PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
PCDHGB1	3	CDH3	3	affinity chromatography technology	Huttlin EL (2017)	1
CDH3	3	CTNNA1	7	biochemical, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999)	3
CFTR	5	CDH1	4	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
CDH1	4	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Hazan RB (1998), Shibata T (1994), Hinck L (1994), Knudsen KA (1992), Geng F (2012), Guo Z (2014)	7
CTNNB1	30	CTNND1	4	affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Kucerova D (2001)	2
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
CFTR	5	CTNNA1	7	affinity chromatography technology	Pankow S (2015)	1
CTNNA3	3	CDH3	3	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	CTNND1	4	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	CDH3	3	affinity chromatography technology	Li J (2013)	1
CDH3	3	CTNNB1	30	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999), Ribeiro AS (2013)	4
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
AP2M1	5	CTNND1	4	affinity chromatography technology	Li J (2013)	1
AP2M1	5	CDH1	4	affinity chromatography technology	Li J (2013)	1
CFTR	5	CTNNB1	30	affinity chromatography technology	Pankow S (2015)	1
CDH3	3	JUP	7	affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000)	2
CDH1	4	CTNND1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid	Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014)	22
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
CDH3	3	CDH3	3	biochemical, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000)	2
CTNNA3	3	CDH1	4	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Janssens B (2001), Waaijers S (2013), Chen TC (2014), Huttlin EL (2017)	4
CTNND1	4	CDH3	3	affinity chromatography technology, affinity chromatography technology	Reynolds AB (1996), Ribeiro AS (2013)	2
JUP	7	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, biochemical, imaging technique	Roe S (1998), Roe S (1998), Sacco PA (1995), Obama H (1997), Bandyopadhyay S (2010), Havugimana PC (2012), Wan C (2015), Chen TC (2014)	8
CFTR	5	CDH3	3	affinity chromatography technology	Pankow S (2015)	1
CTNNA3	3	CTNNA1	7	affinity chromatography technology	Waaijers S (2013)	1
AP2M1	5	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
CTNNA3	3	JUP	7	affinity chromatography technology, affinity chromatography technology	Waaijers S (2013), Waaijers S (2013)	2
CDH3	3	CDH1	4	affinity chromatography technology, affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000), Klingelhoefer J (2000)	3
CTNNA1	7	CTNND1	4	affinity chromatography technology	Daniel JM (1995)	1