PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	DYRK1A	36	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF3	1	DCAF7	4	affinity chromatography technology	van Zuylen WJ (2012)	1
BYSL	3	TROAP	4	two hybrid, two hybrid, pull down	Suzuki N (1998), Suzuki N (1998), Suzuki N (1998)	3
DYRK1B	1	TROAP	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
DCAF7	4	DYRK1B	1	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Varjosalo M (2013), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Hauri S (2016)	9
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
C6orf141	1	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	TROAP	4	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	CDC16	2	affinity chromatography technology	Hill SJ (2014)	1
DYRK1A	36	CLTC	12	affinity chromatography technology, affinity chromatography technology	Murakami N (2009), Murakami N (2009)	2
BRCA1	7	DCAF7	4	affinity chromatography technology	Ertych N (2016)	1
KRT8	3	KRT40	0	two hybrid	Rolland T (2014)	1
BRCA1	7	DYRK1A	36	affinity chromatography technology	Ertych N (2016)	1
LZTS2	4	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
BYSL	3	KRT8	3	two hybrid	Suzuki N (1998)	1
CLTC	12	TROAP	4	affinity chromatography technology	Hein MY (2015)	1
TRAF2	1	CCNJL	3	two hybrid	Rolland T (2014)	1
NINL	1	TROAP	4	bioid	Gupta GD (2015)	1
BYSL	3	KRT31	0	two hybrid	Rolland T (2014)	1
DCAF7	4	DYRK1A	36	biochemical, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Varjosalo M (2013), Miyata Y (2014), Miyata Y (2014), Glenewinkel F (2016), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Boldt K (2016), Hauri S (2016)	18
DCAF7	4	TROAP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
DYRK1A	36	TROAP	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
MAPRE1	0	TRAF2	1	two hybrid	Li D (2014)	1
TRAF3	1	TROAP	4	affinity chromatography technology	van Zuylen WJ (2012)	1
MAPRE1	0	MAPRE3	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Xia P (2012), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	5
DCAF7	4	FNTB	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
PPP2R3A	4	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
TROAP	4	BANP	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
SPICE1	2	TROAP	4	bioid	Gupta GD (2015)	1
KRT31	0	TROAP	4	two hybrid	Rolland T (2014)	1
DYRK1A	36	LZTS2	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
CELA3A	2	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
TROAP	4	KRT40	0	two hybrid	Rolland T (2014)	1
BYSL	3	LZTS2	4	two hybrid	Rolland T (2014)	1
KRT8	3	KRT31	0	two hybrid	Rolland T (2014)	1
BYSL	3	TRO	1	two hybrid	Suzuki N (1998)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TRAF2	1	BANP	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TROAP	4	SUOX	3	affinity chromatography technology	Huttlin EL (2017)	1
ASB3	0	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	LZTS2	4	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	BRCA1	7	affinity chromatography technology	Rodriguez J (2016)	1
TROAP	4	TROAP	4	two hybrid	Suzuki N (1998)	1
TRAF3	1	DYRK1A	36	affinity chromatography technology	van Zuylen WJ (2012)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
SIRT6	2	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
NINL	1	DCAF7	4	bioid	Gupta GD (2015)	1
LYPD4	1	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	ASB3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TROAP	4	TRO	1	pull down	Suzuki N (1998)	1
BYSL	3	KRT40	0	two hybrid	Rolland T (2014)	1
MAPRE1	0	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
DYRK1A	36	FNTB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDC16	2	TROAP	4	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TROAP	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TROAP	4	MAPRE3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
EGLN3	0	TROAP	4	affinity chromatography technology	Rodriguez J (2016)	1
TRAF2	1	TROAP	4	two hybrid	Rolland T (2014)	1
FNTB	0	TROAP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	DYRK1A	36	affinity chromatography technology	Rodriguez J (2016)	1
CCNJL	3	TROAP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TROAP	4	TRIM23	3	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
TROAP	4	MAPRE1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
BRCA1	7	CLTC	12	affinity chromatography technology	Ertych N (2016)	1
DYRK1B	1	LZTS2	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2017)	4
TROAP	4	KRT8	3	pull down	Suzuki N (1998)	1