0	affinity chromatography technology	Koch HB (2007)	1
CCND1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006), Wei S (2008), Yu ZK (1998)	4
CCNB1	3	CKS2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Radulovic M (2010), Hein MY (2015), Huttlin EL (2017)	4
RFWD2	0	HSPA8	4	affinity chromatography technology	Yi C (2006)	1
AKT1	1	UCHL1	1	affinity chromatography technology, two hybrid	Klein JB (2005), Arroyo R (2015)	2
SPDYA	1	SKP2	2	affinity chromatography technology, affinity chromatography technology	Dinarina A (2009), Dinarina A (2009)	2
ELAVL1	0	KPNA4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CCNB1	3	CDKN1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amador V (2007), Garcia-Wilson E (2005), Ando T (2001), Poon RY (1996), Fogeron ML (2013), Chen TC (2014)	6
SKP2	2	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang W (2003), Sitry D (2002), Fujita N (2002), Ji P (2006), Zancai P (2005), Ji P (2004), Iovine B (2011), Calvisi DF (2009), Spruck C (2001), Bashir T (2010), Bashir T (2010), Li P (2004), Boutonnet C (2010), Rosner M (2004), Rosner M (2004), Carrano AC (1999), Carrano AC (1999), Carrano AC (1999), Wu J (2012), Strohmaier H (2001), Rodier G (2008), Rodier G (2008), Ooi LC (2013), Yumimoto K (2013), Ooi LC (2013), Cen B (2010), Enchev RI (2012), Yumimoto K (2012), Shi P (2011), Lovisa S (2016), Cen B (2009), Chan CH (2013), Ma X (2017)	33
CDKN1B	1	KPNA1	5	pull down, affinity chromatography technology, unspecified method	Sekimoto T (2004), Sekimoto T (2004), Sekimoto T (2004)	3
SKP1	0	PSMB1	1	affinity chromatography technology	Hauri S (2016)	1
YWHAZ	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), Yoshida K (2005), So J (2015)	5
MYC	2	TRIM21	0	affinity chromatography technology	Agrawal P (2010)	1
IRF1	0	HSP90AA1	7	affinity chromatography technology	Gao B (2013)	1
CKS2	0	CCNE1	1	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	YWHAZ	1	imaging technique, affinity chromatography technology, pull down, affinity chromatography technology	Su CH (2010), Su CH (2010), Su CH (2010), Su CH (2010)	4
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
PIN1	0	CDKN1B	1	pull down, affinity chromatography technology, unspecified method	Zhou W (2009), Zhou W (2009), Zhou W (2009)	3
CDK1	0	HIST1H1A	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Zhan Q (1999), Horton LE (1997), Pan ZQ (1993), Pan ZQ (1993), Yarden RI (2002), Golsteyn RM (1995), Jiang W (1998), Badea T (2002), Bae Y (2013), Linares JF (2011), Sasaki T (2008), Chen M (2012), Tang J (2008)	13
CDK3	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDK6	0	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Sugimoto M (1999), Lin J (2001), Sweeney KJ (1997), Ruas M (2007), Shu F (2007), Ramachandran N (2004), Ghiani C (2001)	7
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
KAT2B	2	CCND1	1	affinity chromatography technology	McMahon C (1999)	1
UBE2I	0	CDKN1B	1	enzymatic study	Lovisa S (2016)	1
KPNA4	0	NUP50	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
HSP90AA1	7	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAZ	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
CDK2	0	HIST1H1A	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Jeon Y (2007), Lunn CL (2010), Kiviharju-af Haellstroem TM (2007), Kim YB (2000), Xu X (1999), Mori S (1999), Lauper N (1998), Lauper N (1998), Orend G (1998), Wu G (1997), Horton LE (1997), Higashi H (1996), Musgrove EA (1996), Pan ZQ (1993), Pan ZQ (1993), Poon RY (1993), Sueoka N (1999), Baldassarre G (2000), Bendjennat M (2003), Liu S (2009), Sarmento LM (2005), Aprelikova O (1995), Giono LE (2007), Liu Y (2004), Dynlacht BD (1997), Mandal M (1998), Chang TS (2003), Colas P (1996), Jiang W (1998), Ezhevsky SA (1997), Thomas DM (2004), Song MS (2011), Naderi S (1999), Akagi M (1996), Lee B (2006), Grimmler M (2007), Zhang WN (2013), Iyer NG (2007), Morris L (2000), Chen M (2012), Guidoboni M (2005), Ghiani C (2001)	42
CCNE2	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gudas JM (1999), Lauper N (1998), Zariwala M (1998), Zariwala M (1998), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
CDKN1B	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Fujita N (2002), Rosner M (2007)	2
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
CDK1	0	CDK3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK8	3	YWHAZ	1	enzymatic study	Yoshida K (2005)	1
YWHAB	1	SKP2	2	affinity chromatography technology, affinity chromatography technology, pull down	Lin HK (2009), Lin HK (2009), Lin HK (2009)	3
COPS6	0	CKS1B	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CDKN1B	1	CCNA1	3	pull down, affinity chromatography technology	Ji P (2006), Thomas DM (2004)	2
CDK7	0	HIST1H1A	0	enzymatic study	Drapkin R (1996)	1
CDK1	0	TSC1	4	pull down	Astrinidis A (2003)	1
YWHAE	0	IGF1R	5	two hybrid, pull down	Craparo A (1997), Craparo A (1997)	2
CCND1	1	CDK5	0	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	CDK5	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lacy ER (2005), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013)	4
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
CDK3	0	CKS2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
CDKN1B	1	MAPK10	0	pull down	Chang TS (2003)	1
XPO1	8	ABL1	9	unspecified method, unspecified method	Xu D (2012), Hantschel O (2005)	2
CDKN1B	1	TRAF2	1	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
YWHAB	1	RFWD2	0	pull down, affinity chromatography technology	Su CH (2011), Su CH (2011)	2
CKS2	0	CDKN1B	1	affinity chromatography technology	Huttlin EL (2017)	1
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
CDK4	2	SKP1	0	two hybrid	Wang J (2011)	1
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
CDK4	2	HIST1H1A	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Kim YB (2000), Sueoka N (1999), Mandal M (1998), Iyer NG (2007)	4
MYC	2	PIN1	0	affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Yeh E (2004)	2
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
TXNIP	2	CDKN1B	1	affinity chromatography technology, affinity chromatography technology	Yamaguchi F (2008), Yamaguchi F (2008)	2
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
CDK2	0	TRIM21	0	affinity chromatography technology	Neganova I (2011)	1
CCNE2	2	HIST1H1A	0	enzymatic study, affinity chromatography technology	Lauper N (1998), Lauper N (1998)	2
CDKN1B	1	CDK6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Radu M (2008), Bockstaele L (2006), Chen TC (2014), Carrasco-Garcia E (2011), Huttlin EL (2017)	6
RPS6KA1	3	CDKN1B	1	enzymatic study, affinity chromatography technology	Larrea MD (2009), Larrea MD (2009)	2
YWHAZ	1	COPS5	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Bennett EJ (2010)	2
SKP2	2	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Lin HK (2009), Lin HK (2009), Lin HK (2009), Lin HK (2009), Lin HK (2009), Roe JS (2011), Gao D (2009), Gao D (2009), Chan CH (2013)	9
CDKN1B	1	IGF1R	5	genetic interference	Shen JP (2017)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
CDK5	0	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
CDK3	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDKN1B	1	CDK5	0	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lacy ER (2005), Kabuta T (2013), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	7
RBX1	2	CCND1	1	affinity chromatography technology	Maeda I (2001)	1
JAK2	1	HSPA8	4	affinity chromatography technology	Sarkar S (2001)	1
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
RFWD2	0	CDKN1B	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Choi HH (2015), Choi HH (2015), Choi HH (2015), Choi HH (2015), Choi HH (2015)	5
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
CDK4	2	LYN	2	affinity chromatography technology	Ewing RM (2007)	1
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
SKP2	2	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Bashir T (2010), Rosner M (2009), Rosner M (2004), Zhang H (1995), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
CUL4A	2	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
COPS5	0	CDKN1B	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Caballero OL (2002), Kouvaraki MA (2006), Kouvaraki MA (2006), Kouvaraki MA (2006), Hsieh YH (2007), Hwang CY (2004), Hwang CY (2004), Pan Y (2012), Wang Y (2008), Wang Y (2008), Yamaguchi F (2008), Wang Y (2014), Zhang H (2017), Zhang H (2017)	14
CDKN1B	1	RHOA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Larrea MD (2009), Larrea MD (2009), Wei Z (2013)	3
TRIM21	0	CDKN1B	1	affinity chromatography technology	Sabile A (2006)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
HSP90AA1	7	SKP2	2	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	IGF1R	5	affinity chromatography technology	Taipale M (2012)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
GRB2	2	YWHAZ	1	affinity chromatography technology	Bisson N (2011)	1
TRIM21	0	CUL1	7	affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006)	3
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
UBC	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
CDK2	0	ARHGDIA	3	affinity chromatography technology	Neganova I (2011)	1
YWHAB	1	TSC1	4	affinity chromatography technology, affinity chromatography technology	Nellist M (2002), Jin J (2004)	2
UBE2I	0	XPO1	8	biochemical	Havugimana PC (2012)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
LYN	2	JAK2	1	pull down	Chin H (1998)	1
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
TSC1	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Roux PP (2004), Dan HC (2002), Ivanov AA (2017)	3
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
RBX1	2	HSPA8	4	affinity chromatography technology	Dias DC (2002)	1
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
YWHAQ	0	WEE1	2	pull down	Meek SE (2004)	1
DCLRE1C	3	CDKN1B	1	pull down	Yan Y (2011)	1
TSC2	17	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dan HC (2002), Roux PP (2004), Dan HC (2002), Dan HC (2002)	4
UBC	7	UBAC1	2	pull down	Zhang X (2017)	1
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
SRC	2	JAK2	1	affinity chromatography technology	Liang K (2010)	1
TRIM21	0	UBE2I	0	two hybrid	Rolland T (2014)	1
TSC2	17	YWHAZ	1	two hybrid, pull down, affinity chromatography technology	Nellist M (2002), Nellist M (2002), Hernandez G (2011)	3
YWHAB	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
SKP2	2	SIRT6	2	pull down	Inuzuka H (2012)	1
CDK6	0	MYC	2	enzymatic study, fluorescent resonance energy transfe	Anders L (2011), Ivanov AA (2017)	2
CDKN1B	1	UBE3A	4	affinity chromatography technology, enzymatic study	Mishra A (2009), Mishra A (2009)	2
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CCNA2	1	affinity chromatography technology	Bennett EJ (2010)	1
CDKN1A	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	McKenzie PP (2003), McKenzie PP (2003), Jeon Y (2007), Derjuga A (2001), Datta NS (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bresnahan WA (1996), Bendjennat M (2003), Bao GC (2006), Chen J (1996), Chen J (1996), Chen J (1996), Levkau B (1998), Poon RY (1996), Zhao J (1998), Wang J (2011), Fogeron ML (2013), Chen TC (2014)	20
CDK1	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
JAK2	1	SKP2	2	affinity chromatography technology, affinity chromatography technology	Nie L (2011), Nie L (2011)	2
TRIM21	0	CDC34	3	pull down	Wada K (2006)	1
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
UBC	7	ABL1	9	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
UCHL1	1	CDK6	0	affinity chromatography technology	Kabuta T (2013)	1
CDKN1A	1	CKS1B	0	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2017)	2
CCNA2	1	CDK6	0	affinity chromatography technology	Datta NS (1998)	1
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
CUL4A	2	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
RBX1	2	CCND2	2	affinity chromatography technology	Maeda I (2001)	1
SGK1	4	PIN1	0	affinity chromatography technology, affinity chromatography technology, pull down	Jo A (2015), Jo A (2015), Jo A (2015)	3
UBE2D2	0	CCNB1	3	enzymatic study	Tang Z (2001)	1
RFWD2	0	SKP1	0	affinity chromatography technology	Olma MH (2009)	1
AKT1	1	CDKN1A	1	pull down, enzymatic study, imaging technique, enzymatic study	Heron-Milhavet L (2006), Heron-Milhavet L (2006), Chen TC (2014), Roessig L (2001)	4
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
YWHAB	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
COPS5	0	CDK2	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Chun Y (2013)	2
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
TXNIP	2	HSPA8	4	bioid	Forred BJ (2016)	1
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
UCHL1	1	CDK5	0	affinity chromatography technology	Kabuta T (2013)	1
RPS6KA1	3	VCP	6	two hybrid	Vinayagam A (2011)	1
CCND1	1	XPO1	8	pull down	Connor MK (2003)	1
GRB2	2	YWHAB	1	affinity chromatography technology	Bisson N (2011)	1
CCNB1	3	CDK7	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Garrett S (2001), Huttlin EL (2015), Huttlin EL (2017)	3
CDKN1B	1	UCHL1	1	affinity chromatography technology	Caballero OL (2002)	1
CDK5	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2017)	3
SIRT6	2	DDB1	6	affinity chromatography technology	Simeoni F (2013)	1
VCP	6	CDK1	0	affinity chromatography technology	Yu CC (2013)	1
UBE3A	4	YWHAZ	1	two hybrid	Vinayagam A (2011)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
XPO1	8	WEE1	2	affinity chromatography technology	Kirli K (2015)	1
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
CKS1B	0	HSP90AA1	7	pull down	Radulovic M (2010)	1
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
CDK6	0	RCHY1	0	affinity chromatography technology	Huttlin EL (2015)	1
COPS6	0	CDKN1B	1	affinity chromatography technology	Choi HH (2015)	1
CDK1	0	CKS1B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Havugimana PC (2012), Hixon ML (1998), Varjosalo M (2013), Radulovic M (2010), Rolland T (2014), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	11
CUL1	7	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
CCNA2	1	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK3	0	CKS1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
CCND1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006)	2
CDKN1B	1	HIST1H1B	4	enzymatic study	McAndrew CW (2007)	1
CDKN1B	1	IRF1	0	two hybrid	Wang J (2011)	1
DDB1	6	ABL1	9	affinity chromatography technology	Cong F (2002)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
ELAVL1	0	TXNIP	2	affinity chromatography technology	Abdelmohsen K (2009)	1
VHL	0	HSP90AA1	7	affinity chromatography technology, genetic interference	Yang C (2013), Shen JP (2017)	2
ELAVL1	0	CDKN1B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAB	1	RPS6KA1	3	pull down, affinity chromatography technology	Cavet ME (2003), Cavet ME (2003)	2
SGK1	4	CDKN1B	1	enzymatic study	Hong F (2008)	1
SKP2	2	CDC34	3	pull down, enzymatic study, pull down	Cen B (2010), Umanskaya K (2007), Ji P (2006)	3
HIST1H1A	0	RBX1	2	affinity chromatography technology	Kim K (2013)	1
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
VCP	6	CDK4	2	affinity chromatography technology	Yu CC (2013)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
RFWD2	0	CUL1	7	affinity chromatography technology	Olma MH (2009)	1
COPS5	0	VHL	0	affinity chromatography technology	Bemis L (2004)	1
YWHAB	1	IGF1R	5	pull down	Furlanetto RW (1997)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
ELAVL1	0	LYN	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	HIST1H1B	4	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	McAndrew CW (2007), Hale TK (2006), Deep G (2006), Cheng A (2005), Alexandrow MG (2005), Nishimura T (2005), Du J (2004), Matsumoto Y (2004), Kehn K (2004), Harwell RM (2004), Shen WH (2004), Contreras A (2003), Porter LA (2002), Esashi F (2005), Dehde S (2001)	15
PAX5	7	CDKN1B	1	affinity chromatography technology	Perearnau A (2017)	1
MAPK8	3	HSPA8	4	two hybrid	Vinayagam A (2011)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
MYC	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ELAVL1	0	CDK6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDKN1B	1	TSC2	17	affinity chromatography technology, affinity chromatography technology	Rosner M (2004), Rosner M (2007)	2
CUL1	7	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	UBE2D2	0	pull down	Xin H (2011)	1
PIN1	0	TRAF2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CDK1	0	CKS2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Varjosalo M (2013), Radulovic M (2010), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
CDK2	0	YWHAQ	0	affinity chromatography technology	Neganova I (2011)	1
SRC	2	CCNA1	3	two hybrid	Narayanan R (2005)	1
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
CCND1	1	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
SKP2	2	KPNA6	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Gao D (2009), Inuzuka H (2012), Inuzuka H (2012)	3
CDKN1B	1	LYN	2	affinity chromatography technology, enzymatic study	Grimmler M (2007), Grimmler M (2007)	2
CDKN1B	1	UBAC1	2	pull down	Kamura T (2004)	1
DDB1	6	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
CKS1B	0	CCNE2	2	affinity chromatography technology	Huttlin EL (2017)	1
ABL1	9	CCND2	2	pull down	Welch PJ (1995)	1
HSP90AA1	7	CDKN1B	1	genetic interference	Srivas R (2016)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
UBE2B	3	CDKN1B	1	enzymatic study	Ryu KS (2008)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CKS1B	0	CKS2	0	affinity chromatography technology	Huttlin EL (2017)	1
CCNB1	3	HIST1H1A	0	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Zhan Q (1999), Sharma SS (2011), Pan ZQ (1993), Yarden RI (2002), Jiang W (1998)	5
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
ELAVL1	0	YWHAB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
AKT1	1	CDKN1B	1	enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology	Fujita N (2002), Fujita N (2002), Nacusi LP (2006), Chen TC (2014), Zhang H (2017), Zhang H (2017)	6
YWHAE	0	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
YWHAQ	0	ABL1	9	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu C (2012), Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	5
MYC	2	WEE1	2	genetic interference	Toyoshima M (2012)	1
CCND3	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Bockstaele L (2006), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5
CDKN1B	1	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Guidoboni M (2005), Vlach J (1996), Vlach J (1997), Tsai CH (2009), Ciarallo S (2002), Bindra RS (2002), Kossatz U (2006), Grimmler M (2007), Rolland T (2014), Hein MY (2015), Barbash O (2009), Huttlin EL (2017)	13
HSP90AA1	7	CDK6	0	affinity chromatography technology	Taipale M (2012)	1
VCP	6	STMN1	0	affinity chromatography technology	Yu CC (2013)	1
CCNA2	1	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Amador V (2007), Wu G (1997), Lin ML (2011), Chen J (1996), Levkau B (1998), Poon RY (1996), Fogeron ML (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
YWHAB	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
CDK6	0	HIST1H1A	0	enzymatic study, enzymatic study	Jiang W (1998), Iyer NG (2007)	2
HSP90AA1	7	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Varjosalo M (2013)	2
UBC	7	CCNE1	1	affinity chromatography technology	Huang G (2014)	1
VHL	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kohroki J (2005), Kamura T (2002), Kuznetsova AV (2003), Norman JA (2006), Knauth K (2006), Kamura T (2004), Heir P (2013), Essers PB (2014), Lee SB (2016)	10
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
CKS1B	0	CCNE1	1	affinity chromatography technology	Huttlin EL (2017)	1
JAK2	1	CDKN1B	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Jaekel H (2011), Jaekel H (2011), Jaekel H (2011)	3
MYC	2	CUL4A	2	affinity chromatography technology	Choi SH (2010)	1
CDK2	0	UBE2I	0	affinity chromatography technology	Neganova I (2011)	1
CCNA2	1	CDKN1B	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Schulman BA (1998), Datta NS (1998), Vlach J (1997), Levkau B (1998), Grimmler M (2007), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CKS2	0	HSP90AA1	7	pull down	Radulovic M (2010)	1
CDKN1B	1	KPNA4	0	pull down	Sekimoto T (2004)	1
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
SKP2	2	CKS1B	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang W (2003), Wang W (2003), Sitry D (2002), Sitry D (2002), Ganoth D (2001), Calvisi DF (2008), Xu S (2007), Ungermannova D (2005), Spruck C (2001), Yao ZP (2006), Seeliger MA (2005), Huang KS (2005), Rodier G (2008), Ungermannova D (2013), Radulovic M (2010), Huttlin EL (2017)	16
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KPNA1	5	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Bennett EJ (2010), Taipale M (2012)	3
MYC	2	YWHAQ	0	affinity chromatography technology	Koch HB (2007)	1
CKS1B	0	SKP1	0	pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology	Yao ZP (2006), Seeliger MA (2005), Radulovic M (2010), Ungermannova D (2013), Hauri S (2016)	5
CUL1	7	GNL3	3	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
VCP	6	YWHAQ	0	affinity chromatography technology	Yu CC (2013)	1
TSC1	4	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNB1	3	CDKN1B	1	affinity chromatography technology	Hein MY (2015)	1
CDKN1A	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abbas T (2008), Abbas T (2008), Gao J (2015)	3
CDK2	0	YWHAE	0	affinity chromatography technology	Neganova I (2011)	1
CUL1	7	CKS1B	0	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Radulovic M (2010), Huttlin EL (2017)	3
CUL1	7	CDKN1A	1	affinity chromatography technology	Yu ZK (1998)	1
YWHAE	0	TSC2	17	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
CDK2	0	SPDYA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Porter LA (2003), McAndrew CW (2007), Gastwirt RF (2006), Dinarina A (2009), Porter LA (2002), Porter LA (2002), Barnes EA (2003)	7
CDK5	0	CCNB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	5
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
UBC	7	CDK7	0	imaging technique	Zhang X (2017)	1
ELAVL1	0	SKP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
CCNA1	3	HIST1H1B	4	enzymatic study, enzymatic study	Cheng A (2005), Dehde S (2001)	2
UBE3A	4	COPS6	0	affinity chromatography technology, affinity chromatography technology	Gao S (2015), Gao S (2015)	2
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
CUL1	7	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
CCNE1	1	HIST1H1B	4	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nishimura T (2005), Matsumoto Y (2004), Delk NA (2009), Poon RY (1996)	4
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
JAK2	1	HSP90AA1	7	affinity chromatography technology	Cheng MB (2010)	1
CDKN1B	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miranda-Carboni GA (2008), Bondar T (2006), Li B (2006), Li B (2006), Gao J (2015)	5
VHL	0	CDC34	3	pull down	Masson N (2001)	1
KAT2B	2	MYC	2	enzymatic study	Patel JH (2004)	1
MYC	2	YWHAB	1	affinity chromatography technology	Koch HB (2007)	1
VHL	0	HSPA8	4	affinity chromatography technology, pull down	Lai Y (2011), Lai Y (2012)	2
CDK5	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
CCNE2	2	CDKN1A	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lauper N (1998), Zariwala M (1998), Ramachandran N (2004), Fogeron ML (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
DCLRE1C	3	DDB1	6	pull down, affinity chromatography technology	Yan Y (2011), Yan Y (2011)	2
ELAVL1	0	RFWD2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDKN1A	1	CDKN1B	1	genetic interference, imaging technique	Hsu SP (2008), Chen TC (2014)	2
PSMB1	1	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Yuan F (2013), Yuan F (2013), Yuan F (2013), Yuan F (2013), Yuan F (2013)	5
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
COPS6	0	CCNA1	3	affinity chromatography technology	Bennett EJ (2010)	1
CDK4	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	HIST1H1A	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Xu X (1999), Lauper N (1998), Lauper N (1998), Sharma SS (2011), Orend G (1998), Wu G (1997), Horton LE (1997), Higashi H (1996), Ciarallo S (2002), Jiang W (1998), Naderi S (1999), Ghiani C (2001)	12
CDK6	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
XPO1	8	CCNB1	3	affinity chromatography technology	Kirli K (2015)	1
CCNA1	3	SKP2	2	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji P (2006), Ji P (2006), Ji P (2006), Yam CH (2000), Gao D (2009), Ji P (2007)	6
CCND1	1	CDKN1A	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin J (1996), Guidoboni M (2005), Garcia-Wilson E (2005), Santiago FS (2007), Santiago FS (2007), Zheleva DI (2002), Ruas M (2007), Chen J (1996), Chen J (1996), Poon RY (1996), Ramachandran N (2004), Wang J (2011), Fogeron ML (2013), Rolland T (2014), Yu H (2011), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Welcker M (1998)	21
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
COPS5	0	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
KAT2B	2	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
SKP2	2	KPNA1	5	affinity chromatography technology, affinity chromatography technology, unspecified method	Gao D (2009), Inuzuka H (2012), Inuzuka H (2012)	3
CAMK1	4	CDK4	2	enzymatic study	Mallampalli RK (2013)	1
TSC2	17	YWHAB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Y (2003), Shumway SD (2003), Li Y (2002), Nellist M (2002), Shumway SD (2003), Li Y (2002), Cai SL (2006), Nellist M (2002), Jin J (2004), Couzens AL (2013), Li Y (2003)	11
CDKN1B	1	VHL	0	genetic interference	Shen JP (2017)	1
UBC	7	RNF123	11	pull down	Zhang X (2017)	1
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
SIRT6	2	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Thirumurthi U (2014), Thirumurthi U (2014), Thirumurthi U (2014)	3
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
CDK7	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RFWD2	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Choi HH (2011), Choi HH (2011)	4
YWHAE	0	RCHY1	0	affinity chromatography technology	Choudhary C (2009)	1
MAPK8	3	HSP90AA1	7	affinity chromatography technology	Nieto-Miguel T (2008)	1
CCNA2	1	HIST1H1A	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sharma SS (2011), Wu G (1997), Horton LE (1997), Higashi H (1996), Liu S (2009), Ciarallo S (2002), Jiang W (1998)	7
ABL1	9	CDKN1B	1	enzymatic study	Grimmler M (2007)	1
CKS2	0	GRB2	2	two hybrid	Wang J (2011)	1
CDK1	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amador V (2007), Ando T (2001), Lin ML (2011), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
RCHY1	0	UBC	7	enzymatic study	Wu G (2010)	1
CDK1	0	ABL1	9	enzymatic study	Kipreos ET (1990)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
CDKN1A	1	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Dai M (2012), Dai M (2012)	2
CCNA2	1	CKS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Mateo F (2009), Huttlin EL (2015), Huttlin EL (2017)	4
SKP1	0	CDKN1A	1	imaging technique	Chen TC (2014)	1
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
RFWD2	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Higa LA (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Lu G (2014)	7
CCNA1	3	CDK1	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sweeney C (1996), Lukas J (1992), Desai D (1995), Rohaly G (2005)	4
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
AKT1	1	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016)	5
CDK7	0	CDKN1B	1	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1B	1	DDB1	6	affinity chromatography technology	Iovine B (2011)	1
UBC	7	SGK1	4	pull down	Nathan JA (2013)	1
CDKN1A	1	COPS6	0	two hybrid	Vinayagam A (2011)	1
CCNB1	3	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	3
CCND1	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Higashi H (1996), Higashi H (1996), Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	6
CCND3	1	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
SPDYA	1	CDKN1B	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Porter LA (2003), Porter LA (2003), Porter LA (2003), McAndrew CW (2007)	4
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
COPS6	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
UBAC1	2	RNF123	11	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Hara T (2005), Hara T (2005), Hara T (2005), Kotoshiba S (2005), Kotoshiba S (2005), Kamura T (2004), Huttlin EL (2017)	8
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CCND2	2	CDKN1B	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
UBC	7	UCHL1	1	two hybrid, enzymatic study, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, pull down, pull down	Stelzl U (2005), Bremm A (2010), Boudreaux D (2012), Boudreaux DA (2010), Boudreaux DA (2010), Phillips AH (2013), Larsen CN (1998), Duerksen-Hughes PJ (1989), Flierman D (2016), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	13
VHL	0	CDK2	0	affinity chromatography technology	Ewing RM (2007)	1
MYC	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Koch HB (2007), von der Lehr N (2003), Wang J (2011)	3
RNF123	11	CDKN1B	1	affinity chromatography technology, pull down	Kotoshiba S (2005), Kamura T (2004)	2
CCNE1	1	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
VCP	6	CCNB1	3	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
CDK3	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	4
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
CCND2	2	HIST1H1A	0	enzymatic study, enzymatic study	Sweeney KJ (1997), Jiang W (1998)	2
CDK2	0	CKS1B	0	x-ray crystallography, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bourne Y (1996), Xu S (2007), Yao ZP (2006), Seeliger MA (2005), Varjosalo M (2013), Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
CDK5	0	CCND3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDKN1B	1	MYC	2	affinity chromatography technology, protein complementation assay	Bahram F (2016), Bahram F (2016)	2
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
HIST1H1A	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Kim K (2013), Kim K (2013)	2
SKP2	2	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down	Roe JS (2011), Roe JS (2011), Roe JS (2011)	3
NUP50	0	KPNA6	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
CDK3	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
HSPA8	4	VCP	6	affinity chromatography technology, biochemical, affinity chromatography technology	Vij N (2006), Havugimana PC (2012), Yu CC (2013)	3
ELAVL1	0	CCND1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Jin J (2006), He YJ (2006), Olma MH (2009), Lu G (2014), Lu G (2014)	6
CUL1	7	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
CCNA1	3	HIST1H1A	0	enzymatic study, enzymatic study, enzymatic study	Sweeney C (1996), Pan ZQ (1993), Bastians H (1998)	3
YWHAZ	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
AKT1	1	YWHAE	0	affinity chromatography technology	Klein JB (2005)	1
UBC	7	PSMB1	1	affinity chromatography technology	Matsumoto M (2005)	1
MAPK8	3	MYC	2	enzymatic study, pull down, affinity chromatography technology	Noguchi K (1999), Noguchi K (1999), Noguchi K (1999)	3
RFWD2	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CKS1B	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jackman M (2002), Wolthuis R (2008), Mateo F (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
GRB2	2	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
TSC1	4	VHL	0	genetic interference	Shen JP (2017)	1
CDC34	3	CDKN1B	1	enzymatic study, unspecified method	Ryu KS (2008), Duda DM (2012)	2
CDKN1B	1	HIST1H1A	0	enzymatic study	Ciarallo S (2002)	1
PIN1	0	WEE1	2	affinity chromatography technology, far western blotting	Shen M (1998), Shen M (1998)	2
MYC	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RBX1	2	CDC34	3	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wu K (2002), Block K (2005), Block K (2005), Chen A (2000), Cen B (2010), Cen B (2009), DAngiolella V (2010), Spruck C (2001), Shaik S (2012), Kruiswijk F (2012), Tan M (2010), Bashir T (2010), Higa LA (2003), Kanayama A (2004), Lan L (2012), Welcker M (2011), Banks D (2006), Kumar KG (2003), Higa LA (2006), Saha A (2008), Jin J (2005), Cen B (2009), Tedesco D (2002), Choi YS (2010), Duan S (2011), Li X (2003), Wang W (2003), Gallegos JR (2008), Peschiaroli A (2009), Banerjee S (2010), Duan S (2011), Wang F (2011), Chen H (2013), Rodier G (2008), Rossi M (2013), Ungermannova D (2013), Ooi LC (2013), Ziemba A (2013), Huang H (2014), Herrero-Ruiz J (2014), Kim J (2014), Min SH (2012), Watanabe M (2011), Gao D (2010), Zhou W (2014), Canettieri G (2010), Morimoto M (2003), Chen A (2002), Pashkova N (2010), Read MA (2000), Bassermann F (2005), Duda DM (2008), Enchev RI (2012), Fukushima H (2013), Tintignac LA (2005), Ungermannova D (2005), Low TY (2014), Walter D (2016), Gao J (2015), Orthwein A (2015), Wu K (2016), Wu K (2016), Nateri AS (2004), Pierce NW (2009), Kim JH (2015), Shimizu K (2017), Gschweitl M (2016), Ibarra R (2016), Kuang P (2016), Kuang P (2016), Kuang P (2016), Ferretti LP (2016), Kuchay S (2017), Gazdoiu S (2007), Dai X (2017)	75
CUL1	7	AKT1	1	affinity chromatography technology	Reitsma JM (2017)	1
CDK1	0	WEE1	2	enzymatic study	Watanabe N (2004)	1
UBE2I	0	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
RBX1	2	CCND3	1	affinity chromatography technology	Maeda I (2001)	1
UBE3A	4	TSC2	17	pull down, affinity chromatography technology, pull down	Lu Z (2004), Zheng L (2008), Zheng L (2008)	3
CUL1	7	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
SIRT6	2	HSPA8	4	affinity chromatography technology	Simeoni F (2013)	1
CDKN1B	1	SKP1	0	unspecified method, unspecified method	Carrano AC (1999), Ooi LC (2013)	2
VHL	0	PSMB1	1	affinity chromatography technology	Ewing RM (2007)	1
COPS5	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Wang J (2006), Wang J (2006)	2
IRF1	0	KAT2B	2	pull down, pull down, affinity chromatography technology	Masumi A (1999), Masumi A (1999), Gao B (2013)	3
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
CDK1	0	HIST1H1B	4	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Deep G (2006), Olsen BB (2008), Porter LA (2002), Kabuta T (2013), Ling YH (1998), Thompson LJ (1996), Vincent I (2001)	7
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
YWHAZ	1	TRIM21	0	affinity chromatography technology	Jin J (2004)	1
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
VCP	6	YWHAB	1	affinity chromatography technology	Yu CC (2013)	1
MYC	2	YWHAE	0	affinity chromatography technology	Koch HB (2007)	1
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
TSC1	4	YWHAZ	1	two hybrid	Nellist M (2002)	1
CDK1	0	CDK7	0	enzymatic study	Garrett S (2001)	1
CDKN1B	1	CDK4	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Cariou S (2000), Guidoboni M (2005), Bustany S (2011), Hsu SP (2008), Radu M (2008), Mori S (1999), Kokontis JM (1998), Orend G (1998), Vlach J (1996), Vlach J (1997), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Mandal M (1998), Larrea MD (2009), Seo DW (2006), Kossatz U (2006), Kossatz U (2006), Mallampalli RK (2013), Varjosalo M (2013), Huttlin EL (2015), Chen TC (2014), Carrasco-Garcia E (2011), Huttlin EL (2017)	25
UCHL1	1	UBE2I	0	two hybrid	Caballero OL (2002)	1
CDKN1B	1	NUP50	0	two hybrid, pull down	Smitherman M (2000), Smitherman M (2000)	2
CCND1	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Zhang H (1993), Hein MY (2015), Huttlin EL (2017)	4
COPS6	0	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
UCHL1	1	HSP90AA1	7	affinity chromatography technology, pull down	Kabuta T (2008), Kabuta T (2008)	2
CDK7	0	CDK6	0	enzymatic study	Aprelikova O (1995)	1
CCND2	2	TSC2	17	affinity chromatography technology	Zacharek SJ (2005)	1
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
CKS1B	0	CCNA1	3	pull down	Radulovic M (2010)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
YWHAE	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
CDK7	0	CCND2	2	enzymatic study	Denicourt C (2008)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
SGK1	4	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chun J (2004), Chun J (2004)	2
CDK2	0	UCHL1	1	affinity chromatography technology	Neganova I (2011)	1
RFWD2	0	UBE2D2	0	pull down, pull down, pull down	Dornan D (2006), Dornan D (2004), Choi HH (2011)	3
YWHAE	0	TSC1	4	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
KAT2B	2	CDKN1B	1	pull down, affinity chromatography technology, pull down, enzymatic study	Perez-Luna M (2012), Perez-Luna M (2012), Perez-Luna M (2012), Perez-Luna M (2012)	4
CDK2	0	LYN	2	affinity chromatography technology	Mou S (1999)	1
ARHGDIA	3	CDKN1B	1	two hybrid	Stelzl U (2005)	1
MYC	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Hwang IY (2012), Hwang IY (2012)	2
CCNA2	1	HIST1H1B	4	enzymatic study, enzymatic study	Esashi F (2005), Poon RY (1996)	2
CDKN1B	1	MAPK8	3	pull down, affinity chromatography technology, affinity chromatography technology	Chang TS (2003), Chang TS (2003), Chang TS (2003)	3
CCND3	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
STMN1	0	CDKN1B	1	affinity chromatography technology	Baldassarre G (2005)	1
HSPA8	4	ABL1	9	pull down, affinity chromatography technology	Tsukahara F (2010), Tsukahara F (2010)	2
GRB2	2	TSC2	17	two hybrid	Wang J (2008)	1
CCND3	1	CDKN1A	1	two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Rual JF (2005), Datta NS (1998), Chen J (1996), Ramachandran N (2004), Wang J (2011), Fogeron ML (2013), Lodewick J (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	12
KAT2B	2	UBE2D2	0	pull down	Morgan JE (2017)	1
CCND2	2	CDKN1A	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Kehn K (2004), Bao GC (2006), Chen J (1996), Fogeron ML (2013), Rolland T (2014), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Welcker M (1998)	10
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
CCNE1	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
VHL	0	JAK2	1	affinity chromatography technology, affinity chromatography technology	Russell RC (2011), Russell RC (2011)	2
CDKN1B	1	PRB2	2	affinity chromatography technology	Howard CM (2000)	1
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
CDK3	0	SKP1	0	affinity chromatography technology	Varjosalo M (2013)	1
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
CKS2	0	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
PIN1	0	DDB1	6	pull down	Ingham RJ (2005)	1
CDKN1A	1	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abbas T (2008), Abbas T (2008), Nishitani H (2008), Fogeron ML (2013)	4
CDKN1A	1	CDK6	0	affinity chromatography technology, pull down, affinity chromatography technology	Selma Dagtas A (2010), Ramachandran N (2004), Huttlin EL (2017)	3
CDK4	2	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugimoto M (1999), Sugimoto M (1999), Serrano M (1993), Lin J (2001), Taules M (1998), Cariou S (2000), Coleman KG (1997), Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Diehl JA (1997), Okabe H (2007), Bustany S (2011), Gladden AB (2003), Sweeney KJ (1997), Musgrove EA (1996), Vlach J (1996), Garcia-Morales P (2006), Bindra RS (2002), Ruas M (2007), Poon RY (1996), Ramachandran N (2004), Larrea MD (2009), Waaijers S (2013), Mallampalli RK (2013), Rolland T (2014), Chen TC (2014), Barbash O (2009), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Ghiani C (2001), Ito H (2016), Huttlin EL (2017), Roessig L (2001), Qie S (2017)	35
COPS6	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
TXNIP	2	COPS5	0	affinity chromatography technology	Yamaguchi F (2008)	1
KAT2B	2	CCNA2	1	affinity chromatography technology, pull down, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3
HSPA8	4	CDK4	2	affinity chromatography technology, affinity chromatography technology	Jose-Eneriz ES (2008), Jose-Eneriz ES (2008)	2
UBE2D2	0	CDKN1B	1	enzymatic study	Ryu KS (2008)	1
CDK5	0	HIST1H1B	4	enzymatic study	Vincent I (2001)	1
TRIM21	0	SKP1	0	affinity chromatography technology, biochemical	Sabile A (2006), Sabile A (2006)	2
CDK6	0	CCND3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Lin J (2001), Meyerson M (1994), Datta NS (1998), Bockstaele L (2006), Shu F (2007), Ramachandran N (2004), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	11
CDK4	2	VHL	0	genetic interference	Shen JP (2017)	1
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
CDK6	0	VHL	0	genetic interference	Shen JP (2017)	1
CCND3	1	CDKN1B	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Lin J (2001), Lin J (2001), Zhang Q (1999), Barnouin K (1999), Barnouin K (1999), Datta NS (1998), Vlach J (1996), Bockstaele L (2006), Bockstaele L (2006), Waaijers S (2013), Waaijers S (2013), Huttlin EL (2015), Huttlin EL (2017)	14
VCP	6	YWHAZ	1	affinity chromatography technology, two hybrid	Yu CC (2013), Wang J (2011)	2
CDK1	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Radu M (2008), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CASP8	1	VHL	0	genetic interference	Shen JP (2017)	1
CDK5	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Guidato S (1998), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
ABL1	9	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bali P (2005), Sun H (2011), Tsukahara F (2010), Taipale M (2012), Wu LX (2006)	5
VCP	6	CDKN1A	1	affinity chromatography technology	Yu CC (2013)	1
COPS5	0	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK6	0	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
RBX1	2	CDKN1B	1	enzymatic study	Duda DM (2008)	1
CKS1B	0	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Wang W (2003), Sitry D (2002), Zhou W (2009), Ooi LC (2013), Huttlin EL (2017)	5
MYC	2	DDB1	6	affinity chromatography technology	Choi SH (2010)	1
CASP8	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
CDKN1B	1	GRB2	2	pull down, biochemical	Sugiyama Y (2001), Sugiyama Y (2001)	2
CAMK1	4	CDKN1B	1	affinity chromatography technology, enzymatic study	Mallampalli RK (2013), Mallampalli RK (2013)	2
STMN1	0	HSPA8	4	pull down	Manceau V (1999)	1
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
COPS5	0	CCNA2	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
CDK3	0	CCNE2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Zariwala M (1998), Huttlin EL (2015), Huttlin EL (2017)	3
HSP90AA1	7	CDKN1A	1	affinity chromatography technology	Jascur T (2005)	1
SRC	2	CDKN1B	1	enzymatic study, affinity chromatography technology	Chu I (2007), Chu I (2007)	2
CDK5	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
SKP1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
CDK4	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
VCP	6	TRIM21	0	affinity chromatography technology	Yu CC (2013)	1
UBE2D2	0	UBE3A	4	enzymatic study, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Hatakeyama S (1997), Hatakeyama S (1997), Louria-Hayon I (2009), Jacobson AD (2014), Mortensen F (2015), Rolfe M (1995), Kuslansky Y (2016)	8
RCHY1	0	CDKN1B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Hattori T (2007), Hattori T (2007), Huang X (2011)	3
HSPA8	4	HIST1H1B	4	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1B	1	HSPA8	4	affinity chromatography technology	Imamura Y (2016)	1
CCND2	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1B	1	TSC1	4	affinity chromatography technology	Rosner M (2004)	1
WEE1	2	CDKN1B	1	genetic interference	Srivas R (2016)	1
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
CCND2	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
COPS6	0	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
UCHL1	1	CDK1	0	affinity chromatography technology	Kabuta T (2013)	1
PIN1	0	TSC2	17	two hybrid	Vinayagam A (2011)	1
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
COPS5	0	CCNA1	3	affinity chromatography technology	Bennett EJ (2010)	1
KAT2B	2	HIST1H1B	4	enzymatic study	Brand M (1999)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	KPNA1	5	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CCNB1	3	CKS1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Hein MY (2015), Huttlin EL (2017)	3
UCHL1	1	CDK4	2	affinity chromatography technology	Kabuta T (2013)	1
CUL1	7	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
CAMK1	4	CCND1	1	enzymatic study	Mallampalli RK (2013)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ELAVL1	0	SGK1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
CASP8	1	CDKN1B	1	genetic interference	Shen JP (2017)	1
RFWD2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Olma MH (2009)	2
RCHY1	0	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hattori T (2007), Duan S (2007), Sheng Y (2008), Wu G (2010), Corcoran CA (2009), Abe K (2008), Shloush J (2011), Bohgaki M (2013), Abou Zeinab R (2013)	9
KAT2B	2	CDK2	0	pull down, affinity chromatography technology, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3
CDKN1B	1	CUL1	7	unspecified method, pull down	Carrano AC (1999), Enchev RI (2012)	2
CDKN1A	1	HSPA8	4	affinity chromatography technology	Fogeron ML (2013)	1
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
ELAVL1	0	KPNA6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RFWD2	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
CDKN1B	1	KPNA6	1	pull down	Inuzuka H (2012)	1