PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
URI1	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mita P (2016), Mita P (2016), Mita P (2016), Mita P (2016)	4
MDM2	2	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nihira NT (2017), Nihira NT (2017), Nihira NT (2017)	3
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
CBX1	0	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Chang CW (2008), Chang CW (2008), Ryan RF (1999), Rosnoblet C (2011), Moriyama T (2015), Huttlin EL (2017), Hauri S (2016)	8
ATM	9	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Bhatia N (2013), Li X (2017), Li X (2017), Li X (2017)	4
UBE2I	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rizos H (2005), Wang S (2015), Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	5
TRIM28	1	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique	Li X (2010), Li X (2010), Li X (2010), Li X (2010), Li X (2010)	5
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
PPP1CB	9	TRIM28	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Li X (2010), Li X (2010), Li X (2010), Li X (2010)	4
PPP1CB	9	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016), Mita P (2016)	3
CHD3	19	TP73	2	two hybrid	Minty A (2000)	1
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
IRF7	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Liang Q (2011), Liang Q (2011), Liang Q (2011), Liang Q (2011)	4
TRIM28	1	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Neo SH (2015), Neo SH (2015), Neo SH (2015), Neo SH (2015)	4
CBX5	3	ZNF274	3	affinity chromatography technology	Nozawa RS (2010)	1
PPP1CB	9	CDKN2A	1	affinity chromatography technology	Flores-Delgado G (2007)	1
CBX5	3	TRIM28	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2002), Cammas F (2002), Cammas F (2002), Nielsen AL (2001), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Ryan RF (1999), Rosnoblet C (2011), Hu C (2012), Hu C (2012), White D (2012), Nozawa RS (2010), Kubota S (2013), Kubota S (2013), Kubota S (2013), Garvin AJ (2013), Huttlin EL (2017), Hauri S (2016)	21
TP73	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Satija YK (2016), Satija YK (2016), Satija YK (2016), Satija YK (2016)	4
CBX3	1	TRIM28	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Bandyopadhyay S (2010), Ryan RF (1999), Higo S (2010), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	7
TRIM28	1	TRIM28	1	fluorescent resonance energy transfe, affinity chromatography technology, biochemical, pull down, enzymatic study, biochemical, pull down, pull down, enzymatic study	Germain-Desprez D (2003), Germain-Desprez D (2003), Peng H (2000), Peng H (2002), Doyle JM (2010), Peng H (2000), Peng H (2000), Kentsis A (2002), Garvin AJ (2013)	9
ZNF350	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee YK (2007), Liao G (2005), Nishitsuji H (2012), Lin LF (2013)	4
UBE2I	0	MDM2	2	pull down, affinity chromatography technology, enzymatic study, unspecified method	Buschmann T (2001), Buschmann T (2001), Buschmann T (2001), Buschmann T (2001)	4
TRIM28	1	SMARCAD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Seki Y (2010), Rowbotham SP (2011), Rowbotham SP (2011), Rowbotham SP (2011), Rowbotham SP (2011)	5
ATM	9	MAGEC2	0	affinity chromatography technology	Bhatia N (2013)	1
UBE2I	0	TP73	2	two hybrid	Minty A (2000)	1
SMARCAD1	1	CBX3	1	affinity chromatography technology, affinity chromatography technology	Rowbotham SP (2011), Rowbotham SP (2011)	2
RNF4	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Bruderer R (2011), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014)	5
MAGEA3	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Doyle JM (2010), Doyle JM (2010), Doyle JM (2010), Bhatia N (2011), Jin X (2017)	5
PPP1CA	3	MDM2	2	affinity chromatography technology	Liu X (2016)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
SIRT1	3	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lin Z (2012), Lin YH (2015), Lin YH (2015), Lin YH (2015)	4
UBE2I	0	RNF4	1	two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010)	2
ZNF10	0	TRIM28	1	two hybrid, pull down, biochemical, pull down, pull down, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, two hybrid, pull down	Moosmann P (1996), Peng H (2000), Peng H (2000), Losson R (2010), Frietze S (2010), Peng H (2007), Peng H (2007), Friedman JR (1996), Peng H (2000), Peng H (2000), Venturini L (1999), Peng H (2000)	12
FES	2	TRIM28	1	two hybrid, pull down, affinity chromatography technology, enzymatic study	Delfino FJ (2006), Delfino FJ (2006), Delfino FJ (2006), Delfino FJ (2006)	4
TRIM28	1	CHD3	19	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stelzl U (2005), Goodarzi AA (2011), Goodarzi AA (2011), Ivanov AV (2007), Garvin AJ (2013)	5
ZNF10	0	ZNF274	3	biochemical	Peng H (2007)	1
ZNF274	3	TRIM28	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Frietze S (2010), Frietze S (2010), Frietze S (2010), Frietze S (2010), Addison JB (2015), Huttlin EL (2017)	6
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
ZNF10	0	CBX3	1	pull down	Losson R (2010)	1
SIRT1	3	TP73	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Dai JM (2007), Dai JM (2007), Dai JM (2007)	3
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
ZNF274	3	MDM2	2	affinity chromatography technology	Huttlin EL (2017)	1
PPP1CA	3	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Cloutier P (2017), Mita P (2016), Yadav L (2017), Yadav L (2017)	8
FBP1	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Jin X (2017), Jin X (2017), Jin X (2017), Jin X (2017), Jin X (2017)	5
ATM	9	MDM2	2	enzymatic study, enzymatic study	Wang Z (2012), Luo H (2016)	2
PPP1CA	3	ATM	9	affinity chromatography technology	Flores-Delgado G (2007)	1
UBE2I	0	TRIM28	1	affinity chromatography technology, pull down, enzymatic study, pull down	Liang Q (2011), Garvin AJ (2013), Ivanov AV (2007), Neo SH (2015)	4
SIRT1	3	CHD3	19	affinity chromatography technology	Kim JE (2008)	1
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
MAGEC2	0	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Doyle JM (2010), Doyle JM (2010), Doyle JM (2010), Bhatia N (2011), Bhatia N (2011), Bhatia N (2013), Hao J (2014), Song X (2017), Jin X (2017)	10
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
SIRT1	3	UBE2I	0	enzymatic study	Hsieh YL (2013)	1