PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXO7	1	GSK3B	1	enzymatic study, affinity chromatography technology, pull down	Teixeira FR (2016), Teixeira FR (2016), Teixeira FR (2016)	3
730211	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
FBXO7	1	AKT3	3	enzymatic study	Teixeira FR (2016)	1
730211	0	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
TOX2	0	AKT3	3	affinity chromatography technology	Huttlin EL (2017)	1
AKT3	3	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT3	3	RPE	3	biochemical	Wan C (2015)	1
TCL1A	0	AKT3	3	affinity chromatography technology	Laine J (2002)	1
AKT3	3	PRMT6	2	affinity chromatography technology	Huttlin EL (2017)	1
AKT3	3	FKBP5	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT3	3	SNX8	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	AKT3	3	affinity chromatography technology	Reitsma JM (2017)	1
AKT1	1	TTC3	1	affinity chromatography technology, enzymatic study, pull down	Suizu F (2009), Suizu F (2009), Suizu F (2009)	3
AKT3	3	664618	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT3	3	3327	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
TCL1A	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid	Laine J (2002), Laine J (2000), French SW (2002), French SW (2002), Rolland T (2014), Daakour S (2016)	6
CDC37	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Basso AD (2002), Basso AD (2002), Kim H (2014), Sun L (2012)	4
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
PIANP	0	AKT3	3	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	EIF4EBP1	1	imaging technique	Chen TC (2014)	1
AKT1	1	RPE	3	biochemical	Wan C (2015)	1
AKT1	1	HSP90AB1	2	affinity chromatography technology	Sato S (2000)	1
GSK3B	1	HSP90AA1	7	enzymatic study	Muller P (2012)	1
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
AKT3	3	PLEKHO1	1	affinity chromatography technology	Tokuda E (2007)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
AKT3	3	3323	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT3	3	TTC3	1	affinity chromatography technology	Suizu F (2009)	1
AKT1	1	PPP2CA	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Beaulieu JM (2008), Beaulieu JM (2008), Calvo N (2010), Calvo N (2010), Xiao L (2010), Guo J (2016), Guo J (2016), Guo J (2016)	8
PRKCZ	5	GSK3B	1	imaging technique	Chen TC (2014)	1
AKT3	3	EIF4EBP1	1	biochemical	Wan C (2015)	1
FKBP5	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
PRKCZ	5	HSP90AA1	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Taipale M (2012), Taipale M (2012)	3
CUL1	7	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
AKT3	3	HSP90AB1	2	affinity chromatography technology	Huttlin EL (2017)	1
3327	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
AKT3	3	HSP90AA1	7	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	AKT3	3	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
GSK3B	1	EIF4EBP1	1	two hybrid	Vinayagam A (2011)	1
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
CASP3	0	AKT3	3	imaging technique	Chen TC (2014)	1
CUL1	7	AKT1	1	affinity chromatography technology	Reitsma JM (2017)	1
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
PLEKHO1	1	AKT1	1	pull down, affinity chromatography technology	Tokuda E (2007), Tokuda E (2007)	2
FKBP5	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mistafa O (2010), Luo K (2017), Luo K (2017)	3
AKT3	3	AKT1	1	affinity chromatography technology	Huttlin EL (2017)	1
PPP2CA	7	AKT3	3	affinity chromatography technology, pull down	Guo J (2016), Guo J (2016)	2
NEDD4L	3	AKT3	3	enzymatic study	Persaud A (2009)	1
KCTD12	0	AKT3	3	affinity chromatography technology	Zhong Y (2017)	1
CUL1	7	HSP90AB1	2	affinity chromatography technology	Bennett EJ (2010)	1
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
NEDD4	2	CUL1	7	affinity chromatography technology	Liu J (2014)	1
AKT3	3	730211	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKCZ	5	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Doornbos RP (1999), Wang J (2008), Wang J (2008), Joshi J (2008), Joshi J (2008)	5
AKT3	3	PRKCZ	5	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Hodgkinson CP (2002), Hodgkinson CP (2002), Hodgkinson CP (2002), Hodgkinson CP (2002), Chen TC (2014)	5
AKT3	3	GSK3B	1	enzymatic study, enzymatic study	Dragoi AM (2005), Guo J (2016)	2