PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MARK4	6	MTCL1	8	affinity chromatography technology	Brajenovic M (2004)	1
RNF41	2	UBE2D3	1	pull down, pull down	Yu F (2008), Qiu XB (2004)	2
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF41	2	SF1	9	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	CEP192	5	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	P4HA1	1	affinity chromatography technology	Hein MY (2015)	1
CEP192	5	CACYBP	0	bioid	Firat-Karalar EN (2014)	1
ELAVL1	0	NAV1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
NAV1	5	APP	1	pull down	Olah J (2011)	1
RNF41	2	IRS4	2	two hybrid	Wijesuriya TM (2017)	1
RNF41	2	UPF3A	2	affinity chromatography technology	Hein MY (2015)	1
TACC1	2	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
MARK4	6	RNF41	2	affinity chromatography technology	Brajenovic M (2004)	1
IRS4	2	CACYBP	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
IRS4	2	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
MTNR1A	1	RNF41	2	two hybrid	Benleulmi-Chaachoua A (2016)	1
SUGT1	1	RNF41	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
KIFC3	3	TSG101	1	two hybrid	Rolland T (2014)	1
USP8	7	ERBB4	5	affinity chromatography technology	Meijer IM (2013)	1
MTNR1B	1	IRS4	2	pull down	Benleulmi-Chaachoua A (2016)	1
UBE2D3	1	RNF166	0	two hybrid	Markson G (2009)	1
ELAVL1	0	P4HA1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF41	2	RASIP1	2	affinity chromatography technology	Hein MY (2015)	1
MTNR1A	1	CLASP1	5	two hybrid	Benleulmi-Chaachoua A (2016)	1
RNF41	2	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
RNF41	2	CLASP1	5	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	UBASH3B	4	affinity chromatography technology, pull down	Yang M (2015), Yang M (2015)	2
ZAP70	5	APP	1	pull down	Olah J (2011)	1
RFC4	1	RNF41	2	two hybrid, two hybrid, protein complementation assay	Rolland T (2014), Yu H (2011), Lievens S (2016)	3
PRKN	1	UBASH3A	3	pull down	Ikeda F (2007)	1
RNF41	2	ARL6IP4	2	two hybrid, protein complementation assay	Rolland T (2014), Lievens S (2016)	2
IFIT5	0	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF41	2	ASB6	1	two hybrid, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, fluorescent resonance energy transfe	Rolland T (2014), Huttlin EL (2017), Masschaele D (2017), Lievens S (2016), Lievens S (2016), Lievens S (2016)	6
ELAVL1	0	DVL2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF166	0	RNF41	2	two hybrid	Woodsmith J (2012)	1
MARK2	6	CLASP1	5	affinity chromatography technology	Hein MY (2015)	1
USP8	7	BIRC6	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pohl C (2008), Ge C (2015), Ge C (2015), Ge C (2015)	4
RNF41	2	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
ADRB2	0	TSG101	1	protein complementation assay	Kittanakom S (2014)	1
RNF41	2	KIFC3	3	affinity chromatography technology	Hein MY (2015)	1
ASB6	1	APP	1	pull down	Olah J (2011)	1
UPF3A	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRIM32	2	RNF41	2	two hybrid	Woodsmith J (2012)	1
UBE2Z	0	RNF166	0	two hybrid	Markson G (2009)	1
MTNR1A	1	IRS4	2	affinity chromatography technology, pull down	Daulat AM (2007), Benleulmi-Chaachoua A (2016)	2
CD247	1	RNF41	2	affinity chromatography technology, affinity chromatography technology	Yang M (2015), Yang M (2015)	2
IRS4	2	RCN1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
UBE2D3	1	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
LZTS2	4	SOGA1	1	affinity chromatography technology	Huttlin EL (2017)	1
MARK2	6	MARK4	6	affinity chromatography technology	Sowa ME (2009)	1
ITSN2	7	TACC1	2	two hybrid	Wong KA (2012)	1
ELAVL1	0	KDM3B	9	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D3	1	RFWD3	5	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
MNAT1	0	RNF41	2	two hybrid	Woodsmith J (2012)	1
ELAVL1	0	RNF41	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBASH3B	4	UBASH3A	3	affinity chromatography technology	Brehme M (2009)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
RNF41	2	NAV1	5	affinity chromatography technology	Hein MY (2015)	1
CREB3	1	RNF41	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
UBE2U	0	RNF41	2	two hybrid	van Wijk SJ (2009)	1
RNF41	2	DVL2	5	affinity chromatography technology	Sun EG (2017)	1
RNF41	2	EVI5	2	affinity chromatography technology	Hein MY (2015)	1
MARK2	6	SOGA1	1	affinity chromatography technology	Hein MY (2015)	1
C1orf109	1	LZTS2	4	two hybrid	Rolland T (2014)	1
RNF41	2	KDM3B	9	two hybrid	Masschaele D (2017)	1
RNF41	2	ERBB4	5	pull down, affinity chromatography technology, affinity chromatography technology	Diamonti AJ (2002), Sun EG (2017), Sun EG (2017)	3
HOMER2	0	LZTS2	4	two hybrid	Rolland T (2014)	1
RNF41	2	BIRC6	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wu X (2004), Qiu XB (2004), Qiu XB (2004), Qiu XB (2004)	4
HOMER2	0	APP	1	pull down	Olah J (2011)	1
PRKN	1	UBASH3B	4	pull down	Ikeda F (2007)	1
ERBB4	5	VANGL1	2	affinity chromatography technology	Sun EG (2017)	1
VPS52	0	RNF41	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, protein complementation assay, affinity chromatography technology, fluorescent resonance energy transfe	Rolland T (2014), Wijesuriya TM (2017), Masschaele D (2017), Masschaele D (2017), Masschaele D (2017), Masschaele D (2017), Masschaele D (2017), Lievens S (2016), Lievens S (2016), Lievens S (2016)	10
VPS52	0	C1orf109	1	two hybrid	Rolland T (2014)	1
MARK4	6	SOGA1	1	affinity chromatography technology	Brajenovic M (2004)	1
ZNF517	0	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF41	2	LZTS2	4	two hybrid	Rolland T (2014)	1
RNF41	2	RNF41	2	two hybrid, two hybrid, fluorescent resonance energy transfe	Woodsmith J (2012), Rolland T (2014), Masschaele D (2017)	3
TADA2A	1	RNF41	2	affinity chromatography technology	Krebs AR (2010)	1
HOMER2	0	RNF41	2	two hybrid, two hybrid, protein complementation assay	Rolland T (2014), Masschaele D (2017), Lievens S (2016)	3
ELAVL1	0	EVI5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
KIFC3	3	C1orf109	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TADA2A	1	MARK2	6	affinity chromatography technology	Krebs AR (2010)	1
KIFC3	3	APP	1	pull down	Olah J (2011)	1
GIP	0	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	UBASH3B	4	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2U	0	TRIM32	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
RNF41	2	ZAP70	5	affinity chromatography technology, pull down	Yang M (2015), Yang M (2015)	2
RNF41	2	LPGAT1	1	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	RTN4	4	affinity chromatography technology, affinity chromatography technology	Hatakeyama J (2016), Hatakeyama J (2016)	2
UBE2Z	0	RNF41	2	two hybrid	van Wijk SJ (2009)	1
TSG101	1	RNF41	2	two hybrid	Markson G (2009)	1
BHLHA15	0	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
H3F3A	1	RNF41	2	affinity chromatography technology	Heo K (2007)	1
RNF41	2	UBASH3A	3	affinity chromatography technology, pull down	Yang M (2015), Yang M (2015)	2
CD247	1	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mustelin T (1995), Wang HY (2001), La Face DM (1997), Huang H (2010), Huang H (2010), Hubert P (1996), Yang M (2015)	7
ERBB3	3	ZAP70	5	unspecified method	Jones RB (2006)	1
ELAVL1	0	ARHGAP19	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CLASP1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF41	2	MARK2	6	affinity chromatography technology, enzymatic study	Lewandowski KT (2013), Lewandowski KT (2013)	2
USP8	7	MAGEL2	6	two hybrid, bioid	Wijesuriya TM (2017), Wijesuriya TM (2017)	2
TTC1	3	RNF41	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay	Taipale M (2014), Taipale M (2014), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Lievens S (2016)	6
RNF41	2	PRKN	1	enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Yu F (2008), Zhong L (2005), Zhong L (2005), Zhong L (2005), Zhong L (2005)	5
UBE2K	0	RNF41	2	two hybrid	Markson G (2009)	1
RNF41	2	USP8	7	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe	Wu X (2004), Wu X (2004), Avvakumov GV (2006), Avvakumov GV (2006), Wijesuriya TM (2017), De Ceuninck L (2013), De Ceuninck L (2013), De Ceuninck L (2013)	8
TRIM8	6	RNF41	2	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
ENOPH1	0	RNF41	2	affinity chromatography technology, protein complementation assay	Huttlin EL (2017), Lievens S (2016)	2
RNF41	2	MTCL1	8	affinity chromatography technology	Hein MY (2015)	1
LCP1	0	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
ADRB2	0	RNF41	2	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
IRS4	2	P4HA1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
IL23A	0	RNF41	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	UBE2Z	0	pull down	Kazlauskaite A (2014)	1
PRKN	1	UBE2K	0	pull down	Kazlauskaite A (2014)	1
RFWD3	5	APP	1	pull down	Olah J (2011)	1
RNF41	2	C1GALT1C1	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	RFWD3	5	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF41	2	C1orf109	1	two hybrid	Rolland T (2014)	1
RNF41	2	APP	1	pull down	Olah J (2011)	1
TADA2A	1	C1orf109	1	two hybrid	Rolland T (2014)	1
VPS52	0	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
RNF41	2	CLEC16A	5	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	RFC4	1	affinity chromatography technology	Zanon A (2013)	1
ELAVL1	0	LPGAT1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ARHGAP19	4	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
RCN1	0	RNF41	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
ELAVL1	0	ASB6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
KIFC3	3	LZTS2	4	two hybrid	Rolland T (2014)	1
RNF41	2	SOGA1	1	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	N4BP3	0	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	VANGL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun EG (2017), Sun EG (2017), Wald JH (2017)	3
DVL2	5	ARL6IP4	2	affinity chromatography technology	Hein MY (2015)	1
MTNR1B	1	CLASP1	5	two hybrid	Benleulmi-Chaachoua A (2016)	1
SUGT1	1	CACYBP	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RNF41	2	RFWD3	5	affinity chromatography technology	Hein MY (2015)	1
ENOPH1	0	VPS52	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2U	0	RNF166	0	two hybrid	van Wijk SJ (2009)	1
MARK2	6	MTCL1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Hutchins JR (2010), Sato Y (2013), Sato Y (2013), Sato Y (2013), Sato Y (2013), Hein MY (2015)	7
RNF41	2	LEPR	3	protein complementation assay	Wauman J (2011)	1
MTNR1B	1	RNF41	2	two hybrid	Benleulmi-Chaachoua A (2016)	1
VANGL2	2	VANGL1	2	affinity chromatography technology	Puvirajesinghe TM (2016)	1
CACYBP	0	RNF41	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RNF41	2	ISCA2	1	two hybrid, protein complementation assay	Rolland T (2014), Lievens S (2016)	2
RNF41	2	ERBB3	3	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Diamonti AJ (2002), Qiu XB (2002), Qiu XB (2002), Fry WH (2011), Fry WH (2011), Bouyain S (2007), Hatakeyama J (2016)	7
ELAVL1	0	IFIT5	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1
RNF41	2	NPAT	4	affinity chromatography technology	Hein MY (2015)	1
VANGL2	2	RNF41	2	affinity chromatography technology	Wald JH (2017)	1