PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TOPORS	6	H2AFX	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Seong KM (2012), Seong KM (2012), Seong KM (2012), Seong KM (2012)	4
SFPQ	2	SERBP1	2	biochemical	Wan C (2015)	1
ZNF324B	1	TRIM28	1	affinity chromatography technology	Huttlin EL (2017)	1
SATB1	1	UBE2I	0	two hybrid, two hybrid, two hybrid, enzymatic study	Rual JF (2005), Tan JA (2010), Tan JA (2008), Gocke CB (2005)	4
EEF1A1	0	NIFK	1	biochemical	Havugimana PC (2012)	1
HNRNPL	3	UBE2E3	0	affinity chromatography technology	Fei T (2017)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
HNRNPA1	1	EEF1A1	0	affinity chromatography technology, biochemical	Roy R (2014), Wan C (2015)	2
TP53	0	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Al Rashid ST (2005), Al Rashid ST (2005)	2
TRIM28	1	UBE2E1	1	pull down	Doyle JM (2010)	1
HNRNPL	3	GTF2I	1	affinity chromatography technology	Fei T (2017)	1
TRIM28	1	SIN3A	13	pull down	Nomura T (2004)	1
NKAP	1	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPM	1	SFPQ	2	biochemical	Havugimana PC (2012)	1
PARP1	3	UBE2I	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, enzymatic study	Masson M (1997), Masson M (1997), Masson M (1997), Zilio N (2013), Matafora V (2009), Zilio N (2013), Gocke CB (2005)	7
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
TOPORS	6	EEF1A1	0	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	PSMC1	2	two hybrid, affinity chromatography technology	Czub B (2016), Czub B (2016)	2
SPIN2B	0	SPIN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	HNRNPA1	1	biochemical	Wan C (2015)	1
TOPORS	6	DDB2	1	affinity chromatography technology	Pungaliya P (2007)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
ZNF263	2	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
CLK3	0	PNN	2	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPA1	1	GTF2I	1	affinity chromatography technology	Roy R (2014)	1
H2AFX	1	PML	7	affinity chromatography technology	Dittmann K (2011)	1
SATB1	1	SIN3A	13	biochemical	Yasui D (2002)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
TOPORS	6	UBE2D1	0	pull down, affinity chromatography technology, two hybrid, pull down, pull down	Park HJ (2008), Park HJ (2008), van Wijk SJ (2009), Guan B (2008), Rajendra R (2004)	5
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
DHX15	5	NKAP	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SUMO2	0	RBBP7	1	pull down	Ouyang J (2009)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBE2J1	1	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
UBE2I	0	SFPQ	2	enzymatic study	Matafora V (2009)	1
SFPQ	2	SIN3A	13	affinity chromatography technology, imaging technique, affinity chromatography technology	Tyson-Capper AJ (2009), Dong X (2007), Liu L (2011)	3
HNRNPA1	1	DHX15	5	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
TOPORS	6	UBC	7	enzymatic study	Rajendra R (2004)	1
UBE2D3	1	TOPORS	6	two hybrid, pull down	van Wijk SJ (2009), Rajendra R (2004)	2
CASP8	1	TOPORS	6	affinity chromatography technology	Yao Z (2007)	1
TP53	0	GTF2I	1	affinity chromatography technology	Horikawa I (2014)	1
UBE2D1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TOPORS	6	RBBP4	3	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	UPF3A	2	affinity chromatography technology	Pungaliya P (2007)	1
HNRNPA1	1	SAFB2	3	affinity chromatography technology	Hein MY (2015)	1
NONO	3	SIN3A	13	affinity chromatography technology	Liu L (2011)	1
TRIM28	1	UBE2N	1	pull down	Doyle JM (2010)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
H2AFX	1	NONO	3	affinity chromatography technology, affinity chromatography technology	Yang X (2010), Yang X (2010)	2
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
TOPORS	6	PARP1	3	affinity chromatography technology	Pungaliya P (2007)	1
NKX3-1	2	TOP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Bowen C (2007), Bowen C (2007), Bowen C (2007)	3
TOPORS	6	S100A9	0	affinity chromatography technology	Pungaliya P (2007)	1
UBC	7	HNRNPM	1	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
SUMO1	0	RANGAP1	4	pull down	Tatham MH (2003)	1
UBE2I	0	GTF2I	1	enzymatic study	Gocke CB (2005)	1
SFPQ	2	NONO	3	two hybrid, affinity chromatography technology, pull down, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Peng R (2002), Peng R (2002), Peng R (2002), Ito T (2008), Dong X (2007), Havugimana PC (2012), Wang J (2011), Hall-Pogar T (2007), Wan C (2015), Huttlin EL (2017)	10
UBC	7	DHX15	5	pull down	Nathan JA (2013)	1
NKAP	1	PNN	2	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
UBE2I	0	NONO	3	enzymatic study	Matafora V (2009)	1
CLK3	0	ZNF263	2	two hybrid	Rolland T (2014)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
ZNF786	3	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
LLGL2	4	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
SATB1	1	TOPORS	6	two hybrid, two hybrid	Tan JA (2010), Tan JA (2008)	2
TP53	0	TOP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Gobert C (1999), Mao Y (2002), Restle A (2008)	3
TRIM28	1	PARP1	3	affinity chromatography technology	Quenet D (2008)	1
UBE2W	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
TRIM28	1	UBE2D3	1	pull down	Doyle JM (2010)	1
EEF1A1	0	HNRNPL	3	biochemical	Havugimana PC (2012)	1
SUMO2	0	TOPORS	6	two hybrid	Hecker CM (2006)	1
HNRNPL	3	SFPQ	2	biochemical	Havugimana PC (2012)	1
TOPORS	6	SMARCC2	9	affinity chromatography technology	Pungaliya P (2007)	1
SUMO2	0	TRIM28	1	pull down	Ouyang J (2009)	1
TRIM28	1	UBE2D2	0	pull down	Doyle JM (2010)	1
TOP1	1	NONO	3	affinity chromatography technology	Czubaty A (2005)	1
HNRNPM	1	NONO	3	biochemical	Havugimana PC (2012)	1
DHX15	5	S100A9	0	biochemical	Havugimana PC (2012)	1
SERBP1	2	TOPORS	6	two hybrid	Lemos TA (2006)	1
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
TOPORS	6	NONO	3	affinity chromatography technology	Pungaliya P (2007)	1
PNN	2	ZC3H18	4	biochemical	Wan C (2015)	1
TOPORS	6	UBE2I	0	two hybrid, pull down	Weger S (2003), Weger S (2005)	2
DHX15	5	SF3B1	12	biochemical	Wan C (2015)	1
TOPORS	6	RANGAP1	4	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	NKX3-1	2	pull down, enzymatic study	Guan B (2008), Guan B (2008)	2
CLK3	0	ZC3H18	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	TRIM28	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Doyle JM (2010)	2
EPM2A	1	TOPORS	6	two hybrid	Viana R (2015)	1
TP53	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
NONO	3	HABP4	1	biochemical	Wan C (2015)	1
SATB1	1	SUMO1	0	two hybrid	Tan JA (2008)	1
TOPORS	6	HNRNPL	3	affinity chromatography technology	Pungaliya P (2007)	1
ZNF324B	1	SPIN1	1	affinity chromatography technology	Huttlin EL (2017)	1
S100A9	0	TOP1	1	biochemical	Havugimana PC (2012)	1
UBC	7	GTF2I	1	pull down	Zhang X (2017)	1
H2AFX	1	UBC	7	affinity chromatography technology	Sharma N (2013)	1
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
TRIM28	1	UBE2D1	0	pull down	Doyle JM (2010)	1
TOP1	1	SF3B1	12	affinity chromatography technology, unspecified method	Czubaty A (2005), Trzcinska AM (2002)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2D2	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
TOPORS	6	SAFB2	3	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	GTF2I	1	affinity chromatography technology	Pungaliya P (2007)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TOP1	1	HNRNPL	3	affinity chromatography technology	Czubaty A (2005)	1
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
SF3B1	12	SFPQ	2	biochemical	Havugimana PC (2012)	1
UBE2E3	0	RANGAP1	4	enzymatic study	Okuma T (1999)	1
SFPQ	2	UBC	7	two hybrid, two hybrid, affinity chromatography technology, pull down	Stelzl U (2005), Stelzl U (2005), Matsumoto M (2005), Nathan JA (2013)	4
HABP4	1	TOPORS	6	two hybrid	Nery FC (2006)	1
TOPORS	6	SUMO1	0	two hybrid, two hybrid	Weger S (2003), Hecker CM (2006)	2
H2AFX	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Yang X (2010), Yang X (2010), Huttlin EL (2017)	8
NKAP	1	ZC3H18	4	affinity chromatography technology	Huttlin EL (2017)	1
TOPORS	6	UBE2E1	1	pull down	Rajendra R (2004)	1
CLK3	0	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
SIN3A	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Murphy M (1999), Murphy M (1999), Murphy M (1999), Zilfou JT (2001)	4
HNRNPA1	1	SFPQ	2	affinity chromatography technology, affinity chromatography technology, biochemical	Close P (2012), Close P (2012), Wan C (2015)	3
ZNF324B	1	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
TOPORS	6	SFPQ	2	affinity chromatography technology	Pungaliya P (2007)	1
SMARCC2	9	SFPQ	2	affinity chromatography technology	Huttlin EL (2017)	1
PNN	2	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	DHX15	5	biochemical	Wan C (2015)	1
SUMO2	0	EEF1A1	0	pull down	Ouyang J (2009)	1
TOPORS	6	RBBP7	1	affinity chromatography technology	Pungaliya P (2007)	1
HNRNPL	3	HNRNPM	1	biochemical	Havugimana PC (2012)	1
HNRNPL	3	SPIN1	1	affinity chromatography technology	Fei T (2017)	1
SAFB2	3	TP53	0	affinity chromatography technology	Peidis P (2011)	1
PML	7	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Khan MM (2001)	2
TP53	0	HABP4	1	pull down, affinity chromatography technology, affinity chromatography technology	Nery FC (2006), Nery FC (2006), Nery FC (2006)	3
TOPORS	6	PML	7	imaging technique	Renner F (2010)	1
TOP1	1	PARP1	3	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, biochemical	Czubaty A (2005), Yung TM (2004), Yung TM (2004), Yung TM (2004), Yung TM (2004)	5
TOP1	1	UBE2I	0	two hybrid, pull down, pull down	Mao Y (2000), Mao Y (2000), Mao Y (2000)	3
PML	7	SATB1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kumar PP (2007), Kumar PP (2007), Kumar PP (2007), Kumar PP (2007), Tan JA (2008)	5
TOPORS	6	SF3B1	12	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	TOP1	1	affinity chromatography technology, two hybrid, enzymatic study, enzymatic study	Haluska P (1999), Haluska P (1999), Pelisch F (2010), Hammer E (2007)	4
UBE2N	1	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
RBBP7	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Kuzmichev A (2002), Nakamura T (2002), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HNRNPA1	1	NONO	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Close P (2012), Close P (2012), Roy R (2014)	3
HNRNPM	1	SF3B1	12	biochemical	Havugimana PC (2012)	1
UBE2I	0	HNRNPM	1	enzymatic study, enzymatic study	Matafora V (2009), Gocke CB (2005)	2
ZNF214	1	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	RBBP4	3	affinity chromatography technology	Fei T (2017)	1
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
ZC3H18	4	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	PSMC1	2	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
HNRNPM	1	TOP1	1	biochemical	Havugimana PC (2012)	1
SIN3A	13	SMARCC2	9	affinity chromatography technology	Nakamura T (2002)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
TOPORS	6	HNRNPA1	1	affinity chromatography technology	Pungaliya P (2007)	1
TP53	0	RBBP4	3	affinity chromatography technology	Fogeron ML (2013)	1
UBE2E3	0	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	TRIM28	1	affinity chromatography technology	Dittmann K (2011)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
UBE2N	1	EPM2A	1	affinity chromatography technology, affinity chromatography technology	Sanchez-Martin P (2015), Sanchez-Martin P (2015)	2
SIN3A	13	RBBP4	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hassig CA (1997), Zhang Y (1998), Nakamura T (2002), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Bantscheff M (2011), Hauri S (2016)	8
MTDH	1	TOPORS	6	two hybrid, pull down	Luxton HJ (2014), Luxton HJ (2014)	2
TOP1	1	HNRNPA1	1	affinity chromatography technology	Czubaty A (2005)	1
TOP1	1	DDB2	1	unspecified method	Trzcinska AM (2002)	1
TOPORS	6	TRIM28	1	affinity chromatography technology	Pungaliya P (2007)	1
HABP4	1	UBE2I	0	two hybrid	Nery FC (2006)	1
ZNF816	0	TOPORS	6	affinity chromatography technology	Huttlin EL (2017)	1
CLK3	0	SAFB2	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TOPORS	6	TP53	0	two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Weger S (2002), Rajendra R (2004), Pungaliya P (2007), Yao Z (2007), Yao Z (2007), Weger S (2005)	6
EEF1A1	0	GTF2I	1	biochemical	Havugimana PC (2012)	1
UBC	7	RBBP4	3	affinity chromatography technology	Matsumoto M (2005)	1
TOPORS	6	HNRNPM	1	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	DHX15	5	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	SIN3A	13	affinity chromatography technology, enzymatic study	Pungaliya P (2007), Pungaliya P (2007)	2
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2I	0	TRIM28	1	affinity chromatography technology, pull down, enzymatic study, pull down	Liang Q (2011), Garvin AJ (2013), Ivanov AV (2007), Neo SH (2015)	4
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
TOP1	1	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Straub T (1998), Czubaty A (2005)	2
LLGL2	4	NKAP	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPA1	1	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
TOPORS	6	IKBKE	2	imaging technique, affinity chromatography technology	Renner F (2010), Renner F (2010)	2
CLK3	0	TP53	0	affinity chromatography technology	Varjosalo M (2013)	1
UBE2L6	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
UBXN7	3	TOPORS	6	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
HNRNPA1	1	HNRNPM	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
TP53	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
TP53	0	RBBP7	1	affinity chromatography technology	Fogeron ML (2013)	1
SPIN1	1	TOPORS	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF816	0	ZC3H18	4	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
SERBP1	2	TP53	0	affinity chromatography technology	Nery FC (2006)	1
H2AFX	1	HNRNPA1	1	affinity chromatography technology	Yang X (2010)	1
ZNF214	1	ZC3H18	4	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	PARP1	3	affinity chromatography technology, affinity chromatography technology	Robu M (2013), Robu M (2013)	2
HNRNPA1	1	PNN	2	affinity chromatography technology	Close P (2012)	1
UBE2D4	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
NIFK	1	TOPORS	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	RANGAP1	4	affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Knipscheer P (2008), Shiio Y (2003), Gruenwald M (2011), Gareau JR (2012), Lee GW (1998), Zhang J (2008), Yang SH (2006), Yang SH (2006), Wang J (2011), Meulmeester E (2008), Hsieh YL (2013), Hsieh YL (2013), Oh YH (2007), Wang J (2010), Cooper HJ (2005), Hu G (2010), Galisson F (2011), Hein MY (2015), Huttlin EL (2017), Xiong Y (2017)	22
SPIN2B	0	TOPORS	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLK1	0	TOPORS	6	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang X (2009), Yang X (2010), Seong KM (2012), Yang X (2009)	4
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
SUMO2	0	RBBP4	3	pull down	Ouyang J (2009)	1
H2AFX	1	EEF1A1	0	affinity chromatography technology	Heo K (2008)	1
PML	7	IKBKE	2	imaging technique	Renner F (2010)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
S100A9	0	ZC3H18	4	biochemical	Havugimana PC (2012)	1
CASP8	1	PARP1	3	enzymatic study	Betin VM (2009)	1