PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ID2	0	ID4	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	OLIG2	2	two hybrid	Wang J (2011)	1
TCF3	7	ID4	1	affinity chromatography technology	Teachenor R (2012)	1
ID4	1	OLIG2	2	affinity chromatography technology, affinity chromatography technology	Samanta J (2004), Samanta J (2004)	2
TP53	0	OLIG2	2	genetic interference	Mehta S (2011)	1
OLIG2	2	TCF3	7	affinity chromatography technology	Samanta J (2004)	1
ELSPBP1	1	OLIG2	2	affinity chromatography technology	Samanta J (2004)	1
ID2	0	OLIG2	2	affinity chromatography technology	Samanta J (2004)	1
SRRM1	2	OLIG2	2	affinity chromatography technology	McCracken S (2005)	1
ID2	0	TCF3	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Teachenor R (2012), Mathas S (2009), Langlands K (1997), Lee SB (2016), Huttlin EL (2017)	6
CUL3	17	SRRM1	2	affinity chromatography technology	Bennett EJ (2010)	1