PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK9	3	TOB1	1	affinity chromatography technology, pull down, enzymatic study	Maekawa M (2002), Maekawa M (2002), Maekawa M (2002)	3
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
TOB1	1	PABPC1	5	affinity chromatography technology, pull down, affinity chromatography technology	Funakoshi Y (2007), Ezzeddine N (2007), Ezzeddine N (2007)	3
RNF219	1	CNOT2	2	affinity chromatography technology	Li S (2014)	1
TOB1	1	CNOT11	1	affinity chromatography technology	Huttlin EL (2017)	1
CORO7	0	TOB1	1	affinity chromatography technology, two hybrid, enzymatic study	Watanabe M (2011), Watanabe M (2011), Watanabe M (2011)	3
TOB1	1	APP	1	pull down	Olah J (2011)	1
FHL2	0	SMAD4	9	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
FBXL13	1	TOB1	1	affinity chromatography technology	Fung E (2018)	1
SKP2	2	TOB1	1	affinity chromatography technology, affinity chromatography technology	Hiramatsu Y (2006), Hiramatsu Y (2006)	2
CNOT2	2	CNOT11	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	3
CNOT11	1	FHL2	0	affinity chromatography technology	Huttlin EL (2017)	1
CNOT7	0	CNOT6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fabian MR (2009), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	4
TOB1	1	ATE1	2	affinity chromatography technology	Huttlin EL (2017)	1
CNOT11	1	CNOT10	0	affinity chromatography technology	Huttlin EL (2017)	1
CNOT6	2	CNOT1	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2007), Hein MY (2015), Boldt K (2016)	3
UBR5	13	TOB1	1	affinity chromatography technology	Su H (2011)	1
SMAD4	9	SMAD9	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Nishita M (1999), Li X (2015)	3
TOB1	1	CHAF1A	1	affinity chromatography technology	Ezzeddine N (2007)	1
CNOT1	10	CNOT9	1	biochemical, biochemical, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Chen Y (2014), Chen Y (2014), Chen Y (2014)	6
CNOT11	1	CNOT6L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
NXF1	0	CTNNB1	30	affinity chromatography technology	Castello A (2012)	1
CHAF1A	1	SETDB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loyola A (2009), Sarraf SA (2004), Sarraf SA (2004)	3
CNOT6	2	CNOT2	2	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
TOB1	1	SETDB1	3	two hybrid	Stelzl U (2005)	1
TOB1	1	SMAD4	9	affinity chromatography technology	Yoshida Y (2000)	1
CNOT6	2	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
SMAD4	9	SMAD5	2	affinity chromatography technology, two hybrid, two hybrid	Hanai J (1999), Haag J (2006), Colland F (2004)	3
CNOT2	2	TNKS1BP1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
ELAVL1	0	CNOT8	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TOB1	1	SMAD5	2	affinity chromatography technology	Yoshida Y (2000)	1
CNOT1	10	FHL2	0	affinity chromatography technology	Hein MY (2015)	1
PAN2	3	ELAVL1	0	affinity chromatography technology	Bett JS (2013)	1
MAPK1	1	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Purcell NH (2004), Purcell NH (2004), Purcell NH (2004), Purcell NH (2004)	4
MAPK1	1	SMAD1	0	enzymatic study, enzymatic study, enzymatic study	Sapkota G (2007), Alarcon C (2009), Fuentealba LC (2007)	3
TOB1	1	CNOT6	2	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	SKP2	2	affinity chromatography technology	Castello A (2012)	1
CNOT8	1	CNOT10	0	affinity chromatography technology	Ewing RM (2007)	1
CNOT7	0	CNOT9	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
DTL	0	TOB1	1	enzymatic study	Suzuki T (2012)	1
ELAVL1	0	CNOT6	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MARCKS	0	TOB1	1	affinity chromatography technology, pull down	Jin Cho S (2001), Jin Cho S (2001)	2
TOB1	1	RNF219	1	affinity chromatography technology	Huttlin EL (2017)	1
CNOT8	1	CNOT1	10	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Albert TK (2000), Winkler GS (2006), Winkler GS (2006), Hein MY (2015)	5
CNOT7	0	CNOT1	10	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
RNF219	1	TNKS1BP1	3	affinity chromatography technology	Li S (2014)	1
TOB1	1	CNOT6L	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	MAPK9	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee MH (2009), Lee MH (2009), Lee MH (2009)	3
CNOT2	2	FHL2	0	affinity chromatography technology	Hein MY (2015)	1
CNOT1	10	RAVER1	2	affinity chromatography technology	Hein MY (2015)	1
CNOT6L	1	CNOT3	11	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007)	2
CNOT7	0	CNOT2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
CNOT2	2	CNOT3	11	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Winkler GS (2006), Wan C (2015), Hein MY (2015)	4
CNOT11	1	CNOT8	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SMAD5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
ELAVL1	0	CNOT7	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CNOT7	0	CNOT3	11	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
ELAVL1	0	RAVER1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
ELAVL1	0	CNOT11	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CNOT11	1	CNOT6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CNOT7	0	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CNOT2	2	CNOT9	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
TOB1	1	TNKS1BP1	3	affinity chromatography technology	Huttlin EL (2017)	1
PABPC1	5	UBR5	13	x-ray crystallography	Kozlov G (2010)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
CNOT6L	1	CNOT6	2	affinity chromatography technology	Boldt K (2016)	1
SMAD3	1	PABPC1	5	affinity chromatography technology	Brown KA (2008)	1
ELAVL1	0	PABPC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
CNOT7	0	RAVER1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF219	1	CNOT1	10	affinity chromatography technology, affinity chromatography technology	Li S (2014), Hein MY (2015)	2
CNOT7	0	TNKS1BP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
CNOT6L	1	CNOT9	1	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007)	2
PAN2	3	PABPC1	5	affinity chromatography technology, pull down, affinity chromatography technology	Uchida N (2004), Ezzeddine N (2007), Bett JS (2013)	3
CNOT1	10	TOB1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
FHL2	0	APP	1	pull down	Olah J (2011)	1
TOB1	1	FHL2	0	affinity chromatography technology	Huttlin EL (2017)	1
TOB1	1	CNOT2	2	affinity chromatography technology	Huttlin EL (2017)	1
CNOT6	2	TNKS1BP1	3	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
CNOT1	10	CNOT11	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CNOT7	0	CNOT6L	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
CNOT6	2	CHAF1A	1	affinity chromatography technology	Morita M (2007)	1
ELAVL1	0	SKP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TOB1	1	CNOT10	0	affinity chromatography technology	Huttlin EL (2017)	1
CNOT7	0	CNOT11	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
CNOT11	1	RAVER1	2	affinity chromatography technology	Huttlin EL (2017)	1
TOB1	1	CTNNB1	30	affinity chromatography technology	Xiong B (2006)	1
RPS6KA1	3	TOB1	1	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Suzuki T (2001), Suzuki T (2001), Suzuki T (2001), Suzuki T (2001)	4
PABPC1	5	CNOT6	2	pull down	Ezzeddine N (2007)	1
CNOT11	1	CNOT3	11	affinity chromatography technology	Huttlin EL (2017)	1
CNOT6L	1	CNOT1	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007), Hein MY (2015)	3
CNOT2	2	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
TOB1	1	RAVER1	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	RNF219	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TOB1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TOB1	1	CNOT8	1	affinity chromatography technology	Huttlin EL (2017)	1
CNOT1	10	CNOT3	11	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Winkler GS (2006), Wan C (2015), Hein MY (2015)	4
MAPK1	1	UBR5	13	enzymatic study, affinity chromatography technology	Eblen ST (2003), Eblen ST (2003)	2
CNOT6L	1	CNOT2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2007), Hein MY (2015), Boldt K (2016)	3
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
SMAD1	0	APP	1	pull down	Olah J (2011)	1
CNOT1	10	TNKS1BP1	3	affinity chromatography technology	Hein MY (2015)	1
TOB1	1	SMAD9	0	affinity chromatography technology	Yoshida Y (2000)	1
CNOT6L	1	CHAF1A	1	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007)	2
CDC7	2	APP	1	pull down	Olah J (2011)	1
PABPC1	5	CHAF1A	1	pull down	Ezzeddine N (2007)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
TOB1	1	CNOT7	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi Y (2007), Ikematsu N (1999), Funakoshi Y (2007), Huttlin EL (2015), Huttlin EL (2017)	5
CNOT6	2	CNOT9	1	affinity chromatography technology	Morita M (2007)	1
SMAD4	9	SKP2	2	affinity chromatography technology, affinity chromatography technology, pull down	Yang L (2006), Liang M (2004), Liang M (2004)	3
MAPK1	1	TOB1	1	two hybrid, affinity chromatography technology, pull down, enzymatic study	Maekawa M (2002), Maekawa M (2002), Maekawa M (2002), Maekawa M (2002)	4
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
CNOT7	0	APP	1	pull down	Olah J (2011)	1
CNOT7	0	PABPC1	5	affinity chromatography technology, pull down	Funakoshi Y (2007), Funakoshi Y (2007)	2
NXF1	0	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
CNOT11	1	TNKS1BP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CNOT3	11	CNOT9	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CNOT3	11	CNOT8	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Albert TK (2000), Albert TK (2000), Winkler GS (2006)	3
CNOT1	10	CNOT2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Albert TK (2000), Winkler GS (2006), Winkler GS (2006), Hein MY (2015), Hein MY (2015), Boldt K (2016)	6
TOB1	1	SMAD3	1	affinity chromatography technology	Xiong B (2006)	1
SMAD3	1	SMAD9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD3	1	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
CNOT11	1	CNOT9	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
UBR5	13	CTNNB1	30	affinity chromatography technology	Flack JE (2017)	1
ELAVL1	0	MARCKS	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TOB1	1	CDC7	2	affinity chromatography technology, enzymatic study	Suzuki T (2012), Suzuki T (2012)	2
CNOT6L	1	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
CNOT2	2	CNOT8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Winkler GS (2006), Winkler GS (2006), Hein MY (2015)	3
ELAVL1	0	CNOT9	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CNOT6	2	CNOT3	11	affinity chromatography technology	Morita M (2007)	1
RPS6KA1	3	MAPK1	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Roux PP (2003), Eblen ST (2003), Smith JA (1999), Ding Q (2005), Varjosalo M (2013), Jahrling JB (2014), Smith JA (2000)	7
CNOT6L	1	TNKS1BP1	3	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
TOB1	1	SMAD1	0	affinity chromatography technology	Yoshida Y (2000)	1
CDC7	2	CHAF1A	1	enzymatic study, affinity chromatography technology	Gerard A (2006), Gerard A (2006)	2
TOB1	1	SCMH1	1	two hybrid	Stelzl U (2005)	1
TOB1	1	CNOT9	1	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	SMAD3	1	enzymatic study, affinity chromatography technology	Alarcon C (2009), Brown KA (2008)	2
NXF1	0	TOB1	1	affinity chromatography technology	Castello A (2012)	1
CNOT1	10	CNOT10	0	affinity chromatography technology	Hein MY (2015)	1
TOB1	1	CNOT3	11	affinity chromatography technology	Huttlin EL (2017)	1
RNF219	1	CNOT10	0	affinity chromatography technology	Li S (2014)	1
TOB1	1	PAN2	3	affinity chromatography technology	Ezzeddine N (2007)	1
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1
CTNNB1	30	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Wei Y (2003), Wei Y (2003), Wei Y (2003), Wei Y (2003)	4