PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
TRIM25	5	ZYX	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	NR2F2	4	affinity chromatography technology	Choudhury NR (2017)	1
HIPK3	5	NR2F2	4	two hybrid	Colland F (2004)	1
HNRNPA2B1	2	SRSF5	0	biochemical	Havugimana PC (2012)	1
CREB1	1	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Giebler HA (2000), Giebler HA (2000), Giebler HA (2000), Okoshi R (2011), Borger DR (2006), Chen TC (2014)	6
HNRNPA1	1	HNRNPH1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Wan C (2015), Hein MY (2015)	7
HIPK3	5	ZYX	2	two hybrid	Colland F (2004)	1
HNRNPL	3	LIMD1	4	affinity chromatography technology	Fei T (2017)	1
SUMO1	0	TP73	2	two hybrid	Minty A (2000)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
HIPK3	5	TP73	2	two hybrid	Minty A (2000)	1
UBE2I	0	HNRNPA1	1	biochemical	Wan C (2015)	1
SRSF5	0	TRA2B	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TRIM25	5	HIPK3	5	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
CREB1	1	TOX4	0	two hybrid	Bandyopadhyay S (2010)	1
HIPK3	5	TP53	0	two hybrid, affinity chromatography technology	Minty A (2000), Varjosalo M (2013)	2
HIPK3	5	GORASP1	1	two hybrid	Colland F (2004)	1
HIPK3	5	FAS	2	affinity chromatography technology	Rochat-Steiner V (2000)	1
UBE2I	0	SRSF1	0	affinity chromatography technology	Pelisch F (2010)	1
HIPK3	5	LIMS2	1	two hybrid	Colland F (2004)	1
HIPK3	5	HNRNPA1	1	unspecified method	Venables JP (2005)	1
HIPK3	5	SIAH2	0	two hybrid	Colland F (2004)	1
HIPK3	5	SUMO1	0	two hybrid	Minty A (2000)	1
TRIM25	5	GLUL	2	affinity chromatography technology	Choudhury NR (2017)	1
HIPK3	5	SIAH1	2	two hybrid	Colland F (2004)	1
HIPK3	5	HNRNPA2B1	2	unspecified method	Venables JP (2005)	1
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
TP53	0	HNRNPH1	3	affinity chromatography technology	Fogeron ML (2013)	1
GRB2	2	HNRNPA2B1	2	affinity chromatography technology	Li J (2013)	1
HIPK3	5	HNRNPH1	3	unspecified method	Venables JP (2005)	1
HIPK3	5	LIMK2	0	two hybrid	Colland F (2004)	1
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
HIPK3	5	ZNF107	2	two hybrid	Colland F (2004)	1
FAS	2	UBE2I	0	affinity chromatography technology, two hybrid, pull down, two hybrid	Becker K (1997), Wright DA (1996), Wright DA (1996), Wright DA (1996)	4
ARRB2	5	HNRNPA2B1	2	affinity chromatography technology	Xiao K (2007)	1
SRSF1	0	SRSF5	0	pull down	Xiao SH (1998)	1
UBE2I	0	TP73	2	two hybrid	Minty A (2000)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPH1	3	HNRNPA2B1	2	affinity chromatography technology, biochemical, biochemical	Jeronimo C (2007), Havugimana PC (2012), Wan C (2015)	3
HIPK3	5	ARRB2	5	two hybrid	Colland F (2004)	1
HIPK3	5	LIMD1	4	two hybrid	Colland F (2004)	1
HIPK3	5	FADD	1	affinity chromatography technology	Rochat-Steiner V (2000)	1
HIPK3	5	TGFB1I1	2	two hybrid	Colland F (2004)	1
HNRNPL	3	HIPK3	5	affinity chromatography technology	Fei T (2017)	1
HNRNPA1	1	SRSF1	0	affinity chromatography technology	Close P (2012)	1
TRIM25	5	HNRNPA2B1	2	affinity chromatography technology	Choudhury NR (2017)	1
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
SRSF1	0	TRA2B	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HIPK3	5	C1QA	0	two hybrid	Colland F (2004)	1
ARRB2	5	HNRNPH1	3	affinity chromatography technology	Xiao K (2007)	1
SIAH2	0	ZYX	2	pull down, affinity chromatography technology, affinity chromatography technology	Ma B (2016), Ma B (2016), Ma B (2016)	3
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPA1	1	HNRNPA2B1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Wan C (2015), Hein MY (2015)	6
SUMO1	0	FAS	2	two hybrid, pull down	Okura T (1996), Okura T (1996)	2
HIPK3	5	TOX4	0	two hybrid	Colland F (2004)	1
HNRNPL	3	ZNF107	2	affinity chromatography technology	Fei T (2017)	1
HIPK3	5	TRA2B	3	unspecified method	Venables JP (2005)	1
TRIM25	5	HNRNPA1	1	affinity chromatography technology	Choudhury NR (2017)	1
CREB1	1	HIPK3	5	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	HNRNPH1	3	affinity chromatography technology	Choudhury NR (2017)	1
HIPK3	5	MTMR4	1	two hybrid	Colland F (2004)	1
UBE2I	0	HIPK3	5	two hybrid	Bandyopadhyay S (2010)	1
TP53	0	HNRNPA2B1	2	affinity chromatography technology	Fogeron ML (2013)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
HNRNPA1	1	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
ARRB2	5	HNRNPA1	1	affinity chromatography technology	Xiao K (2007)	1
HIPK3	5	SRSF1	0	unspecified method	Venables JP (2005)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
TP53	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
HNRNPA2B1	2	HNRNPL	3	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hamilton BJ (1999), Havugimana PC (2012), Yao P (2013), Yao P (2013), Yao P (2013), Fei T (2017)	6
HIPK3	5	HEYL	1	two hybrid	Colland F (2004)	1
HIPK3	5	SRSF5	0	unspecified method	Venables JP (2005)	1
GLUL	2	HIPK3	5	two hybrid	Bandyopadhyay S (2010)	1
HNRNPH1	3	HNRNPL	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SIAH2	0	UBE2I	0	two hybrid, two hybrid, two hybrid	Depaux A (2007), Hu G (1997), Wang J (2011)	3
GLUL	2	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
HNRNPA1	1	TRA2B	3	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SRSF1	0	TP53	0	enzymatic study, affinity chromatography technology	Pelisch F (2010), Pelisch F (2010)	2
HNRNPL	3	ARRB2	5	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	MTMR4	1	affinity chromatography technology	Choudhury NR (2017)	1
GRB2	2	HIPK3	5	two hybrid	Bandyopadhyay S (2010)	1