PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS8	2	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
USH1C	2	TUBB1	1	affinity chromatography technology	Boldt K (2016)	1
USH1C	2	MIPOL1	1	two hybrid	Rolland T (2014)	1
USH1C	2	TUBA3C	1	affinity chromatography technology	Boldt K (2016)	1
USH1C	2	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
GPS1	1	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
FBXO7	1	USH1C	2	enzymatic study	Teixeira FR (2016)	1
FBXO7	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
USH1C	2	USHBP1	1	two hybrid, pull down	Ishikawa S (2001), Ishikawa S (2001)	2
USH1C	2	LTV1	1	affinity chromatography technology	Boldt K (2016)	1
COPS8	2	GPS1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Stotland A (2012), Sharon M (2009), Sun Y (2002), Kristensen AR (2012), Lingaraju GM (2014), Lyapina S (2001), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
UBA1	1	USH1C	2	biochemical	Havugimana PC (2012)	1
USH1C	2	MYO7A	6	pull down	Boeda B (2002)	1
RAC1	7	USH1C	2	two hybrid	Rolland T (2014)	1
USH1C	2	USH1C	2	two hybrid	Siemens J (2002)	1
COPS8	2	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
USH1G	1	USH1C	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
USH1C	2	WDR61	0	biochemical	Havugimana PC (2012)	1
CDH23	9	USH1C	2	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Boeda B (2002), Boeda B (2002), Siemens J (2002), Siemens J (2002), Siemens J (2002)	5
FBXO7	1	QKI	1	enzymatic study	Teixeira FR (2016)	1
SAAL1	0	USH1C	2	biochemical	Havugimana PC (2012)	1
USH1C	2	WDR20	6	affinity chromatography technology	Boldt K (2016)	1
USP46	5	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Cohn MA (2009), Cohn MA (2009), Lehoux M (2014), Lehoux M (2014), Huttlin EL (2015), Olazabal-Herrero A (2015), Olazabal-Herrero A (2015), Yin J (2015), Yin J (2015), Cukras S (2016), Huttlin EL (2017)	14
CTNNAL1	3	USH1C	2	two hybrid	Rolland T (2014)	1
WDR20	6	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Kee Y (2010), Kee Y (2010), Kee Y (2010), McClurg UL (2015), Cukras S (2016), Huttlin EL (2017)	8
QKI	1	USH1C	2	two hybrid	Lim J (2006)	1
WDR48	2	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
COPS8	2	USHBP1	1	two hybrid	Rolland T (2014)	1
USP46	5	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
USP46	5	WDR20	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Kee Y (2010), Joo HY (2011), Huttlin EL (2015), Huttlin EL (2017)	6
CDH23	9	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1