Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
SH2B3	10019	RUXOLITINIB	CHEMBL1789941		CGI	22897847, 22955920
SH2B3	10019	PAZOPANIB	CHEMBL477772	inhibitor	DrugBank	23072642

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
SH2B3	rs3184504	T	hydrochlorothiazide	efficacy	no	Not significant when using Bonferroni-corrected alpha of 0.0014. Response was assessed by change in diastolic blood pressure (DBP) after 9 weeks of treatment.	Allele T is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele C.	23087401	1183491528
SH2B3	rs3184504	C	hydrochlorothiazide	efficacy	no	Not significant when using Bonferroni-corrected alpha of 0.0014. Response was assessed by change in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after 9 weeks of treatment.	Allele C is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele T.	23087401	1183491511
SH2B3	rs3184504	T	candesartan	efficacy	yes	The T allele was significantly associated with a decrease in systolic blood pressure compared to the C allele.	Allele T is associated with increased response to candesartan in people with Hypertension as compared to allele C.	31327267	1451117480