Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TSPAN5	rs11947402	G	citalopram	efficacy	no	This is one of SNP showed some association with plasma serotonin concentrations and was suspected to be associated with SSRI clinical response. When tested in the PGRN-AMPS GWAS and in two independent SSRI response GWAS (STAR*D and ISPC) it was not associated with response in any cohort.	Allele G is not associated with response to citalopram and escitalopram in people with Depressive Disorder as compared to allele A.	26903268	1447979364
TSPAN5	rs11947402	G	serotonin	other	yes	in patients taking citalopram or escitalopram. Baseline plasma serotonin concentrations before SSRI therapy, as well as changes in serotonin were used as a biomarker for response to SSRIs and GWAS was done w/respect to changes in plasma serotonin concentration. The G allele was associated with higher baseline plasma serotonin concentrations, as well as greater decreases in plasma serotonin concentrations at 4 and 8 weeks after beginning SSRI therapy.	Allele G is associated with decreased concentrations of serotonin in people with Depressive Disorder as compared to allele A.	26903268	1447979316