Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ADA 100 DIPYRIDAMOLE CHEMBL932 inhibitor TdgClinicalTrial, TEND, DrugBank, TTD 11752352
ADA 100 CHEMBL125386 CHEMBL125386 DrugBank 10592235
ADA 100 CHEMBL93560 CHEMBL93560 DrugBank 10592235
ADA 100 CHEMBL327830 CHEMBL327830 DrugBank 10592235
ADA 100 CHEMBL92404 CHEMBL92404 DrugBank 10592235
ADA 100 CHEMBL1255648 CHEMBL1255648 NCI 10639753
ADA 100 METHOTREXATE CHEMBL34259 NCI 2431676
ADA 100 CLADRIBINE CHEMBL1619 inhibitor TTD
ADA 100 CHEMBL328139 CHEMBL328139 DrugBank 10592235
ADA 100 PENTOSTATIN CHEMBL1580 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 2433905, 11752352, 17309302, 10887639
ADA 100 CHEMBL93647 CHEMBL93647 DrugBank 10592235
ADA 100 CHEMBL338076 CHEMBL338076 DrugBank 10592235
ADA 100 AMITRIPTYLINE CHEMBL629 NCI 16283318
ADA 100 LEVODOPA CHEMBL1009 NCI 11134247
ADA 100 FLUDARABINE CHEMBL1568 inhibitor TTD
ADA 100 CHEMBL115824 CHEMBL115824 DrugBank 17139284, 17016423, 10592235
ADA 100 NEBULARINE CHEMBL1399702 DrugBank 17139284, 17016423, 10592235
ADA 100 (+)-EHNA CHEMBL296435 DrugBank 10592235
ADA 100 CHEMBL23094 CHEMBL23094 NCI 3496090
ADA 100 EHNA CHEMBL50378 inhibitor GuideToPharmacologyInteractions
ADA 100 HYDROCORTISONE CHEMBL389621 NCI 2395837
ADA 100 HYDROGEN PEROXIDE CHEMBL71595 NCI 15966013
ADA 100 GARLIC CHEMBL2108463 NCI 7604070
ADA 100 TARGININE CHEMBL256147 NCI 1846547

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ADA rs244076 C methotrexate efficacy yes although not significant after Bonferroni correction. Allele C is associated with decreased response to methotrexate in people with Arthritis, Rheumatoid. 19902562 769173638
ADA rs73598374 C methotrexate toxicity no Discontinuation due to adverse effects. Please note that alleles have been complemented to the plus chromosomal strand. Allele C is not associated with discontinuation of methotrexate in people with Arthritis, Rheumatoid as compared to allele T. 27217051 1449164974