PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
PTPRN2	8	HGS	5	bioid	St-Denis N (2016)	1
JAK2	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Olayioye MA (1999), Olayioye MA (1999), Jones RB (2006), He K (2013)	4
STAM	3	ITCH	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Malik R (2012), Malik R (2012), Malik R (2012), OConnor HF (2015)	4
TP53	0	STAM2	0	genetic interference	Xie L (2013)	1
PHF10	3	STAM2	0	two hybrid	Wang J (2011)	1
ACTN1	5	STAM2	0	biochemical	Kristensen AR (2012)	1
RNF11	0	EPS15	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2004), Kostaras E (2012), Kostaras E (2014)	3
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
ABI2	4	STAM2	0	two hybrid	Rolland T (2014)	1
DCAF8	1	XPO1	8	affinity chromatography technology, affinity chromatography technology	Wu F (2012), Kirli K (2015)	2
JAK2	1	STAM	3	enzymatic study, affinity chromatography technology	Takeshita T (1997), Takeshita T (1997)	2
TYK2	1	JAK1	6	affinity chromatography technology	Domanski P (1995)	1
UBQLN4	2	KLHL42	1	two hybrid	Lim J (2006)	1
JAK1	6	STAM2	0	enzymatic study, affinity chromatography technology	Pandey A (2000), Endo K (2000)	2
PPP1R13B	9	STAM2	0	biochemical	Wan C (2015)	1
XPO1	8	SEC13	0	affinity chromatography technology	Kirli K (2015)	1
UBE2H	3	STAM2	0	enzymatic study	Hoeller D (2007)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
UBE2D2	0	EPS15	1	enzymatic study	Hoeller D (2007)	1
UBQLN4	2	HGS	5	two hybrid	Lim J (2006)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
7179	0	STAM	3	bioid	St-Denis N (2016)	1
MAP3K1	4	UBQLN1	1	enzymatic study	Charlaftis N (2014)	1
RNF11	0	STAMBP	2	two hybrid, pull down, affinity chromatography technology	Li H (2004), Li H (2004), Li H (2004)	3
STAM2	0	KLHL42	1	two hybrid	Rolland T (2014)	1
PHF10	3	L3MBTL2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STAM2	0	USP8	7	unspecified method, pull down, affinity chromatography technology, pull down, protein complementation assay	Kaneko T (2003), Kato M (2000), Kato M (2000), Kato M (2000), Berlin I (2010)	5
NAPA	2	STAM2	0	biochemical	Havugimana PC (2012)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
STAM2	0	TYK2	1	affinity chromatography technology	Endo K (2000)	1
PTPN23	7	TSG101	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), Kharitidi D (2015)	3
HGS	5	UBQLN1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Regan-Klapisz E (2005)	2
VCP	6	PTPN23	7	affinity chromatography technology	Yu CC (2013)	1
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
STAM2	0	EPS15	1	affinity chromatography technology	Bache KG (2003)	1
FBF1	2	STAM2	0	bioid	Gupta GD (2015)	1
EGFR	5	USP8	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mizuno E (2005), Meijer IM (2013), Meijer IM (2013), Ali N (2013), Reincke M (2015), Reincke M (2015), Jeong CH (2015)	7
ZFYVE9	5	TSG101	1	affinity chromatography technology, affinity chromatography technology	Kostaras E (2012), Kostaras E (2012)	2
STAM	3	SEC31A	7	affinity chromatography technology	Rismanchi N (2009)	1
PTPN23	7	USP8	7	affinity chromatography technology	Ali N (2013)	1
JAK3	3	TYK2	1	affinity chromatography technology	Doucet C (2002)	1
TMEM17	0	STAM2	0	bioid	Gupta GD (2015)	1
USP8	7	UBC	7	enzymatic study, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, pull down	Faesen AC (2011), Ernst A (2013), Row PE (2007), Ernst A (2013), Wauer T (2015), Reincke M (2015), Kwasna D (2018)	7
HGS	5	LITAF	0	two hybrid	Rolland T (2014)	1
UBE2D3	1	EPS15	1	enzymatic study	Hoeller D (2007)	1
PTPRN2	8	STAM2	0	bioid	St-Denis N (2016)	1
PTPN23	7	STAM	3	affinity chromatography technology	Kharitidi D (2015)	1
TMEM216	0	STAM2	0	bioid	Gupta GD (2015)	1
RNF11	0	ZFYVE9	5	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, two hybrid	Kostaras E (2012), Kostaras E (2012), Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2014), Kostaras E (2012)	7
STAM2	0	VPS37C	3	two hybrid	Rolland T (2014)	1
UBC	7	ZFYVE9	5	pull down	Kostaras E (2012)	1
TP53	0	TP53BP2	5	two hybrid, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology	Iwabuchi K (1994), Iwabuchi K (1994), Iwabuchi K (1994), Naumovski L (1996), Naumovski L (1996), Naumovski L (1996), Gillotin S (2011)	7
ZFYVE9	5	STAM2	0	affinity chromatography technology	Kostaras E (2012)	1
LITAF	0	UBQLN1	1	two hybrid	Rolland T (2014)	1
DCAF8	1	STAM2	0	biochemical	Kristensen AR (2012)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
STAM	3	STAMBP	2	pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, pull down	Kato M (2000), Tanaka N (1999), Tanaka N (1999), Tanaka N (1999), Kim MS (2006), Agromayor M (2006), McCullough J (2004), Sierra MI (2010), Sierra MI (2010), Sierra MI (2010), Row PE (2006), Kikuchi K (2003), McCullough J (2006), McCullough J (2006), Tsang HT (2006), Davies CW (2013), Davies CW (2013), McCullough J (2006)	18
LITAF	0	TSG101	1	affinity chromatography technology, affinity chromatography technology	Shirk AJ (2005), Li W (2015)	2
PTPN1	2	TYK2	1	affinity chromatography technology	Myers MP (2001)	1
UBQLN1	1	EPS15	1	pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Heir R (2006), Heir R (2006), Regan-Klapisz E (2005), Regan-Klapisz E (2005), NDiaye EN (2008)	5
TSG101	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Li L (2001), Li L (2001)	2
XRN1	4	CBX5	3	two hybrid	Lehner B (2004)	1
RNF11	0	UBQLN4	2	two hybrid	Colland F (2004)	1
PTPN23	7	HGS	5	affinity chromatography technology, affinity chromatography technology	Ali N (2013), Kharitidi D (2015)	2
XPO1	8	STAM2	0	affinity chromatography technology	Kirli K (2015)	1
STAM2	0	JAK2	1	affinity chromatography technology	Endo K (2000)	1
MAP3K1	4	STAM	3	enzymatic study	Charlaftis N (2014)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
XPO1	8	SRP19	0	affinity chromatography technology	Kirli K (2015)	1
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
PPP1R13B	9	TP53	0	affinity chromatography technology, genetic interference	Gillotin S (2011), Xie L (2013)	2
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
STAM2	0	TP53BP2	5	biochemical	Wan C (2015)	1
TMEM17	0	SEC31A	7	bioid	Gupta GD (2015)	1
STAM	3	ARRDC3	0	affinity chromatography technology	Tian X (2016)	1
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
HGS	5	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
XRN1	4	STAM2	0	two hybrid	Lehner B (2004)	1
STAM2	0	SH2D4A	0	two hybrid	Rolland T (2014)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
PTPN1	2	JAK2	1	affinity chromatography technology, enzymatic study	Myers MP (2001), Lund IK (2005)	2
LITAF	0	STAM2	0	two hybrid	Rolland T (2014)	1
PTPN1	2	STAM2	0	affinity chromatography technology, pull down	Stuible M (2010), Stuible M (2010)	2
STAM	3	UBC	7	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, unspecified method, pull down, pull down, x-ray crystallography, pull down	Kim MS (2006), Mizuno E (2006), Hong YH (2009), Nathan JA (2013), Nathan JA (2013), Stuible M (2010), Lim J (2011), Baiady N (2016), Kharitidi D (2015), Sundd M (2012), Zhang X (2017)	11
ZFYVE9	5	DAZAP2	1	two hybrid	Colland F (2004)	1
7179	0	STAM2	0	bioid	St-Denis N (2016)	1
ACTN1	5	SRP19	0	biochemical	Kristensen AR (2012)	1
VCP	6	FBF1	2	affinity chromatography technology	Fogeron ML (2013)	1
MAP3K1	4	PLEKHB2	4	enzymatic study	Charlaftis N (2014)	1
KRT8	3	STAM2	0	biochemical	Havugimana PC (2012)	1
EGFR	5	STAM2	0	affinity chromatography technology, pull down	Kong C (2007), Morino C (2004)	2
VCP	6	ATXN1	2	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
VCP	6	ACTN1	5	affinity chromatography technology	Yu CC (2013)	1
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
TP53BP2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gao K (2015), Gao K (2015), Gao K (2015), Gao K (2015), Gen Y (2017), Gen Y (2017)	6
FAM189A2	2	UBQLN1	1	two hybrid	Rolland T (2014)	1
SF3A3	2	HGS	5	biochemical	Kristensen AR (2012)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
FBF1	2	STAM	3	bioid	Gupta GD (2015)	1
TIMM8A	0	STAM	3	two hybrid, pull down, affinity chromatography technology	Blackstone C (2003), Blackstone C (2003), Blackstone C (2003)	3
PTPRN2	8	STAM	3	bioid	St-Denis N (2016)	1
UBQLN1	1	STAM2	0	affinity chromatography technology	Regan-Klapisz E (2005)	1
TSG101	1	HGS	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, unspecified method, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Rual JF (2005), Lu Q (2003), Lu Q (2003), Lu Q (2003), Kim BY (2007), Im YJ (2010), Schlundt A (2009), Schlundt A (2009), Pornillos O (2003), Pornillos O (2003), Bache KG (2003), Bache KG (2003), Bouamr F (2007), Kim HJ (2007), Kumar B (2016), Kumar B (2016)	16
UBQLN4	2	STAM2	0	two hybrid	Lim J (2006)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
STAM2	0	L3MBTL2	1	two hybrid	Rual JF (2005)	1
LCP2	0	STAM2	0	two hybrid	Rolland T (2014)	1
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
SEC31A	7	STAM2	0	affinity chromatography technology	Rismanchi N (2009)	1
OFD1	3	TP53	0	affinity chromatography technology	Gupta GD (2015)	1
RIN1	1	STAM2	0	affinity chromatography technology, affinity chromatography technology	Kong C (2007), Balaji K (2012)	2
UBE2D3	1	STAM2	0	enzymatic study	Hoeller D (2007)	1
ARRDC3	0	HGS	5	affinity chromatography technology	Han SO (2012)	1
UBE2D3	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
STAM2	0	STAMBP	2	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, x-ray crystallography	Rual JF (2005), Sierra MI (2010), Sierra MI (2010), Tsang HT (2006), Venkatesan K (2009), Hologne M (2016)	6
DAZAP2	1	VPS37C	3	two hybrid	Rolland T (2014)	1
HGS	5	ABI2	4	two hybrid	Rolland T (2014)	1
STAM2	0	SF3A3	2	biochemical	Kristensen AR (2012)	1
STAM2	0	JAK3	3	affinity chromatography technology	Endo K (2000)	1
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
UBQLN4	2	PTPRN2	8	two hybrid	Lim J (2006)	1
UBE2D2	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
UBC	7	VPS37C	3	pull down	Nathan JA (2013)	1
ATXN1	2	LITAF	0	two hybrid	Suter B (2013)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
EGFR	5	TSG101	1	affinity chromatography technology	Yao Z (2017)	1
VCP	6	TSG101	1	affinity chromatography technology	Yu CC (2013)	1
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TMEM216	0	STAM	3	bioid	Gupta GD (2015)	1
STAM	3	HGS	5	two hybrid, affinity chromatography technology, biochemical, pull down, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Asao H (1997), Bache KG (2003), Malik R (2010), Kanazawa C (2003), Kanazawa C (2003), Havugimana PC (2012), Sirisaengtaksin N (2014), Sirisaengtaksin N (2014), Holleman J (2014), Holleman J (2014), Wan C (2015), Berlin I (2010), Huttlin EL (2017)	14
XPO1	8	SEC31A	7	affinity chromatography technology	Kirli K (2015)	1
TMEM17	0	HGS	5	bioid	Gupta GD (2015)	1
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
SEC13	0	SEC31A	7	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Loiodice I (2004), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	8
EGFR	5	RIN1	1	affinity chromatography technology	Kong C (2007)	1
ARRDC3	0	ITCH	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBQLN4	2	UBC	7	pull down	Su V (2010)	1
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
EGFR	5	COG7	2	affinity chromatography technology	Foerster S (2013)	1
SEC13	0	STAM2	0	affinity chromatography technology	Rismanchi N (2009)	1
DAZAP2	1	STAM2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STAM	3	JAK3	3	affinity chromatography technology	Takeshita T (1997)	1
7179	0	XPO1	8	affinity chromatography technology	Yadav L (2017)	1
STAM2	0	UBC	7	x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Lange A (2010), Lange A (2012), Lange A (2012), Stuible M (2010), Baiady N (2016), Zhang X (2017), Hologne M (2016)	7
UBC	7	PTPN23	7	pull down	Kharitidi D (2015)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
FAM189A2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAM2	0	ARRDC3	0	two hybrid	Rolland T (2014)	1
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
STAM2	0	COG7	2	biochemical	Wan C (2015)	1
PTPN23	7	EGFR	5	affinity chromatography technology	Ali N (2013)	1
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
STAM2	0	PTPN23	7	affinity chromatography technology, affinity chromatography technology	Ali N (2013), Ali N (2013)	2
SEC31A	7	UBC	7	affinity chromatography technology	McGourty CA (2016)	1
ITCH	1	LITAF	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Eaton HE (2011), Eaton HE (2011), Li W (2015)	3
EGFR	5	SEC13	0	affinity chromatography technology	Wu SL (2006)	1
FAM189A2	2	STAM2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
FBF1	2	OFD1	3	bioid	Gupta GD (2015)	1
EGFR	5	LCP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
DAZAP2	1	PLEKHB2	4	two hybrid	Rolland T (2014)	1
STAM2	0	VCP	6	biochemical	Kristensen AR (2012)	1
ATXN1	2	STAM2	0	two hybrid	Suter B (2013)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
TMEM216	0	PTPN1	2	bioid	Gupta GD (2015)	1
XPO1	8	L3MBTL2	1	affinity chromatography technology	Kirli K (2015)	1
STAMBP	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
STAM2	0	TSG101	1	biochemical	Wan C (2015)	1
UBE2H	3	EPS15	1	enzymatic study	Hoeller D (2007)	1
DCAF8	1	ACTN1	5	biochemical	Kristensen AR (2012)	1
TIMM8A	0	STAM2	0	two hybrid	Rolland T (2014)	1
RNF11	0	STAM2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2012)	4
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
VCP	6	NAPA	2	affinity chromatography technology	Yu CC (2013)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
OFD1	3	STAM2	0	bioid	Gupta GD (2015)	1
TMEM17	0	EPS15	1	bioid	Gupta GD (2015)	1
MAP3K1	4	HGS	5	enzymatic study	Charlaftis N (2014)	1
OFD1	3	TP53BP2	5	bioid	Gupta GD (2015)	1
MAP3K1	4	ACTN1	5	two hybrid	Gallagher ED (2004)	1
FBF1	2	TP53BP2	5	bioid	Gupta GD (2015)	1
ATXN1	2	UBQLN4	2	two hybrid, two hybrid	Davidson JD (2000), Lim J (2006)	2
UBE2D1	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
MAP3K1	4	STAM2	0	enzymatic study	Charlaftis N (2014)	1
ACTN1	5	SF3A3	2	biochemical	Kristensen AR (2012)	1
UBQLN1	1	KLHL42	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STAM2	0	PLEKHB2	4	two hybrid	Rolland T (2014)	1
RNF11	0	HGS	5	affinity chromatography technology	Kostaras E (2012)	1
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
TMEM17	0	PTPN1	2	bioid	Gupta GD (2015)	1
STAM2	0	CBX5	3	unspecified method	Lechner MS (2005)	1
UBE2D1	0	EPS15	1	enzymatic study	Hoeller D (2007)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
UBE2D1	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
PLEKHB2	4	ITCH	1	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
TMEM17	0	STAM	3	bioid	Gupta GD (2015)	1
STAM	3	UBQLN4	2	biochemical	Havugimana PC (2012)	1
XPO1	8	XRN1	4	affinity chromatography technology	Kirli K (2015)	1
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
VPS37C	3	HGS	5	two hybrid, two hybrid	Eastman SW (2005), Rolland T (2014)	2
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1
SRP19	0	STAM2	0	biochemical	Kristensen AR (2012)	1
XPO1	8	EPS15	1	affinity chromatography technology	Kirli K (2015)	1
TSG101	1	VPS37C	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical	Eastman SW (2005), Eastman SW (2005), Stefani F (2011), Stefani F (2011), Wunderley L (2014), Rolland T (2014), Wan C (2015)	7
STAM2	0	KIF15	4	biochemical	Kristensen AR (2012)	1
STAM2	0	ITCH	1	pull down, pull down	Malik R (2012), Malik R (2012)	2
USP8	7	STAM	3	pull down, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Kato M (2000), Berlin I (2010), Berlin I (2010), Row PE (2006)	4
UBQLN4	2	DAZAP2	1	two hybrid	Lim J (2006)	1
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
EPS15	1	USP8	7	affinity chromatography technology, enzymatic study	Mizuno E (2006), Mizuno E (2006)	2